LOCUS       NM_152220               3271 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus syntaxin 3 (Stx3), transcript variant A, mRNA.
ACCESSION   NM_152220 XM_985376
VERSION     NM_152220.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3271)
  AUTHORS   Chatterjee,R., Nair,A.V., Singh,A., Mehta,N., Setty,S.R.G. and
            Chakravortty,D.
  TITLE     Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of
            Salmonella containing vacuole
  JOURNAL   Traffic 24 (7), 270-283 (2023)
   PUBMED   37114883
  REMARK    GeneRIF: Syntaxin 3 SPI-2 dependent crosstalk facilitates the
            division of Salmonella containing vacuole.
REFERENCE   3  (bases 1 to 3271)
  AUTHORS   Janecke,A.R., Liu,X., Adam,R., Punuru,S., Viestenz,A., Strauss,V.,
            Laass,M., Sanchez,E., Adachi,R., Schatz,M.P., Saboo,U.S.,
            Mittal,N., Rohrschneider,K., Escher,J., Ganesh,A., Al Zuhaibi,S.,
            Al Murshedi,F., AlSaleem,B., Alfadhel,M., Al Sinani,S.,
            Alkuraya,F.S., Huber,L.A., Muller,T., Heidelberger,R. and Janz,R.
  TITLE     Pathogenic STX3 variants affecting the retinal and intestinal
            transcripts cause an early-onset severe retinal dystrophy in
            microvillus inclusion disease subjects
  JOURNAL   Hum Genet 140 (8), 1143-1156 (2021)
   PUBMED   33974130
REFERENCE   4  (bases 1 to 3271)
  AUTHORS   Kakakhel,M., Tebbe,L., Makia,M.S., Conley,S.M., Sherry,D.M.,
            Al-Ubaidi,M.R. and Naash,M.I.
  TITLE     Syntaxin 3 is essential for photoreceptor outer segment protein
            trafficking and survival
  JOURNAL   Proc Natl Acad Sci U S A 117 (34), 20615-20624 (2020)
   PUBMED   32778589
  REMARK    GeneRIF: Syntaxin 3 is essential for photoreceptor outer segment
            protein trafficking and survival.
REFERENCE   5  (bases 1 to 3271)
  AUTHORS   Jurado,S.
  TITLE     The dendritic SNARE fusion machinery involved in AMPARs insertion
            during long-term potentiation
  JOURNAL   Front Cell Neurosci 8, 407 (2014)
   PUBMED   25565955
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3271)
  AUTHORS   Lehtonen,S., Riento,K., Olkkonen,V.M. and Lehtonen,E.
  TITLE     Syntaxin 3 and Munc-18-2 in epithelial cells during kidney
            development
  JOURNAL   Kidney Int 56 (3), 815-826 (1999)
   PUBMED   10469351
REFERENCE   7  (bases 1 to 3271)
  AUTHORS   Gerst,J.E.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   8  (bases 1 to 3271)
  AUTHORS   Riento,K., Galli,T., Jansson,S., Ehnholm,C., Lehtonen,E. and
            Olkkonen,V.M.
  TITLE     Interaction of Munc-18-2 with syntaxin 3 controls the association
            of apical SNAREs in epithelial cells
  JOURNAL   J Cell Sci 111 (Pt 17), 2681-2688 (1998)
   PUBMED   9701566
REFERENCE   9  (bases 1 to 3271)
  AUTHORS   Riento,K., Jantti,J., Jansson,S., Hielm,S., Lehtonen,E.,
            Ehnholm,C., Keranen,S. and Olkkonen,V.M.
  TITLE     A sec1-related vesicle-transport protein that is expressed
            predominantly in epithelial cells
  JOURNAL   Eur J Biochem 239 (3), 638-646 (1996)
   PUBMED   8774707
REFERENCE   10 (bases 1 to 3271)
  AUTHORS   Ibaraki,K., Horikawa,H.P., Morita,T., Mori,H., Sakimura,K.,
            Mishina,M., Saisu,H. and Abe,T.
