LOCUS       NM_009294               1456 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus syntaxin 4A (placental) (Stx4a), transcript variant 1,
            mRNA.
ACCESSION   NM_009294
VERSION     NM_009294.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1456)
  AUTHORS   Yu,X., Benitez,G., Wei,P.T., Krylova,S.V., Song,Z., Liu,L.,
            Zhang,M., Xiaoli,A.M., Wei,H., Chen,F., Sidoli,S., Yang,F.,
            Shinoda,K., Pessin,J.E. and Feng,D.
  TITLE     Involution of brown adipose tissue through a Syntaxin 4 dependent
            pyroptosis pathway
  JOURNAL   Nat Commun 15 (1), 2856 (2024)
   PUBMED   38565851
  REMARK    GeneRIF: Involution of brown adipose tissue through a Syntaxin 4
            dependent pyroptosis pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1456)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1456)
  AUTHORS   Kioumourtzoglou,D., Black,H.L., Al Tobi,M., Livingstone,R.,
            Petrie,J.R., Boyle,J.G., Gould,G.W. and Bryant,N.J.
  TITLE     Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives
            Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell
            Surface
  JOURNAL   Biomolecules 13 (12), 1738 (2023)
   PUBMED   38136609
  REMARK    GeneRIF: Phosphorylation of Syntaxin 4 by the Insulin Receptor
            Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the
            Cell Surface.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1456)
  AUTHORS   Tondeur,E.G.M., Voerman,J.S.A., Geleijnse,M.A.A., van
            Hofwegen,L.S., van Krimpen,A., Koerner,J., Mishra,G., Song,Z. and
            Schliehe,C.
  TITLE     Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation
            of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long
            Peptide In Vitro
  JOURNAL   J Immunol 211 (8), 1203-1215 (2023)
   PUBMED   37638825
  REMARK    GeneRIF: Sec22b and Stx4 Depletion Has No Major Effect on
            Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a
            Synthetic Long Peptide In Vitro.
REFERENCE   5  (bases 1 to 1456)
  AUTHORS   Schrauwen,I., Ghaffar,A., Bharadwaj,T., Shah,K., Rehman,S.,
            Acharya,A., Liaqat,K., Lin,N.S., Everard,J.L., Khan,A., Ahmed,Z.M.,
            Ahmad,W., Riazuddin,S. and Leal,S.M.
  TITLE     Syntaxin 4 is essential for hearing in human and zebrafish
  JOURNAL   Hum Mol Genet 32 (7), 1184-1192 (2023)
   PUBMED   36355422
REFERENCE   6  (bases 1 to 1456)
  AUTHORS   Lehtonen,S., Riento,K., Olkkonen,V.M. and Lehtonen,E.
  TITLE     Syntaxin 3 and Munc-18-2 in epithelial cells during kidney
            development
  JOURNAL   Kidney Int 56 (3), 815-826 (1999)
   PUBMED   10469351
REFERENCE   7  (bases 1 to 1456)
  AUTHORS   Min,J., Okada,S., Kanzaki,M., Elmendorf,J.S., Coker,K.J.,
            Ceresa,B.P., Syu,L.J., Noda,Y., Saltiel,A.R. and Pessin,J.E.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
REFERENCE   8  (bases 1 to 1456)
  AUTHORS   Gerst,J.E.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   9  (bases 1 to 1456)
  AUTHORS   Tellam,J.T., Macaulay,S.L., McIntosh,S., Hewish,D.R., Ward,C.W. and
            James,D.E.
  TITLE     Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes.
