LOCUS       NM_007941               2937 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus syntaxin 2 (Stx2), transcript variant 1, mRNA.
ACCESSION   NM_007941
VERSION     NM_007941.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2937)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2937)
  AUTHORS   Yamada,M., Hirai,Y., Inoue,D., Komatsu,S., Uchida,T., Kojima,T.,
            Tomiyasu,T., Yoshikawa,N. and Oda,T.
  TITLE     Increased expression of epimorphin in a peritoneal fibrosis mouse
            model
  JOURNAL   Perit Dial Int 42 (5), 522-529 (2022)
   PUBMED   34641723
  REMARK    GeneRIF: Increased expression of epimorphin in a peritoneal
            fibrosis mouse model.
REFERENCE   3  (bases 1 to 2937)
  AUTHORS   Ogonuki,N., Kyogoku,H., Hino,T., Osawa,Y., Fujiwara,Y., Inoue,K.,
            Kunieda,T., Mizuno,S., Tateno,H., Sugiyama,F., Kitajima,T.S. and
            Ogura,A.
  TITLE     Birth of mice from meiotically arrested spermatocytes following
            biparental meiosis in halved oocytes
  JOURNAL   EMBO Rep 23 (7), e54992 (2022)
   PUBMED   35587095
REFERENCE   4  (bases 1 to 2937)
  AUTHORS   Kuno,A., Ikeda,Y., Ayabe,S., Kato,K., Sakamoto,K., Suzuki,S.R.,
            Morimoto,K., Wakimoto,A., Mikami,N., Ishida,M., Iki,N., Hamada,Y.,
            Takemura,M., Daitoku,Y., Tanimoto,Y., Dinh,T.T.H., Murata,K.,
            Hamada,M., Muratani,M., Yoshiki,A., Sugiyama,F., Takahashi,S. and
            Mizuno,S.
  TITLE     DAJIN enables multiplex genotyping to simultaneously validate
            intended and unintended target genome editing outcomes
  JOURNAL   PLoS Biol 20 (1), e3001507 (2022)
   PUBMED   35041655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2937)
  AUTHORS   Osawa,Y., Murata,K., Usui,M., Kuba,Y., Le,H.T., Mikami,N.,
            Nakagawa,T., Daitoku,Y., Kato,K., Shawki,H.H., Ikeda,Y., Kuno,A.,
            Morimoto,K., Tanimoto,Y., Dinh,T.T.H., Yagami,K.I., Ema,M.,
            Yoshida,S., Takahashi,S., Mizuno,S. and Sugiyama,F.
  TITLE     EXOC1 plays an integral role in spermatogonia pseudopod elongation
            and spermatocyte stable syncytium formation in mice
  JOURNAL   Elife 10, e59759 (2021)
   PUBMED   33973520
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2937)
  AUTHORS   Zha,H., Remmers,E.F., Szpirer,C., Szpirer,J., Zhang,H., Kozak,C.A.
            and Wilder,R.L.
  TITLE     The epimorphin gene is highly conserved among humans, mice, and
            rats and maps to human chromosome 7, mouse chromosome 5, and rat
            chromosome 12
  JOURNAL   Genomics 37 (3), 386-389 (1996)
   PUBMED   8938452
REFERENCE   7  (bases 1 to 2937)
  AUTHORS   Riento,K., Jantti,J., Jansson,S., Hielm,S., Lehtonen,E.,
            Ehnholm,C., Keranen,S. and Olkkonen,V.M.
  TITLE     A sec1-related vesicle-transport protein that is expressed
            predominantly in epithelial cells
  JOURNAL   Eur J Biochem 239 (3), 638-646 (1996)
   PUBMED   8774707
REFERENCE   8  (bases 1 to 2937)
  AUTHORS   Hirai,Y.
  TITLE     Sodium-dodecyl-sulfate-resistant complex formation of epimorphin
            monomers and interaction of the 150-kDa complex with the cell
            surface
  JOURNAL   Eur J Biochem 225 (3), 1133-1139 (1994)
   PUBMED   7957204
REFERENCE   9  (bases 1 to 2937)
  AUTHORS   Inoue,A. and Akagawa,K.
