LOCUS       NM_144552               4309 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus syntaxin binding protein 6 (amisyn) (Stxbp6),
            transcript variant 1, mRNA.
ACCESSION   NM_144552
VERSION     NM_144552.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4309)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   3  (bases 1 to 4309)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4309)
  AUTHORS   Suzuki,M., Kobayashi,M., Ohno,T., Kanamori,S., Tateishi,S.,
            Murai,A. and Horio,F.
  TITLE     Genetic dissection of the fatty liver QTL Fl1sa by using congenic
            mice and identification of candidate genes in the liver and
            epididymal fat
  JOURNAL   BMC Genet 17 (1), 145 (2016)
   PUBMED   27855657
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4309)
  AUTHORS   Collins,S.C., Do,H.W., Hastoy,B., Hugill,A., Adam,J.,
            Chibalina,M.V., Galvanovskis,J., Godazgar,M., Lee,S.,
            Goldsworthy,M., Salehi,A., Tarasov,A.I., Rosengren,A.H., Cox,R. and
            Rorsman,P.
  TITLE     Increased Expression of the Diabetes Gene SOX4 Reduces Insulin
            Secretion by Impaired Fusion Pore Expansion
  JOURNAL   Diabetes 65 (7), 1952-1961 (2016)
   PUBMED   26993066
  REMARK    GeneRIF: These data suggest that increased SOX4 expression inhibits
            insulin secretion and increased diabetes risk by the upregulation
            of STXBP6 and an increase in kiss-and-run exocytosis at the expense
            of full fusion.
REFERENCE   6  (bases 1 to 4309)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 4309)
  AUTHORS   Huang,T.N., Chuang,H.C., Chou,W.H., Chen,C.Y., Wang,H.F., Chou,S.J.
            and Hsueh,Y.P.
  TITLE     Tbr1 haploinsufficiency impairs amygdalar axonal projections and
            results in cognitive abnormality
  JOURNAL   Nat Neurosci 17 (2), 240-247 (2014)
   PUBMED   24441682
REFERENCE   8  (bases 1 to 4309)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   9  (bases 1 to 4309)
  AUTHORS   Vadasz,C., Saito,M., Gyetvai,B.M., Oros,M., Szakall,I.,
            Kovacs,K.M., Prasad,V.V., Morahan,G. and Toth,R.
  TITLE     Mapping of QTLs for oral alcohol self-administration in B6.C and
            B6.I quasi-congenic RQI strains
  JOURNAL   Neurochem Res 32 (7), 1099-1112 (2007)
   PUBMED   17273929
REFERENCE   10 (bases 1 to 4309)
  AUTHORS   Ghazalpour,A., Doss,S., Zhang,B., Wang,S., Plaisier,C.,
            Castellanos,R., Brozell,A., Schadt,E.E., Drake,T.A., Lusis,A.J. and
            Horvath,S.
  TITLE     Integrating genetic and network analysis to characterize genes
            related to mouse weight
  JOURNAL   PLoS Genet 2 (8), e130 (2006)
   PUBMED   16934000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974582.5, AC159616.2 and AC159234.2.
