LOCUS       NM_177204               5370 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus striatin interacting protein 2 (Strip2), transcript
            variant 1, mRNA.
ACCESSION   NM_177204
VERSION     NM_177204.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5370)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5370)
  AUTHORS   Eden,M., Meder,B., Volkers,M., Poomvanicha,M., Domes,K.,
            Branchereau,M., Marck,P., Will,R., Bernt,A., Rangrez,A., Busch,M.,
            Hrabe de Angelis,M., Heymes,C., Rottbauer,W., Most,P., Hofmann,F.
            and Frey,N.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     Myoscape controls cardiac calcium cycling and contractility via
            regulation of L-type calcium channel surface expression
  JOURNAL   Nat Commun 7, 11317 (2016)
   PUBMED   27122098
  REMARK    GeneRIF: Myoscape/FAM40B/STRIP2 knockout (KO) mice display
            impairment of cardiac function progressing to advanced heart
            failure.
            Erratum:[Nat Commun. 2016 May 26;7:11835. doi:
            10.1038/ncomms11835.. PMID: 27225593]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5370)
  AUTHORS   Scheffer,D.I., Shen,J., Corey,D.P. and Chen,Z.Y.
  TITLE     Gene Expression by Mouse Inner Ear Hair Cells during Development
  JOURNAL   J Neurosci 35 (16), 6366-6380 (2015)
   PUBMED   25904789
REFERENCE   4  (bases 1 to 5370)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 5370)
  AUTHORS   Wagh,V., Doss,M.X., Sabour,D., Niemann,R., Meganathan,K.,
            Jagtap,S., Gaspar,J.A., Ardestani,M.A., Papadopoulos,S.,
            Gajewski,M., Winkler,J., Hescheler,J. and Sachinidis,A.
  TITLE     Fam40b is required for lineage commitment of murine embryonic stem
            cells
  JOURNAL   Cell Death Dis 5 (7), e1320 (2014)
   PUBMED   25010986
  REMARK    GeneRIF: Fam40b is essential for the lineage commitment of murine
            embryonic stem cells into differentiated somatic cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5370)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042073.1 and AC079216.4.
            
            On Dec 14, 2005 this sequence version replaced NM_177204.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.196783.1, AK042073.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2920              AK042073.1         2-2921
            2921-5370           AC079216.4         191771-194220
FEATURES             Location/Qualifiers
     source          1..5370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..5370
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /note="striatin interacting protein 2"
                     /db_xref="GeneID:320609"
                     /db_xref="MGI:MGI:2444363"
     exon            1..218
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2597
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM40B; family with sequence similarity 40, member
                     B; striatin-interacting proteins 2"
                     /codon_start=1
                     /product="striatin-interacting proteins 2 isoform a"
                     /protein_id="NP_796178.2"
                     /db_xref="CCDS:CCDS19967.1"
