LOCUS       NM_019719               1232 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus STIP1 homology and U-Box containing protein 1 (Stub1),
            transcript variant 1, mRNA.
ACCESSION   NM_019719
VERSION     NM_019719.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Qiu,C., Zhang,L., Yong,C., Hu,R., Sun,Y., Wang,B., Fang,L.,
            Zhu,G.J., Lu,Q., Wang,J., Ma,X., Zhang,L. and Wan,G.
  TITLE     Stub1 promotes degradation of the activated Diaph3: A negative
            feedback regulatory mechanism of the actin nucleator
  JOURNAL   J Biol Chem 300 (10), 107813 (2024)
   PUBMED   39322015
  REMARK    GeneRIF: Stub1 promotes degradation of the activated Diaph3: A
            negative feedback regulatory mechanism of the actin nucleator.
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Cao,Y., Chen,F., Zhu,S., Zhu,D. and Qi,H.
  TITLE     Staphylococcus aureus infection initiates hypoxia-mediated STIP1
            homology and U-box containing protein 1 upregulation to trigger
            osteomyelitis
  JOURNAL   Toxicon 248, 108049 (2024)
   PUBMED   39059559
  REMARK    GeneRIF: Staphylococcus aureus infection initiates hypoxia-mediated
            STIP1 homology and U-box containing protein 1 upregulation to
            trigger osteomyelitis.
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Mao,Z., Zhao,J., Cui,F., Li,Z., Cao,J., Zhou,J., Hou,M. and Qian,Z.
  TITLE     STUB1 increases adiponectin expression by inducing ubiquitination
            and degradation of NR2F2, thereby reducing hepatic stellate cell
            activation and alleviating non-alcoholic fatty liver disease
  JOURNAL   Tissue Cell 88, 102345 (2024)
   PUBMED   38471267
  REMARK    GeneRIF: STUB1 increases adiponectin expression by inducing
            ubiquitination and degradation of NR2F2, thereby reducing hepatic
            stellate cell activation and alleviating non-alcoholic fatty liver
            disease.
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Wang,J., Zhang,H., Chen,L., Fu,K., Yan,Y. and Liu,Z.
  TITLE     CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via
            facilitating STUB1-mediated PARK7 ubiquitination degradation
  JOURNAL   J Gastroenterol 59 (3), 229-249 (2024)
   PUBMED   38310161
  REMARK    GeneRIF: CircDCBLD2 alleviates liver fibrosis by regulating
            ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination
            degradation.
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Zheng,H., Zhang,X., Fu,J., Xue,Y., Chen,Z., Yang,G., Chen,Y.,
            Chen,D. and Yuan,G.
  TITLE     CHIP inhibits odontoblast differentiation through promoting DLX3
            polyubiquitylation and degradation
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37213079
  REMARK    GeneRIF: CHIP inhibits odontoblast differentiation through
            promoting DLX3 polyubiquitylation and degradation.
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Jiang,J., Cyr,D., Babbitt,R.W., Sessa,W.C. and Patterson,C.
  TITLE     Chaperone-dependent regulation of endothelial nitric-oxide synthase
            intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP
  JOURNAL   J Biol Chem 278 (49), 49332-49341 (2003)
   PUBMED   14507928
  REMARK    GeneRIF: results demonstrate a novel co-chaperone(CHIP)-dependent
            mechanism through which eNOS trafficking is regulated and suggest a
            potentially generalized role for CHIP in protein trafficking
            through the Golgi compartment
REFERENCE   7  (bases 1 to 1232)
  AUTHORS   Imai,Y., Soda,M., Hatakeyama,S., Akagi,T., Hashikawa,T.,
            Nakayama,K.I. and Takahashi,R.
  TITLE     CHIP is associated with Parkin, a gene responsible for familial
            Parkinson's disease, and enhances its ubiquitin ligase activity
  JOURNAL   Mol Cell 10 (1), 55-67 (2002)
   PUBMED   12150907
  REMARK    GeneRIF: CHIP is associated with Parkin, a gene responsible for
            familial Parkinson's disease, and enhances its ubiquitin ligase
            activity.
REFERENCE   8  (bases 1 to 1232)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
REFERENCE   9  (bases 1 to 1232)
  AUTHORS   Fukunishi,Y., Suzuki,H., Yoshino,M., Konno,H. and Hayashizaki,Y.
  TITLE     Prediction of human cDNA from its homologous mouse full-length cDNA
            and human shotgun database
  JOURNAL   FEBS Lett 464 (3), 129-132 (1999)
   PUBMED   10618491
  REMARK    Erratum:[FEBS Lett 2000 Apr 14;471(2-3):261]
REFERENCE   10 (bases 1 to 1232)
  AUTHORS   Ballinger,C.A., Connell,P., Wu,Y., Hu,Z., Thompson,L.J., Yin,L.Y.
            and Patterson,C.
