LOCUS       NM_011503               3125 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus syntaxin binding protein 2 (Stxbp2), transcript
            variant 2, mRNA.
ACCESSION   NM_011503
VERSION     NM_011503.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3125)
  AUTHORS   Yang,M., Jiang,H., Ding,C., Zhang,L., Ding,N., Li,G., Zhang,F.,
            Wang,J., Deng,L., Liu,J. and Xu,Y.
  TITLE     STING activation in platelets aggravates septic thrombosis by
            enhancing platelet activation and granule secretion
  JOURNAL   Immunity 56 (5), 1013-1026 (2023)
   PUBMED   36944334
  REMARK    GeneRIF: STING activation in platelets aggravates septic thrombosis
            by enhancing platelet activation and granule secretion.
REFERENCE   2  (bases 1 to 3125)
  AUTHORS   Wu,Y., Shen,C., Wu,T., Huang,X., Li,H. and Zheng,B.
  TITLE     Syntaxin binding protein 2 in sertoli cells regulates
            spermatogonial stem cell maintenance through directly interacting
            with connexin 43 in the testes of neonatal mice
  JOURNAL   Mol Biol Rep 49 (8), 7557-7566 (2022)
   PUBMED   35604625
  REMARK    GeneRIF: Syntaxin binding protein 2 in sertoli cells regulates
            spermatogonial stem cell maintenance through directly interacting
            with connexin 43 in the testes of neonatal mice.
REFERENCE   3  (bases 1 to 3125)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3125)
  AUTHORS   Cardenas,E.I., Gonzalez,R., Breaux,K., Da,Q., Gutierrez,B.A.,
            Ramos,M.A., Cardenas,R.A., Burns,A.R., Rumbaut,R.E. and Adachi,R.
  TITLE     Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet
            exocytosis, hemostasis, and thrombosis
  JOURNAL   J Biol Chem 294 (13), 4784-4792 (2019)
   PUBMED   30696774
  REMARK    GeneRIF: results indicate that Munc18-2, but not Munc18-1 or
            Munc18-3, is essential for regulated exocytosis in platelets and
            platelet participation in thrombosis and hemostasis.
REFERENCE   5  (bases 1 to 3125)
  AUTHORS   Jaramillo,A.M., Piccotti,L., Velasco,W.V., Delgado,A.S.H.,
            Azzegagh,Z., Chung,F., Nazeer,U., Farooq,J., Brenner,J.,
            Parker-Thornburg,J., Scott,B.L., Evans,C.M., Adachi,R., Burns,A.R.,
            Kreda,S.M., Tuvim,M.J. and Dickey,B.F.
  TITLE     Different Munc18 proteins mediate baseline and stimulated airway
            mucin secretion
  JOURNAL   JCI Insight 4 (6), 124815 (2019)
   PUBMED   30721150
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3125)
  AUTHORS   Riento,K., Galli,T., Jansson,S., Ehnholm,C., Lehtonen,E. and
            Olkkonen,V.M.
  TITLE     Interaction of Munc-18-2 with syntaxin 3 controls the association
            of apical SNAREs in epithelial cells
  JOURNAL   J Cell Sci 111 (Pt 17), 2681-2688 (1998)
   PUBMED   9701566
REFERENCE   7  (bases 1 to 3125)
  AUTHORS   Ziegler,S.F., Mortrud,M.T., Swartz,A.R., Baker,E., Sutherland,G.R.,
            Burmeister,M. and Mulligan,J.T.
  TITLE     Molecular characterization of a nonneuronal human UNC18 homolog
  JOURNAL   Genomics 37 (1), 19-23 (1996)
   PUBMED   8921365
REFERENCE   8  (bases 1 to 3125)
  AUTHORS   Riento,K., Jantti,J., Jansson,S., Hielm,S., Lehtonen,E.,
            Ehnholm,C., Keranen,S. and Olkkonen,V.M.
  TITLE     A sec1-related vesicle-transport protein that is expressed
            predominantly in epithelial cells
  JOURNAL   Eur J Biochem 239 (3), 638-646 (1996)
   PUBMED   8774707
REFERENCE   9  (bases 1 to 3125)
  AUTHORS   Tellam,J.T., McIntosh,S. and James,D.E.
