LOCUS       NM_133887               2320 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus syntaxin 12 (Stx12), mRNA.
ACCESSION   NM_133887
VERSION     NM_133887.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Hara,Y., Katsuyama,T., Fukaya,M., Sugawara,T., Shiroshima,T.,
            Sadakata,T., Osumi,N. and Sakagami,H.
  TITLE     ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through
            N-Cadherin Trafficking during Cerebral Cortical Development
  JOURNAL   eNeuro 10 (11) (2023)
   PUBMED   37848288
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Castonguay,J., Orth,J.H.C., Muller,T., Sleman,F., Grimm,C.,
            Wahl-Schott,C., Biel,M., Mallmann,R.T., Bildl,W., Schulte,U. and
            Klugbauer,N.
  TITLE     The two-pore channel TPC1 is required for efficient protein
            processing through early and recycling endosomes
  JOURNAL   Sci Rep 7 (1), 10038 (2017)
   PUBMED   28855648
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Zhang,M., Chen,D., Xia,J., Han,W., Cui,X., Neuenkirchen,N.,
            Hermes,G., Sestan,N. and Lin,H.
  TITLE     Post-transcriptional regulation of mouse neurogenesis by Pumilio
            proteins
  JOURNAL   Genes Dev 31 (13), 1354-1369 (2017)
   PUBMED   28794184
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Jani,R.A., Purushothaman,L.K., Rani,S., Bergam,P. and Setty,S.R.
  TITLE     STX13 regulates cargo delivery from recycling endosomes during
            melanosome biogenesis
  JOURNAL   J Cell Sci 128 (17), 3263-3276 (2015)
   PUBMED   26208634
  REMARK    GeneRIF: STX13 acts as a fusion SNARE in melanosomal trafficking
            pathways.
REFERENCE   6  (bases 1 to 2320)
  AUTHORS   Richardson,S.C., Winistorfer,S.C., Poupon,V., Luzio,J.P. and
            Piper,R.C.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
REFERENCE   7  (bases 1 to 2320)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2320)
  AUTHORS   Sarria,J.C., Catsicas,S., Hornung,J.P. and Hirling,H.
  TITLE     Developmental and spatial expression pattern of syntaxin 13 in the
            mouse central nervous system
  JOURNAL   Cell Tissue Res 309 (2), 209-218 (2002)
   PUBMED   12172780
  REMARK    GeneRIF: the developmentally regulated syntaxin 13 expression in
            various neuronal populations is consistent with its involvement in
            endocytic trafficking and neurite outgrowth.
REFERENCE   9  (bases 1 to 2320)
  AUTHORS   Steiner,P., Sarria,J.C., Glauser,L., Magnin,S., Catsicas,S. and
            Hirling,H.
  TITLE     Modulation of receptor cycling by neuron-enriched endosomal protein
            of 21 kD
  JOURNAL   J Cell Biol 157 (7), 1197-1209 (2002)
   PUBMED   12070131
REFERENCE   10 (bases 1 to 2320)
  AUTHORS   Hirling,H., Steiner,P., Chaperon,C., Marsault,R., Regazzi,R. and
            Catsicas,S.
  TITLE     Syntaxin 13 is a developmentally regulated SNARE involved in
            neurite outgrowth and endosomal trafficking
  JOURNAL   Eur J Neurosci 12 (6), 1913-1923 (2000)
   PUBMED   10886332
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL671190.10.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_133887.5.
