LOCUS       NM_029075               2396 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus syntaxin 11 (Stx11), transcript variant 1, mRNA.
ACCESSION   NM_029075 XM_001472888 XM_001473721 XM_203312 XM_896683 XM_896707
            XM_920202 XM_920212 XM_920225
VERSION     NM_029075.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Kogl,T., Chang,H.F., Staniek,J., Chiang,S.C.C., Thoulass,G.,
            Lao,J., Weissert,K., Dettmer-Monaco,V., Geiger,K., Manna,P.T.,
            Beziat,V., Momenilandi,M., Tu,S.M., Keppler,S.J., Pattu,V.,
            Wolf,P., Kupferschmid,L., Tholen,S., Covill,L.E., Ebert,K.,
            Straub,T., Gross,M., Gather,R., Engel,H., Salzer,U., Schell,C.,
            Maier,S., Lehmberg,K., Cornu,T.I., Pircher,H., Shahrooei,M.,
            Parvaneh,N., Elling,R., Rizzi,M., Bryceson,Y.T., Ehl,S., Aichele,P.
            and Ammann,S.
  TITLE     Patients and mice with deficiency in the SNARE protein SYNTAXIN-11
            have a secondary B cell defect
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38722309
  REMARK    GeneRIF: Patients and mice with deficiency in the SNARE protein
            SYNTAXIN-11 have a secondary B cell defect.
            Erratum:[J Exp Med. 2024 Jul 1;221(7):e2022112205142024c. doi:
            10.1084/jem.2022112205142024c.. PMID: 38771261]
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Wang,J., Li,D.L., Zheng,L.F., Ren,S., Huang,Z.Q., Tao,Y., Liu,Z.,
            Shang,Y., Pang,D., Guo,H., Zeng,T., Wang,H.R., Huang,H., Du,X.,
            Ye,H., Zhou,H.M., Li,P. and Zhao,T.J.
  TITLE     Dynamic palmitoylation of STX11 controls injury-induced fatty acid
            uptake to promote muscle regeneration
  JOURNAL   Dev Cell 59 (3), 384-399 (2024)
   PUBMED   38198890
  REMARK    GeneRIF: Dynamic palmitoylation of STX11 controls injury-induced
            fatty acid uptake to promote muscle regeneration.
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Kinoshita,D., Sakurai,C., Morita,M., Tsunematsu,M., Hori,N. and
            Hatsuzawa,K.
  TITLE     Syntaxin 11 regulates the stimulus-dependent transport of Toll-like
            receptor 4 to the plasma membrane by cooperating with SNAP-23 in
            macrophages
  JOURNAL   Mol Biol Cell 30 (9), 1085-1097 (2019)
   PUBMED   30811271
  REMARK    GeneRIF: Findings suggest that stx11 regulates the
            stimulus-dependent transport of TLR4 to the plasma membrane by
            cooperating with SNAP-23 in macrophages. Our results clarify the
            regulatory mechanisms underlying intracellular transport of TLR4
            and have implications for microbial pathogenesis and immune
            responses.
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Sepulveda,F.E., Debeurme,F., Menasche,G., Kurowska,M., Cote,M.,
            Pachlopnik Schmid,J., Fischer,A. and de Saint Basile,G.
  TITLE     Distinct severity of HLH in both human and murine mutants with
            complete loss of cytotoxic effector PRF1, RAB27A, and STX11
  JOURNAL   Blood 121 (4), 595-603 (2013)
   PUBMED   23160464
  REMARK    GeneRIF: Distinct severity of HLH in both human and murine mutants
            with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
REFERENCE   7  (bases 1 to 2396)
  AUTHORS   D'Orlando,O., Zhao,F., Kasper,B., Orinska,Z., Muller,J.,
            Hermans-Borgmeyer,I., Griffiths,G.M., Zur Stadt,U. and
            Bulfone-Paus,S.