                     /db_xref="GeneID:320609"
                     /db_xref="MGI:MGI:2444363"
                     /translation="MDDPAAPGPAGSPANDNGNGNGNGNGNGNGGKGKPAVPKGRETF
                     RNQRRESEGSVDCPTLEFEYGDSDGHAAELSELYSYTENLEFTTNRKCFEEDFRTQVQ
                     DTKEWLELEEDAQKTYVMGLLDRLEVVSREKRLKVARAVLYLAQGTFGECDSEVDVLH
                     WSRYNCFLLYQMGTFSAFLELLHMEIDNSQASSSALRKPAVSIADSTELRVLLSVMYL
                     MVENIRLEREIDPCGWRTARETFRTELSFSTHNEEPFALLLFSMVTKFCSGLAPHFPI
                     KKVLLLLWKVVMFTLGGFEHLQALKIQKRAELGLPPLAEDSIQVVKSMRAASPPSYTL
                     DLGESQLAPPPSKLRGRRGSRRQLLTKQDSLDIYNERDLFKTEEPATEEEEESAADGE
                     RTLDGELDLLEQDPLVPPPPSQTPLSTDRVAFPKGLPWAPKVRQKDIEHFLEMSRNKF
                     IGFTLGQDTDTLVGLPRPIHESVKTLKQHKYISIADIQIKNEEELEKCPLSLGEEVVP
                     ETPSEILYQGMLYSLPQYMIALLKILLAAAPTSKAKTDSINILADVLPEEMPVTVLQS
                     MKLGIDVNRHKEIIVKSISALLLLLLKHFKLNHIYQFEYVSQHLVFANCIPLILKFFN
                     QNILSYITAKNSISVLDYPCCTIQDLPELTTESLEAGDNSQFCWRNLFSCINLLRLLN
                     KLTKWKHSRTMMLVVFKSAPILKRALKVKQAMLQLYVLKLLKIQTKYLGRQWRKSNMK
                     TMSAIYQKVRHRMNDDWAYGNDIDARPWDFQAEECTLRANIEAFNSRRYDKPQDSEFS
                     PVDNCLQSVLGQRLDLPEDFHYSYELWLEREVFSQPICWEELLQNH"
     exon            219..288
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            289..363
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            364..501
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            502..622
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            623..691
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            692..798
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            799..926
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1130
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1366
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1432
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1496
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1568
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1643
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1741
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1868
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1969
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2036
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2141
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2346
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..5370
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5348..5353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /note="hexamer: AAGAAA"
     polyA_site      5366
                     /gene="Strip2"
                     /gene_synonym="D330017J20Rik; Fam40b; Myoscape"
                     /note="major polyA site"
ORIGIN      
        1 agagatcttg gagctacggt agggagccgc tgaggcgaac cgctgaaggg aaccttccca
       61 gcatggacga ccccgcggca ccggggcccg ccggctctcc tgctaatgac aacggcaacg
      121 ggaacggcaa tgggaacggg aacggcaacg gcggcaaagg gaagccggcc gtgcccaagg
      181 gcagggaaac gttccgcaac cagcggcggg agtcggaggg ctctgtggac tgccctactc
      241 tggagtttga atatggagat tcagacgggc atgcagcaga attgtcagaa ttatatagct
