LOCUS       NM_011504               2406 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus syntaxin binding protein 3 (Stxbp3), mRNA.
ACCESSION   NM_011504 XM_910404
VERSION     NM_011504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2406)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2406)
  AUTHORS   Guo,L., Zhu,Z., Wang,G., Cui,S., Shen,M., Song,Z. and Wang,J.H.
  TITLE     microRNA-15b contributes to depression-like behavior in mice by
            affecting synaptic protein levels and function in the nucleus
            accumbens
  JOURNAL   J Biol Chem 295 (20), 6831-6848 (2020)
   PUBMED   32209659
  REMARK    GeneRIF: microRNA-15b contributes to depression-like behavior in
            mice by affecting synaptic protein levels and function in the
            nucleus accumbens.
REFERENCE   3  (bases 1 to 2406)
  AUTHORS   Jaramillo,A.M., Piccotti,L., Velasco,W.V., Delgado,A.S.H.,
            Azzegagh,Z., Chung,F., Nazeer,U., Farooq,J., Brenner,J.,
            Parker-Thornburg,J., Scott,B.L., Evans,C.M., Adachi,R., Burns,A.R.,
            Kreda,S.M., Tuvim,M.J. and Dickey,B.F.
  TITLE     Different Munc18 proteins mediate baseline and stimulated airway
            mucin secretion
  JOURNAL   JCI Insight 4 (6), 124815 (2019)
   PUBMED   30721150
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2406)
  AUTHORS   Gutierrez,B.A., Chavez,M.A., Rodarte,A.I., Ramos,M.A.,
            Dominguez,A., Petrova,Y., Davalos,A.J., Costa,R.M., Elizondo,R.,
            Tuvim,M.J., Dickey,B.F., Burns,A.R., Heidelberger,R. and Adachi,R.
  TITLE     Munc18-2, but not Munc18-1 or Munc18-3, controls compound and
            single-vesicle-regulated exocytosis in mast cells
  JOURNAL   J Biol Chem 293 (19), 7148-7159 (2018)
   PUBMED   29599294
  REMARK    GeneRIF: observed an almost complete absence of exocytosis in
            Munc18-2-deficient MCs but intact exocytosis in MCs lacking
            Munc18-1 or Munc18-3
REFERENCE   5  (bases 1 to 2406)
  AUTHORS   Dolai,S., Liang,T., Orabi,A.I., Xie,L., Holmyard,D., Javed,T.A.,
            Fernandez,N.A., Xie,H., Cattral,M.S., Thurmond,D.C., Thorn,P. and
            Gaisano,H.Y.
  TITLE     Depletion of the membrane-fusion regulator Munc18c attenuates
            caerulein hyperstimulation-induced pancreatitis
  JOURNAL   J Biol Chem 293 (7), 2510-2522 (2018)
   PUBMED   29284677
  REMARK    GeneRIF: Pancreatic acini from Munc18c-depleted mice (Munc18c(+/-))
            and human pancreas (lenti-Munc18c-shRNA-treated) exhibit normal
            apical exocytosis of zymogen granules (ZGs) in response to
            physiologic stimulation with the intestinal hormone cholecystokinin
            (CCK-8).
REFERENCE   6  (bases 1 to 2406)
  AUTHORS   Widberg,C.H., Bryant,N.J., Girotti,M., Rea,S. and James,D.E.
  TITLE     Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays
            a role in insulin-stimulated GLUT4 translocation
  JOURNAL   J Biol Chem 278 (37), 35093-35101 (2003)
   PUBMED   12832401
REFERENCE   7  (bases 1 to 2406)
  AUTHORS   Chen,G., Liu,P., Thurmond,D.C. and Elmendorf,J.S.
  TITLE     Glucosamine-induced insulin resistance is coupled to O-linked
            glycosylation of Munc18c
  JOURNAL   FEBS Lett 534 (1-3), 54-60 (2003)
   PUBMED   12527361
  REMARK    GeneRIF: our data suggest that the mechanism by which glucosamine
            inhibits insulin-stimulated GLUT4 translocation involves
            modification of Munc18c.
