LOCUS       NM_172440              12064 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus syntaxin binding protein 5-like (Stxbp5l), transcript
            variant xb, mRNA.
ACCESSION   NM_172440
VERSION     NM_172440.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12064)
  AUTHORS   Geerts,C.J., Mancini,R., Chen,N., Koopmans,F.T.W., Li,K.W.,
            Smit,A.B., van Weering,J.R.T., Verhage,M. and Groffen,A.J.A.
  TITLE     Tomosyn associates with secretory vesicles in neurons through its
            N- and C-terminal domains
  JOURNAL   PLoS One 12 (7), e0180912 (2017)
   PUBMED   28746398
  REMARK    GeneRIF: Data indicate that bidirectional moving tomosyn-1 (Stxbp5)
            and tomosyn-2 (Stxbp5l) puncta were observed.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12064)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 12064)
  AUTHORS   Geerts,C.J., Plomp,J.J., Koopmans,B., Loos,M., van der Pijl,E.M.,
            van der Valk,M.A., Verhage,M. and Groffen,A.J.
  TITLE     Tomosyn-2 is required for normal motor performance in mice and
            sustains neurotransmission at motor endplates
  JOURNAL   Brain Struct Funct 220 (4), 1971-1982 (2015)
   PUBMED   24744148
  REMARK    GeneRIF: tomosyn-2 supports motor performance by regulation of
            transmitter release willingness to sustain synaptic strength during
            high-frequency transmission, which makes this gene a candidate for
            involvement in neuromuscular disorders.
REFERENCE   4  (bases 1 to 12064)
  AUTHORS   Bhatnagar,S., Soni,M.S., Wrighton,L.S., Hebert,A.S., Zhou,A.S.,
            Paul,P.K., Gregg,T., Rabaglia,M.E., Keller,M.P., Coon,J.J. and
            Attie,A.D.
  TITLE     Phosphorylation and degradation of tomosyn-2 de-represses insulin
            secretion
  JOURNAL   J Biol Chem 289 (36), 25276-25286 (2014)
   PUBMED   25002582
  REMARK    GeneRIF: Data indicate that glucose induces phosphorylation,
            ubiquitination, and degradation of tomosyn-2.
REFERENCE   5  (bases 1 to 12064)
  AUTHORS   Li,Q., Zheng,S., Han,A., Lin,C.H., Stoilov,P., Fu,X.D. and
            Black,D.L.
  TITLE     The splicing regulator PTBP2 controls a program of embryonic
            splicing required for neuronal maturation
  JOURNAL   Elife 3, e01201 (2014)
   PUBMED   24448406
  REMARK    Erratum:[Elife. 2017 Oct 09;6:. PMID: 28990924]
REFERENCE   6  (bases 1 to 12064)
  AUTHORS   Schmidt,C., Gonzaludo,N.P., Strunk,S., Dahm,S., Schuchhardt,J.,
            Kleinjung,F., Wuschke,S., Joost,H.G. and Al-Hasani,H.
  TITLE     A meta-analysis of QTL for diabetes-related traits in rodents
  JOURNAL   Physiol Genomics 34 (1), 42-53 (2008)
   PUBMED   18397992
REFERENCE   7  (bases 1 to 12064)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 12064)
  AUTHORS   Groffen,A.J., Jacobsen,L., Schut,D. and Verhage,M.
  TITLE     Two distinct genes drive expression of seven tomosyn isoforms in
            the mammalian brain, sharing a conserved structure with a unique
            variable domain
  JOURNAL   J Neurochem 92 (3), 554-568 (2005)
   PUBMED   15659226
REFERENCE   9  (bases 1 to 12064)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human LLGL4 gene and mouse
            Llgl4 gene in silico
  JOURNAL   Int J Oncol 24 (3), 737-742 (2004)
   PUBMED   14767561
REFERENCE   10 (bases 1 to 12064)
  AUTHORS   Stoehr,J.P., Nadler,S.T., Schueler,K.L., Rabaglia,M.E.,
            Yandell,B.S., Metz,S.A. and Attie,A.D.