            
            On Aug 24, 2022 this sequence version replaced NM_144552.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.162229.1,
                                           ERR3363658.1366449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               CR974582.5         143161-143431       c
            272-460             CR974582.5         88433-88621         c
            461-591             AC159616.2         86165-86295
            592-757             AC159616.2         87116-87281
            758-915             AC159616.2         127773-127930
            916-4309            AC159234.2         148191-151584       c
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 20.71 cM"
     gene            1..4309
                     /gene="Stxbp6"
                     /note="syntaxin binding protein 6 (amisyn)"
                     /db_xref="GeneID:217517"
                     /db_xref="MGI:MGI:2384963"
     exon            1..271
                     /gene="Stxbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            272..460
                     /gene="Stxbp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..939
                     /gene="Stxbp6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amisyn; syntaxin-binding protein 6"
                     /codon_start=1
                     /product="syntaxin-binding protein 6 isoform 1"
                     /protein_id="NP_653135.2"
                     /db_xref="CCDS:CCDS25898.1"
                     /db_xref="GeneID:217517"
                     /db_xref="MGI:MGI:2384963"
                     /translation="MSAKSAISKEIFAPLDERMLGAIQVKRRTKKKIPFLATGGQGEY
                     LTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNRDSAEFDL
                     LFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAAD
                     SVTSAVQKASQALNERGERLGRAEEKTEDMKNSAQQFAETAHKLAMKHKC"
     exon            461..591
                     /gene="Stxbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            592..757
                     /gene="Stxbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            758..915
                     /gene="Stxbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            916..4309
                     /gene="Stxbp6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1545..1550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stxbp6"
                     /note="hexamer: AATAAA"
     polyA_site      1572
                     /gene="Stxbp6"
     regulatory      4284..4289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stxbp6"
                     /note="hexamer: ATTAAA"
     polyA_site      4309
                     /gene="Stxbp6"
                     /note="major polyA site"
ORIGIN      
        1 gcactcggcg gcagcgggcc ggcgcgaggc tgcagctgga gctctggcgc ccggagttgg
       61 agttgccagg agtttccccg acccctccct cctcgcgcac agcggcagga gcccgcgcgg
      121 gagcggcgag ccgcgatcag ccagaagccg agccggccca gcttagtctg cagccccgat
      181 ctccgcgcgg ggcagccgcg ggggagccct gtcttcggtt gggacgcgtg ccgcgcacta
      241 ggcaccgccc gagcacgagc caggctgcac gaaaattccc tgcgtgccct cctgggtggc
      301 tctacaatga gtgccaagtc tgccatcagc aaggaaattt ttgcacctct tgatgaaaga
      361 atgctgggag ccatccaagt caagagaagg acaaagaaaa agattccttt cttggcaact
      421 gggggtcaag gcgaatactt aacttatatc tgcctgtcag tgacaaacaa aaaacccaca
      481 caggcatcta tcacgaaggt caaacagttt gagggctcca catcattcgt ccgaagatcc
      541 caatggatgc ttgagcagct tcgccaagtt aatggtattg atcctaatcg ggattctgca
      601 gagtttgatt tgttgtttga aaatgccttt gaccagtggg ttgctagcac ggcctcagaa
      661 aagtgcacct tcttccagat cctccaccac acctgccaga ggtacctcac agacaggaag
      721 ccagagttta ttaactgcca atccaaaatt atgggaggaa acagcatcct ccattcagca
      781 gctgatagtg tgaccagtgc agtacagaag gcaagccagg ccttgaacga gcgtggggaa
      841 cggttaggcc gagcagagga gaagacagaa gacatgaaga acagtgccca gcagtttgca
      901 gaaaccgcac acaagcttgc catgaagcat aaatgttgag aaactgccta tcctggtgaa
      961 gctctaaaga aagtggagga gtttgttcag cagttattac aagacgtcca gacggggctg
     1021 cttctttggt tttgctgttt tgtttgtttg tttgtttctc tttctttctt tctttccttc