REFERENCE   8  (bases 1 to 2406)
  AUTHORS   Macaulay,S.L., Grusovin,J., Stoichevska,V., Ryan,J.M.,
            Castelli,L.A. and Ward,C.W.
  TITLE     Cellular munc18c levels can modulate glucose transport rate and
            GLUT4 translocation in 3T3L1 cells
  JOURNAL   FEBS Lett 528 (1-3), 154-160 (2002)
   PUBMED   12297296
  REMARK    GeneRIF: Cellular munc18c levels can modulate glucose transport
            rate and GLUT4 translocation in 3T3L1 cells.
REFERENCE   9  (bases 1 to 2406)
  AUTHORS   Gengyo-Ando,K., Kitayama,H., Mukaida,M. and Ikawa,Y.
  TITLE     A murine neural-specific homolog corrects cholinergic defects in
            Caenorhabditis elegans unc-18 mutants
  JOURNAL   J Neurosci 16 (21), 6695-6702 (1996)
   PUBMED   8824310
REFERENCE   10 (bases 1 to 2406)
  AUTHORS   Tellam,J.T., McIntosh,S. and James,D.E.
  TITLE     Molecular identification of two novel Munc-18 isoforms expressed in
            non-neuronal tissues
  JOURNAL   J Biol Chem 270 (11), 5857-5863 (1995)
   PUBMED   7890715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D30798.1.
            
            On Dec 7, 2005 this sequence version replaced XM_910404.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155133.1, BC062901.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 47.73 cM"
     gene            1..2406
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /note="syntaxin binding protein 3"
                     /db_xref="GeneID:20912"
                     /db_xref="MGI:MGI:107362"
     exon            1..83
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1813
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /note="unc-18C; MUNC-18-3; unc-18 homolog 3; mammalian
                     homolog of Unc-18c; protein unc-18 homolog 3; protein
                     unc-18 homolog C; syntaxin binding protein 3A"
                     /codon_start=1
                     /product="syntaxin-binding protein 3"
                     /protein_id="NP_035634.1"
                     /db_xref="CCDS:CCDS17768.1"
                     /db_xref="GeneID:20912"
                     /db_xref="MGI:MGI:107362"
                     /translation="MAPPVSERGLKSVVWRKIKTAVFDDCRKEGEWKIMLLDEFTTKL
                     LSSCCKMTDLLEEGITVIENIYKNREPVRQMKALYFISPTPKSVDCFLRDFGSKSEKK
                     YKAAYIYFTDFCPDSLFNKIKASCSKSIRRCKEINISFIPQESQVYTLDVPDAFYYCY
                     SPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDY
                     YKIDEKGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGK
                     EKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKM
                     PHFRKQISKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQRVKDSMLVLLP
                     VLLNKNHDNCDKIRAVLLYIFGINGTTEENLDRLIHNVKIEDDSDMIRNWSHLGVPIV
                     PPSQQAKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCPAVWNGS
                     GAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTH
                     ILTPRKLLDDIKMLNKSKDKVSFKDE"
     exon            84..133
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            134..215
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            216..292
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            293..371
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            372..472
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..627
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..718
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            719..843
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..939
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            940..997