  TITLE     Genetic obesity unmasks nonlinear interactions between murine type
            2 diabetes susceptibility loci
  JOURNAL   Diabetes 49 (11), 1946-1954 (2000)
   PUBMED   11078464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116468.13, AC113964.18 and AC155254.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by NM_172440.4.
            
            On Feb 14, 2008 this sequence version replaced NM_172440.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY542324.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC116468.13        72689-72837         c
            150-343             AC116468.13        71391-71584         c
            344-441             AC116468.13        32950-33047         c
            442-523             AC116468.13        17755-17836         c
            524-624             AC113964.18        5598-5698
            625-759             AC113964.18        38163-38297
            760-823             AC113964.18        40876-40939
            824-907             AC113964.18        67259-67342
            908-1031            AC113964.18        73294-73417
            1032-1110           AC113964.18        81278-81356
            1111-1265           AC113964.18        87733-87887
            1266-1338           AC113964.18        92924-92996
            1339-1486           AC113964.18        113156-113303
            1487-1554           AC113964.18        114309-114376
            1555-1595           AC113964.18        119016-119056
            1596-1813           AC113964.18        120965-121182
            1814-1986           AC113964.18        124648-124820
            1987-2112           AC113964.18        128525-128650
            2113-2264           AC113964.18        140506-140657
            2265-2336           AC113964.18        142504-142575
            2337-2402           AC113964.18        154864-154929
            2403-2573           AC155254.1         30675-30845
            2574-2813           AC155254.1         33038-33277
            2814-3174           AC155254.1         38588-38948
            3175-3340           AC155254.1         43157-43322
            3341-3452           AC155254.1         51211-51322
            3453-3673           AC155254.1         57069-57289
            3674-12064          AC155254.1         57424-65814
FEATURES             Location/Qualifiers
     source          1..12064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.32 cM"
     gene            1..12064
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /note="syntaxin binding protein 5-like"
                     /db_xref="GeneID:207227"
                     /db_xref="MGI:MGI:2443815"
     exon            1..149
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..343
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3715
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /note="isoform xb is encoded by transcript variant xb;
                     tomosyn 2; lethal(2) giant larvae protein homolog 4;
                     insulin level locus 1"
                     /codon_start=1
                     /product="syntaxin-binding protein 5-like isoform xb"
