LOCUS       NM_026959               2519 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus syntaxin 18 (Stx18), transcript variant 1, mRNA.
ACCESSION   NM_026959
VERSION     NM_026959.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Hatsuzawa,K., Hashimoto,H., Hashimoto,H., Arai,S., Tamura,T.,
            Higa-Nishiyama,A. and Wada,I.
  TITLE     Sec22b is a negative regulator of phagocytosis in macrophages
  JOURNAL   Mol Biol Cell 20 (20), 4435-4443 (2009)
   PUBMED   19710423
  REMARK    GeneRIF: Domain analyses of Sec22b revealed that the R-SNARE motif,
            a selective domain for forming a SNARE complex with syntaxin18
            and/or D12, was responsible for the inhibition of phagocytosis.
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Laniosz,V., Nguyen,K.C. and Meneses,P.I.
  TITLE     Bovine papillomavirus type 1 infection is mediated by SNARE
            syntaxin 18
  JOURNAL   J Virol 81 (14), 7435-7448 (2007)
   PUBMED   17475643
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Hatsuzawa,K., Tamura,T., Hashimoto,H., Hashimoto,H., Yokoya,S.,
            Miura,M., Nagaya,H. and Wada,I.
  TITLE     Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized
            SNARE protein, in ER-mediated phagocytosis
  JOURNAL   Mol Biol Cell 17 (9), 3964-3977 (2006)
   PUBMED   16790498
  REMARK    GeneRIF: Syntaxin 18 is involved in endoplasmic reticulum
            (ER)-mediated phagocytosis, presumably by regulating the specific
            and direct fusion of the ER and plasma or phagosomal membranes.
REFERENCE   6  (bases 1 to 2519)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY037320.1, AK169273.1 and AC115931.7.
            
            On Jan 23, 2014 this sequence version replaced NM_026959.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169273.1, SRR1660815.14409.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY037320.1         1-56
            57-2172             AK169273.1         1-2116
            2173-2519           AC115931.7         34784-35130
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.21 cM"
     gene            1..2519
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /note="syntaxin 18"
                     /db_xref="GeneID:71116"
                     /db_xref="MGI:MGI:1918366"
     exon            1..270
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1107
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="syntaxin-18 isoform 1"
                     /protein_id="NP_081235.2"
                     /db_xref="CCDS:CCDS19250.1"
                     /db_xref="GeneID:71116"
                     /db_xref="MGI:MGI:1918366"
                     /translation="MAVDITLLFRASVKTVKTRNKALGVAVGGGADGSRDELFRRSPR
                     PKGDFSSRAREVISHIGKLRDFLLEHRKEYINAYSHTMSDYGRMTDTERDQIDQDAQI
                     FIRTCSEAIHQLRTEAHKEIHSQQVKEHRTAVLDFVDDYLKRVCKLYSEQRAIRVKRV
                     VDKKRLSKLEPEPHTKRKDSTSEKAPQNASQDSEGKPAAEELPEKPLAESQPELGTWG
                     DGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGKVVEISRLQEIFTEKVLQQ
                     ETEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS
                     "
     exon            271..338
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            339..454
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            455..532
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..599
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..712
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            713..801
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            802..860
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..930
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1011
