LOCUS       NM_024222               4395 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus STT3, subunit of the oligosaccharyltransferase
            complex, homolog B (S. cerevisiae) (Stt3b), mRNA.
ACCESSION   NM_024222 XM_358385
VERSION     NM_024222.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4395)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4395)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   3  (bases 1 to 4395)
  AUTHORS   Hsu,J.M., Xia,W., Hsu,Y.H., Chan,L.C., Yu,W.H., Cha,J.H.,
            Chen,C.T., Liao,H.W., Kuo,C.W., Khoo,K.H., Hsu,J.L., Li,C.W.,
            Lim,S.O., Chang,S.S., Chen,Y.C., Ren,G.X. and Hung,M.C.
  TITLE     STT3-dependent PD-L1 accumulation on cancer stem cells promotes
            immune evasion
  JOURNAL   Nat Commun 9 (1), 1908 (2018)
   PUBMED   29765039
  REMARK    GeneRIF: N-glycosyltransferases STT3A and STT3B isoforms are
            sufficient and required for effective PD-L1 protein induction in
            the general cell population of mesenchymal-like cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4395)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   5  (bases 1 to 4395)
  AUTHORS   Lee,J.H., Yu,W.H., Kumar,A., Lee,S., Mohan,P.S., Peterhoff,C.M.,
            Wolfe,D.M., Martinez-Vicente,M., Massey,A.C., Sovak,G.,
            Uchiyama,Y., Westaway,D., Cuervo,A.M. and Nixon,R.A.
  TITLE     Lysosomal proteolysis and autophagy require presenilin 1 and are
            disrupted by Alzheimer-related PS1 mutations
  JOURNAL   Cell 141 (7), 1146-1158 (2010)
   PUBMED   20541250
REFERENCE   6  (bases 1 to 4395)
  AUTHORS   Kelleher,D.J., Karaoglu,D., Mandon,E.C. and Gilmore,R.
  TITLE     Oligosaccharyltransferase isoforms that contain different catalytic
            STT3 subunits have distinct enzymatic properties
  JOURNAL   Mol Cell 12 (1), 101-111 (2003)
   PUBMED   12887896
REFERENCE   7  (bases 1 to 4395)
  AUTHORS   McBride,K., Baron,C., Picard,S., Martin,S., Boismenu,D., Bell,A.,
            Bergeron,J. and Perreault,C.
  TITLE     The model B6(dom1) minor histocompatibility antigen is encoded by a
            mouse homolog of the yeast STT3 gene
  JOURNAL   Immunogenetics 54 (8), 562-569 (2002)
   PUBMED   12439619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152899.1, BC052433.1 and AI852345.1.
            
            On Jun 20, 2018 this sequence version replaced NM_024222.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052433.1, AK148065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AK152899.1         2-48
            48-4268             BC052433.1         1-4221
            4269-4395           AI852345.1         1-127               c
FEATURES             Location/Qualifiers
     source          1..4395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 67.71 cM"
     gene            1..4395
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /note="STT3, subunit of the oligosaccharyltransferase
                     complex, homolog B (S. cerevisiae)"
                     /db_xref="GeneID:68292"
                     /db_xref="MGI:MGI:1915542"
     exon            1..717
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..2884
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /EC_number="2.4.99.18"
                     /note="source of immunodominant MHC-associated peptides;
                     B6dom1 antigen; oligosaccharyl transferase subunit STT3B"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit STT3B"
                     /protein_id="NP_077184.2"
                     /db_xref="CCDS:CCDS23599.1"
                     /db_xref="GeneID:68292"
                     /db_xref="MGI:MGI:1915542"
                     /translation="MAEPSAPESKHKSSLNSSPWSGLMALGNSRHGHHGPGTQSASRA
                     AAPKPGPPAGLSGGLSQPAGWQSLLSFTILFLAWLAGFSSRLFAVIRFESIIHEFDPW
                     FNYRSTHHLASHGFYEFLNWFDERAWYPLGRIVGGTVYPGLMITAGLIHWILNTLNIT