                     /protein_id="NP_766028.2"
                     /db_xref="CCDS:CCDS28159.2"
                     /db_xref="GeneID:207227"
                     /db_xref="MGI:MGI:2443815"
                     /translation="MKKFNFRKVLDGLTASSPGSGSSSGSNSGGAGSGSVHPGGTAGL
                     PREEIQESLTSDYFQICKTVRHGFPYQPTALAFDPVQKILAIGTRTGAIRILGRPGVD
                     CYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYC
                     HLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPR
                     DEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLW
                     NLKSPSRPFQTTVPHGKSQREGRKSESCKPILKVEYKTCRNSEPFIIFSGGLSYDKAC
                     RRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQ
                     TNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPVSGG
                     AWNLGAQTYPEIIITGHADGTIKFWDASAMTLQMLYKLKTSKVFEKQKAGEGKQTCEL
                     VEEDPFAVQMIYWCPESRIFCVSGVSAYVIIYKFSRHEVTTEIVSLEVRLQCDVEDII
                     TPEPETSPPFPDLSSQLPPSRSLSGSTNTVSSEGVTKDSIPCLSVKTRPVRMPPGYQA
                     DLVIQLVWVDGEPPQQITSLSISSAYGIVAFGNCTGLVVVDFIQKTVLLSMGTIDLYR
                     SSDLYQRQPRSPRKNRQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLEL
                     ERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEI
                     SLPVTTEETRENSYNRSRSSSISSIDKDSKEAITALYFMESFARKNDSTVSPCLFVGT
                     SLGMVVLISLNLPSSDEQRFTEPVVVLPSGTFLSLKGAVLTFSCMDRTGSLMQPPYEV
                     WRDPNNTDENEKTWKRKLVMNYSSSSQEMGDHQYTIICSEKQAKVFSLPSQTCLYVHN
                     ITETSFILQADVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTF
                     CFTNEGQALYLVSPTEIQRLTYSQEMCDNIQDMLGDLFTPIETPEAQNRGFLKGLFGG
                     SGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERG
                     QRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF"
     exon            344..441
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..523
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..624
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..759
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..823
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..907
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1031
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1110
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1265
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1338
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1486
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1554
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1595
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1813
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1986
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2112
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2264
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2336
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2402
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2573
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2813
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..3174
