LOCUS       NM_026343               5777 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus syntaxin 17 (Stx17), mRNA.
ACCESSION   NM_026343
VERSION     NM_026343.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5777)
  AUTHORS   Wang,X., Hu,M., Chen,J., Lou,X., Zhang,H., Li,M., Cheng,J., Ma,T.,
            Xiong,J., Gao,R., Chen,X. and Wang,J.
  TITLE     Key roles of autophagosome/endosome maturation mediated by
            Syntaxin17 in methamphetamine-induced neuronal damage in mice
  JOURNAL   Mol Med 30 (1), 4 (2024)
   PUBMED   38172666
  REMARK    GeneRIF: Key roles of autophagosome/endosome maturation mediated by
            Syntaxin17 in methamphetamine-induced neuronal damage in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5777)
  AUTHORS   Xu,H., Yu,W., Sun,M., Bi,Y., Wu,N.N., Zhou,Y., Yang,Q., Zhang,M.,
            Ge,J., Zhang,Y. and Ren,J.
  TITLE     Syntaxin17 contributes to obesity cardiomyopathy through promoting
            mitochondrial Ca2+ overload in a Parkin-MCUb-dependent manner
  JOURNAL   Metabolism 143, 155551 (2023)
   PUBMED   36948287
  REMARK    GeneRIF: Syntaxin17 contributes to obesity cardiomyopathy through
            promoting mitochondrial Ca[2+] overload in a Parkin-MCUb-dependent
            manner.
REFERENCE   3  (bases 1 to 5777)
  AUTHORS   Rong,Y., Zhang,S., Nandi,N., Wu,Z., Li,L., Liu,Y., Wei,Y., Zhao,Y.,
            Yuan,W., Zhou,C., Xiao,G., Levine,B., Yan,N., Mou,S., Deng,L.,
            Tang,Z., Liu,X., Kramer,H. and Zhong,Q.
  TITLE     STING controls energy stress-induced autophagy and energy
            metabolism via STX17
  JOURNAL   J Cell Biol 221 (7) (2022)
   PUBMED   35510944
  REMARK    GeneRIF: STING controls energy stress-induced autophagy and energy
            metabolism via STX17.
REFERENCE   4  (bases 1 to 5777)
  AUTHORS   An,Z. and Ding,W.
  TITLE     Acinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the
            degradation of STX17 by blocking the activation of YY1
  JOURNAL   Virulence 12 (1), 1965-1979 (2021)
   PUBMED   34304694
  REMARK    GeneRIF: Acinetobacter baumannii up-regulates LncRNA-GAS5 and
            promotes the degradation of STX17 by blocking the activation of
            YY1.
REFERENCE   5  (bases 1 to 5777)
  AUTHORS   Chen,L., Xia,Y.F., Shen,S.F., Tang,J., Chen,J.L., Qian,K., Chen,Z.,
            Qin,Z.H. and Sheng,R.
  TITLE     Syntaxin 17 inhibits ischemic neuronal injury by resuming autophagy
            flux and ameliorating endoplasmic reticulum stress
  JOURNAL   Free Radic Biol Med 160, 319-333 (2020)
   PUBMED   32828953
  REMARK    GeneRIF: Syntaxin 17 inhibits ischemic neuronal injury by resuming
            autophagy flux and ameliorating endoplasmic reticulum stress.
REFERENCE   6  (bases 1 to 5777)
  AUTHORS   Arasaki,K., Mikami,Y., Shames,S.R., Inoue,H., Wakana,Y. and
            Tagaya,M.
  TITLE     Legionella effector Lpg1137 shuts down ER-mitochondria
            communication through cleavage of syntaxin 17
  JOURNAL   Nat Commun 8, 15406 (2017)
   PUBMED   28504273
  REMARK    GeneRIF: L. pneumophila Lpg1137 can shut down ER-mitochondria
            communication through cleavage of syntaxin 17
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5777)
  AUTHORS   Hubert,V., Peschel,A., Langer,B., Groger,M., Rees,A. and Kain,R.
  TITLE     LAMP-2 is required for incorporating syntaxin-17 into
            autophagosomes and for their fusion with lysosomes
  JOURNAL   Biol Open 5 (10), 1516-1529 (2016)
   PUBMED   27628032
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5777)
  AUTHORS   McLelland,G.L., Lee,S.A., McBride,H.M. and Fon,E.A.