  TITLE     Molecular identification of two novel Munc-18 isoforms expressed in
            non-neuronal tissues
  JOURNAL   J Biol Chem 270 (11), 5857-5863 (1995)
   PUBMED   7890715
REFERENCE   10 (bases 1 to 3125)
  AUTHORS   Katagiri,H., Terasaki,J., Murata,T., Ishihara,H., Ogihara,T.,
            Inukai,K., Fukushima,Y., Anai,M., Kikuchi,M., Miyazaki,J. et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247044.1, AK133419.1 and CO043581.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_011503.6.
            
            On Oct 21, 2017 this sequence version replaced NM_011503.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133419.1, AK088364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY247044.1         156-206
            52-2754             AK133419.1         2-2704
            2755-3125           CO043581.1         1-371               c
FEATURES             Location/Qualifiers
     source          1..3125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..3125
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /note="syntaxin binding protein 2"
                     /db_xref="GeneID:20911"
                     /db_xref="MGI:MGI:107370"
     exon            1..96
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1841
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     syntaxin binding protein Munc18-2; protein unc-18 homolog
                     2; protein unc-18 homolog B"
                     /codon_start=1
                     /product="syntaxin-binding protein 2 isoform 2"
                     /protein_id="NP_035633.1"
                     /db_xref="CCDS:CCDS22067.1"
                     /db_xref="GeneID:20911"
                     /db_xref="MGI:MGI:107370"
                     /translation="MAPLGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSC
                     CKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAA
                     HIFFTDTCPEPLFSELGRSRLAKAVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPF
                     RAGERGRQLDALAQQIATLCATLQEYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPS
                     LGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSESRE
                     KAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESKRLTTDKANIKDLSHILKKMP
                     QYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDAMKLIVPV
                     LLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQSYSSLIRNLEQLGGTVTN
                     SAGSGTSSRLERRERMEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVPSS
                     QAAVSARFGHWHKNKAGVEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLIG
                     SSHILTPTRFLDDLKTLDQKLEGVALP"
     exon            97..146
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            147..228
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            229..305
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            306..384
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            385..488
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            489..637
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            638..722
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            723..853
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            854..961
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1019
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1085
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1166
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1305
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1415
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1511
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1597
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1755
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..3108
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1879..1884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /note="hexamer: AATAAA"
     polyA_site      1905
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /note="major polyA site"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /note="hexamer: AATAAA"
     polyA_site      2732
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