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3340
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3452
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3673
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..12064
                     /gene="Stxbp5l"
                     /gene_synonym="9430094L02; A830015P08Rik; LLGL4; T2dm1;
                     t2md1; tomosyn-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttaggacc tcggagagcg ccaggcacca ggaccagagg gacccgagaa gcggccggat
       61 ccgggctgga ccttcgcccg cctgtgagcc tgcagcctcc gcgccctccg cctcacgggc
      121 tggccggcgg ctagtggcgt ctgaggaagt gtttaaaatg aagaagttta atttccgaaa
      181 agttttggat ggcttaactg cctcttcccc tggcagtggt agcagcagtg gcagtaacag
      241 tggtggggct ggaagtggct ctgtccatcc aggagggact gcagggcttc cgagagagga
      301 aattcaggaa agcctgactt cagactattt ccagatttgc aagacagttc ggcatgggtt
      361 tccttatcag cccacagcat tggcctttga tccagtccag aaaatcttag ctattggaac
      421 aagaacaggt gctatacgaa tacttgggag gcctggtgtt gactgttact gccaacatga
      481 aagtggtgcg gctgtcttgc agctccaatt cctcatcaat gagggcgcgt tggtcagtgc
      541 gagttcagat gacacgcttc atttgtggaa tctgagacag aaaaggccgg ccattctcca
      601 ttctcttaaa tttaacagag aacgaattac ttactgtcat ctacctttcc agagtaaatg
      661 gctctatgtt ggaacagaaa gaggaaatac acatattgta aatattgaat ctttcattct
      721 ttctggatat gtcatcatgt ggaacaaggc aattgaactc tccaccaaga ctcatccagg
      781 cccagttgta catttaagtg atagcccaag agatgaagga aaactgttaa taggttacga
      841 gaatggcact gtggtgttct gggacttgaa atctaaaaga gcagaactga gagtttatta
      901 tgatgaggct attcattcaa ttgattggca tcatgagggc aaacaattca tgtgcagcca
      961 ctcagatggt agcttgactt tatggaacct gaaaagccca agccgccctt tccaaaccac
     1021 agtcccacat ggaaaaagtc aaagagaagg aagaaagtct gagtcttgta aacctattct
     1081 taaagtagaa tacaaaacgt gcaggaacag tgaaccattt ataatattct ctggcgggct
     1141 gtcatatgac aaagcttgca gaagaccaag tttaaccatc atgcatggga aagcaattac
     1201 agtgcttgag atggatcatc ctattgttga gtttctaacg ttatgtgaaa cgccctatcc
     1261 aaatgaattt caagaaccct atgctgttgc tgtacttcta gagaaagatc tcatcgtagt
     1321 tgacctgaca caaaccaatt ttccaatctt tgaaaatcca tatccaatgg acattcatga
     1381 gtcacctgtt acatgcacag catattttgc cgattgccct ccagatttga ttctagtact
     1441 ctattctata ggagtcaagc ataaaaaaca aggatacagt aataaggaat ggccagtcag
     1501 tggaggagct tggaacctcg gagcacaaac ttatccagaa attattatta ctggtcatgc
     1561 tgatggaaca ataaaatttt gggatgcttc agcaatgaca ctgcagatgt tgtacaagct
     1621 aaaaacttcc aaagtgtttg aaaagcagaa ggcaggagaa ggcaaacaga cgtgtgaact
     1681 tgtagaggaa gatccctttg ctgtgcagat gatctactgg tgtccagaga gcagaatatt
     1741 ttgtgtctct ggagtctctg catatgtcat aatttataaa ttcagcagac atgaagtcac
     1801 aacagaaata gtgtcactag aggtacgact tcagtgtgat gttgaagaca ttattactcc
     1861 tgagccagaa acaagccctc catttccaga tctctcctct caacttcctc cttcaaggag
     1921 tctttctgga agcactaata ctgtgtctag tgaaggagtg acaaaggaca gcatcccgtg
     1981 cctcagtgtt aaaacacggc cagtacgaat gccgccgggc tatcaagcag atcttgttat
     2041 tcagttggtg tgggtagatg gtgagcctcc tcagcaaatt accagccttt ctataagctc
     2101 agcatatgga atagtggcat ttggaaactg cactgggctg gttgtggtgg atttcataca
