LOCUS       NM_172675               3768 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus syntaxin 16 (Stx16), transcript variant 1, mRNA.
ACCESSION   NM_172675
VERSION     NM_172675.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Hara,Y., Katsuyama,T., Fukaya,M., Sugawara,T., Shiroshima,T.,
            Sadakata,T., Osumi,N. and Sakagami,H.
  TITLE     ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through
            N-Cadherin Trafficking during Cerebral Cortical Development
  JOURNAL   eNeuro 10 (11) (2023)
   PUBMED   37848288
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Beaton,N., Rudigier,C., Moest,H., Muller,S., Mrosek,N., Roder,E.,
            Rudofsky,G., Rulicke,T., Ukropec,J., Ukropcova,B., Augustin,R.,
            Neubauer,H. and Wolfrum,C.
  TITLE     TUSC5 regulates insulin-mediated adipose tissue glucose uptake by
            modulation of GLUT4 recycling
  JOURNAL   Mol Metab 4 (11), 795-810 (2015)
   PUBMED   26629404
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Chua,C.E. and Tang,B.L.
  TITLE     Syntaxin 16 is enriched in neuronal dendrites and may have a role
            in neurite outgrowth
  JOURNAL   Mol Membr Biol 25 (1), 35-45 (2008)
   PUBMED   17852734
  REMARK    GeneRIF: Syntaxin 16 may thus play a role in neurite outgrowth and
            perhaps other specific dendritic anterograde/retrograde traffic.
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Frohlich,L.F., Bastepe,M., Ozturk,D., Abu-Zahra,H. and Juppner,H.
  TITLE     Lack of Gnas epigenetic changes and pseudohypoparathyroidism type
            Ib in mice with targeted disruption of syntaxin-16
  JOURNAL   Endocrinology 148 (6), 2925-2935 (2007)
   PUBMED   17317779
  REMARK    GeneRIF: Mice genetically altered to carry the equivalent of
            STX16del4-6 contributing to pseudohypoparathyroidism type 1b.
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   10 (bases 1 to 3768)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY122006.1, BC095989.1 and BP763202.1.
            
            On Aug 23, 2007 this sequence version replaced NM_172675.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078110.1, BC095989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY122006.1         1-20
            21-3623             BC095989.1         1-3603
            3624-3768           BP763202.1         26-170              c
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.85 cM"
     gene            1..3768
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /note="syntaxin 16"
                     /db_xref="GeneID:228960"
                     /db_xref="MGI:MGI:1923396"
     exon            1..139
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..988
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="syntaxin-16 isoform a"
                     /protein_id="NP_766263.2"
                     /db_xref="CCDS:CCDS17147.2"
                     /db_xref="GeneID:228960"
                     /db_xref="MGI:MGI:1923396"
                     /translation="MATRRLTDAFLLLRNNSIQTRQLLAEQVSSHTTSSPLHSRSIAA
                     ELDELADDRMALVSGISLDPEAAIGVTKRSPPKWVDGVDEIQYDVGRIKQKMKELASL
                     HDKHLNRPTLDDSSEEEHAIEITTQEVTQLFHRCQRAVQALPSRARRACSEQEERLLR
                     NVVASLAQALQELSTSFRHAQSDYLKRMKNREERSQHFFDTPVPLMDDGDDATLYGQG
                     FTDDQLVLVEQNTLMVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNV
                     EQSCVKTEDGLKQLHKAEQYQKKNRKMLVIVILVAVIIVLLVALVAVKSR"
     exon            140..151
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     exon            152..259
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     exon            260..400
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     exon            401..566
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     exon            567..658
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     exon            659..802
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     exon            803..883
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     exon            884..3736
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3544..3549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /note="hexamer: AATAAA"
     polyA_site      3563
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /note="major polyA site"
     regulatory      3597..3602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /note="major polyA site"
     regulatory      3708..3713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
                     /note="hexamer: AATAAA"
     polyA_site      3736
                     /gene="Stx16"
                     /gene_synonym="4930401D03; 5430410K23Rik; 6330500A18Rik;
                     Syn16"
ORIGIN      
