LOCUS       NM_016801               2206 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus syntaxin 1A (brain) (Stx1a), transcript variant 1,
            mRNA.
ACCESSION   NM_016801
VERSION     NM_016801.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   Nakayama,T., Singh,A.K., Fukutomi,T., Uchida,N., Terao,Y.,
            Hamada,H., Muraoka,T., Muthusamy,E., Kundu,T.K. and Akagawa,K.
  TITLE     Activator of KAT3 histone acetyltransferase family ameliorates a
            neurodevelopmental disorder phenotype in the syntaxin 1A ablated
            mouse model
  JOURNAL   Cell Rep 43 (4), 114101 (2024)
   PUBMED   38613786
  REMARK    GeneRIF: Activator of KAT3 histone acetyltransferase family
            ameliorates a neurodevelopmental disorder phenotype in the syntaxin
            1A ablated mouse model.
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Salazar Lazaro,A., Trimbuch,T., Vardar,G. and Rosenmund,C.
  TITLE     The stability of the primed pool of synaptic vesicles and the
            clamping of spontaneous neurotransmitter release rely on the
            integrity of the C-terminal half of the SNARE domain of syntaxin-1A
  JOURNAL   Elife 12, 90775 (2024)
   PUBMED   38512129
  REMARK    GeneRIF: The stability of the primed pool of synaptic vesicles and
            the clamping of spontaneous neurotransmitter release rely on the
            integrity of the C-terminal half of the SNARE domain of
            syntaxin-1A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2206)
  AUTHORS   Martinez-Marmol,R., Muhaisen,A., Cotrufo,T., Rosello-Busquets,C.,
            Ros,O., Hernaiz-Llorens,M., Perez-Branguli,F., Andres,R.M.,
            Parcerisas,A., Pascual,M., Ulloa,F. and Soriano,E.
  TITLE     Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent
            macropinocytosis and chemorepulsion
  JOURNAL   Front Mol Neurosci 16, 1253954 (2023)
   PUBMED   37829513
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2206)
  AUTHORS   Taura,Y., Tozawa,T., Fujimoto,T., Ichise,E., Chiyonobu,T., Itoh,K.
            and Iehara,T.
  TITLE     Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to
            Transport Syntaxin1A to the Plasma Membrane
  JOURNAL   Neuroscience 524, 256-268 (2023)
   PUBMED   37315734
  REMARK    GeneRIF: Myosin Va, a Novel Interaction Partner of STXBP1, Is
            Required to Transport Syntaxin1A to the Plasma Membrane.
REFERENCE   6  (bases 1 to 2206)
  AUTHORS   Riento,K., Jantti,J., Jansson,S., Hielm,S., Lehtonen,E.,
            Ehnholm,C., Keranen,S. and Olkkonen,V.M.
  TITLE     A sec1-related vesicle-transport protein that is expressed
            predominantly in epithelial cells
  JOURNAL   Eur J Biochem 239 (3), 638-646 (1996)
   PUBMED   8774707
REFERENCE   7  (bases 1 to 2206)
  AUTHORS   Burmeister,M., Novak,J., Liang,M.Y., Basu,S., Ploder,L.,
            Hawes,N.L., Vidgen,D., Hoover,F., Goldman,D., Kalnins,V.I.,
            Roderick,T.H., Taylor,B.A., Hankin,M.H. and McInnes,R.R.
  TITLE     Ocular retardation mouse caused by Chx10 homeobox null allele:
            impaired retinal progenitor proliferation and bipolar cell
            differentiation
  JOURNAL   Nat Genet 12 (4), 376-384 (1996)
   PUBMED   8630490
REFERENCE   8  (bases 1 to 2206)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   9  (bases 1 to 2206)
  AUTHORS   Newman,L.S., McKeever,M.O., Okano,H.J. and Darnell,R.B.
  TITLE     Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific
            vesicle coat protein
  JOURNAL   Cell 82 (5), 773-783 (1995)
   PUBMED   7671305
REFERENCE   10 (bases 1 to 2206)
  AUTHORS   Katagiri,H., Terasaki,J., Murata,T., Ishihara,H., Ogihara,T.,
            Inukai,K., Fukushima,Y., Anai,M., Kikuchi,M., Miyazaki,J. et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY240737.1 and BC047133.1.