     2161 gaagacagtg ctattaagca tggggaccat tgacctctat agatcaagtg acctgtacca
     2221 gcgacagccc cggtctcctc gaaagaacag gcagttcatt gcagacaact tttgcatgcg
     2281 tgggctgtct aacttttatc ctgatttaac gaaacggatc cgtacttcct atcagagctt
     2341 aacagagctg aatgatagtc cagttcccct ggaacttgag cgctgcaagt cccccacctc
     2401 agaccatgta aatggacact gcacaagtcc aacctctcag agttgcagtt ctggaaaacg
     2461 tctttccagt gctgacgttt caaaagtaaa tcgctggggt cctggaagac caccatttag
     2521 aaaggcacag tcagctgctt gcatggagat ttctttacca gttacaactg aagaaacccg
     2581 agagaattcc tataatcgct ccaggagctc tagcatctcc agtattgaca aagattctaa
     2641 agaagcaatt acagctttat acttcatgga atcctttgca cggaaaaatg actctaccgt
     2701 ttccccttgt ctgtttgttg gaactagtct gggaatggta gtactcatct ccctaaatct
     2761 accatcatca gatgaacaaa ggtttacaga gccggtggtg gtattgccaa gtggtacatt
     2821 cctctcactg aaaggagcag tgctaacatt ttcctgcatg gacagaactg gcagtttaat
     2881 gcagcctcca tacgaagtat ggagagatcc aaacaacaca gatgaaaatg aaaaaacctg
     2941 gaaaaggaaa ttggtcatga actactcgtc ttcatcccaa gagatgggag accatcagta
     3001 tacgataatc tgctcagaaa aacaagccaa agtcttctca ctgccttccc agacctgcct
     3061 ttatgttcac aacatcaccg agacgtcgtt catattgcaa gcagatgtgg tggtcatgtg
     3121 caacagtgcc tgcctggcct gcttttgtgc aaatgggcat atcatgataa tgagcttacc
     3181 tagtcttcgc ccaatgttgg atgttaatta tttgccactg acagacatga gaatagcacg
     3241 gacattttgt tttactaatg aaggacaggc attatacctc gtctctccca ctgaaattca
     3301 acggttaaca tatagccaag aaatgtgtga taatattcag gacatgttag gcgatttgtt
     3361 tactcccata gagacaccag aagcccaaaa tagaggcttt ctcaagggac tatttggtgg
     3421 aagtggacag acattcgaca gagaagaact cttcggggaa gcctcagcag gaaaagcatc
     3481 ccgaagcctc gcacagcaca tccctgggcc aggtagtata gaagggatga aaggtgctgc
     3541 tggcggggtg atgggagagc tgacccgagc ccggattgca cttgatgaga gagggcagcg
     3601 tctgggcgag ctggaagaga agactgcggg catgatgacc agcgcagaag cgttttccaa
     3661 gcacgcacat gagctaatgc tgaagtataa ggataagaag tggtaccagt tctaaccttc
     3721 gaaagaagct gtgactgctt tgagaaacca ttattcaggg aaaccaaatt tattcccagc
     3781 atcactattc aactgctaga agccagtttc ttctacaaaa tgttccatta tagtccatct
     3841 gaagttatca taagggagac ttatcaaagg caaagatgct gtacaacaga aaggctggaa
     3901 cccctgttaa aatcccaaga taatggccga atttgtcttt ccccatgtgg aatggatatt
     3961 atcatcttgg catgtcattt gctaagaatt catgtttgga aactatgggg agtccttttg
     4021 atttgaaatt tcctgtacaa acaaaagcat taatgcactt aatgaaaaaa aattctttgc
     4081 atgaaaaatt aacatcttaa gaggaaaaga aacaaaagca tgttataaca gaagaaaagg
     4141 atttatggta aactactttc atgaattggg ccacacccaa caattttaaa atatgcatta
     4201 gaagatatca atgcgtttta agtgtatttg ccctacccaa ctgaaaggaa tcaaaatagc
     4261 cccagaattt tcttctcatc tgaaactttc cttagtatac taggacgttc ctgaattctt
     4321 acgtcaagaa tctgattgca tttttctctc tctgtagtaa ttcacatcat ttgcagctct
     4381 cattcattca taaccaagga ttgccaggag agtgaagtat ccccaacact tttctttcca
     4441 cgtctgccac cttcaagatg aattcctagt tttagttata aaccgtgcag ggttgaatca
     4501 cctcaaagca atttttttcg gcctggttta tattctacag aggaggtggc aataagtttg
     4561 cagaaactag actataggaa cagtgcagtt agctttgaga actgatttca caaagagtgg
