LOCUS       NM_052973               4164 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus striatin, calmodulin binding protein 3 (Strn3),
            transcript variant 1, mRNA.
ACCESSION   NM_052973 XM_912881 XM_922503 XM_922507 XM_922512 XM_922517
            XM_922522
VERSION     NM_052973.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Cull,J.J., Cooper,S.T.E., Alharbi,H.O., Chothani,S.P.,
            Rackham,O.J.L., Meijles,D.N., Dash,P.R., Kerkela,R., Ruparelia,N.,
            Sugden,P.H. and Clerk,A.
  TITLE     Striatin plays a major role in angiotensin II-induced cardiomyocyte
            and cardiac hypertrophy in mice in vivo
  JOURNAL   Clin Sci (Lond) 138 (10), 573-597 (2024)
   PUBMED   38718356
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   Rehmani,T., Dias,A.P., Kamal,M., Salih,M. and Tuana,B.S.
  TITLE     Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3
            (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of
            Myocardium without Affecting Hippo Pathway
  JOURNAL   Int J Mol Sci 25 (5), 2888 (2024)
   PUBMED   38474134
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   Zhang,Q., Li,H., Chen,X., Gu,F., Zhang,L., Zhang,L., Chen,T.,
            Chen,Q., Meng,W., Wu,Y., Chang,H., Liu,T., Chen,C., Ma,H. and
            Liu,Y.
  TITLE     Identifying STRN3-RARA as a new fusion gene for acute promyelocytic
            leukemia
  JOURNAL   Blood 142 (17), 1494-1499 (2023)
   PUBMED   37624915
  REMARK    GeneRIF: Identifying STRN3-RARA as a new fusion gene for acute
            promyelocytic leukemia.
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Gupta,R., Kumar,G., Jain,B.P., Chandra,S. and Goswami,S.K.
  TITLE     Ectopic expression of 35 kDa and knocking down of 78 kDa SG2NAs
            induce cytoskeletal reorganization, alter membrane sialylation, and
            modulate the markers of EMT
  JOURNAL   Mol Cell Biochem 476 (2), 633-648 (2021)
   PUBMED   33083950
  REMARK    GeneRIF: Ectopic expression of 35 kDa and knocking down of 78 kDa
            SG2NAs induce cytoskeletal reorganization, alter membrane
            sialylation, and modulate the markers of EMT.
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Tanti,G.K. and Goswami,S.K.
  TITLE     SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to
            protect cells from oxidative damage
  JOURNAL   Free Radic Biol Med 75, 1-13 (2014)
   PUBMED   25035075
  REMARK    GeneRIF: SG2NA associates with the antioxidant protein DJ-1 and the
            survival kinase Akt resulting in resistance to apoptosis induced by
            oxidative stress.
REFERENCE   7  (bases 1 to 4164)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 4164)
  AUTHORS   Sanghamitra,M., Talukder,I., Singarapu,N., Sindhu,K.V., Kateriya,S.
            and Goswami,S.K.
  TITLE     WD-40 repeat protein SG2NA has multiple splice variants with tissue
            restricted and growth responsive properties
  JOURNAL   Gene 420 (1), 48-56 (2008)
   PUBMED   18571342
  REMARK    GeneRIF: Taken together, splicing variation of SG2NA might have
            some critical roles in differentiation and maturation in metazoan
            cells.
REFERENCE   9  (bases 1 to 4164)
  AUTHORS   Gaillard,S., Bailly,Y., Benoist,M., Rakitina,T., Kessler,J.P.,
            Fronzaroli-Molinieres,L., Dargent,B. and Castets,F.
  TITLE     Targeting of proteins of the striatin family to dendritic spines:
            role of the coiled-coil domain
  JOURNAL   Traffic 7 (1), 74-84 (2006)
   PUBMED   16445688
REFERENCE   10 (bases 1 to 4164)
  AUTHORS   Castets,F., Rakitina,T., Gaillard,S., Moqrich,A., Mattei,M.G. and
            Monneron,A.
  TITLE     Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat
            proteins principally expressed in the brain
  JOURNAL   J Biol Chem 275 (26), 19970-19977 (2000)
   PUBMED   10748158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164967.1, AF307777.1, BC138055.1, BB821090.1, AK040913.1 and
            AK164987.1.