      301 acacggagaa cctggaattt accactaaca ggaagtgctt tgaagaagat ttcaggactc
      361 aagtgcaaga cactaaggaa tggctggagt tggaagaaga tgcccagaag acctatgtga
      421 tgggacttct ggaccgactg gaggtggtca gtagggagaa acggcttaag gtggcccggg
      481 ctgttctcta tctagctcaa ggcactttcg gggaatgtga ttccgaggtc gatgtgctac
      541 actggtccag atacaattgc ttcctgctct accagatggg gaccttctcg gccttcctgg
      601 agctactcca catggaaatc gacaacagcc aggcctcgag tagtgccctt cggaaaccag
      661 ctgtctccat tgctgacagc actgagctca gggtactgct gagtgtcatg tacctaatgg
      721 tggaaaatat ccgcctggag cgagaaatag acccttgtgg gtggaggaca gcccgagaga
      781 ccttccgaac tgaactgagt ttctccacac ataatgaaga gccgtttgca ctcctgctgt
      841 tttccatggt taccaaattc tgcagtggcc tggcccccca ctttccaata aagaaggttc
      901 tgcttctgct ctggaaggtg gtcatgttta cccttggtgg atttgagcac cttcaggctc
      961 tcaaaataca gaagcgtgca gagttgggcc tgcctccact agctgaagac agtatccagg
     1021 ttgtaaagag catgcgtgct gcctccccgc cttcttacac tcttgatctg ggggagtctc
     1081 agctggctcc tccaccctcc aagctgcggg gacgccgtgg ttctcgaagg caactcctca
     1141 ccaagcaaga cagcctggac atctacaatg aaagggatct cttcaagact gaggaaccag
     1201 ccacagagga ggaagaagaa tctgcggctg atggagaacg aaccttggat ggagagttag
     1261 acctgctaga acaggatcct ctggtgccac ctccaccctc acagacacct ctctctactg
     1321 accgggtagc ctttcccaag ggcctgccct gggccccgaa ggttagacag aaggatattg
     1381 aacacttctt ggagatgagc agaaacaagt tcattggatt cactctgggg caggacacag
     1441 ataccttggt tggattacct cgacccatcc atgagagtgt gaagactcta aagcagcaca
     1501 agtatatctc cattgcagat atacagataa agaatgaaga ggagctggag aaatgtccct
     1561 tgtctttggg agaagaggtg gtaccagaaa caccgagtga aatcctctac cagggcatgc
     1621 tgtacagcct cccccagtac atgattgcac tgcttaagat tctgctggct gcagctccca
     1681 cctccaaggc taagacagac tctatcaata tcctggcaga tgtcctgcct gaagagatgc
     1741 ctgtaactgt tctccagagc atgaagctag gcattgacgt gaacagacac aaggaaatca
     1801 ttgtaaagag tatctctgcc ctgctccttc tacttctcaa acacttcaaa ctcaaccata
     1861 tctaccagtt tgaatatgta tcacaacatt tagtgtttgc caactgcatc cccttgatcc
     1921 tgaagttctt caatcaaaac atcctgtcct atatcactgc caaaaacagc atttcagtgc
     1981 tggattaccc gtgctgcacc atccaggatt tgccagagct tactaccgag agtctggaag
     2041 ccggagacaa tagccagttc tgctggagga acctcttttc ctgcatcaac ctcctgaggc
     2101 tgctcaataa gctgaccaaa tggaagcatt ccaggaccat gatgttagtg gtgtttaagt
     2161 cagctccaat cttaaagcga gctctcaaag tcaaacaggc catgctacaa ctttatgtcc
     2221 tgaagctact aaagatacag accaagtacc ttgggcgcca gtggagaaaa agcaacatga
     2281 agaccatgtc agccatttac cagaaagtgc gccaccgcat gaatgatgac tgggcttatg
     2341 ggaatgacat cgatgccaga ccatgggact tccaagcaga agaatgtacc ctgagggcca
     2401 acattgaggc ttttaacagc cgccgatatg ataagcctca ggactcagaa ttctcacctg
     2461 tggataactg cttgcagagc gtgctggggc agaggctaga tctgcctgaa gatttccatt
     2521 attcctatga gctctggctg gagagagagg tgttctcaca gcccatctgc tgggaggagc
     2581 tgctccagaa tcactgagct cttgtcagca acgcagcgga cggaggttgg ctccagtaat
     2641 gtgctttgcc tgtcctgccc actcagcctt catactgaac tctaggaatg tgtgtcaagg
     2701 gcagttccag cccagcatcc agcacagaca gacacccagc atagttcagg gctattctgg
     2761 ataccaatag actcaaaggt ggttgcaaga ctggggtcct gagtcaaagc aaatggatca