     4621 aatttcacac accccaattt tagtttccaa agcgatatat ttttaaagca ccatttgtac
     4681 ccttatctgc caattacaca gtatattact gttcagaccc tgtagggtct actatcccaa
     4741 ggtgcttttg cagcctgcta ttcacagacc aaactggtca ttgtctttga agtgattcag
     4801 taaagcctca gctaatgttt tagggaagag agtctgactc ctcacacttc tgatgcacaa
     4861 gggctttcat tagaacacat tctagggtcc agcacttatt actggaaacc cttatgaaat
     4921 gtagagctgt tttagctatc ttggccacag tcatcattat gggtaacaca aatccagaga
     4981 taatttaatg atataaaatc aatagctttg tcactagatt gattaatata agtcaaaggc
     5041 atgtgtcagt aaataccaaa taccttctaa aaactctcaa gggtaaagag cagctcgagc
     5101 aagataaaac gatccgtcat gacccagcag agaagcactg caaaggaaaa caaaggaaga
     5161 ttcccacttg ctctgttgaa catgcttgga agtcagagtc acgggactcc cctgacagga
     5221 tgctcttcct gtttttaaaa tcttaaatta tgtgatgcgt tcattgggtt ttgaggtctt
     5281 actggatttg catttgtgtt taagatacgg gcacttcctt aaatccaact taatagatga
     5341 agttattttt tttcatttgt cttttgtttg tgtttgaagt ggtgctgcct tttaattttt
     5401 ctcagtgatt ttgaagaaaa agcagagatg attaaaagaa ccagaaaatg cacactagag
     5461 tagcatttat cagagtcctt aaattctggt ttcttaaaat tgtctgtaaa tctgcctcct
     5521 gttatagcat gactataaga ggacttggtt ggaaatacag acaatataca cagacaatat
     5581 atacagtaaa atattaacga aatttcaagc caggacttgg aaaacattgg cagccaaact
     5641 gcaacacaaa atatatgcaa tctctttttt aggacccaag tttctgattt ttagcatttc
     5701 tggaattttt gttgttgttt gtgtgtgtgt gtgtttgatt gcttgtttgt gtgttatttt
     5761 tgtcttgttt tggtttttgc ttttctgagg caggatttct ttatgttaca gccctggctg
     5821 tcctgaaact cactttgtag accaggctgg ccttgaactc acagagatcc acctgcctct
     5881 gcctcccaat gttgggatta cagacatgcc ccaaaacacc cagtggtact ttaacatttc
     5941 tacattttaa agtgaccaga agaataagat atttctttta tttagaaata gtgatttttc
     6001 aatccaaagt agcattgaat tcaatggcta gctctgaaac tccctgtaat atgtaactag
     6061 agatgtagtg cagggtagag tgcttgcttg cccaccatgt tcaagattat ggatttcatc
     6121 atcagtaccc caggtgtgtg tgcatgcgcg cgcgcgcaca cacacacaca cacacacaca
     6181 cacacacact tgttctatag caagggttct gaaaggcagc accatcagca caaaattctt
     6241 tgggatgtta gcagtgtcct tggcttctgc cctctagatg ccagtcagaa tcttctagta
     6301 ataacagtaa aaaaaaaaaa atctttttga caaaattgct tccagctgag agctactatt
     6361 ttacatcatt taaagagaca gactgtgaaa tgtatgatat gtttttacag aaaatagcat
     6421 acaataagag cacattttct tagcaagaga agtcctgccc taaatatgtg tgtgattcat
     6481 atgcaagaga ggtaaatttt tggagaatta gtggactaac aatatataga ctaattccaa
     6541 gcacacacag aatacatcaa gaagaatatc cgtatttcac aatagacatg cttaaagttc
     6601 tggctccagc aaatccatca aaagtttata aatagacatc acttggagta gttgcctctg
     6661 ccatgcttga aaagaacaag ttctcgtaaa tatttaaagt ttaaatatgc ttacaaaact
     6721 gtttgccgaa acctttctta agggtaactg atgccacaaa ccaacaatta gcagaatcca
     6781 aattaatgag gttttactgt atcaaaatta tttttataat tcagaagtag caataacaat
     6841 aatttaacca tggatgtgat ttttctcttt gaacttttgc attaatcttc acacacacac
     6901 acacacacac acacacacac acgatcacct taccaccacc accaccacca ccatttttgt
     6961 catcattgtc aacttaagga aatgattaat gttggtaaat agaatctttt tcatgttctc
     7021 atctctcttc tgtttggacc ataagaaaaa ctaccccaga aaccttaata gtgctgcaga