  TITLE     Identification of four different forms of syntaxin 3
  JOURNAL   Biochem Biophys Res Commun 211 (3), 997-1005 (1995)
   PUBMED   7598732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126266.3, BC056949.1, AK133830.1, BG079344.2, BX634318.1,
            CJ058200.1, BG064925.2 and BF318335.1.
            
            On Nov 8, 2013 this sequence version replaced NM_152220.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171135.1, AK133830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC126266.3         89488-89551         c
            65-794              BC056949.1         65-794
            795-1673            AK133830.1         318-1196
            1674-2221           BG079344.2         52-599
            2222-2470           BX634318.1         1-249               c
            2471-2735           CJ058200.1         146-410
            2736-3270           BG064925.2         1-535               c
            3271-3271           BF318335.1         4-4                 c
FEATURES             Location/Qualifiers
     source          1..3271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.52 cM"
     gene            1..3271
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /note="syntaxin 3"
                     /db_xref="GeneID:20908"
                     /db_xref="MGI:MGI:103077"
     exon            1..712
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             683..1552
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /note="isoform A is encoded by transcript variant A"
                     /codon_start=1
                     /product="syntaxin-3 isoform A"
                     /protein_id="NP_689344.1"
                     /db_xref="CCDS:CCDS29613.1"
                     /db_xref="GeneID:20908"
                     /db_xref="MGI:MGI:103077"
                     /translation="MKDRLEQLKAKQLTQDDDTDEVEIAIDNTAFMDEFFSEIEETRL
                     NIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHI
                     EEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKT
                     TDEELEEMLESGNPAIFTSGIIDSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDI
                     AMLVENQGEMLDNIELNVMHTVDHVEKARDETKRAMKYQGQARKKLIIIIVVVVVLLG
                     ILALIIGLSVGLK"
     exon            713..796
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..896
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            897..971
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1039
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1148
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1222
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1357
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1468
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1582
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..3271
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3242..3247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /note="hexamer: AATAAA"
     polyA_site      3269
                     /gene="Stx3"
                     /gene_synonym="Syn-3"
                     /note="major polyA site"
ORIGIN      
        1 cttcgagagg ccccacaacc actagcatca taatccccaa attcctcgcc gcagcccgat
       61 ccagggcatc tcatctgcag ttacgcccta cgggaacaag tctctgagcc cgaaccgcac
      121 agattttata cccaacaggt cccttcttta aggcggaata tctcttgagc atcatcggaa
      181 cgttttccct catcaaaggg agcaggaacc agcttgtctt caacctgagg agtccgcaga
      241 gggccgaaca ataagaacag tgcggaaaat acggaatcga agccagacag accacccccg
      301 cctttttttt tttttttttt tgtttctgcc tttcgagggg catgggaagg tgtgcccgga
      361 atgcttccgg cgctggagcg cgctggccct ttaagcagga gctcggggag cggcccaggt