     2821 acttgcccta ggctcagcta ggtgcctagt tggccttcaa atctcccgat ggatcagacc
     2881 tggacagact cttggaaacc tgctttaatc ttgcctagaa ccctgctcac ttttgtcagc
     2941 cacaatagtg aaaggaagtt tgtcatggca tttgacccac gacattcatc tccagcaggg
     3001 ggatagggac aggccataaa ataagccttg tcttcttgcc cactcaaaat gcctgggacg
     3061 tatcatttag caaaaccaac tttagactgt atttcacact tcaaatgttg atgctcatct
     3121 cttcataaaa tcatcattgg ttctaagatg gtttgagagc actgcatctt tataaaggat
     3181 gactgtttcc aaaacactgc atgttccaga acagcatact gtgtagggtt ttttttttcc
     3241 ttaagagctc tgtgttcaat gtaaaaaatt atttcatgtg tattttctat agcacattga
     3301 atgcttcatc atttgaaaag aaccacaatt aatataatat ggccttctct aggaatagct
     3361 tagacttttt acaaagtact tcagtttttt cctatgaatg ccagctttat tactcatgta
     3421 ccatctacag acgtaaaacc caacagcccc ctgccccaag aaggaagttg aaaaaacatt
     3481 aacgaaaaga gcctatgcca gggagtccgg aatcctgtga catgccatct ctgcgtcggt
     3541 acccagaaga gagtggaaga ctcatgaagg cttccaaaga ttcggggagt ccagagtcat
     3601 tttgagagga ctctggggtt ctgcctggta gtccctcctg atgtacagtg gcgacagcac
     3661 agtttccaat tcttgcgggc cttagacaac cgcttgagct tcatctcacg ccttttcctg
     3721 aagaaccaaa tcctggtgtc tccttttgtc agtttgagtg cgtcagccta ggcttccaga
     3781 gtctcctctt tggtggcagt ctttctcaaa gtgctttctt agctcctgga actgctcata
     3841 ggtgaaccca gaggattcat ctcagcagga caaacttgga gttgtcgctg agaatcccgg
     3901 ttacttctgt cttggctgca gctcacttga gttctgtcct tcagtttgag gctctactat
     3961 aggattttcc actctttcat gtttttaaac agctgagtgc actgcagaaa attactgtct
     4021 aatataagcc cagatcttca cctgagtggc catgggagcc aggcagatcc ggctttgcag
     4081 ccctggctag gccagacctt actgtacagc caggctggcc ttgaacttgg agtgatcctc
     4141 cttcctctgt ctgctgagtg tcacaggcct gggccaccac ctccaacaag ttcattttaa
     4201 atgattatag gaggttttat ttactgaaat ttgtccatgt tagctgattt ttttaatgag
     4261 aagcaatagc accagtttaa ttttctctcc catggttatt gttttttacc ctttctctct
     4321 ctctctcttt tttttaactg ctagcagttt caatgtggtt tgtactggaa gtatcatata
     4381 tttcacggag gagtctttat tcctcctaca tagaaaaatc acatttttat cttctgcttt
     4441 tcaattttag tctttgaacc ttttcatttt aaaggtctcc tcactgccca ggcactaatg
     4501 aatcttttta tgatagcaca aggacacttt attcctagag agctggtcca gactggctca
     4561 tttactcttc cctttgtcaa gcacagtctc attttaggtc actatagaga ccaacattat
     4621 ccaagggagc tatcagtacc tctgtgcttc gggtagcagg gtttcctact gtggaaaatg
     4681 gcagagaatg tgaagtacgt aacagatgaa gtatcttaaa ataatttgca aattgtatca
     4741 aagcatgaca gcaatcctca tttcaaacag cttactgaat gtagcatcag gcaactttat
     4801 tcatctaggg tcaggctact atgattttaa tttctgagta aaagataatt ttccaggaaa
     4861 cagagttatt accaatctac tttaaagtta tattcaattc tgtaaagaaa aaattagttg
     4921 ccttttaaaa aaaacacata aatgctttct gaggcacaga agtatactaa gctttaatat
     4981 gttgtatttt attatttata actcttgaga atattaattc tcaatgcaga tggaaaaact
     5041 attacacctt gcaagaaaaa gaatgattaa cttaaatcac attttcccca caacttgctg
     5101 tggctaactt tctggtatcc acagcgagcc ctatgtctaa gataactggg ttagatctcc
     5161 cagtttgaga gatagcatat gtggttagga atagcttcag attaaccagc atttaatggt
     5221 gattacagtt tccacataga agcatgccat ttgtatgatt tataatataa ggactttctt
     5281 tgtgaatatt tccatgaagt ttatgttgat tgataatatt gttcatctca ctgaacactt
     5341 taataaaaag aaaaacctgg acttaagaaa
//