     7081 agatgaccct gagtcttggt tcccatcaaa ttgcattctg tctacgaagt ggcgtctgga
     7141 gataaggctt gtgaagctcc atcaggacaa ggtgacttta tcccttattc cttcctcaac
     7201 agagaagcct ttcccggtgt tcctgcagaa atgaaccttt tattctattc atcgataaca
     7261 aaagacatgt ttgtttccct gcttctcaca gtaatgtaag ccatgatccc actgtgaaac
     7321 cacccatttg tcttgggttt ggggagggcg attgacttag caagcatttc aatcccccga
     7381 agatgtgcat ttctgactta gcttgtctga gtctcagact tagcactcaa gcaccatgag
     7441 ggtcattgtg tgacatcaac ttcaagtgta cagtgacaaa actgagaagt tgtctagcaa
     7501 ttctatcgca gaaacatttc tcaaatcctt tggaattgat tctcaataaa atctgtctct
     7561 actcctcaaa aatgtaaaga gaccttaaaa ggtaaagttc ccttttatat gtcccaccaa
     7621 tagcatttta aaggtattgt ttacccatta tctgtgccag tctgagaaaa taaaaagtac
     7681 gattaggccc aatattggtt gaaattaagg taggttcttt gagatactaa gctgtcaggc
     7741 atttggacag aataataaaa tgaagctagc ccagaaagga aaacaatatt tcccttggcc
     7801 tatgactagg atattctttg taccacaggc ttccttgggg ggaatgtaca aacaccattc
     7861 ccttaccaca ctgattcaca gagagcaatg acatagaaag ccagcatgtc agatccggtc
     7921 cagctctcag tgtgttagga gaaacaacag ctttgcagct tcttcaccta cagttactca
     7981 gctccatctt aggtggtagt actgtgtatc cacacaaccc aggtatcaga gatgatcatc
     8041 aaccaacagg ttgaccattg tctctcatat gcaagattcc aggaagcatg tgctaaaaag
     8101 tctagtattt ctatctactg gcctgaatag tatatctgtc ttcctgaata gaagacatca
     8161 gtaaggtctc atctagaaac aggacagagg gtatagcgtg ggggaaacct gtgggtatga
     8221 ggagggatat gagagtctga gggaagtgag gaggttttga tacaaccaaa acagaatgcc
     8281 tttattaata ttttttttct ggaagagtga tagtcagcct tggctgtata taacagtcat
     8341 ttgagatttt taaaattcca atgatttcaa aatgtcttag actgggaaag gaactcagta
     8401 ttcttgaaag ctctaaacat gggtccagtg tccagccaac cttgggtaac cactgcttta
     8461 tgaactgact aagaaagact cttgccttca ttggctgatt cttagcccct tcctagggac
     8521 cggggaagac agaatgtaaa agagacagtc ttatcttgat tggcatttat tctgtgactc
     8581 tcacagaaca aaagtgagtg tacatttcta accagtcaac tccactaagt ctttgtaact
     8641 ctgtaatatt actgtgtgac ttgatttcag ttatttaagt caaggatgta aattttgact
     8701 gtcttttaga taagacacta gaaatatcat aaaatcagca gtataaaagg ctaaatggta
     8761 aaattaatct caatatctag acattggaaa ttccccaaaa cactcactaa atcctctgaa
     8821 gtttattagg cacccttctc caggagcaga catgttgaga ggcgcctgct ctgctgtggg
     8881 tgtcctgctg gacctgaggt tagcaaacag ggagaacaac tcttccttgt tttattgcta
     8941 ttcctaaagc tcccagggcc acttgaattt gttctttgac ttatggggta tgtgcataaa
     9001 tggaaaaatc ataatctgag aacaagtgcc ctgaaaaagt gctcacactc cagcaagaaa
     9061 gagtccagcc agtgggaggc aatgacacaa aaacactccg agtcctctcc ctcacgccac
     9121 ttcccctctc atcttggccc actgttctca acagcaaagc cagaagatga actaggtggt
     9181 ggttttggat agttgtacac agtatcaaaa atctctaata acctatcacg tttagtactg
     9241 aattatgcga tgttttactc taggaaataa cagacaggtg acaccattga tgaatctttc
     9301 tctcatcttc agaatttttg catcttttca gaaaaggaca aattactatt tttctgttgc
     9361 attcagcaat tgtgactata cctaaaattc ttgtagtctg tagagatatc aataaaattg
     9421 tatatgtttg tacatagatg ctctcttatg tcatgatgtc atatactaat gatttttgcc
     9481 aagattaaat atatagaggt aaaacattca tttgcaaagt gttaactgta gttttaccaa
     9541 gaatggatgt ttttaaaaga catggagggg atgaagagaa cacactgaat tgagcaaaaa