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2519
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1549..1554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1568
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /note="major polyA site"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
                     /note="hexamer: CATAAA"
     polyA_site      2519
                     /gene="Stx18"
                     /gene_synonym="1810035L21Rik; 4933425D03Rik"
ORIGIN      
        1 ggagtgcgaa atcggaacgt ccctcagcaa ccgagttctt gccggggtcg ctagctgctg
       61 acgtgtgcct ggccggcttc aggccctggg ttgcgggtcg ctatggcggt ggacatcaca
      121 ctgctcttcc gggctagcgt caagacagtg aagacgcgga ataaggctct gggagtggcc
      181 gtgggtggcg gggccgatgg cagccgggac gagctgttcc gcagaagccc tcggcccaag
      241 ggagacttct ccagccgggc ccgtgaagtg atttctcaca ttgggaagct gagagatttt
      301 ctcctggagc acaggaagga gtatattaat gcctacagcc acaccatgtc tgactatggg
      361 aggatgacag acacagagcg agaccagata gaccaggatg ctcagatatt cataaggacc
      421 tgttcagaag caatccatca actcagaaca gaagcccaca aggagataca ttcccagcaa
      481 gtgaaggaac acaggactgc cgttttggat ttcgttgacg attacttaaa aagagtgtgt
      541 aagctttact ctgaacaaag agccatccga gtgaagcgcg tggtggacaa gaaaagacta
      601 tctaagctgg aacctgagcc acataccaag aggaaagact ccacatctga gaaagcccct
      661 cagaacgctt cccaggactc tgaaggaaag cctgctgctg aggagctgcc agaaaagcct
      721 ttggctgaat cacagcccga actgggaacc tggggcgatg gcaagggtga agatgagctg
      781 tctccagaag agatacagat gtttgaacaa gaaaatcagc gactcattgg tgaaatgaac
      841 agcttgtttg acgaagtgag gcaaatcgaa gggaaagtcg ttgaaatttc cagactccaa
      901 gagatattca ccgaaaaggt tttgcaacag gaaactgaga tcgacagcat tcaccagtta
      961 gtcgtggggg caactgaaaa tattaaggaa ggcaacgaag acatccgaga ggccatcaaa
     1021 aacaatgcag gtttccgagt gtggatcctc ttcttcctcg tgatgtgttc cttttccttg
     1081 ctcttcctcg actggtatga cagctagccc accagggctg agcctgcgcc tgcgcctgtg
     1141 ccttggacgc accacgtgcc agcatgtgtc tcatcggctg tggagctgtg taaggtccaa
     1201 gggctgggaa aacaccgccc ccaagccaac ctttggaacc tctcaggacc tggaaataca
     1261 tggattgcaa gtgcccttca gggtggaaaa taaaaggcca tcaggagcag caccttcagg
     1321 acaggccaca agcatggtgg ggactgagca gagcaaggaa atggcaggcc tcctatctcc
     1381 attacaggct tggggcccat ctcctgccct tcccacgccc gtagcttcag gggagaacat
     1441 gcctaatgtt gctaaagtca tcagttctta tttccttgtg gcatctaatg tgtgctgata
     1501 catggccatt ttgtcataga caataattca catctgcctt gtcgagctaa taaatgcaat
     1561 tacagccact tattgcagtc agtgagtctc cactgagccc ctctggccac cacctggctg
     1621 gacaggcagg ctctggggcc ctccactaag cctctctcct gacctggctc cctgtcttgt
     1681 taacatcaaa gctagggcct agaggcacac gaagcctcat ttcctgccac tgagtcccag
     1741 atatttgtgt tccaagaagg gtgtggacct cagaagagtg ggccttctgc tcttgctcct
     1801 gcatactcgc ccctctagaa gaggccacag ggttgcctgt tgagaactag aagtgtatag
     1861 cacatggcct acatctgtgt acagatgtat cctgggttac acaattcctg cggaagcaca
     1921 tgagtacaga cagtccagtg tgcggcttaa gtacccacga gctctttatt tgtagagtaa
     1981 aaatgagaaa ttacattggg agagttcaca gtgggtaaag ggctacgtta gaaaacacag
     2041 agggcctgcc tactgcacgc acacggccca tgagtcggat ccctctacag acaagttttg
     2101 gcacatgtgt attgctcttt gcgcattcct cgcagctttc caatgcactt caagctcgtg
     2161 actgtgtggc ccctccccct gtgctgagct catgcccttt gttttagaac acctcaacaa
     2221 tacatgatgt tgtctcagta gcacacctca ggaagcagca gtggagctga tggtggccac
     2281 catgcttgtt cacaaaggtc tcagactatt tgccatttat ttctgaccta ctaaaggacg
     2341 ccgagacttc tgacatgccc accagaaaca acacattctg agaacatgga agaaaacaat
     2401 caggaatagc tttttctatt taattgtctt acacatttag tttacctact ggtgattttg
     2461 taaacatata ctttaatgtc aagattcaga ttgaaacata aacatacttt tcttacaaa
//