  TITLE     Neuron-specific antigen HPC-1 from bovine brain reveals strong
            homology to epimorphin, an essential factor involved in epithelial
            morphogenesis: identification of a novel protein family
  JOURNAL   Biochem Biophys Res Commun 187 (2), 1144-1150 (1992)
   PUBMED   1530610
REFERENCE   10 (bases 1 to 2937)
  AUTHORS   Hirai,Y., Takebe,K., Takashina,M., Kobayashi,S. and Takeichi,M.
  TITLE     Epimorphin: a mesenchymal protein essential for epithelial
            morphogenesis
  JOURNAL   Cell 69 (3), 471-481 (1992)
   PUBMED   1581962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110566.17, AK146462.1, BC046279.1 and CJ232084.1.
            
            On Oct 26, 2013 this sequence version replaced NM_007941.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10475.1, BC046279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC110566.17        92290-92360         c
            72-1583             AK146462.1         1-1512
            1584-2930           BC046279.1         1508-2854
            2931-2937           CJ232084.1         433-439
FEATURES             Location/Qualifiers
     source          1..2937
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 67.99 cM"
     gene            1..2937
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /note="syntaxin 2"
                     /db_xref="GeneID:13852"
                     /db_xref="MGI:MGI:108059"
     exon            1..179
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1019
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /note="isoform a is encoded by transcript variant 1;
                     epimorphin"
                     /codon_start=1
                     /product="syntaxin-2 isoform a"
                     /protein_id="NP_031967.2"
                     /db_xref="CCDS:CCDS19692.1"
                     /db_xref="GeneID:13852"
                     /db_xref="MGI:MGI:108059"
                     /translation="MRDRLPDLTACRTNDDGDTAVVIVEKDHFMDGFFHQVEEIRSSI
                     ARIAQHVEDVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANRIRGKLKSIEQSCDQ
                     DENGNRTSVDLRIRRTQHSVLSRKFVDVMTEYNEAQILFRERSKGRIQRQLEITGRTT
                     TDDELEEMLESGKPSIFISDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMD
                     MAMFVETQGEMVNNIERNVVNSVDYVEHAKEETKKAIKYQSKARRKKWIIAAVAVAVI
                     AVLALIIGLSVGK"
     exon            180..257
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..357
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..432
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..506
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..615
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..689
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..827
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..938
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1063
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..2937
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2906..2911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2937
                     /gene="Stx2"
                     /gene_synonym="Epim; G1-536-1; repro34; Syn-2"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgcgg ttgccgtggc agcgcctgcc cgagggaggg cggcggcgcg gggccaggac
       61 cccggcaggc agaggcggcg acgcggccac cggagagtgt gcggcggggc agctgagcgg
      121 cgggtgcccc gccctgctgg ccggtgggga tgcgggaccg gctgcccgac ctcacggcgt