  TITLE     Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles
            to the endolysosomal system
  JOURNAL   J Cell Biol 214 (3), 275-291 (2016)
   PUBMED   27458136
  REMARK    GeneRIF: Syntaxin-17 can be traced to the last eukaryotic common
            ancestor, hinting that the removal of damaged mitochondrial content
            may represent one of the earliest vesicle transport routes in the
            cell.
REFERENCE   9  (bases 1 to 5777)
  AUTHORS   Itakura,E., Kishi-Itakura,C. and Mizushima,N.
  TITLE     The hairpin-type tail-anchored SNARE syntaxin 17 targets to
            autophagosomes for fusion with endosomes/lysosomes
  JOURNAL   Cell 151 (6), 1256-1269 (2012)
   PUBMED   23217709
  REMARK    GeneRIF: Study identifies syntaxin 17 (Stx17) as the autophagosomal
            SNARE required for fusion with the endosome/lysosome.
REFERENCE   10 (bases 1 to 5777)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB586682.1, BY766411.1, AK034718.1 and AL683893.26.
            
            On Jan 7, 2006 this sequence version replaced NM_026343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154503.1, AK034718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BB586682.1         24-42
            20-351              BY766411.1         16-347
            352-2403            AK034718.1         341-2392
            2404-5777           AL683893.26        201460-204833
FEATURES             Location/Qualifiers
     source          1..5777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.07 cM"
     gene            1..5777
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /note="syntaxin 17"
                     /db_xref="GeneID:67727"
                     /db_xref="MGI:MGI:1914977"
     exon            1..40
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            41..225
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1008
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /codon_start=1
                     /product="syntaxin-17"
                     /protein_id="NP_080619.2"
                     /db_xref="CCDS:CCDS18164.1"
                     /db_xref="GeneID:67727"
                     /db_xref="MGI:MGI:1914977"
                     /translation="MSEDEEKVKLRRLEPAIQKFTKIVIPTDLERLRKHQINIEKYQR
                     CRIWDKLHEEHINAGRTVQQLRSNIREMEKLCLKVHKDDLVLLKRMIDPVKEAAATAT
                     AEFLQLHLESVEELKKQVNDEELLQPSLTRSTTVDGVLHTGEAEAASQSLTQIYALPE
                     IPQDQNAAESWETLEADLIELSHLVTDMSLLVSSQQEKIDSIADHVNSAAVNVEEGTK
                     NLQKAAKYKLAALPVAGALIGGVVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQR
                     RKQKMMEKLTSSCPDLPSQSDKKRS"
     exon            226..291
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            292..514
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            515..630
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            631..681
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            682..768
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            769..5777
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1490
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
     regulatory      2370..2375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2388
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
     regulatory      5748..5753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5777
                     /gene="Stx17"
                     /gene_synonym="4833418L03Rik; 6330411F21Rik;
                     9030425C21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagtgtg tatcgacggc ctcgagcgcc taggcgggag gtgtttctgt ttgagagaag
