LOCUS       NM_001369306             287 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus small transmembrane regulator of ion transport 1
            (Strit1), transcript variant 2, mRNA.
ACCESSION   NM_001369306
VERSION     NM_001369306.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Stege,N.M., Oliveira Nunes Teixeira,V., Zijlstra,S.N.,
            Feringa,A.M., de Boer,R.A. and Sillje,H.H.W.
  TITLE     Deletion of DWORF does not affect cardiac function in aging and in
            PLN-R14del cardiomyopathy
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (3), H870-H876 (2024)
   PUBMED   38334971
  REMARK    GeneRIF: Deletion of DWORF does not affect cardiac function in
            aging and in PLN-R14del cardiomyopathy.
REFERENCE   2  (bases 1 to 287)
  AUTHORS   Makarewich,C.A., Munir,A.Z., Schiattarella,G.G., Bezprozvannaya,S.,
            Raguimova,O.N., Cho,E.E., Vidal,A.H., Robia,S.L., Bassel-Duby,R.
            and Olson,E.N.
  TITLE     The DWORF micropeptide enhances contractility and prevents heart
            failure in a mouse model of dilated cardiomyopathy
  JOURNAL   Elife 7, e38319 (2018)
   PUBMED   30299255
  REMARK    GeneRIF: Here the show that DWORF has a higher apparent binding
            affinity for SERCA than PLN and that DWORF overexpression mitigates
            the contractile dysfunction associated with PLN overexpression,
            substantiating its role as a potent activator of SERCA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 287)
  AUTHORS   Nelson,B.R., Makarewich,C.A., Anderson,D.M., Winders,B.R.,
            Troupes,C.D., Wu,F., Reese,A.L., McAnally,J.R., Chen,X.,
            Kavalali,E.T., Cannon,S.C., Houser,S.R., Bassel-Duby,R. and
            Olson,E.N.
  TITLE     A peptide encoded by a transcript annotated as long noncoding RNA
            enhances SERCA activity in muscle
  JOURNAL   Science 351 (6270), 271-275 (2016)
   PUBMED   26816378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121840.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.101451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC121840.3         21182-21273
            93-188              AC121840.3         23707-23802
            189-287             AC121840.3         23895-23993
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3"
     gene            1..287
                     /gene="Strit1"
                     /gene_synonym="DWORF; Gm34302"
                     /note="small transmembrane regulator of ion transport 1"
                     /db_xref="GeneID:102637511"
                     /db_xref="MGI:MGI:5593461"
     exon            1..92
                     /gene="Strit1"
                     /gene_synonym="DWORF; Gm34302"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..184
                     /gene="Strit1"
                     /gene_synonym="DWORF; Gm34302"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Sarcoplasmic/endoplasmic reticulum calcium ATPase
                     regulator DWORF; SERCA regulator DWORF"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase regulator DWORF isoform 2"
                     /protein_id="NP_001356235.1"
                     /db_xref="CCDS:CCDS89629.1"
                     /db_xref="GeneID:102637511"
                     /db_xref="MGI:MGI:5593461"
                     /translation="MAEKESTSPHLIVPILLLVGWIVGCIIVIYIVFF"
     exon            93..188
                     /gene="Strit1"
                     /gene_synonym="DWORF; Gm34302"
                     /inference="alignment:Splign:2.1.0"
     exon            189..287
                     /gene="Strit1"
                     /gene_synonym="DWORF; Gm34302"
                     /inference="alignment:Splign:2.1.0"
     regulatory      249..254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strit1"
                     /gene_synonym="DWORF; Gm34302"
                     /note="hexamer: ATTAAA"
     polyA_site      270
                     /gene="Strit1"
                     /gene_synonym="DWORF; Gm34302"
                     /note="major polyA site"
ORIGIN      
        1 ttaaagttca aagaggtgca ggataacaat aaggaagaaa gactcctggc cctgactaag
       61 ccacccaaca atagaaataa tggctgagaa agagtcaaca tcaccacacc tcatagttcc
      121 cattcttctc ctggttggat ggattgtagg ctgcatcatc gttatttaca ttgtcttctt
      181 ctagaaaagg aagaagactt caatctgaca ccatttagaa gaataaaaat acaggaatat
      241 aactgattat taaaggtgtc ttgtattaaa tagctgtagt atttcct
//