            
            On May 1, 2007 this sequence version replaced NM_133887.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077678.1, AB019211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AL671190.10        101595-101805       c
            212-281             AL671190.10        88935-89004         c
            282-381             AL671190.10        85515-85614         c
            382-519             AL671190.10        80506-80643         c
            520-563             AL671190.10        80173-80216         c
            564-669             AL671190.10        77891-77996         c
            670-742             AL671190.10        75766-75838         c
            743-825             AL671190.10        74647-74729         c
            826-2320            AL671190.10        71411-72905         c
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.01 cM"
     gene            1..2320
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /note="syntaxin 12"
                     /db_xref="GeneID:100226"
                     /db_xref="MGI:MGI:1931027"
     exon            1..211
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..918
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /note="syntaxin 13"
                     /codon_start=1
                     /product="syntaxin-12"
                     /protein_id="NP_598648.1"
                     /db_xref="CCDS:CCDS18737.1"
                     /db_xref="GeneID:100226"
                     /db_xref="MGI:MGI:1931027"
                     /translation="MSYGPLDMYRNPGPSGPQPRDFNSIIQTCSGNIQRISQATAQIK
                     NLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSASEQRQQKLQ
                     KERLMNDFSSALNNFQVVQRKVSEKEKESIARARAGSRLSAEDRQREEQLVSFDSHEE
                     WNQMQSQEEEAAITEQDLELIKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDS
                     IEANVESSEVHVERATDQLQRAAYYQKKSRKKMCILVLVLSVIVTVLVVVIWVASK"
     exon            212..281
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     exon            282..381
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     exon            382..519
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     exon            520..563
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     exon            564..669
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     exon            670..742
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     exon            743..825
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     exon            826..2320
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /note="hexamer: AATAAA"
     polyA_site      2320
                     /gene="Stx12"
                     /gene_synonym="Stx13"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcccgg ttttcctctc agctgctggg cccggtcagt ggcagcttcc ggtaggagcg
       61 ccgcgaagcg cgacccggtc tctgctcact gtcatgtcct acggtccctt agacatgtat
      121 cggaaccccg ggccgtcggg gcctcagccc cgggacttca acagcatcat ccagacatgc
      181 agtggcaaca tccagcggat cagccaagcc actgctcaga taaagaattt gatgagccaa
      241 cttggaacta agcaggactc aagcaaactc caggaaaatt tgcaacagtt acagcactcc
      301 acaaatcagc tggccaagga aacaaatgag ttgctgaagg aattagggtc cttgccccta
      361 cccttgtctg catcagagca gcgccagcag aagcttcaga aggagcggct catgaatgac
      421 ttctcgtcgg ccttaaacaa tttccaggtt gtgcagagaa aggtatctga gaaggaaaag
      481 gagagcatcg cgagagcgag agccggatct cgtctttctg cagaagacag gcagagagaa
      541 gagcagctcg tctcatttga cagccatgaa gagtggaacc aaatgcagag ccaggaggaa
      601 gaggcggcca tcactgagca agacctggaa ctcatcaaag agagggaaac ggcgattcgg
      661 cagctggagg ctgacatttt ggatgtcaat cagatattta aagatttagc tatgatgatc
      721 catgaccaag gtgatctgat cgatagcata gaagccaatg tggaaagctc ggaggtgcat
      781 gtggaaagag ccactgatca gctacaaaga gctgcttact atcagaaaaa atctcgcaag
      841 aagatgtgta tcctcgtgct tgtcctgtca gtgattgtta cagtcttggt agttgttatc
      901 tgggttgctt ctaaatgaag tgcttgcctc agagcctcct cctgctgagt tgttttcaag
      961 ggcaagtgct tgagagagtc ttgccagaac agactgacca cagaagagag tgtaccagag
     1021 tgtcctgtga taatttagct agaatctaac tactaactag tccttggaat tagtgaccat
     1081 ggagacagta tttatcagtt tatgcataca ttctattcat ttgtcaaata acgaattacc
     1141 ttattccttt gtattttcct ttctcttgta ttttgattgc ccttattgca agtgtttatt
     1201 gacagttcca tcgtggatat tctttttgac aggtgacact acatcataaa tttgtctttt
     1261 tgtatatacg caaactttac ctttttatga gtatctgaga taaatttcca tctggagcca
     1321 gcctattaga gtctgagaaa ctgtacaata tgccagcaat ttttattatt taacattttg
     1381 attttgtttc tgaggggtct gttttctgtt ttgtaagatt ttggcactat atataactgg
     1441 ggattaagaa cattgcaccc gtgacttcag acaaaatgag aagaacctgg cagagccggc
     1501 ccactgccag gttgtgtggg acagtctggg tctgaggtga attgccttta ttgtctgctg
     1561 gtgtttacag agtccatcct cgaacactaa gccatcccac tcctgtttag agaggatcgg
     1621 ttcattacca tgcttacaat cagtcgggtc tctcccacct gtctgcatag aacggaagaa
     1681 ttaggcacag cccgattttg gatagtaaat gtggatcgtt tggcatgatt ccatctcgtt
     1741 cacctgtggc tttcattctg gtgaatgata aatgttgctg tcaaaggcta atcctgaccc
     1801 ttgtaagtaa gggttgcctg gctttgatgg caagattttg aaatttagac tgaagtgggg
     1861 tttaaaactc agtctgtgaa cctattgata tagcaaaaca aaggttcatt ttgtaaataa
     1921 tactggttta gtgatgttag acttagccta atttatgaac aagagatcaa actctgtgta
     1981 gttttagatg aaaacagttt taataaaatg tttctgtctt gtatataaat gttgtctact
     2041 gccctttttc acaggcctag aacagtcaag agagtgtgta attggtttag gctctcagat
     2101 aaatgtgaat tgaggccaga aatgtcagct catctttctc tgagttagag gatctggcta
     2161 ctgtggctgt atttatgttt gtttcttctc ttcctcataa tgttacttaa tcttgttcta
     2221 cactaatgtg accagcagag aaacaagggc ccacatgcat aagtttctct gcgcttttgc
     2281 accatcccac ctacttaata ccaataaaca tttaaaagct
//