       61 agagctgctg caagaggaag tagcggctca tcaggcttca ggatgtctga agatgaggaa
      121 aaggtgaagt tacgcaggct tgagccagcg atacagaaat tcactaagat cgtgatccca
      181 acagacctgg agaggctaag aaaacaccag ataaacatcg agaagtatca gcggtgcaga
      241 atttgggaca agttgcacga agagcacatc aacgcagggc gcacggttca gcaactgcgc
      301 tccaatatcc gagaaatgga gaagctttgc ttgaaagtgc acaaggatga tctggtcctt
      361 ttgaagcgaa tgatagatcc tgtcaaggaa gcagcagcaa cagctacggc agagttcctc
      421 cagctccact tggaatctgt tgaagaactc aagaaacaag tcaacgatga agaattactt
      481 cagccttctc tgaccagatc cacaactgtt gatggagtgc tccacactgg ggaggctgaa
      541 gctgcttctc agagtctgac tcagatatat gccttgcctg aaattcctca agaccaaaat
      601 gctgctgagt cctgggaaac cttagaagcg gacttaattg agctgagcca tctggtcact
      661 gacatgtccc tcctagtgag ttctcagcag gagaagattg acagcattgc agaccatgtc
      721 aacagtgccg ctgtgaatgt tgaagaggga accaaaaact tgcagaaggc tgcaaaatac
      781 aagctggcag ctctgcctgt ggcaggtgca ctcatcggag gagtggtagg gggtcccatc
      841 ggcctcctcg caggcttcaa agtggcagga attgcagctg cacttggtgg tggggtgtta
      901 ggcttcacag gtggaaaatt gatacaaaga aggaaacaga aaatgatgga gaagctcact
      961 tccagctgtc cagatctccc tagccaaagt gacaaaaaac gcagttaaag cccaagcttc
     1021 cagctgctgc tgtgcaccga gctaaggagc agttgctgtt gctggaagtg ttaggaagtg
     1081 gctctccctg tccatgcagt gttgaaccac catgagtgga tgtgtttgtt agctgggtgt
     1141 taatggagat tttagaggtg gaggagcctg gccagagggt gtctgtcagg tcaagtttaa
     1201 agactgccaa agagcaaagg ttaggcctgg aaatgtgaaa actggatcca taactaagga
     1261 tctaagaagt gtagacatgt agtggacacc tgaggtcagt gtatttgtca attatttctt
     1321 cctataggga ggaacagaat tcgagttcag gagtctctgt caggtaggga tgttgccgct
     1381 caacaggggg cacgggtgaa ctacttgtgg acttgagggc tgttgtactt agacccatct
     1441 gtattttctg gggaaggaaa ttaacactat aaaatagaaa gagaagccca ttttctcttt
     1501 acagtttctt cattgtgaca tgggtgtttt ttctgaagtc tttcctgcct ctccagataa
     1561 ggagcacaaa acctcaatgc tagacctact aaaccagcca ccaagcccat ttccagctgg
     1621 tgattcagat aactgtctat tctactcttc tgattcctac ccatgttata aggattttcc
     1681 tcataatctg cctttttata tagttttcca cttctagcta cccctacctg taatctctac
     1741 aatctcttta gttgaaaaaa gaaaatttaa atatttccaa cgttatttag gttaagggga
     1801 gtgagtacaa gatcatatca cagggcactt tagaaggggc tggcatacct gctgcctcca
     1861 gggattgccg cccctcagtc ttcttgggcg tccaagaagg agctttctac ctcacatctg
     1921 tcactgctgc cctttcccag gccgtctccc ctcctgccgc tgtcctcgca gtggtcacgc
     1981 ttaacctctc tcacattcta gatgggaaaa ctcatgattc agacccaagg aaagatctgt
     2041 ggtgctaacc caacagttgg catgcacagc aggcatgtcc acttcaactc cgtgtctctc
     2101 tcaaaacaga aaggtttgag attcagaaga aaggaatagg aagaagccac tggtcccgca
     2161 actctcatct cttcctgaga agagtgcacc agcagccaga gcacagggtc aggggccgaa
     2221 gggttacctc ttagcttctt ttaagtgctg agttgatgtt tggcctctgt gggttgctac
     2281 ctttccctct gtgttataac ttccttcctt cccttcaatg ctttgtgagt cttaccagtg
     2341 catccctatg aaacaaagaa ctacaccgta ttaaaagatc ggaaagtatt gagtatttat
     2401 ttcttatccg ctgtcttaag actttaataa caaacaaaat ttgaataatt ttcggatcct
     2461 gaaatattgc caaacacact gggcattaag taattacttt tattgtcatc ctttgttctc
     2521 tggttcttgc tgctccttta agatagcatg tcaaacctga gcagggggca ttcagaatgc
     2581 atccagattt tacttcaaat aagattcctt tttgttttgt tttatttttc aagatgtttt
     2641 ctctgtatag tcctgaccta gctgtcctgg aactctctct gtagaccagg ctggccttga
     2701 actcagagat ccatctgtct ctgcctccgg agtgctggga ttaaaggtgt gttgccatac
     2761 ccagctaaaa caagattctt gaactttggc cccggggaaa ttccgataca gccagtccat
     2821 cctgattagc tagtattgtg aggataagaa gtgttgttta attctttagt ctcccatggt
     2881 ctacttcatc ttcctcatta cttaatactc aattccatga atccccaaag tgccatcagt