            
            On Dec 1, 2015 this sequence version replaced NM_016801.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047133.1, BC100446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               BY240737.1         1-101
            102-2206            BC047133.1         1-2105
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.95 cM"
     gene            1..2206
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /note="syntaxin 1A (brain)"
                     /db_xref="GeneID:20907"
                     /db_xref="MGI:MGI:109355"
     exon            1..129
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..966
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     syntaxin-1A; neuron-specific antigen HPC-1; syntaxin 1 a"
                     /codon_start=1
                     /product="syntaxin-1A isoform 1"
                     /protein_id="NP_058081.2"
                     /db_xref="CCDS:CCDS19731.1"
                     /db_xref="GeneID:20907"
                     /db_xref="MGI:MGI:109355"
                     /translation="MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFI
                     DKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQ
                     EEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTT
                     TSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLETSIRELHDMFMD
                     MAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILG
                     IIIASTIGGIFG"
     exon            130..207
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..307
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..382
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..456
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..565
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..639
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..777
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..888
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..2162
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /note="hexamer: AATAAA"
     polyA_site      2162
                     /gene="Stx1a"
                     /gene_synonym="HPC-1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggggc gcgggctggc gctgcgcagc cgcggggcgg catccgcgca tgcgggactt
       61 actcggttgc agccggcgcc tactgccact cccgggagca tgaaggaccg aacccaggag
      121 ctccgcacgg ccaaggacag cgatgacgac gacgatgtca ctgtcactgt ggaccgagac
      181 cgcttcatgg atgaattctt tgaacaggtg gaagagatcc ggggctttat tgacaagatt
      241 gccgaaaacg tggaggaggt gaagcggaaa cacagcgcca tcctggcctc cccgaacccc
      301 gatgagaaga caaaggagga actggaggag ctcatgtcgg acattaagaa gacagcgaac
      361 aaagttcgct ccaagctaaa gagcattgag cagagcatcg agcaggagga aggtctgaac
      421 cgctcatcag ccgacctgag gatccggaag acgcagcact ccacgctgtc ccgaaagttt
      481 gtggaggtca tgtccgagta caacgccact cagtcagact accgagaacg ctgcaaaggg
      541 cgcatccaga ggcagctgga gatcaccggc cggaccacga ccagtgagga attggaagac
      601 atgctggaga gtgggaaccc tgccatcttt gcctctggga tcatcatgga ctccagcatc
      661 tcgaagcagg ccctcagtga gatcgagacc agacacagtg agatcatcaa gctggagacc
      721 agcatccggg agctgcacga catgttcatg gacatggcca tgctggtgga gagccagggg
      781 gagatgattg acaggatcga gtacaatgtg gagcacgccg tggactacgt ggagagggcc
      841 gtgtcagaca ccaagaaggc cgtcaagtac cagagcaagg cgcgcaggaa gaagatcatg
      901 atcatcattt gctgtgtgat tctgggcatc atcatcgcct ccaccatcgg gggcatcttt
      961 ggatagaaac caccccaccc actgctccat tctggatggg tctccctgag gaggcccctg
     1021 gctgctgcac ctagctgggt tgccctcccc actcctgcct tctggctggg agtccttttc
     1081 cctcccatcc cacactgctc cctctctgcc atgaggctcc cgtccccacc accctgcccc
     1141 aagccgtgtc gtgtgcatga tcttgtgaca gtgtgtgtct gtacaggagg cagagtcggg
     1201 agcaggattg ggaacagcca gagtggctgg gtacaggcca gtgcggggca agactcgggc
     1261 cctggccagg tctgcctttc ttcagcctgg ggtctacact tccctgggac tcaggctcct
     1321 ttctggaccc caaccttgcc ctcacttgtc ccgtcctctg gcttctccag ctcttcccac
     1381 catgccaagg cacctggaag gtggggacca gctggtcaca tggtgctgct tttcaggtta
     1441 ggggtgggga tagctcagca ctgagtcttt gttagctgcc ccttgcccgg aggctcaggg
     1501 tgccacggct gcgggtgtta ggagcaccta gtaccctctc tttgggcaaa gcctgacagt
     1561 gtctctggcc ctgggagtca tgttcctggg ctgggcctga gcctagtgac cctttactaa
     1621 gaagcttagt ggtgtcatct ccagccttgc tttgagttgg agggatggag caggccatag
     1681 tcctaacagg catggtaagt tgtggccaga gttgcatgtt ggggacagca gttccctgcg
     1741 ccctttatgc tctgaaagcc aggtgtcact ttgggcctgt agtctcaccc tgccccgtct
     1801 cccattgatg tgccacgtgg tatcaggtgt actggatgca gtattcagca gccagctggg
     1861 gagggggctc cccacttccc cccttgccat cttggggctt ctcagagtca aaactgtacc
     1921 ccctgcccca ggaccccttt ctcgcccaca ggcaaggagt atgcatgcga gtgcatgcag
     1981 cgggagctgg ggccgtgtct gtgtgccccc tttccctcag ctttgctcct gcccagtgac
     2041 tgtgaccact gtccgtgctg ccttctcacg gccacctccc tttacccctt caccaaaggt
     2101 cttggtacaa ccagctgccc attttgtgag atttttatgt agaataaaca tttgtatctg
     2161 taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