        1 ggagacaatg gccaccaggc gtttaaccga cgctttcttg ttgttgcgga ataattccat
       61 ccaaacccgg cagctgttag ccgagcaagt gagtagtcac accacctcca gccctctgca
      121 ttcacgtagc attgctgcgg agctggacga gcttgctgat gaccgcatgg cgctggtatc
      181 aggcatcagc ctagatccag aagcagcaat tggcgtgaca aagcggtcgc ctcccaagtg
      241 ggtggatggc gtggacgaaa tacagtatga tgttggccgc attaaacaga agatgaagga
      301 gttagccagc cttcatgata agcatttgaa cagacccacc ctggatgaca gcagtgagga
      361 ggaacatgcc atcgagatca ccacccagga agtcacacag ctcttccata ggtgccagcg
      421 tgctgtgcag gccctgccca gccgggcacg aagggcctgc tcggagcagg aagagcggct
      481 actgcggaac gtggtggcct ccttggcaca ggccctgcag gagctgtcca ccagcttccg
      541 gcatgcacag tctgactacc tgaaacgcat gaaaaaccga gaggagagat cgcagcattt
      601 cttcgacacc ccagtaccac taatggatga tggagatgat gctactctgt atggtcaggg
      661 cttcacggat gaccagctgg tgctggtaga gcaaaacaca ctgatggtgg aggagaggga
      721 gcgagagatc cgtcagattg tgcagtccat ttcagacctc aatgaaatct tcagggactt
      781 gggagccatg attgtggagc agggaacagt ccttgataga attgactata atgttgaaca
      841 gtcctgtgtc aagaccgaag atggcttgaa acagcttcac aaggctgagc agtaccagaa
      901 gaagaaccgg aagatgcttg tgatcgtgat cctggtggcc gtcatcatag tcctcctcgt
      961 ggccctcgtc gccgtaaagt ctcgctagtg gcaccaggtt cccgagagtg ctactgtgtg
     1021 gattattggt gataggactt ggctggtgcc tcaccgctgc actgtgtaaa gagcacagcc
     1081 cactggtcca tcagtgggca gcagaccttc ccgtggacac cttctaacca gtgggctggc
     1141 gtgtaggcac ggccatgttt tccatctctg tccagagtct aaggacttga tgctgttgcc
     1201 gaagagactg gcctatgatg agctgtcgtg tgaatacgtg ctttagtgaa aggagtggaa
     1261 ggtttacagg cactgccaaa gctccgtgtc gtgtgtgcat gctcattttt agcactaatg
     1321 tctgagcagc atgttaaata atttttggga aatttttttt ttaaccatct ggtttttaag
     1381 aagtttggta ccaaaaattt atgagtgtag aggcagtgcc tcttcatctt cccagctgaa
     1441 aacaaagcaa gaagtccttc aaggatttat aatctgttcc attaacttaa tttagctttc
     1501 catcactgtt aacgatcaga gtaacaaagt gtgaaaaata agaaaccatc attgacgtta
     1561 attaacacat ttagacgggc cagttaaacc agcttcatgc gtttaaatca attgtaaata
     1621 gcatattcct cattcagaat ttttgccctg cattttctac tgtaaaccaa gaggggttac
     1681 taagcaaaac ctcctgaatc agaaacttgg tcatttgaac caacctcaca ttacaagaaa
     1741 gcttgacagt gtgtccccag ccatccttcc tcagtccatt acttacattc tagctacgta
     1801 atgacctgtc caaacctgac tccgtttaat gaactgtgaa tttacacaga ggccatttta
     1861 aatgggtcac cccatttagg attagtggat ctcaaattat taaccaaaca tcactccatt
     1921 tcaaagtaaa atattctaca catgatttga tttatcgact cttgccactt aaatgcccag
     1981 aaaacgggtg tattcctgag gacagtgaga acgtcagcta gggaaaccct gtgtgtgtgt
     2041 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttctgag ggttttttgg ggggtttttg
     2101 ggtttttgtt tgtttgtttt ttgcgtacgt gtgtgagcat atcatgtatt atcagatggc
     2161 caaagtaggg ttctgtttac tccctgttaa ctctatggtg ctcgtgtgct ctacagaact
     2221 agagcgatgc ggaccaggct gtcggagctt tgagagcgtg cgtatctcac tcgctctgtt
     2281 tgcatcaaca ctgctggagt tagagtgatt gttgtataac tgttgacggc ttgaaaaaac
     2341 tctctgtgtc tcttaaatta tttaaacacc gtggccctgt taagtgtgtt atatttttat
     2401 ttagaccagg catatgaaat gcctctctgg gactcactga agggtgtctc aaaactccag
     2461 ctcagaccta gaaatggagt catgtagacc catcatgaac tcactctccc tgcctgggcc
     2521 atggaataat gagatctaaa ggttttctgg attctttggc aatgttagta gagaggctta
     2581 gaaaagagga ggcagcaccc accccaccac ttcagaattg gggaagggac tctgcagtct
     2641 ctctcaacct ctgaggttag acaagctgtt cctgggtaga ctggccaaat tagggaaact
     2701 gcttcaagca atctatggag atcatgctaa gtaattgtga aagccttgaa aaaaagtgac
     2761 cttttaagaa aggatcacta tttatttata atttatttcc ctgaatagat tttattttgg
     2821 tgggggtgtt ggttcccccc cccccccaat ccatccatct ggttagaaac tgtcccaagg
     2881 acctatgggg agagggactg tccccttctg cctggaggca gtgtggtgct ggtctgggcc
     2941 cacgccaccc tggtgagagt ccggaagggc ttggatactg ggctttgccg agctccagag
     3001 ctctgtgcac tcgctctctg gggccccact gccctttgcc gttgagcctg ttctggggga
     3061 aagaggagaa gttagtaccc atgtcctgct aggtccctca cggtaatggc ttttggaaga
     3121 ggactcttgt acctgctgac ggccgctgtc tgtgcgtcca tccttccctt caggctggcc
     3181 atggaggcga caatcacaca gactcgtctg tccctgtgcc tgggaagccc ggcctctgga
     3241 cggacaccac ctccctctgc tgccctgctg gcttttgtag aattggggtg gaaggggaga
     3301 gggaaagaac tgttggtcct tcggggcccc tgatctttcc taagactagc ataaaatttc
     3361 tgtctgtcat tctgtttgtt gggggtggag ggacattggg gtgctggctg ggccactgtg
     3421 tgaagcaatg tgtgtctaat ttaacggatg taccattttc tctgctaatt gagagagcat
     3481 tatttatttg ttttgacaca agtgcgtgca gtgtttcatc ccagctaatg gcttcttaaa
     3541 ggtaataaaa cccttcaacc taattggtca gataagactt tttccttgta tgcttaaata
     3601 aagcaattag tgaaacgctt caatccaaaa tgactttttt tttgtccttt tttttttttt
     3661 ttttttaaaa aaaaagctaa tttactgtta ctggaaactt tttgtacaat aaagcaatct
     3721 cacagattga agagcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
