LOCUS       NM_009293               2283 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus steroid sulfatase (Sts), mRNA.
ACCESSION   NM_009293 XM_918599
VERSION     NM_009293.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Feng,Y., Xie,Y., Xu,M., Li,L., Selcer,K.W., Oberly,P.J.,
            Poloyac,S.M., Wang,H., Li,C., Dong,F., Yu,C. and Xie,W.
  TITLE     Hepatic steroid sulfatase critically determines estrogenic
            activities of conjugated equine estrogens in human cells in vitro
            and in mice
  JOURNAL   J Biol Chem 294 (32), 12112-12121 (2019)
   PUBMED   31217279
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Bi,Y., Jiang,M., Guo,W., Guan,X., Xu,M., Ren,S., Yang,D.,
            Gaikwad,N.W., Selcer,K.W. and Xie,W.
  TITLE     Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase
            in Adipose Inflammation and Energy Homeostasis
  JOURNAL   Endocrinology 159 (9), 3365-3377 (2018)
   PUBMED   30060148
  REMARK    GeneRIF: Results revealed an essential role of the adipose STS in
            energy homeostasis in sex- and sex hormone-dependent manner.
            Adipose expression of Sts was induced in the high-fat diet (HFD)
            and ob/ob models of obesity and type 2 diabetes.
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Jiang,M., He,J., Kucera,H., Gaikwad,N.W., Zhang,B., Xu,M.,
            O'Doherty,R.M., Selcer,K.W. and Xie,W.
  TITLE     Hepatic overexpression of steroid sulfatase ameliorates mouse
            models of obesity and type 2 diabetes through sex-specific
            mechanisms
  JOURNAL   J Biol Chem 289 (12), 8086-8097 (2014)
   PUBMED   24497646
  REMARK    GeneRIF: Overexpression of STS in the liver improved metabolic
            functions in mouse models of obesity and type 2 diabetes through
            sex-specific mechanisms.
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Trent,S., Fry,J.P., Ojarikre,O.A. and Davies,W.
  TITLE     Altered brain gene expression but not steroid biochemistry in a
            genetic mouse model of neurodevelopmental disorder
  JOURNAL   Mol Autism 5 (1), 21 (2014)
   PUBMED   24602487
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Trent,S., Cassano,T., Bedse,G., Ojarikre,O.A., Humby,T. and
            Davies,W.
  TITLE     Altered serotonergic function may partially account for behavioral
            endophenotypes in steroid sulfatase-deficient mice
  JOURNAL   Neuropsychopharmacology 37 (5), 1267-1274 (2012)
   PUBMED   22189290
  REMARK    GeneRIF: These data suggest that inactivating mutations and
            functional variants within STS might exert their influence on ADHD
            vulnerability, and disorder endophenotypes through modulation of
            the serotonergic system.
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Amar,L.C., Dandolo,L., Hanauer,A., Cook,A.R., Arnaud,D.,
            Mandel,J.L. and Avner,P.
  TITLE     Conservation and reorganization of loci on the mammalian X
            chromosome: a molecular framework for the identification of
            homologous subchromosomal regions in man and mouse
  JOURNAL   Genomics 2 (3), 220-230 (1988)
   PUBMED   2899541
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Nagamine,C.M., Michot,J.L., Roberts,C., Guenet,J.L. and Bishop,C.E.
  TITLE     Linkage of the murine steroid sulfatase locus, Sts, to sex
            reversed, Sxr: a genetic and molecular analysis
  JOURNAL   Nucleic Acids Res 15 (22), 9227-9238 (1987)
   PUBMED   3479751
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Soriano,P., Keitges,E.A., Schorderet,D.F., Harbers,K., Gartler,S.M.
            and Jaenisch,R.
  TITLE     High rate of recombination and double crossovers in the mouse
            pseudoautosomal region during male meiosis
  JOURNAL   Proc Natl Acad Sci U S A 84 (20), 7218-7220 (1987)
   PUBMED   3478692
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Keitges,E.A., Schorderet,D.F. and Gartler,S.M.
  TITLE     Linkage of the steroid sulfatase gene to the sex-reversed mutation
            in the mouse
  JOURNAL   Genetics 116 (3), 465-468 (1987)
   PUBMED   3475232
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Keitges,E. and Gartler,S.M.
  TITLE     Dosage of the Sts gene in the mouse
  JOURNAL   Am J Hum Genet 39 (4), 470-476 (1986)
   PUBMED   3464202
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U37545.1.