                     VHIRDVCVFLAPTFSGLTSISTFLLTRELWNQGAGLLAACFIAIVPGYISRSVAGSFD
                     NEGIAIFALQFTYYLWVKSVKTGSVFWTMCCCLSYFYMVSAWGGYVFIINLIPLHVFV
                     LLLMQRYSKRVYIAYSTFYIVGLILSMQIPFVGFQPIRTSEHMAAAGVFALLQAYAFL
                     QYLRDRLTKQEFQTLFFLGVSLAAGAVFLSVIYLTYTGYIAPWSGRFYSLWDTGYAKI
                     HIPIIASVSEHQPTTWVSFFFDLHILVCTFPAGLWFCIKNINDERVFVALYAISAVYF
                     AGVMVRLMLTLTPVVCMLSAIAFSNVFEHYLGDDMKRENPPVEDSSDEDDKRNPGNLY
                     DKAGKVRKHVTEQEKPEEGLGPNIKSIVTMLMLMLLMMFAVHCTWVTSNAYSSPSVVL
                     ASYNHDGTRNILDDFREAYFWLRQNTDEHARVMSWWDYGYQIAGMANRTTLVDNNTWN
                     NSHIALVGKAMSSNETAAYKIMRSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGE
                     HPKDIREGDYFTQQGEFRVDKAGSPTLLNCLMYKMSYYRFGEMQLDFRTPPGFDRTRN
                     AEIGNKDIKFKHLEEAFTSEHWLVRIYKVKAPDNRETLGHKPRVTNIVPKQKYLSKKT
                     TKRKRGYVKNKLVFKKGKKTSKKTV"
     exon            718..826
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1114
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1180
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1280
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1379
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1526
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1575
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1730
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1942
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2130
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2302
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2476
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2590
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2803
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..4379
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4243..4248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /note="hexamer: AATAAA"
     polyA_site      4268
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /note="major polyA site"
     regulatory      4355..4360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /note="hexamer: AATAAA"
     polyA_site      4379
                     /gene="Stt3b"
                     /gene_synonym="1300006C19Rik; Simp"
                     /note="major polyA site"
ORIGIN      
        1 gtgctcctcg cggctgggcg ggcgggggaa tgtcattgcc gctccgagcc gccgctcctc
       61 tggcgccctc gtcccgtcgg ctctcgccgc caccgccgcc tcctcagccg cacgggggac
      121 acggatggct agtggggcgc aggggccttt tgggttgaga ccgcgacggt cgcggccact
      181 gttgaggcgg agacttcgga tcgctgccgc ctccaccacc cccagtgtcc cggcctcgcg
      241 gtgctgaggg cgggagcgcg cccagctctt cctccgcctc cgcctcctcc tcctcctcgt
      301 tgtcgtcgcc gtcgccctcc tcctcctcct ctgggtctcc gcccagcacc cctcgctcca
      361 ggcggcggcg gtggccgcgg aggacgagcg agacccgccg ccggggcaca acatggcgga
      421 gccctcggcc ccggagagca agcacaagtc gtccctcaac tcgtccccgt ggagcggcct
      481 catggctctg gggaacagcc gccacgggca ccatgggccc ggaacccaga gcgcgtccag
      541 ggcggcggcg ccgaagccgg ggccccccgc ggggctgtcc gggggcttgt cgcagccggc
      601 cgggtggcag tcgttgctct ccttcaccat cctcttcctg gcctggctgg ccggcttcag
      661 ctcgcgcctc ttcgccgtca tccgcttcga gagcatcatc cacgagttcg acccgtggtt
      721 taactataga tcaacacatc atcttgcatc tcatggattc tatgagtttc taaattggtt
      781 tgatgaaaga gcatggtacc cactgggaag aatagtgggt ggcaccgttt acccagggtt
      841 gatgataaca gctggcctta ttcattggat tttaaataca ttgaacataa cagttcacat
      901 aagagatgtg tgtgtattcc ttgcaccaac ttttagcggc cttacatcca tatctacgtt
      961 cctgctaact agagaactgt ggaaccaagg agcaggactt ctagctgctt gcttcattgc
     1021 tatcgtacca gggtacatat ctcggtcagt ggcgggatcc tttgataatg aaggcattgc
     1081 catttttgcg cttcagttca cttactactt atgggtaaag tctgtgaaga ccgggtctgt
     1141 gttctggaca atgtgctgct gcttgtcata tttctacatg gtctctgcgt ggggaggtta
     1201 tgtgttcatc atcaacctca tccctctcca tgtgtttgtg ttgctgctga tgcagaggta
     1261 cagcaagaga gtctacatag catatagcac tttctacatt gtgggtttaa tattatccat