  TITLE     Identification of CHIP, a novel tetratricopeptide repeat-containing
            protein that interacts with heat shock proteins and negatively
            regulates chaperone functions
  JOURNAL   Mol Cell Biol 19 (6), 4535-4545 (1999)
   PUBMED   10330192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159277.3.
            
            On Jul 14, 2018 this sequence version replaced NM_019719.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002752.1, BC027427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AC159277.3         200449-200676
            229-427             AC159277.3         201124-201322
            428-593             AC159277.3         201407-201572
            594-681             AC159277.3         201737-201824
            682-738             AC159277.3         202003-202059
            739-855             AC159277.3         202150-202266
            856-1232            AC159277.3         202358-202734
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.93 cM"
     gene            1..1232
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /note="STIP1 homology and U-Box containing protein 1"
                     /db_xref="GeneID:56424"
                     /db_xref="MGI:MGI:1891731"
     exon            1..228
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..981
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /EC_number="2.3.2.27"
                     /note="carboxy terminus of Hsp70-interacting protein;
                     RING-type E3 ubiquitin transferase CHIP"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CHIP"
                     /protein_id="NP_062693.1"
                     /db_xref="CCDS:CCDS28533.1"
                     /db_xref="GeneID:56424"
                     /db_xref="MGI:MGI:1891731"
                     /translation="MKGKEEKEGGARLGTGGGGSPDKSPSAQELKEQGNRLFVGRKYP
                     EAAACYGRAITRNPLVAVYYTNRALCYLKMQQPEQALADCRRALELDGQSVKAHFFLG
                     QCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQES
                     ELHSYLTRLIAAERERELEECQRNHEGHEDDGHIRAQQACIEAKHDKYMADMDELFSQ
                     VDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPL
                     TQEQLIPNLAMKEVIDAFISENGWVEDY"
     exon            229..427
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            428..593
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            594..681
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            682..738
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            739..855
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1232
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1211..1216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /note="hexamer: AATAAA"
     polyA_site      1230
                     /gene="Stub1"
                     /gene_synonym="0610033N24Rik; 2210017D18Rik;
                     2310040B03Rik; Chip"
                     /note="major polyA site"
ORIGIN      
        1 gatcgctgcg cgggctgcga gatctaggtg gccgggcgcg gagcccaagc cgtgccgcgc
       61 ggcgccatga agggcaagga ggaaaaggag ggcggcgcgc ggctgggcac tggtggcggc
      121 ggcagccctg ataagagccc gagtgcgcaa gagctcaagg agcagggaaa ccggctcttc
      181 gtgggccgca agtacccgga ggcggcggcc tgctacggcc gcgccatcac tcggaaccca
      241 cttgtggcag tgtactacac taaccgggcc ctgtgctatc tgaagatgca gcagcctgaa
      301 caggcacttg ctgactgccg gcgagccctg gagctggacg ggcagtctgt gaaggcgcac
      361 ttcttcctgg ggcagtgcca gctggagatg gagagttatg atgaggccat tgccaatctg
      421 cagcgagcct atagtttggc caaggagcag cgactcaact ttggggatga tattcctagt
      481 gcccttcgca ttgctaagaa gaagcgctgg aacagtatcg aggaacggcg catccaccag
      541 gagagtgagc tgcattcata tctcaccagg ctcattgctg ctgagcgaga gagggaactg
      601 gaggagtgtc agcggaacca cgagggtcat gaagatgatg gccacatccg ggcccagcag
      661 gcctgcattg aggccaagca cgataaatac atggcagata tggatgagct cttctctcag
      721 gtggacgaga aaagaaagaa gcgagatatc cctgactact tgtgtggcaa gattagcttt
      781 gagctgatgc gggaaccctg cattacaccc agtggtatca cctatgaccg caaggacatt
      841 gaggagcacc tgcagcgtgt gggccacttt gaccctgtga cccggagccc tctgacccag
      901 gaacagctca tccccaactt ggccatgaag gaagtcattg acgctttcat ctctgagaac
      961 ggctgggtag aggactattg aggccccatg tcctgcctgg caccctggcc caggaggatc
     1021 tggagacgga agctccagtc cctgtatagt ttgtgtccct gggcctgccc ccatcggccc
     1081 tgctgatggg ttctgaactg ctccccttct cagcataccc cttgctggac catgagcctc
     1141 ccttgtcccc cttctgggct ggagagtggg tgagggtggg ctgaggttgc tgctgctgcc
     1201 actgtcctgt aataaagtct gtgagcacta ca
//