            
            On Feb 3, 2010 this sequence version replaced NM_052973.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF307777.1, SRR7974084.10970.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK164967.1         3-30
            29-2484             AF307777.1         13-2468
            2485-2673           BC138055.1         2184-2372
            2674-3060           BB821090.1         62-448
            3061-3912           AK040913.1         368-1219
            3913-4164           AK164987.1         947-1198
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 22.11 cM"
     gene            1..4164
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /note="striatin, calmodulin binding protein 3"
                     /db_xref="GeneID:94186"
                     /db_xref="MGI:MGI:2151064"
     exon            1..493
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2602
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     striatin-3 35 kDa; s/G2 antigen; cell cycle autoantigen
                     SG2NA; nuclear autoantigen"
                     /codon_start=1
                     /product="striatin-3 isoform 1"
                     /protein_id="NP_443205.1"
                     /db_xref="CCDS:CCDS36440.1"
                     /db_xref="GeneID:94186"
                     /db_xref="MGI:MGI:2151064"
                     /translation="MDELAGGGGGGQGMAAPPRPQQGPGGNLSLPPGANGAPGGGGPP
                     AAEAAGPPAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQG
                     ERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDVE
                     APPAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVEAK
                     NLEQILNGGESPKQKGQEIKRPPGDVLETFNFLENADDSDEEENDMIEGIPEGKDKLR
                     IHKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLS
                     PTAEVWDVDQGLISKLKEQYKKERKGKKGVKRVNRTNLCDMITDLGDDELPHIPSGII
                     NQSRSASTRMADHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTN
                     DADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL
                     QKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNV
                     DPYDTYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKLPCVCTY
                     NGDKEHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVMLSSQVDSGLQSSNH
                     INRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSG
                     SHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHPSKAYIASAGADALAKVFV"
     exon            494..597
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            598..671
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            672..753
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            754..927
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1054
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1196
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1307
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1448
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1582
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1758
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1806
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1928
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2096
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2237
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2345
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2432
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..4164
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3894..3899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /note="hexamer: AATAAA"
     polyA_site      3922
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
     regulatory      4061..4066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /note="hexamer: AATAAA"
     polyA_site      4086
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /note="major polyA site"
     regulatory      4120..4125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /note="hexamer: AATAAA"
     regulatory      4143..4148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
                     /note="hexamer: ATTAAA"
     polyA_site      4148
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
     polyA_site      4164
                     /gene="Strn3"
                     /gene_synonym="Gs2na; SG2NA"
ORIGIN      
        1 gagtgagtga gacgggcaga tggaggaggt accgtaatgg cggcggccgg cagctccctg
       61 ctctgatccg cggcaagcac acggcaacga ccccctcccc ggccgtctcc cggccggccc
      121 cccgccctgc ggtcggcgcg gggccaccgt cccggccctc cccgcagctg tcggcgtctg
      181 gcactgcgcc ccggccgggg ccccacacac aatggacgag ctggccggag gcggcggcgg
      241 cggccagggg atggcagccc ctccccggcc gcagcaggga cccgggggga acctgagcct
      301 gccgccggga gcgaacggag cgccgggcgg cgggggtcct ccggccgccg aggcggcggg