      421 atggggcggg cccaggggcg ggcgagccct gagccggcgc ggtctcgtag ccggatttgg
      481 agcgcggcgc cggcgggggc cggagggggc ggcgcggcgg acctcggtgg cctcggacgc
      541 tcctcctcga gagcggccgc cgcccgcctc cgcccgctct agcagctctc tcgccccggc
      601 cggcagccgc cgccgctcca ggccgctcac ttgggacgcg ctcacctgag acaaggcgcc
      661 cgccgccctc acctgggcca ggatgaagga ccggctggag cagctgaagg ccaagcagct
      721 gacgcaggat gatgacacgg acgaggttga gattgccatt gacaacacag ccttcatgga
      781 cgagttcttc tctgagatcg aggaaacacg gctcaacatt gacaagatct cggagcatgt
      841 agaggaagct aagaaactct acagtatcat tctctctgca ccgatcccag agccaaaaac
      901 caaagatgac cttgaacagc tcacaactga gatcaagaaa agggccaaca acgtccggaa
      961 caagctgaag agcatggaga agcacattga ggaagatgag gttcggtcat ctgcagacct
     1021 tcggatacga aagtcccagc actccgtcct ctcccggaag tttgtggagg tgatgacaaa
     1081 gtacaatgag gctcaggtgg acttccgtga acgcagcaaa gggcgcatcc aacggcagct
     1141 tgaaattact ggcaagaaga caacagatga ggagctggaa gagatgttgg agagtggcaa
     1201 cccagccatc ttcacttctg ggatcattga ctcccagatt tccaagcaag ccctcagcga
     1261 gattgagggt cggcacaagg acatcgtaag gctggagagc agcatcaagg agctccatga
     1321 catgtttatg gacatcgcca tgctggtgga aaatcagggg gagatgttag ataacataga
     1381 gttgaatgtc atgcacacag tggaccatgt ggagaaggca cgggatgaaa ctaaaagagc
     1441 catgaagtat cagggtcagg ctcggaagaa attgataatt atcattgtgg tagtagttgt
     1501 gttgctgggc attttagcgt tgattattgg actgtccgtt gggctgaaat aagagtggcc
     1561 taaggggctg ctgcactgaa ataaccagct ttcactccag cttggcctga ccactcttgt
     1621 ctccagacgg gaacagagtt tgaaaggcct ccctgagaat gagggggtac ctgttacttt
     1681 atttccttat aaccatcctt ggacctggct cagcaaacaa tctaccccca gaagaatcta
     1741 acctacctga tgcagtcctg agttctcatc aaaaccacct cccatcctag cagctgaagt
     1801 accctcttct ggactctgtg aagcaaccct gtgtgttggt gtgtaggtta tgctttgtgc
     1861 cttggacaat ccccgtgaga caagccaagg cactgtattt ctacctcatg gagtattctc
     1921 ctggaatata ctttgtaggg gaataactaa caaagtagag gaattctaag tttagtagta
     1981 aatgtggctt ggaacagagt ccctagctgg caggatgcca atccttagtt tgttgtttgc
     2041 tgtcctgaaa acatgaaaga ctaatagatg ccattttggt cttacaagtt ggcttatttg
     2101 aaatttacct tttaattaag ctctaacttc attgtgggtc acattggttt ttctctatat
     2161 tcactcttgt ttatttagag agaccagggt gacaggtctt ctgaagctac cattggcaaa
     2221 gagtaaggtt atagaatttg ctggctagtc actgttagat aattgctctt tgtgaagaca
     2281 ttactttgag gccaaccaga accagggatt taaaactggt ccagggacaa ggtgctacag
     2341 tctcaggctc tggaaatgtc agtcatttgt gtgttccagg tgtacttttg taattatgta
     2401 tgtgagagat atgtacataa ttgtctgcct ctcaggaagt aggaaaacta gaagatacta
     2461 tgacctcaaa aaaaaaaaaa aaaaaaaaga caaaggtaag cagcagctaa aatcagctag
     2521 ggaatatatg cttacctcaa gtgaatcact gtagaaatgt gattttttcc ccccttgcca
     2581 tcaagcttgt tttctggatg gctgctgata tgggaatcaa atgagacctt tggagtaagg
     2641 actaaattgg ttcccatcga agttttctgc atagcagata gtgtgtaata tttacctcca
     2701 tctgttgctt acaagagggt tgtccagaga acctctcaca cccgtctgat gttatttaca
     2761 ctatccatgt gatgtttctg tctggcggaa gaattgggag gctctagagc agttcttcct
     2821 gctttctttt gtctcctgta attcttatca tggaggcaat agcctggaaa tcgttagtga
     2881 taagcctcag acctttggtg gtccctgcca gtatcccgga ttttgggtat ataacccccc
     2941 aatttaatgt ttctatggga tagatgagta gtaatctagt ctaggcactg cctatgagct
     3001 ttctttgtaa aggtacctcc tcagtcaccc agcattcaag atggagcctc agggatgcct
     3061 tcctcccttt ggctgtgatg tctggcagga ctgactccgg ctaggagggg aaacaaccct
     3121 tagtgcaggc cttttctctc ctccttcagg ccagctgaaa gtttgaaatg ccacatatga
     3181 agggcttttg ttgtttgtaa ttttttaaat gtaaacttga ttattttatt gctaatttaa
     3241 aaataaatga ctttatactg attgtaaaac a
//