     9601 gcagaaaaca aaatctaagt tccctagatg tatacagatt ctgtttaaat ttatggattg
     9661 actcgggtta gaaataccta ttcagatttt ctatcaaatt gcagacatgt gtaagagttt
     9721 agtgaaaatt taaagacaaa ctgtaaggct attgattaac tgggacctgc ggtggaataa
     9781 atataaaggc aaacttgata acagtgccca caagacactg tggtggtgca aggacttaca
     9841 cctcagggtg gccttgaccg ccttcctgct tttacagctc aagctggaag aatgagtctg
     9901 ctgtgagttt atgcttccat ctagtggtca tggaatcctc tgatttgctc tgctctcacc
     9961 agctggttga ttctccttct ggtattttcc tatatggtgg ccttagccaa ctgatcgtat
    10021 tcttcttcca aagttctaat tatcttagga aaattcttcc tccaccacaa gctttcttct
    10081 atagctgaaa ggaacgacaa ctagccttgg gctaaaaaat acttttgagt aaaagaaaaa
    10141 ggtatagggc cttttaaaat ataaatgcta gtctctattt cagatctgtc tcagcagaat
    10201 cagtttgtct ttctgtgatg acaacataag tccacaaaac tctgttctcc attttcttct
    10261 gcttcccccc ccccctcgtc tcccttcctc tgtcattccg ttcctgcctc ccctgctccc
    10321 tcactcccat tcaacaggac ttccttcctc aagccgctcc tgccatctgc tctatttaaa
    10381 gggcaagccc agcactgggg caggttagca gtggcaagct cacatagaag tgggtaccac
    10441 aggggtgaag taagaggtgc acccacagag ctgagcgggg ggaggggcag ctgagacttc
    10501 cctggtcagt gaccttggaa tttgaggtcg tctttgaagc agggcagagg caaccccttt
    10561 ggttctggag ggtggccaca ttcaaggaat tgagcattta aataaattca ttgaggacat
    10621 gggagccaag tttctcacag agactgcaga agggtataca attaaaagaa aaacctaaaa
    10681 tgctttaaat tttggtgctt ctacatatag cacggtaact ggggctgtaa cttttatgct
    10741 caaaatggat aaagaagagg acttttaagt gttccaccac aaagaggtga cagttgaggg
    10801 ggtgattatg ctaaggatgt acaggactat caaatattcc ctgtcagtat agttattatg
    10861 tctcaattta aaataataaa acttcttaaa gaagaaaagg taggaaaact cttgtaatgt
    10921 cgaatacaat tggttatcag tgtgaacatg attgtccata tatatatata tacatatata
    10981 tatatactat acatatttat ataattgtat ctatataaat agctatatac atagatacac
    11041 atataaatat atattatatg tgtgtgtatg catgctgaaa aggtgtgtat atgttgtata
    11101 taaatatttc ctaattctga acactgaata gacagaaaga tacaaagcaa tcaagacaat
    11161 taatgctgga ttatgatttc caagtattct ttcctgctaa tgggctagag catcatgaag
    11221 agtgactggt tcaattctgg aatatagtct gtatcagaag gtgaagtatt cgatgaaaga
    11281 tagctacgtt tcagaagcac tcaaaaacag cttgaaagag cttacacagg ccaagtcaag
    11341 gataatttaa ctataaaaca tagtaataga ataaaatagg aacccatgaa ttcacactga
    11401 taataagtaa atatggaaga gagaaagtta ttcacacaat caaatgccag ctaataagtg
    11461 taaatggaat ttaaaagttg ctgttagata accattgtta taatatgttg ggcggtatat
    11521 accagttagt gctcaagcta atggggtgaa gtaggatctc agtagagaat gatttacatc
    11581 atctccaagt gtcttcaaaa ctgttaaaca ttaaaagaca tttacaccaa aaaaacatgg
    11641 aagataccat atttgttatt gagggaccaa agtcctgtca ccagtgatgg ggcaaatcaa
    11701 catcctgttc tgcctttgac aagaacacag catccctgcc aagatgcaag ctaggtctcg
    11761 tcctgtggaa atgttaaata gaactacact tggcaatttc taaatacggc tgccccctag
    11821 gaagtttggt ataacaaaag atgaggaaag acagatattc cagatctagg aagccaaaat
    11881 ccatgacaac tgcatgtaat acatgatcat agattgaaac attttgccat agatgtcatg
    11941 acataaatgg agcaattatc aaaactcgag tgtggtttcc cactggatta tgattctttg
    12001 taccattctt gaaactttta tttagatttg agctgatttc aaaataaagt tataaaaata
    12061 aaaa
//