            
            On Dec 7, 2005 this sequence version replaced XM_918599.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37545.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X"
     gene            1..2283
                     /gene="Sts"
                     /gene_synonym="ArsC"
                     /note="steroid sulfatase"
                     /db_xref="GeneID:20905"
                     /db_xref="MGI:MGI:98438"
     CDS             256..2130
                     /gene="Sts"
                     /gene_synonym="ArsC"
                     /EC_number="3.1.6.2"
                     /note="steryl-sulfatase; ASC; arylsulfatase C;
                     steryl-sulfate sulfohydrolase"
                     /codon_start=1
                     /product="steryl-sulfatase precursor"
                     /protein_id="NP_033319.1"
                     /db_xref="GeneID:20905"
                     /db_xref="MGI:MGI:98438"
                     /translation="MPRPRPLLLAVMAATLADIILAADPAPAGPAPRPPNFLLIMADD
                     LGIGDLGCYGNKTLRTPHLDRLAREGVKLTQHLAAAPLCTPSRAAFLTGRYPPRSGMA
                     AHGRVGVYLFTASSGGLPPSEVTMARLLKGRGYATALIGKWHLGLSCRGATDFCHHPL
                     RHGFDRFLGVPTTNLRDCRPGAGTVFGPALRVFAAGPLAALGASLAAMAAARWAGLAR
                     VPGWALAGTAAAMLAVGGPRSASCLGFRPANCFLMDDLAVAQRPTDYGGLTRRLADEA
                     ALFLRRNRARPFLLFLSFLHVHTAHFADPGFAGRSLHGAYGDSVEEMDWGVGRVLAAL
                     DELGLARETLVYFTSDHGAHVEELGPRGERMGGSNGVFRGGKGNNWEGGVRVPCLVRW
                     PRELSPGRVVAEPTSLMDVFPTVARLAGAELPGDRVIDGRDLMPLLRGDAQRSEHEFL
                     FHYCNAYLQAVRWHNGSAVWKAFYFTPNFAPAGANGCFSTHVCLCAGPAHVTAHDPPL
                     LFDLTRDPGERRPLTPEAEPRHREVLDAIDAAARAHRARLRPAPDQLAPRHLMWKPWL
                     QLWGGGGAGGGAGAQDDSGHAHGDGSHAHDDPGHAQDRGDDDAHYGGHATTRTQATPR
                     "
ORIGIN      
        1 cggggcttcc cgggcccgac cccgcccccg cgcgatgatt gaggcgcgcg atgtaaacaa
       61 ggccggcgcc gcccccgcgc gcgtgacccg tgaccccgcg acctgtgacc ccgtgacccg
      121 cggtataaac agccgcggcc aggccggcgg aacagaaccc gcggaccggt gaggaccgct
      181 gaccccgcgc tgaccccgcc gggaccaccg cgacccctga cctccgaccc cgccgtcgcc
      241 acgcagccgc cggccatgcc caggccccgc cccctgctcc tcgccgtcat ggccgccacg
      301 ctcgctgaca tcatcctcgc cgcggatccc gcccccgcag gccccgcccc ccggccgccc
      361 aacttcctgc tcatcatggc cgacgacctg ggcatcggtg acctcggctg ctacggcaac
      421 aaaacgctca ggacgccgca cctcgaccgc ctggcccgcg agggggtgaa gctgacgcag
      481 cacctggcgg ccgccccgct ctgcaccccc agccgcgccg ccttcctgac cgggcgctac
      541 ccgccgcgct caggcatggc ggcgcacggc cgcgtgggcg tgtacctgtt cacggcgtcg
      601 tcggggggcc tcccgcccag cgaggtcacc atggcgcggc tgctgaaggg gcggggctac
      661 gccacggcgc tcattgggaa gtggcacctg ggtctgagct gccgcggggc caccgacttc
      721 tgccaccacc ccctgcgcca cggcttcgac cgcttcctgg gcgtcccgac caccaacctg
      781 cgcgactgcc ggccgggggc gggcaccgtg ttcggccccg ccctgcgcgt gttcgcggcc
      841 gggcccctgg cggcgctggg ggcgtcgctg gcggccatgg cggcggcgcg gtgggcgggg
      901 ctggcgcggg tgccgggctg ggccctggcg gggacggcgg cggccatgtt ggcggtgggc
      961 gggccgcgct cggcttcctg cctcggcttc cgcccggcca actgcttcct catggacgac
     1021 ctcgccgtgg cgcagcggcc cacggactac ggcggactca cgcggcgcct ggcggacgag
     1081 gccgcgctct tcctgcggag gaaccgggcc cgccccttcc tgctcttcct gtccttcctg
     1141 cacgtccaca ccgcgcactt cgccgacccc gggttcgcgg ggcggagcct gcacggggcc
     1201 tacggcgaca gcgtggagga gatggactgg ggcgtgggcc gcgtgctggc ggcgctggac
     1261 gagctgggcc tggcgcgcga gacgctcgtc tacttcacct cggaccacgg ggcccacgtg
     1321 gaggagctgg ggccgcgcgg cgagcgcatg ggcggcagca acggcgtctt ccgcggcggg
     1381 aagggcaaca actgggaggg cggcgtccgc gtcccctgcc tcgtgcgttg gccccgcgag
     1441 ctcagccccg gccgcgtcgt cgcggagccc acgagcctca tggacgtctt ccccaccgtg
     1501 gcgcggctgg cgggggcgga gctgcccggg gacagggtga ttgacggccg ggacctgatg
     1561 ccgctgctgc gcggcgacgc ccagcgctcg gagcacgagt tcctgttcca ctactgcaac
     1621 gcctacctgc aggccgtgcg ctggcacaac ggcagcgcgg tgtggaaggc cttctacttc
     1681 acgcccaact tcgcgcccgc gggcgccaac ggctgcttct cgacccacgt ctgcctctgc
     1741 gccggccccg cccacgtcac cgcccacgac ccccccctgc tgttcgacct cacgcgcgac
     1801 cccggcgagc gccgccccct gacccccgag gccgagcccc ggcaccgcga ggtcctggac
     1861 gccatcgacg ccgccgcccg cgcccaccgc gcccggctcc gccccgcgcc cgaccagctc
     1921 gccccgcggc acctgatgtg gaagccgtgg ctgcagctgt ggggcggggg cggggccggg
     1981 ggcggggccg gcgcccagga cgactcaggc cacgcccacg gcgatggaag ccacgcccac
     2041 gacgacccag gccacgccca ggacagaggc gatgacgacg cccactacgg aggccacgcc
     2101 acgacacgga ctcaggccac gccacgatga agcaggacgc gcccaccgcg atgcaagcca
     2161 cgcccacgat gaagcaggac acgcccaccg cgatggaagc cacgcccacg gctacggagg
     2221 ccacgcccag gacagactcg atgacgccgc ccactataga ggccacgcca accacgaccc
     2281 aag
//