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1063
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1144
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1283
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1390
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1483
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1569
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1721
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..2406
                     /gene="Stxbp3"
                     /gene_synonym="Munc-18c; Stxbp3a; Sxtbp3; Unc18-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcggtgg ctgtagctcc acggctgggg gaagatggcg ccgccggtat cggagcgggg
       61 actgaagagc gtcgtgtggc ggaagataaa aacagccgtg ttcgatgact gccggaaaga
      121 aggcgaatgg aagataatgc tgttagatga gtttaccacc aaacttttgt cgtcatgctg
      181 caaaatgaca gaccttctag aggagggcat aactgttata gagaatattt ataagaatcg
      241 tgaacctgtc agacaaatga aagctcttta tttcatctct ccaacaccaa aatctgtaga
      301 ttgtttcttg agagattttg gaagtaaatc tgagaaaaaa tacaaagcag cgtatatata
      361 cttcactgac ttttgtcctg acagtctctt taacaagatt aaagcatctt gctccaagtc
      421 aataagaaga tgtaaggaaa taaacatttc cttcattcca caggaatctc aggtttatac
      481 tcttgatgta ccggacgcat tctattactg ttacagtcca gaccctagta acgccagcag
      541 gaaagaagtg gtcatggagg caatggctga gcagattgtg acagtgtgtg ccactctgga
      601 tgaaaaccct ggagtgaggt acaagagtaa acctctagat aatgccagta agcttgcaca
      661 gctggttgag aaaaagcttg aagactacta caaaattgat gaaaaaggcc taataaaggg
      721 taaaactcag tcccagctct taataattga ccgtggcttt gaccctgtgt ccactgtcct
      781 gcatgaactg acctttcagg caatggcata tgatctacta ccaattgaga atgatacata
      841 caagtacaaa acagatggaa aagagaagga ggcagttctt gaagaagacg acgacctgtg
      901 ggtgcgggtt cgacaccggc acatcgcggt tgtgttggag gaaattccaa agcttatgaa
      961 ggaaatttca tcaacaaaga aagctacaga ggggaagaca tcacttagcg ctcttaccca
     1021 gctgatgaaa aagatgccgc acttccgaaa gcagatctcg aagcaagtag tccatcttaa
     1081 cttagctgaa gactgcatga ataagtttaa gctgaatatt gagaagctct gcaaaactga
     1141 gcaggacctg gcacttggaa cagatgctga aggccagcgg gtgaaggact ccatgctggt
     1201 gctcctccca gtgctgctca acaaaaacca tgacaactgc gacaaaatac gggcagtcct
     1261 gctctacatc ttcgggatta atggaaccac tgaagaaaat ctggacagac tgatccacaa
     1321 tgtaaagata gaagatgata gtgatatgat tcgtaactgg agccaccttg gtgttcccat
     1381 tgttccccca tcccagcaag ccaaaccact gagaaaggat cggtctgcag aagagacttt
     1441 tcagctttct cgatggacac cttttatcaa agatatcatg gaggatgcca ttgataatag
     1501 attagattcc aaagagtggc cgtattgttc ccggtgccca gcagtgtgga atggctctgg
     1561 agctgtgagt gctcgccaga aacccagaac taactactta gagctggacc ggaaaaatgg
     1621 gtcaaggctg attatttttg taattggagg aattacgtac tctgagatgc ggtgtgctta
     1681 tgaagtttcc caggcacata aatcctgtga ggttattatt ggttccacac atattttaac
     1741 acccagaaag ctcctggatg atataaaaat gctgaataaa tcaaaggata aagtttcctt
     1801 taaggatgag taacttttta tggttgtcgt ttagaggttt tgttaatacg atcggctaca
     1861 gcaaatgttg ctgttgtaat ttaagcggtg taaatagtgt atggagtaat gtggttttca
     1921 agtgtacatc ttacagaagc ttatgtgtta tggatttgcc atttctaata atttaaatac
     1981 tgttgctgct ttgtacaaga tctgacacta cagggctttc taatcaggat gtcttcaccc
     2041 tagggacaga atctgttagg agggatgggt agtttttaca gcctgctgta tacatactag
     2101 ttactgtata cttacgctga aatatagtgt tgggggcaaa atgattttga atgaagagat
     2161 tataaaagta aaaactgtaa atgtatgtat gatagaatta tttcttataa gtgcagtttc
     2221 ttaaaactga gattcataat tttttatgtg taaaataatt ccagtgttta atatgatttc
     2281 actgtgtata ttacctgtga aataattcta aagaacacaa ttttatatgt ttgagatcat
     2341 gtctgcttaa gttagacgcc aaaaataatc atgaacattc taagagaaaa taaatatatt
     2401 attgtc
//
