LOCUS       NM_024414               1574 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus syntaxin 1B (Stx1b), mRNA.
ACCESSION   NM_024414 NM_019560
VERSION     NM_024414.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Martinez-Marmol,R., Muhaisen,A., Cotrufo,T., Rosello-Busquets,C.,
            Ros,O., Hernaiz-Llorens,M., Perez-Branguli,F., Andres,R.M.,
            Parcerisas,A., Pascual,M., Ulloa,F. and Soriano,E.
  TITLE     Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent
            macropinocytosis and chemorepulsion
  JOURNAL   Front Mol Neurosci 16, 1253954 (2023)
   PUBMED   37829513
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Vardar,G., Salazar-Lazaro,A., Zobel,S., Trimbuch,T. and
            Rosenmund,C.
  TITLE     Syntaxin-1A modulates vesicle fusion in mammalian neurons via
            juxtamembrane domain dependent palmitoylation of its transmembrane
            domain
  JOURNAL   Elife 11, e78182 (2022)
   PUBMED   35638903
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Vardar,G., Salazar-Lazaro,A., Brockmann,M., Weber-Boyvat,M.,
            Zobel,S., Kumbol,V.W., Trimbuch,T. and Rosenmund,C.
  TITLE     Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion
            from central murine synapses
  JOURNAL   Elife 10, e69498 (2021)
   PUBMED   34427183
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Mishima,T., Fujiwara,T., Kofuji,T., Saito,A., Terao,Y. and
            Akagawa,K.
  TITLE     Syntaxin 1B regulates synaptic GABA release and extracellular GABA
            concentration, and is associated with temperature-dependent
            seizures
  JOURNAL   J Neurochem 156 (5), 604-613 (2021)
   PUBMED   32858780
  REMARK    GeneRIF: Syntaxin 1B regulates synaptic GABA release and
            extracellular GABA concentration, and is associated with
            temperature-dependent seizures.
REFERENCE   5  (bases 1 to 1574)
  AUTHORS   Kunii,M., Noguchi,Y., Yoshimura,S.I., Kanda,S., Iwano,T.,
            Avriyanti,E., Atik,N., Sato,T., Sato,K., Ogawa,M. and Harada,A.
  TITLE     SNAP23 deficiency causes severe brain dysplasia through the loss of
            radial glial cell polarity
  JOURNAL   J Cell Biol 220 (1) (2021)
   PUBMED   33332551
REFERENCE   6  (bases 1 to 1574)
  AUTHORS   Vosseller,K., Hansen,K.C., Chalkley,R.J., Trinidad,J.C., Wells,L.,
            Hart,G.W. and Burlingame,A.L.
  TITLE     Quantitative analysis of both protein expression and serine /
            threonine post-translational modifications through stable isotope
            labeling with dithiothreitol
  JOURNAL   Proteomics 5 (2), 388-398 (2005)
   PUBMED   15648052
REFERENCE   7  (bases 1 to 1574)
  AUTHORS   Bouwman,J., Maia,A.S., Camoletto,P.G., Posthuma,G., Roubos,E.W.,
            Oorschot,V.M., Klumperman,J. and Verhage,M.
  TITLE     Quantification of synapse formation and maintenance in vivo in the
            absence of synaptic release
  JOURNAL   Neuroscience 126 (1), 115-126 (2004)
   PUBMED   15145078
REFERENCE   8  (bases 1 to 1574)
  AUTHORS   Aguado,F., Carmona,M.A., Pozas,E., Aguilo,A.,
            Martinez-Guijarro,F.J., Alcantara,S., Borrell,V., Yuste,R.,
            Ibanez,C.F. and Soriano,E.
  TITLE     BDNF regulates spontaneous correlated activity at early
            developmental stages by increasing synaptogenesis and expression of
            the K+/Cl- co-transporter KCC2
  JOURNAL   Development 130 (7), 1267-1280 (2003)
   PUBMED   12588844
REFERENCE   9  (bases 1 to 1574)
  AUTHORS   Kablar,B.
  TITLE     Determination of retinal cell fates is affected in the absence of
            extraocular striated muscles
  JOURNAL   Dev Dyn 226 (3), 478-490 (2003)
   PUBMED   12619134
REFERENCE   10 (bases 1 to 1574)
  AUTHORS   Yang,S.N., Larsson,O., Branstrom,R., Bertorello,A.M., Leibiger,B.,
            Leibiger,I.B., Moede,T., Kohler,M., Meister,B. and Berggren,P.O.