     1081 tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt tctttctttc
     1141 tttctttccc aatataagga cattgaaggg tttgattctt catggtcaga tgttaatatg
     1201 aatgaatggc agcatgctgt gggcatatat ttccctatct tgctaaagaa tgctgcaata
     1261 gtgtcagctt catttttact ttttccattg tctgtgtgtg tgtgtgtgtg tgtatgtgtg
     1321 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatgtatatc tgtgtgtgtg
     1381 catatgttcc ttttgaagaa aaattgtttt tgtagttcaa atacgaaatt cagaccaaat
     1441 aataagccag gtataaattg gcaaaatgta tttttttgtt tctctctgta actaagcaac
     1501 aaaatagttc aatatggtgg catcaggtga tggtcctggg tacaaataaa agccacataa
     1561 tgctttcgcc tactctccta gtcctcttca tttgaagaga aaaattaaaa tttattatct
     1621 tgagactcaa gtctgtactg tggtaaacac atgggcatat caggggaatt ggattttgtc
     1681 ttttcatgtt aatctttttg catgaaccat caagagcatt cacaaaatac aaatcagaat
     1741 ctcaaataga aatctactct ctgggctgac acataaacat ttctgttcct tccttccagt
     1801 ctgactagtt ggaattatca tatgaaggac aaaaatttga atgtaaagac ctaccgtaaa
     1861 atataattta aaacttccat agatttatgg atatttctct tgttgtcatt atatcatagc
     1921 taacatgggg gtggggagga cttatatttc taacaacaaa tagtatatct agggtcagtg
     1981 aggtggctcg gtgaatgaag gtgcttatgg cataaacctg gccactagac cccacagatt
     2041 tgacctctga cctccaccca catttcccag cacacatatg tacaccatat aaagacacat
     2101 acacaaaaca acataataat gcataaagtc aaataaaaag aagtaatttg tctagataaa
     2161 agtatataaa ttataacgtg tcaagatgct actttgtttt ttgctctttt gacaaagcta
     2221 agcctaattt tagaggctct ctcacaagat ccttgggaat gaacctttag tttcttggta
     2281 tctgggtttt ggaggtttcg gtattgttgt gttttttagt ttctttcgtg ccgtttaaca
     2341 tgtacttctt gatagattgc atactcgtca gtttcaactt gcctggtctg atacaggcag
     2401 cacaatgaca ggcctttaca gtgctgtcag attgaacaga gtctcttcca ggcctttggg
     2461 ttatgtgttg ctcaaggtaa tactgcactt agactgtgga aattttgttt tctcgagggt
     2521 taaaagctaa acattaaaaa taaaataaaa aacatgcttg ttcctcataa agcaatgagg
     2581 caagctacac atgccacata ctgcagtgca tggagttttc agacgcctgg gtcgccagga
     2641 ccctctcctt ctttgctctc caccgagtca cctgtttact tgtgatgtag tctctaataa
     2701 tgcagcaacg taagatgacg ttagattact aatgctgatt taaatagctt acgttttcct
     2761 aataacacat cccctgagaa agagcacatt tttccgtgga ataccatagg tataatgtca
     2821 ggaagaggat gggatttgct gcaaacaagt gtaataatcc ttttaggcag ataatccagg
     2881 tgaagaacat actatacaat gtacatagag gactatgaat gtttactata tcttacgctt
     2941 ttctttaggt gtcttacaat tttaaaaaag ccaggaacct gtcatctgct gactattgga
     3001 actatctgat tcctaaaaaa taagaataaa aggcccccaa ataatacccc aaattggttt
     3061 cattggcaga ctttagctca gaaaacacaa atatttgtct tccaaaactg gattctagtt
     3121 tcagaggact gatataaata gttgagagaa atagtctaac tttccccaca caagtcaaca
     3181 ataaaattgc ttgttggcta tctgacaact ttgggccaac tgttcctgaa caggcagaag
     3241 cacactgaaa gctgagtctt cctccttagc atatagatgt aaatgccctg cacctgccct
     3301 cttcctattc cctctcttga tcagttttgg cctaaaactt gttggaaata gtctgaacta
     3361 aaaggaaccc tcttctcacc cccaaagccc tgttagcttc ctctatggat cagtcagtat
     3421 ctaggccatc accatgactt cggtctatga tccttcctgc ttgtcttcca ccaaacacac
     3481 aggctataag agcaattgct gccccttctc agctgtccag cctcttgcag agaaatccct
     3541 gataacacat gtggaacccc tgatgacaca tgtgaaaccc ttaataacac atgtgaaatc
     3601 cattgcaatc ctttggtaaa aggtactgaa atgtaaaatg ctaacgcagt gtaaccagca
     3661 tgaatttgtt aagaggacgc ctggcgtatg ggaccaggtc atttggttga gcttgctaga
     3721 acacttaagg tgttgatttt gtttctgcac ttcactatga attctggaaa tgctgtcttt
     3781 ctccaaagga ctttgcaaat tatattgaca atgcattaaa aaaggaactt gccagcattt
     3841 ccacttcttc ctggaatgta gctgtagtgg tcttcactag aatgatagat ctctgtgttc
     3901 aggctctatg cagttattca ggttgatgtt tcatttcaaa gaatgtattt gtaaaatgta
     3961 acaggaccag tagctaactt ttttttaagg tctggtagaa gtaatagtat gtgttagact
     4021 taaaattata gtgaaatctg ttttatacta ttgtgactag cagagattat gcatttatgt
     4081 agaaacagtt acagagtgcc ctaaataaga gatactagtt aagataggtt ccattcctaa
     4141 tttcagaatt gtgatgctgc taatgtgtgg tgttcttggt ttttcagaaa ttctctatga
     4201 tattgagtac catttttgtt tcattcagag acaagttaac agctgttctt ttggttcact
     4261 attagagcaa ctcagatttt gtcattaaat attttaactc tctggtgaa
//