                     /note="hexamer: AATACA"
     polyA_site      2756
                     /gene="Stxbp2"
                     /gene_synonym="Munc-18-2; Munc-18b; Munc18b; muSec1;
                     Sxtbp2; Sxtp2; Unc18-2; Unc18b"
ORIGIN      
        1 gtagagccac gcccccacct tgggaccgac ccggaagcag cgctattcct caggggaaga
       61 tggcgccctt ggggctgaag gcggtggtag gggaaaaaat tttaagcggc gtcatccgga
      121 gcgttaagaa ggatggcgag tggaaggtcc tcatcatgga tcacccgagc atgcgaatct
      181 tgtcatcctg ttgtaaaatg tcagatatcc tggcggaggg catcaccatc gtggaagaca
      241 tcaacaaacg gagagaaccc attcccagct tggaggcaat ttatttgctg agtcccacgg
      301 agaagtcggt tcaggccctg attgcggact tccagggaac accaaccttc acctacaaag
      361 cagcccatat cttcttcact gacacatgcc ctgagccctt gttcagtgaa ctgggccgct
      421 ctcgcctggc gaaggcggtg aagacattga aagagatcca ccttgccttc ctcccctatg
      481 aggcccaggt gttctctctg gatgccccac atagcaccta caacctttac tgtccattcc
      541 gagcagggga gcgggggcgg cagctcgatg cactggccca gcagatagcc acactgtgtg
      601 ccactcttca ggaataccca tccatccgat accgcaaggg tccagaagac acagcccagc
      661 tggcccatgc tgtcctggcc aagctgaacg ccttcaaggc agacactccc agtctgggcg
      721 agggcccaga gaaaacacgc tcacagctac tcataatgga ccgggcagca gaccccgtgt
      781 ccccactatt acacgaactc acgttccaag ccatggccta tgatcttctg gacatcgaac
      841 aggacacata caggtatgag accacagggc tgagtgagtc ccgggagaag gctgtcctcc
      901 tggatgaaga tgatgacctg tgggtggaac ttcggcacat gcacatagca gatgtttcca
      961 agaaggtcac agaactcctg aagacattct gtgagagtaa gaggctgacc acagacaagg
     1021 ccaacatcaa agacctgtcc cacatcctga aaaagatgcc acagtatcag aaggagctga
     1081 acaagtactc tacgcacctg catttggcag atgactgcat gaagcatttc aagggctcgg
     1141 tggagaagct gtgcagtgtg gagcaggacc tggccatggg ctctgatgca gagggtgaga
     1201 agatcaagga cgccatgaag ctgattgtcc cggtgctgct ggatgcctcg gtgccaccct
     1261 acgacaagat ccgggttctg ttgctctaca tccttctgcg gaatggggtg agtgaggaga
     1321 acctggccaa gctgatccag catgccaacg tgcagtcgta cagcagcctc atccggaatc
     1381 tggagcagct gggcggcact gtcaccaact ccgcgggctc agggacctct agccggctgg
     1441 agcggagaga gcgcatggag cccacctacc agctgtctcg ctggtcccca gtcatcaagg
     1501 atgtgatgga ggatgtggtg gaggaccggc tagaccgaaa gctgtggccc tttgtgtctg
     1561 accctgcccc tgtgcctagc tcccaggcag ctgtcagcgc tcgctttggc cactggcaca
     1621 aaaacaaagc tggagtagag gcccgggctg ggcctaggct catcgtgtac attgtgggtg
     1681 gtgtcgccat gtcggaaatg agggctgcct atgaggtgac cagggccact gagggcaagt
     1741 gggaggtgct cataggctct tctcacatcc ttactccaac ccgcttcctc gatgacctca
     1801 agacactgga tcagaagctg gagggtgtgg ccctgccctg acacagcccc ttgcctctgc
     1861 cctctcctat tccagagaaa taaacgcttc ccttctgtct tcccaccagg gctcacctca
     1921 ttttcttccc agagggagct gtattgagcc agacctcccc ctgcgttttc actgtcctgc
     1981 ccgaaccttt ccccggcccc cagaagcatc tgtagctttc attaacgctg agaacctggg
     2041 ctgtagggtc agtattggct tgaagtttag gaggcactgg ctctcttgct gggtcctcca
     2101 tccaaaccca ggcctgattt tggcagagga gatagagagg tgcagattag gggttgccag
     2161 ggctgcaacc ccactgtcac tagagttctt taggctgtaa ggttagaaat ataggaaaaa
     2221 ttttaacctt tatctttatt ttgtgtgtta cacttgtatg tatgtttatg catcataagt
     2281 atcagtgcct gtagaggtca gaatagggtg tgggatcccc tggaaccaga gttataaatg
     2341 gttgtgtgaa gccatgaagg ttcttgagtc tgctgtgaga acagctagtc tcttacccac
     2401 tgatgcatct ccagcaccag aaatagaaac ggaaatagag tagacctgaa tcctgactct
     2461 tccccggaac ctcccaggag ctactgcaag tagaacttga atccccaatt ccagcaatca
     2521 gagctagcat ttaaaataca gcaaacttgg ggctggtgag atggctcagc gggtaagagc
     2581 actgactgct cttccaaagg tcctgagttc aaatcccagc aaccacatgg tggctcacaa
     2641 ccatccgtaa tgacatctga cgtcctcttc tggtgtgtct gaagacagtt acagtgtact
     2701 tacatatgat aaataaataa atcttaaaaa aataaataaa atacagcaaa ctctaacacc
     2761 ggcttcctag taaccccccg cacccaacct taagatatgc ctgtagactc ttaattgcag
     2821 gatttaccag agtttttaat ggaggtatat ttgttcagta gggtcaactt ataaactatt
     2881 cctagggcct ggatggctca gaagttaaga gcgtttcctg cccttacagg ggcctggaat
     2941 ttggttccca acacccaatt tgggtgactc aaaactgact gtaactccag ctccagggaa
     3001 ttcagtgctc tctcccggct tcagtgcgaa cccagataca tgtacacctc cccccaacac
     3061 acagcaataa acaaacaaac aggtaaataa atgaataaaa gcacttcaaa aaaaaaaaaa
     3121 aaaaa
//