      361 gcccccggca ggcccggagc tgtcccggcc gcaacagtac acgatcccgg ggatcctaca
      421 ctacatccag cacgagtggg ctcgcttcga gatggagcgg gcgcactggg aggtggagcg
      481 ggccgagctg caggcacgga ttgcattttt acaaggagaa aggaaaggtc aagagaattt
      541 gaagaaggat ttagtgagaa gaataaagat gttagagtat gcattaaaac aagaaagggc
      601 aaagtatcac aaattaaaat atggcacaga actgaaccaa ggtgatttga aaatgcccac
      661 ctttgaatca gaggaaacca aagatgtgga ggctcctcca gcacctcaga atagtcaact
      721 aacatggaag caaggcagac agctattaag acagtatctt caggaagtag gatacacaga
      781 tacaatatta gatgtacgat ctcaacgggt aaggtcatta cttggactgt ctaattcaga
      841 gccaaatgga tctgtagaag caaagaattt agaacagatc ttgaatggtg gtgaatctcc
      901 taagcaaaaa ggacaagaaa tcaaaaggcc ccctggtgat gttctcgaga cattcaattt
      961 cttagaaaat gctgatgaca gtgatgaaga agaaaatgac atgattgagg gcatcccaga
     1021 aggaaaagac aaacttcgga tccataagca caaaataggt aatgaaggtt tagctgctga
     1081 cttaactgat gatccagata ctgaggaagc actgaaagaa ttcgactttt tagtgactgc
     1141 agaagatggt gaaggggctg gtgaagcacg gagttcaggg gatggtacag aatgggataa
     1201 agatgacctc tccccaactg ctgaggtttg ggatgtagac caggggctaa taagtaaact
     1261 gaaggaacag tacaagaagg agcgaaaggg gaagaaaggg gtgaagaggg tcaacaggac
     1321 aaacctctgc gacatgataa ctgatctggg agatgatgag ctgccccaca tcccttcagg
     1381 aatcattaat cagtctaggt cagcttctac tagaatggct gatcatgaag gtgcaagagc
     1441 agaggaagct gaaccaataa cgtttccatc tggaggaggc aagtcattta ttatgggttc
     1501 tgatgatgtt ttgttaagtg tactgggcct tggagacctt gcagacttga cggtaacaaa
     1561 tgatgcagac tatagttatg atttgcctgc caataaagat gcctttcgaa agacttggaa
     1621 ccccaaatac acactacgta gtcattttga tggtgtgaga gcattagctt ttcatcctgt
     1681 agagcctgtg ctcgttactg cctctgagga ccacaccctg aaactttgga acctgcaaaa
     1741 gacagttcct gccaaaaaga gtgcctcttt agatgtagaa cctatctaca catttagggc
     1801 ccacattggc cctgtcctgt cattagctat tagttctaat ggagaacagt gttttagtgg
     1861 tggcattgat gcaaccattc agtggtggaa tatgcctagt cctaatgtgg atccctatga
     1921 tacatatgag tcaaacgttc tagctggcac tttagttgct catacagatg cagtctgggg
     1981 tcttgcctat agtggcataa aaaaccaatt actctcttgc tcagcagatg gcactattag
     2041 gttatggaac ccacaagaaa agctgccatg tgtttgcact tacaatggag acaaggaaca
     2101 tggaatacct acatcagttg attttatagg ctgtgatcca gcccatatgg ttacgtcttt
     2161 caacactggt agtgcggtaa tttatgattt agaaacatca cagtcattag tgatgctttc
     2221 ctcacaggta gattctggtt tacaatctag taatcacatt aacagagtag taagtcaccc
     2281 tacacttcct gttacaataa ctgctcatga agacagacac atcaagtttt ttgacaataa
     2341 aacgggtaaa atgatccatt ctatggtagc tcatttggat gctgttacaa gtttagcagt
     2401 agatcccaat ggaatctatt tgatgtctgg aagccatgac tgttccatta gactatggaa
     2461 tttggacagt aagacatgtg tacaagaaat aacagctcat aggaagaaat tggatgagtc
     2521 aatttatgat gttgctttcc atccatcaaa ggcatatatc gccagtgcag gagctgatgc
     2581 tcttgccaaa gtatttgtgt gaaccaacat agactcgcat cttagaaaaa aaagatttac
     2641 ttggtcagaa agggggtctg catcactgcc atcatgaagg ttcctgacat gacactacat
     2701 gtgatctgcc tggtgattgg ggcaggcaga aattgggaat cacatcctaa tgtcaggttt
     2761 attagtttaa gtgtaattaa ctgtattttg tgggacagaa agaaaaagga ctccagtatc
     2821 tgtgccctat actggatatg aactgagcgg tttttgtttt tgttttttaa ggtgtttaag
     2881 ccaatgtgga gtctgctctt agggggaagg actttttgtt ggactctgtg tgctgcctta
     2941 gggttaggaa tgtggtgctc tggtggggaa gcaagctcca agagtagctt tgttcatctc
     3001 ttagtgatct tatgttcatc agtgaatgcc acagattccc ttttaaagtt attttgcttt
     3061 aaaaaaaaaa aaagaaaaaa gaaaaaagaa agaaaagaaa atttaactta aaatatttta
     3121 gcattagttg cacaaaatgt ttggataaaa ttctagtttt tataagtctt tttatatatt
     3181 tagcctgtca caacagtgct caagatcata ttgatgtttt ttctgcatta tacaacccta
     3241 aaacacagag atctcactaa cctgccacct ataaccactt tctttcctcc ttttacctaa
     3301 tacagctcag ctaagtcctt cataaagatg ataaaccaat cacctttgtc tacatgtctt
     3361 catgaaccaa ggactattaa gtgtattaaa acaaagctgt ggagtttagt actccaaagg
     3421 aactctttaa aaactaatct tgacatccta tcactatgtg atattttgta catcttactg
     3481 tatttacaag tttatttatc aaggattatc catcttgcta atagcctatt atttatttta
     3541 ctttttgttg gtctttatat ccttttatta atgtgctaaa ggaacctgta tatctatttt
     3601 ggaactcttt gaaaagtcta aaatagacta aaaatggaat attttatagt taagttacaa
     3661 accaagatgt ttctccccaa gattcttgat ttaccatgat tccaaaacaa atgaactagt
     3721 tagaaaattg gagaatattt tattaccatt acaaataaga tattaaaaaa aagttgaatc
     3781 aggacacaga agtctgctgg atttggactc acagtctccc tgttttactt tttagatgtg
     3841 cttactttta tggtgtaact gaagattttc tttgtgtaat gcatgattaa gacaataaag
     3901 tattttttct agtcttccaa aagccttttc tgatcagttt gcgagttttg atgagttttg
     3961 taaggttttt gttttacaga ctatgaatca gcagattttt aagattgtac cccagagcaa
     4021 acatagagct gttgaaaaat aatgtatata aaatacatat aataaatatt aaattgtgta
     4081 cctgtatgtt gctcttggcc acattatttc gtgttgaata ataaagtgca atactctcca
     4141 caattaaact aggaaatgaa ggtg
//