      181 gtaggacaaa cgacgatgga gacactgctg tcgtcattgt ggagaaggat catttcatgg
      241 acggtttctt ccatcaggta gaggagattc gaagcagcat agccaggatt gctcagcatg
      301 tagaagacgt gaagaagaac cacagcatca tcctgtctgc tccaaaccca gaaggaaaaa
      361 taaaagaaga gctggaggac ctgaacaaag agatcaagaa aactgctaac aggatccggg
      421 gcaagctgaa gtctattgag cagagctgtg atcaggacga gaatgggaac cgaacttcag
      481 tggatctgcg gatacgaagg acccagcact cggtgctgtc acggaagttt gtggacgtca
      541 tgacagaata caatgaagcg cagatcctgt tccgggagcg aagcaaaggc cgcatccagc
      601 gccagctgga gatcactggg aggaccacca ctgacgacga gctggaagag atgctggaga
      661 gcgggaagcc gtccatcttc atctcggata ttatatcaga ttcacaaatc actaggcaag
      721 ctctcaatga gatcgagtcc cgccacaaag acatcatgaa gctggagacc agcatccgag
      781 agctgcacga gatgttcatg gatatggcca tgtttgtcga gactcagggt gaaatggtca
      841 acaacatcga gagaaatgtg gtgaactctg tagattacgt ggaacatgcc aaggaagaga
      901 cgaagaaagc catcaaatac cagagcaagg ccaggcggaa aaagtggata attgctgctg
      961 tggcggtggc tgtcattgcc gtcctggctc taatcattgg cttgtcggtt ggcaaatgat
     1021 tgcgtagatg gcgctgggtg cttgcctctc cctcagggtg gcaaaggtga tgttcgtcct
     1081 catttgtgta gtcactttgc ttgtgatcct tggaattatt ctcgcaacag cattgtcata
     1141 gcaaccgtac cccaagagct ctttgtcctc ggtgactccg accatacctg cagcttagtc
     1201 agcatcctgt ccttccacga gtgaacctca gactccaggg ctagcgccga gcactgaggt
     1261 ttttattggt gatgaagaag aaagcaccgc agaggtttcg taccatgaaa caccgcgagc
     1321 ccagtggatg cgacatgcca gcccagagag cctgggtctc tctcaaggac accacagaga
     1381 tttcacaaca gtggccttgc cttggtagct ttgaaatagg aatgattgaa aaagcctaat
     1441 ttttaaagac aatgtcagtg ttaaaaatgt atgttgtgtg taattagggt gtgctctgcg
     1501 ctcagctggc agtgctgacg aagagacttc gtgccaggcc tgatctctgt tcatgtcttg
     1561 tttgcagaat catcacagaa ctgttttgta aggcatctgt aagttaagtt ccttaatcta
     1621 ttaacatcta aactcccttt ctaagctaga cactgccttg tgaaggacaa tgggccagcc
     1681 ccgggcaagc atgaacactg ccttacagcc cctcagggcc cttctatagt gccttctggt
     1741 gaccctgact aggaagtgtg agggtctgaa gagccttgaa cgttagctca cggaggggac
     1801 aagcagtcac atgccgcact catgttactc ttccttgttc atgtgagctg atggagtctc
     1861 aaggcaaggc gacagtgacg atggagcaaa cttggtgctc actaaactca agagaatggt
     1921 cccgggtaca tagccactcc tggatggcac ctgaaggacc aggtcctcag cccaacaccc
     1981 acgagtgccc agagttccta agaaaccatg aagtgtggga taaagctgtg cactggttta
     2041 cacttgtgaa tagatggccc agcgaccaag tatgtgaagg ataccatgac tagtgaactc
     2101 tgccaactgc tgactgtgat gagtgctcac tctaccccag cctcacttgg tgggatatga
     2161 tgtagccatg ccgggtcaga acaccaagtg tgagcaagtg ctactgaact atctaaaaac
     2221 catgatcctt tcagtggtga gtgtgccaca ctgtcacctc ctcacacctc ctggtctgac
     2281 accccatgtg ccgagagcta ctgcagcagg ctgggctgtg ggtcctggtc tagagttagc
     2341 ctgtagtgca gccactcctg gctgatagct cacccttcct aactgggagc tcacccttcc
     2401 tgcctggaag ctcacacttc ctgtctggga gctcaccctt cttgcctggg agctcacact
     2461 tcctgtctgg gagctcacac ttccttcctg ggagctcaca cttcctgcct gggagctcac
     2521 ccttcctgcc tgggagctca cacttcctgc ctgggagctc tgaagatgaa cctgggcctt
     2581 tgcagctcac cctctctgca tcagtcagtg ccatcggatt tagctgcaga gaccatgcgt
     2641 accacccagg ctcccaccac ccacagccag gtgtccctcc agtccagcct gagcccttgg
     2701 cctgcagtgt gctcgcagag cgctcaggag acctctcgac caggcaggca gctgaatctg
     2761 gatttccagt gaatcagggg tgtgtgggtg actgagtcag cactccagat acatctctct
     2821 gctgacttca tagcctattt aaaaatatat ttacagattc ccttgttacc ttttccaagc
     2881 atttcttcaa atattttgtg tttacattaa aaagttctca gagatgcaaa caagaaa
//