  TITLE     Syntaxin 11 is required for NK and CD8 T-cell cytotoxicity and
            neutrophil degranulation
  JOURNAL   Eur J Immunol 43 (1), 194-208 (2013)
   PUBMED   23042080
  REMARK    GeneRIF: required for NK and CD8+ T cell cytotoxicity and
            neutrophil degranulation
REFERENCE   8  (bases 1 to 2396)
  AUTHORS   Offenhauser,C., Lei,N., Roy,S., Collins,B.M., Stow,J.L. and
            Murray,R.Z.
  TITLE     Syntaxin 11 binds Vti1b and regulates late endosome to lysosome
            fusion in macrophages
  JOURNAL   Traffic 12 (6), 762-773 (2011)
   PUBMED   21388490
  REMARK    GeneRIF: Results suggest that by regulating the availability of
            Vti1b, Stx11 regulates trafficking steps between late endosomes,
            lysosomes and the cell surface in macrophages.
REFERENCE   9  (bases 1 to 2396)
  AUTHORS   Marcelin,G., Diatloff-Zito,C., Nicole,A. and Robert,J.J.
  TITLE     Developmental methylation program and concerted expression of Stx11
            in mouse tissues
  JOURNAL   Mamm Genome 20 (3), 131-139 (2009)
   PUBMED   19169743
  REMARK    GeneRIF: Stx11 were highly expressed at the end of fetal
            development but downregulated at 4 and 11 weeks in brain, pancreas,
            and heart.
REFERENCE   10 (bases 1 to 2396)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY753247.1, AK153408.1 and AK017897.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_001473721.1, XM_920202.3, XM_920212.2, XM_920225.2,
            XM_001472888.1, XM_896683.3, XM_203312.6, XM_896707.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017897.1, AK153408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY753247.1         2-27
            27-649              AK153408.1         2-624
            650-2396            AK017897.1         473-2219
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 4.54 cM"
     gene            1..2396
                     /gene="Stx11"
                     /gene_synonym="5830405C08Rik"
                     /note="syntaxin 11"
                     /db_xref="GeneID:74732"
                     /db_xref="MGI:MGI:1921982"
     exon            1..260
                     /gene="Stx11"
                     /gene_synonym="5830405C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            261..395
                     /gene="Stx11"
                     /gene_synonym="5830405C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            396..2396
                     /gene="Stx11"
                     /gene_synonym="5830405C08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..1264
                     /gene="Stx11"
                     /gene_synonym="5830405C08Rik"
                     /codon_start=1
                     /product="syntaxin-11"
                     /protein_id="NP_083351.1"
                     /db_xref="CCDS:CCDS48500.1"
                     /db_xref="GeneID:74732"
                     /db_xref="MGI:MGI:1921982"
                     /translation="MKDRLAELQELSRSYDQQFPDGDNDFDAPREDIVFETDHILESL
                     YRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQ
                     KLRSMKELSEQAEARHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIR
                     IQRQLEIMGKDMSGEQIEDMFEQGKWDVFSENLLADLKGARAALNEIESRHRELLRLE
                     GRIRDVHELFLQMAVLVEKQEDTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCR
                     TICCFCCPCVN"
     regulatory      2373..2378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stx11"
                     /gene_synonym="5830405C08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2396
                     /gene="Stx11"
                     /gene_synonym="5830405C08Rik"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggcc ctgcggctca gggctcggac cccggctgag aagcgcagcc cgggccagca
       61 agaagcggag ggggcagagc cgcggggaca cgccgcggtg tcctcccggc gtccggacgc
      121 tggatcagcg ccccgcagga tcacggttcg ttttgtcccg cgagtctgct tagctctcta
      181 actctttcga catcggggac ccaggttcgg ggttggctgg agtggtggac cgcgctggca
      241 gggatgctgc gcagctgcag ctcctcctag gtgctttgga cgctgctttg ctcttcgcgc
      301 ggagaatgag gtgtcttcac acacagctcc tttacagctc tggggaagca gtagagagcg
      361 tagaaccggt ctacaggcag agtcctagaa gcctggcaaa atgaaggatc ggcttgcaga
      421 gcttcaagaa ttgtccagga gctatgacca gcaattccca gatggggaca atgactttga
      481 cgctcctcgg gaggacatag tgttcgagac cgaccacatc ctggagtcct tgtacagggt
      541 catccaggac atccaggatg aaaaccagct gcttctgata gacgtgaggc gcctggggag
      601 gcagaacgtc cgcttcctca cgtccatgcg gcgcctcagc agcattaagc gcgacaccaa
      661 ctccatcgcc aaggccatca agacccgagg cgaaggcatc caccagaagc tgcgctccat
      721 gaaggagctg agcgagcagg ccgaggcccg gcacggcgcg cactcggcgg tggctcgcat
      781 ctcacacgcg cagtacagcg cgctggcccg cgctttccag caagccatgt acgagtacaa
      841 ccaggccgag atgaaacagc gcgacaactg caagatccgc atccagcggc agctggagat
      901 catgggcaag gacatgtcgg gcgagcagat tgaggacatg ttcgagcagg gcaagtggga
      961 tgtattctcc gagaacctgc tggccgactt gaagggcgcg cgggctgcgc tcaacgagat
     1021 cgagagccgc caccgcgagc tcctgcgcct ggagggtcgc attcgcgatg tgcacgagct
     1081 cttcctacag atggccgtgc tagtggagaa gcaggaggac acgctgaacg tcatcgagct
     1141 taacgtgcag aagaccctcg attacacggg cgaggccaag gcgcaggtgc gcaaggcggt
     1201 gcagtacaag aagaagaacc cctgcaggac catctgctgc ttctgttgtc cctgtgtcaa
     1261 ctagccgctg gcttgagtct ccactgcacg tgccatgtgg gaaacatgtc caggatgccc
     1321 agccaaaggc atcttgcact gggccgaggg agagggtccc aataccttgc agaattcaga
     1381 gcatagagaa agtgggggtt gggatgcaag atttggagtc cggcacctgc tgccttcaag
     1441 gaatagttgt taatatccaa tggctactta atgtagacag atttccactg gcgttgtgtg
     1501 atgtcattat aaaatacata gcactcagca tcacggggag gaactaaggt catttgctaa
     1561 gatgtgtgtc ttgaaaggag gaagccaaga gaacaggatg ctaatagtat gagtacatta
     1621 tcaaaagttg cctttgttta tcctctctgg aaagttcctt ggtgctatat ggttttgaat
     1681 gacattcact tcagtattca ttacgtctgt tcattttcgt ggaactttga ccttgggtaa
     1741 attggctgcc attcacttct gattatttat gttgtgtgag ccctgcgtga actccttccc
     1801 ttggctcgct cccactacac agtaaccctc actggacact ggctccttac ctctctcacc
     1861 ttttatatcg tccaccagct tatatatgaa tatttttaaa gcaccaaata ttgaacaagc
     1921 actcaagttg agctttatat tggtcacatt ttatggattt ttcacagata acatttattt
     1981 aaaatttatc tttgtacttc atttcatatg aatatgggtg taattgtaaa ctaatctcca
     2041 ttcctatgtg tacattaatg gccaattaga ttgactttgc ttttggaaat tctgtatata
     2101 aacaacaaga gcagtttttg ctgtgtgcca ttgtttgatg atcctgagtg tatttcatgc
     2161 ctgtctgcac agtccagttt gggtctaact ttattttgaa caactgtgtg ctgtcattaa
     2221 taaagagaag cgaggaagat tggaaacttg tgaagcagct agagatgcta aagtgaggtt
     2281 cttggggata gtaatctacc ttactccgag ccattccttt ctccattaaa gcagagagac
     2341 ttcaagtaaa atcttgtttt tcaaataagt ttaataaata tgaagttata actgtc
//