  TITLE     Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+)
            channels in pancreatic beta cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (18), 10164-10169 (1999)
   PUBMED   10468580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            On or before Feb 1, 2008 this sequence version replaced
            NM_019560.1, NM_024414.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D45207.1, SRR1660819.105615.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AC149222.4         129531-129802
            273-347             AC149222.4         138642-138716
            348-447             AC149222.4         138899-138998
            448-522             AC149222.4         139075-139149
            523-596             AC149222.4         142826-142899
            597-705             AC149222.4         143054-143162
            706-779             AC149222.4         143334-143407
            780-917             AC149222.4         146078-146215
            918-1028            AC149222.4         146296-146406
            1029-1574           AC149222.4         146673-147218
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.75 cM"
     gene            1..1574
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /note="syntaxin 1B"
                     /db_xref="GeneID:56216"
                     /db_xref="MGI:MGI:1930705"
     exon            1..272
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1109
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /note="syntaxin 1B1; syntaxin 1B2"
                     /codon_start=1
                     /product="syntaxin-1B"
                     /protein_id="NP_077725.1"
                     /db_xref="CCDS:CCDS40146.1"
                     /db_xref="GeneID:56216"
                     /db_xref="MGI:MGI:1930705"
                     /translation="MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIE
                     KLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQE
                     EGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTT
                     NEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDM
                     AMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGV
                     VLASSIGGTLGL"
     exon            273..347
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            348..447
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            448..522
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            523..596
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            597..705
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            706..779
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            780..917
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1028
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1574
                     /gene="Stx1b"
                     /gene_synonym="Stx1b2; Stx1bl; Syn1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctccatcc aaccctgtgc cgcagccgca tcgccaccgc agcctaggca gagcccagtc
       61 ggcccaggcc cctgtctctg cctggcctta gctccccgcc cccccgccgc gcaccttatc
      121 cgcacatccc tcggaggtct agcccggtgc ccccagaccc cggcctccag gacagaggca
      181 agaggcagag agcagcagcg gaggcgggag gacgaagaag gggaggagga gcccgtcgca
      241 ggatgaagga tcggactcag gagctgcgga gtgcgaaaga cagtgatgat gaagaggagg
      301 tggtccacgt ggatcgagac cactttatgg atgagttctt cgagcaggtg gaagagatcc
      361 gaggctgcat cgagaaactg tctgaggatg tggagcaagt gaagaaacag cacagcgcca
      421 ttcttgccgc ccccaacccc gatgagaaga ctaaacagga gttggaggac ctcacggcag
      481 acatcaaaaa gacggcaaac aaggtccggt ccaagttgaa agcgatcgag caaagcattg
      541 agcaggaaga ggggctgaat cgttcctctg cggacctgcg catccgtaag acccagcact
      601 ccacactctc acggaagttc gtggaggtaa tgaccgaata taatgcaact cagtccaagt
      661 accgggaccg ctgcaaggac cgaatccaga ggcagctgga gatcactggc aggactacta
      721 ccaatgaaga actagaagac atgttggaaa gcgggaagct ggccatcttc actgatgata
      781 tcaaaatgga ctcgcagatg acaaagcaag ctctgaatga gatcgagaca aggcacaatg
      841 agatcatcaa actggaaacc agcattcgag agctgcacga catgtttgtg gacatggcca
      901 tgctcgtaga gagccagggt gagatgatcg accgaattga gtacaacgtg gaacattccg
      961 tggactacgt ggaacgagcc gtgtctgaca ccaagaaagc tgtgaagtat cagagcaagg
     1021 ccaggaggaa gaaaattatg atcatcattt gctgtgtggt gctgggggtg gtcttggcgt
     1081 catccattgg ggggacactg ggcttgtagg cccctaccct tctcttccct aggaccctcc
     1141 ccacacatcg ggagcaatac cccccgaccc tttcaccttt tccctgctcc aagctcactc
     1201 ccaaaacaga cccaggcagt tccagccact ctcaccctca tgcagaccct ggagtccctg
     1261 gctctcacct tgccgcacat agatagcagc aggcgtgatc acacatgcac accaacatgc
     1321 atgccgaggg cacatgctca agacgtgtgg acaccccagc gtgtgtgtac ttgtgtagat
     1381 gtatgtagat gccccgaccc tcttgctgcc accttcatcc tgtgtggtct gaacttccct
     1441 ctctatctgg ctgctgtgct gactgtagca gcccaccatg gcccaacctg tcctgtgtga
     1501 atagacatgg atagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tagatctgtg
     1561 cccatacagt gtat
//