     1321 gcagatacct tttgtgggat ttcagccaat cagaacaagc gagcacatgg cagctgcagg
     1381 tgtctttgcg ctgctgcaag cttacgcttt tttgcagtat ctgagagacc ggttgacaaa
     1441 acaggagttc cagacccttt tctttttggg tgtctcacta gctgcaggcg ctgtgttcct
     1501 tagtgtcatc tatctgacat acacaggtta tattgcacca tggagtggca ggttttattc
     1561 actatgggat actgggtatg caaaaataca cattccaatt attgcatcag tgtctgaaca
     1621 tcagcctacg acatgggtgt ctttcttctt tgatctacat attcttgtat gtaccttccc
     1681 agcaggccta tggttctgca tcaaaaatat caacgatgaa agagtatttg tcgctctgta
     1741 tgcgatcagt gctgtctact ttgccggagt gatggtgcgg ctgatgctga ctctgacccc
     1801 ggtcgtctgc atgctgtcgg ccatcgcctt ctccaatgtt tttgagcact atttggggga
     1861 tgacatgaaa agggaaaacc cacctgtgga ggacagcagt gatgaggatg acaaaagaaa
     1921 cccaggaaac ttgtatgaca aggcaggtaa agtgaggaag catgtgacag agcaagagaa
     1981 acctgaagag ggcttgggcc ccaacatcaa aagcattgtg accatgctga tgctcatgct
     2041 cctgatgatg ttcgcggtcc actgcacgtg ggtcacaagc aacgcctact ccagtccaag
     2101 tgtggtcctt gcctcctaca atcatgatgg taccaggaat atattagatg attttagaga
     2161 agcgtacttt tggctgagac aaaacacgga tgaacacgcc cgggtcatgt cgtggtggga
     2221 ctacggctat cagattgctg gcatggccaa caggaccact ctggtggata acaacacctg
     2281 gaacaacagc cacatcgcac tggtcggaaa agctatgtct tccaatgaaa cggccgccta
     2341 taaaatcatg aggtcccttg atgtcgatta tgtgttggtt attttcggag gagtgattgg
     2401 ctattccggg gacgatatca acaagttcct ctggatggtc aggatagctg aaggggagca
     2461 tcccaaagac atccgggaag gtgactattt cacccagcag ggagagttcc gagtagacaa
     2521 agctgggtct cctactctgt taaactgcct tatgtataaa atgtcatact acagatttgg
     2581 agaaatgcag ctagattttc gcactccccc aggctttgac cgaacacgta atgctgagat
     2641 tggaaataaa gacattaaat tcaagcattt ggaggaagct tttacatcag agcactggct
     2701 tgtcaggata tataaagtga aagcacctga caacagggag acactaggtc acaaacctcg
     2761 agtcaccaac atcgtcccca aacagaagta tttgtcaaag aagactacta aaaggaagcg
     2821 tggctacgtt aaaaataagc tagtgtttaa gaaaggcaag aagacctcta agaagactgt
     2881 ttaaatgcgc tgttctggcc tcacttgcag cagtccttga gagaaccggt ctttgccttc
     2941 tgctcatgtc ctgtttcaca gcaccaaggg tacagaacat cgctgggcca agtcaatgta
     3001 caaaatgttc tggcaatgcc tcatttaaaa ttaaattggt ttattgagaa cagctgtttc
     3061 tgatgtgtaa cgtgaagcaa gacagagccc tgctgtgagc agctggcaga agattttttt
     3121 tttttaatta ttggtacata ttacccttca aatctgagaa tttggactaa ttgcaccaaa
     3181 gaaccctcta atttggtccc tggcacatgc gtacctgtca actttttttc ttttacaaga
     3241 cctgcatttt atttgaacta cccaaatagc aatatgtaag acagaaatgc agatgtgatg
     3301 agagcttctt gaccagtaaa caaactagcc caggtctgag agagacgtgc taaaggagag
     3361 tctacgtctg ggaactctat ttattttcct gtttctccgg tgtgaagaat gtttcatcaa
     3421 atgtccactt tgtcgctcac tgccgctgta agcagccgct gctgacggtg ggcctccctc
     3481 cgcgtagtta gctgactaga tgtttgtgtt caggcatccg gatgcactgc ggttagcggg
     3541 catcctcacc aggtactcac agagcagatt ccatgcattc ttcattcaag ggctaaattt
     3601 ctctcctttg ggaatcatgg caagcgcaca cagaacgttg ctggccagga tggctgttac
     3661 ctcagtactg aggtcggctc catgttccca cgcagaagat taagggaaag cccttacggt
     3721 ggacaggcat gcagagttca tttctgtgac tctacacagt gacaaaggat ttgtaaactt
     3781 tgcctggatt ttcctcattt tataccagtt ttgttcatca cgatggtttc tgttgaccgc
     3841 ttcatgtttt tataccttaa gcatttgatg aaacactctc tagtgctctc taggcgtttc
     3901 ttacttttat tacaaatgtg acaattgtca aaagatgcac taaaatataa atggagattg
     3961 agcctgttca ttttccagct tataggcaac tttatacaga cttgaaatct ttatccagtt
     4021 gtttagtaaa gtgagagaga ggtttcctgc cacaggagaa cttttacaca acaccccact
     4081 gctttagtgg gacagttgag agcagtgtgt cccttttatg aagaacccgt catttacagc
     4141 gctccgggag agagaatgtt actgcagatc ccttttccac ggtgtagata ctctgattta
     4201 tagaattcat tcttgatcca gatgatggtt ctttcacaga ccaataaaaa aaaaaaagta
     4261 taactaaatc tggatttctg ataccttgtc atttggggga ttttatctta ctttgcttta
     4321 cagttccatg cagagaagtt atgaccatga gggaaataaa gcttattcaa tttgtgtcaa
     4381 aaaaaaaaaa aaaaa
//