            Putative role in insulin-dependent movement of GLUT-4
  JOURNAL   J Biol Chem 272 (10), 6179-6186 (1997)
   PUBMED   9045631
REFERENCE   10 (bases 1 to 1456)
  AUTHORS   Katagiri,H., Terasaki,J., Murata,T., Ishihara,H., Ogihara,T.,
            Inukai,K., Fukushima,Y., Anai,M., Kikuchi,M., Miyazaki,J. et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            On Mar 2, 2023 this sequence version replaced NM_009294.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011491.1, AK145909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC149222.4         111994-112298       c
            306-407             AC149222.4         111697-111798       c
            408-507             AC149222.4         111518-111617       c
            508-582             AC149222.4         111304-111378       c
            583-653             AC149222.4         110420-110490       c
            654-762             AC149222.4         107934-108042       c
            763-839             AC149222.4         107786-107862       c
            840-977             AC149222.4         107437-107574       c
            978-1088            AC149222.4         105564-105674       c
            1089-1187           AC149222.4         105395-105493       c
            1188-1456           AC149222.4         105043-105311       c
FEATURES             Location/Qualifiers
     source          1..1456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.77 cM"
     gene            1..1456
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /note="syntaxin 4A (placental)"
                     /db_xref="GeneID:20909"
                     /db_xref="MGI:MGI:893577"
     exon            1..305
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1172
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     syntaxin-4"
                     /codon_start=1
                     /product="syntaxin-4 isoform 1"
                     /protein_id="NP_033320.1"
                     /db_xref="CCDS:CCDS21880.1"
                     /db_xref="GeneID:20909"
                     /db_xref="MGI:MGI:893577"
                     /translation="MRDRTHELRQGDNISDDEDEVRVALVVHSGAARLGSPDDEFFQK
                     VQTIRQTMAKLESKVRELEKQQVTILATPLPEESMKQGLQNLREEIKQLGREVRAQLK
                     AIEPQKEEADENYNSVNTRMKKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQL
                     KITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIR
                     ELHEIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKIALENQKKARKKKVMI
                     AICVSVTVLILAVIIGITITVG"
     exon            306..407
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            408..507
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            508..582
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            583..653
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            654..762
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            763..839
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            840..977
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1088
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1187
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1456
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /note="hexamer: AAGAAA"
     polyA_site      1456
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /note="major polyA site"
ORIGIN      
        1 atgctcggag tcatcccccg aggggcgggg cggcagctgc gggagcagga tggggggaag
       61 agaagggaat tccaacctgt agaactttgg gggtcctatg atcgggttct tccccacgac
      121 tgtggatggt gaaaggggtg gggcctttgg cggctccggg gtgtactgga gttcgctggg
      181 tgagggaggg ggtgtcaagt gtgagagagg tgcaggactt ccaaatttag aaccttgagg
      241 ccctttgggc tcgggtccag ggcactccga ccaccatgcg cgacaggacc cacgagttga
      301 ggcaggggga taacatctca gacgatgaag atgaggttcg agtcgcgctg gtggtgcact
      361 caggtgctgc ccggttgggc agcccggacg acgagttctt ccagaaggtg cagacaattc
      421 ggcagactat ggccaaactg gagagtaaag tccgggagtt ggagaaacag caggtcacca
      481 tcctggccac gcctcttccc gaggagagca tgaagcaggg cctgcagaac ctgcgagagg
      541 agatcaaaca gctggggaga gaggtccggg cgcagctaaa agccatagag ccccagaagg
      601 aggaagctga tgagaattac aactcagtca acacaaggat gaagaaaacc cagcatggag
      661 tcctgtccca gcaatttgtc gagctcatca acaagtgcaa ctcaatgcag tccgaatacc
      721 gagagaagaa tgtggagcgg atccggaggc agctgaagat caccaatgct ggaatggtgt
      781 ctgacgagga gctggaacag atgctggaca gtgggcagag tgaggtgttt gtgtctaata
      841 tcctgaagga cacgcaggtg actcggcagg ccctgaatga gatctctgcg cggcacagtg
      901 agatccagca gttggagcgc agtatccgag agctccatga gatctttacg tttctagcta
      961 cggaggtgga gatgcagggg gagatgatca accgcatcga gaagaacatc ctgagctcgg
     1021 ccgactacgt ggaacgtggg caagagcacg tcaagatagc cctagagaat cagaagaagg
     1081 cgaggaagaa aaaagtcatg attgccatct gtgtctctgt cactgttctc atcttggctg
     1141 tcatcattgg catcaccata accgttggat aatgtcacat gttcttggca ttgggagaga
     1201 cagagaccca gcttttgtgg aggtggggca ggcctccaac tgaacccgtc cgcacactgg
     1261 accttgtgca gagggcctgc ggctcgtcct gggttggcag ctgctcattc atggagtcct
     1321 cccctggagt cctccacaat gcctgcgaga cagttttcaa tgtcctgttt gtctgggata
     1381 catggttttg taaaaaattt aaaaaaaaaa aaaaaaaaaa aaaagaaaga aagaaaagaa
     1441 taagaagaag cttgga
//