     2941 aagtgccata acagcctcag cacatggaag ccaaagaaac agggctgagg cttggatatg
     3001 aagctcgcac ccttgggacc gcgcatcttc gctgagccag tgtgggaatg tgggaaccat
     3061 cggcatgtta atgaaccatc agtattgggc ttttgactct agccaccgta atggttaagg
     3121 aagttacagt cctctttaaa atttcattat actttaaagt tattgagaaa ttgtttttca
     3181 tttctccaca atagaatcca atagccaact ttttgtggaa atttcttaga agtgtttaat
     3241 caactataaa tgatataaaa gtacttaaac gtataaatta gtcaatatga cacagaaatg
     3301 atcttaaaat tgaatttaat atgccccata gtgtctagtt aaatttatca tctctatgat
     3361 ttatgtctta tttttatttc aactagttaa aaagaatcat tttaatgtct taaaatttgt
     3421 agagacttca tattagtata ggcagtcccc ctaaagactt tttgatgtta taatctgata
     3481 attcctctga aattttgatg tagcccacag taaaaaacgt attaggattg aacgtgtatc
     3541 catgaaaaat gtttaccatt gtgtgcagta cattctgatg ttctgtttct tcaacatgct
     3601 aacttcaacc cacaaaacca gtctcagtct acaaatggat taccaccctc agttttcaga
     3661 aaacaccctt ccctaaggaa gaactggtgt ttcccaagca gtttgccagt tatttatgga
     3721 aagggtaacc gggcctcaga ggaattaagt aatttgcagt ctttccattc attccaaggg
     3781 caggaagcct ggatggaatg ggttctgctg agccacactc tgccatgctg tgctgcctcc
     3841 ctgaagctca gagacttgta aggccagcag gggacaaccc atgctgtccg tttacttctt
     3901 tgtcttctgg cctcatcggg tgtccacagc ctgttcttaa ttgtggccat gcatagaaca
     3961 cagagcttaa gtataaaatg aacactgcta tcccacccta tcctctacac attggttcat
     4021 atcataggct atgatcactg ttcaaaatgt tttatataat taaaagtaaa cactactttt
     4081 aaacaaatct ctcatagcat ttagaatcaa ttaatcatta tgctttaaat gatgcccccg
     4141 ggaagccagg cacaaacggt ggggggcagg caatagccta tttctgaaca tctgcttttg
     4201 gattgccatc aaaaacaaaa ttgcatgtta aataagaaaa gccacatcca gtgtgtcggc
     4261 ctcagactgg tttcccatac cttgtgaccc aattctctcc ccatctcaat tctgtgtctt
     4321 ctgttggctt actcctacct cacacacagg agcctagaat gaagcatact gaagctgcct
     4381 agaactcgcc agacctctgg agcacggact ggggtttacc cgaaactcct acctagccac
     4441 agctgtcctg cctgtccacc ttccgtgttc atgtcttctg cagagtgagg actggaagct
     4501 ggtaacacct actgataaca agaagtttgg aaacacaact acaaatctct agcacacagt
     4561 atttccttcc agtaaaagtc cagaagccaa accttttgag ttgttagaaa acaaaggcat
     4621 ttctcaagaa tgcctcagaa gcccttcact gatcacatgg cctctggaga gaggagtgaa
     4681 agcctggagc aagaccctcc tgggcaagcc acaccttacc atcctagaga agaatgctac
     4741 tgttgctccc aggtgtttac acatgtctgg tgacatcccc aaagttgcct gaggcctagc
     4801 aagtgcttcc cctctggctt cagattcttt ttgtatgtgg agttgtgttg tttctgtttt
     4861 ctgaaatcag gttttactgg aagcccaggc tcgttttgaa cttgcaatcc tcctgctggg
     4921 attacgcaca tccaactctg ttttgtaact gctattaaca cgtattccta atgagtggtt
     4981 ctgtttgtat tcaccagttg gcaccatttc acataagaac ttgagtgtta ataataataa
     5041 aagaactatg tatctacatt gctaccttca aagatactaa cttgtgacaa aaaatatttg
     5101 tgcaatatta acccaacaaa tatattggaa taaaaacaaa aaagtgtcaa aggcaaataa
     5161 tttgcccaag atcacaaagc tactttgtat ctaagatcta agagaatgat ttggggtgtg
     5221 tgtggggggg ggatcctcca tgcgtgtcta ttaaggtttg gttaggccat gtcaagttgc
     5281 ctgatgaagc ttgcactctc tcagctcaac ttcaatggtc taaatcaggc aaaatggaaa
     5341 gaaatgtaag aatataaatt catctaaaaa gaagcaatta gatgcagttt cttagctttc
     5401 caagcagtgc cagtgccttg gcagccaaag cacgaggatc cctgcaacag caagggaagg
     5461 cctatgggct cctgtgagca ctcttgtttg agcaggacac acaatagttt gctttttgca
     5521 tacacatctc aaacatttga gatattcctc ttagtgttaa ttactgaatt gtgttactga
     5581 gtttcatcag ctaaacccct aaaaggagtt ttccacatta ttgaacccta gctgtggcaa
     5641 ggtaaggaca aggaaaggtt aaacggtggg gacttgtgca aaactcaatc ctttctgcat
     5701 ttgtttgctg ttatgttgct gagtgatgct tgaataagga aatatgcaat aaaattcacc
     5761 catttgacaa acataaa
//
