LOCUS       NP_062803                355 aa            linear   ROD 30-APR-2024
DEFINITION  syntaxin-5 [Mus musculus].
ACCESSION   NP_062803
VERSION     NP_062803.4
DBSOURCE    REFSEQ: accession NM_019829.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 355)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 355)
  AUTHORS   Norlin,S., Parekh,V. and Edlund,H.
  TITLE     The ATPase activity of Asna1/TRC40 is required for pancreatic
            progenitor cell survival
  JOURNAL   Development 145 (1) (2018)
   PUBMED   29180572
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 355)
  AUTHORS   Rivera-Monroy,J., Musiol,L., Unthan-Fechner,K., Farkas,A.,
            Clancy,A., Coy-Vergara,J., Weill,U., Gockel,S., Lin,S.Y.,
            Corey,D.P., Kohl,T., Strobel,P., Schuldiner,M., Schwappach,B. and
            Vilardi,F.
  TITLE     Mice lacking WRB reveal differential biogenesis requirements of
            tail-anchored proteins in vivo
  JOURNAL   Sci Rep 6, 39464 (2016)
   PUBMED   28000760
  REMARK    GeneRIF: Stx5 is an autophagy target that is inefficiently
            membrane-targeted by alternative pathways; mice without WRB have
            different biogenesis requirements for tail anchored proteins
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 355)
  AUTHORS   Alldred,M.J., Lee,S.H., Petkova,E. and Ginsberg,S.D.
  TITLE     Expression profile analysis of vulnerable CA1 pyramidal neurons in
            young-Middle-Aged Ts65Dn mice
  JOURNAL   J Comp Neurol 523 (1), 61-74 (2015)
   PUBMED   25131634
REFERENCE   5  (residues 1 to 355)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   6  (residues 1 to 355)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (residues 1 to 355)
  AUTHORS   Floyd,J.A., Gold,D.A., Concepcion,D., Poon,T.H., Wang,X.,
            Keithley,E., Chen,D., Ward,E.J., Chinn,S.B., Friedman,R.A.,
            Yu,H.T., Moriwaki,K., Shiroishi,T. and Hamilton,B.A.
  TITLE     A natural allele of Nxf1 suppresses retrovirus insertional
            mutations
  JOURNAL   Nat Genet 35 (3), 221-228 (2003)
   PUBMED   14517553
REFERENCE   8  (residues 1 to 355)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (residues 1 to 355)
  AUTHORS   Lehtonen,S., Riento,K., Olkkonen,V.M. and Lehtonen,E.
  TITLE     Syntaxin 3 and Munc-18-2 in epithelial cells during kidney
            development
  JOURNAL   Kidney Int 56 (3), 815-826 (1999)
   PUBMED   10469351
REFERENCE   10 (residues 1 to 355)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025794.9, CN539678.1, DV649852.1 and BQ030996.1.
            
            On Nov 17, 2009 this sequence version replaced NP_062803.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: he coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The use of an alternative upstream start codon would result in a
            protein that is 54 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021883.1, AK166087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.45 cM"
     Protein         1..355
                     /product="syntaxin-5"
                     /calculated_mol_wt=39582
     Region          52..74
                     /region_name="Syntaxin-5_N"
                     /note="Syntaxin-5 N-terminal, Sly1p-binding domain;
                     pfam11416"
                     /db_xref="CDD:463276"
     Region          94..324
                     /region_name="COG5325"
                     /note="t-SNARE complex subunit, syntaxin [Intracellular
                     trafficking and secretion]"
                     /db_xref="CDD:227635"
     Region          245..247
                     /region_name="IxM motif, signal for cargo packaging into
                     COPII-coated vesicles.
                     /evidence=ECO:0000250|UniProtKB:Q13190"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1E0.3)"
     Region          266..338
                     /region_name="SNARE_syntaxin5"
                     /note="SNARE motif of syntaxin 5; cd15844"
                     /db_xref="CDD:277197"
     Site            order(267,269..270,272..277,279..281,283..284,286..288,
                     290..291,293..295,297..298,300..305,307..312,314..319,
                     321..323)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277197"
     Site            297
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277197"
     Site            334..354
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1E0.3)"
     CDS             1..355
                     /gene="Stx5a"
                     /gene_synonym="0610031F24Rik; D19Ertd627e; Stx5"
                     /coded_by="NM_019829.4:471..1538"
                     /db_xref="CCDS:CCDS29542.2"
                     /db_xref="GeneID:56389"
                     /db_xref="MGI:MGI:1928483"
ORIGIN      
        1 miprkrygsk ntdqgvylgl sktqvlspat aissssdstp lptpvalvps ppdtmscrdr
       61 tqefqsacks lqsrqngiqt skpalhaarq cseftlmarr igkdlsntfa klekltilak
      121 rkslfddkav eieeltyiik qdinslnkqi aqlqdfvrak gsqsgrhlqt hsntivvslq
      181 sklasmsndf ksvlevrten lkqqrnrreq fsrapvsalp lapnnlgggp iilgaesras
      241 rdvaidmmdp rtsqqlqlid eqdsyiqsra dtmqniesti velgsifqql ahmvkeqeet
      301 iqridenvlg aqldveaahs eilkyfqsvt snrwlmvkif lilivffiif vvfla
//
