LOCUS       NM_080459               5757 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus stereocilin (Strc), mRNA.
ACCESSION   NM_080459
VERSION     NM_080459.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5757)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5757)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5757)
  AUTHORS   Shubina-Oleinik,O., Nist-Lund,C., French,C., Rockowitz,S.,
            Shearer,A.E. and Holt,J.R.
  TITLE     Dual-vector gene therapy restores cochlear amplification and
            auditory sensitivity in a mouse model of DFNB16 hearing loss
  JOURNAL   Sci Adv 7 (51), eabi7629 (2021)
   PUBMED   34910522
REFERENCE   4  (bases 1 to 5757)
  AUTHORS   Avan,P., Le Gal,S., Michel,V., Dupont,T., Hardelin,J.P., Petit,C.
            and Verpy,E.
  TITLE     Otogelin, otogelin-like, and stereocilin form links connecting
            outer hair cell stereocilia to each other and the tectorial
            membrane
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 25948-25957 (2019)
   PUBMED   31776257
  REMARK    GeneRIF: Otogelin, otogelin-like, and stereocilin form links
            connecting outer hair cell stereocilia to each other and the
            tectorial membrane.
REFERENCE   5  (bases 1 to 5757)
  AUTHORS   Dunbar,L.A., Patni,P., Aguilar,C., Mburu,P., Corns,L., Wells,H.R.,
            Delmaghani,S., Parker,A., Johnson,S., Williams,D., Esapa,C.T.,
            Simon,M.M., Chessum,L., Newton,S., Dorning,J., Jeyarajan,P.,
            Morse,S., Lelli,A., Codner,G.F., Peineau,T., Gopal,S.R.,
            Alagramam,K.N., Hertzano,R., Dulon,D., Wells,S., Williams,F.M.,
            Petit,C., Dawson,S.J., Brown,S.D., Marcotti,W., El-Amraoui,A. and
            Bowl,M.R.
  TITLE     Clarin-2 is essential for hearing by maintaining stereocilia
            integrity and function
  JOURNAL   EMBO Mol Med 11 (9), e10288 (2019)
   PUBMED   31448880
REFERENCE   6  (bases 1 to 5757)
  AUTHORS   Kamiya,K., Michel,V., Giraudet,F., Riederer,B., Foucher,I.,
            Papal,S., Perfettini,I., Le Gal,S., Verpy,E., Xia,W., Seidler,U.,
            Georgescu,M.M., Avan,P., El-Amraoui,A. and Petit,C.
  TITLE     An unusually powerful mode of low-frequency sound interference due
            to defective hair bundles of the auditory outer hair cells
  JOURNAL   Proc Natl Acad Sci U S A 111 (25), 9307-9312 (2014)
   PUBMED   24920589
REFERENCE   7  (bases 1 to 5757)
  AUTHORS   Verpy,E., Leibovici,M., Michalski,N., Goodyear,R.J., Houdon,C.,
            Weil,D., Richardson,G.P. and Petit,C.
  TITLE     Stereocilin connects outer hair cell stereocilia to one another and
            to the tectorial membrane
  JOURNAL   J Comp Neurol 519 (2), 194-210 (2011)
   PUBMED   21165971
REFERENCE   8  (bases 1 to 5757)
  AUTHORS   Deans,M.R., Peterson,J.M. and Wong,G.W.
  TITLE     Mammalian Otolin: a multimeric glycoprotein specific to the inner
            ear that interacts with otoconial matrix protein Otoconin-90 and
            Cerebellin-1
  JOURNAL   PLoS One 5 (9), e12765 (2010)
   PUBMED   20856818
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5757)
  AUTHORS   Verpy,E., Weil,D., Leibovici,M., Goodyear,R.J., Hamard,G.,
            Houdon,C., Lefevre,G.M., Hardelin,J.P., Richardson,G.P., Avan,P.
            and Petit,C.
  TITLE     Stereocilin-deficient mice reveal the origin of cochlear waveform
            distortions
  JOURNAL   Nature 456 (7219), 255-258 (2008)
   PUBMED   18849963
  REMARK    GeneRIF: Stereocilin was detected in association with horizontal
            top connectors, lateral links that join adjacent stereocilia within
            the outer hair cell's hair bundle
REFERENCE   10 (bases 1 to 5757)
  AUTHORS   Verpy,E., Masmoudi,S., Zwaenepoel,I., Leibovici,M., Hutchin,T.P.,
            Del Castillo,I., Nouaille,S., Blanchard,S., Laine,S., Popot,J.L.,
            Moreno,F., Mueller,R.F. and Petit,C.
  TITLE     Mutations in a new gene encoding a protein of the hair bundle cause
            non-syndromic deafness at the DFNB16 locus
  JOURNAL   Nat Genet 29 (3), 345-349 (2001)
   PUBMED   11687802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845466.4.
            
            On Dec 28, 2006 this sequence version replaced NM_080459.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF375593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL845466.4         87456-87591         c
            137-922             AL845466.4         85648-86433         c
            923-947             AL845466.4         85537-85561         c
            948-2325            AL845466.4         83293-84670         c
            2326-2388           AL845466.4         82370-82432         c
            2389-2499           AL845466.4         82160-82270         c
            2500-2666           AL845466.4         81850-82016         c
            2667-2853           AL845466.4         81524-81710         c
            2854-2969           AL845466.4         81309-81424         c
            2970-3102           AL845466.4         80930-81062         c
            3103-3285           AL845466.4         80201-80383         c
            3286-3324           AL845466.4         79912-79950         c
            3325-3492           AL845466.4         79570-79737         c
            3493-3558           AL845466.4         79312-79377         c
            3559-3678           AL845466.4         78734-78853         c
            3679-3737           AL845466.4         78378-78436         c
            3738-3861           AL845466.4         77590-77713         c
            3862-3974           AL845466.4         77368-77480         c
            3975-4110           AL845466.4         75576-75711         c
            4111-4307           AL845466.4         74987-75183         c
            4308-4398           AL845466.4         74740-74830         c
            4399-4555           AL845466.4         74249-74405         c
            4556-4725           AL845466.4         73249-73418         c
            4726-4881           AL845466.4         72394-72549         c
            4882-5024           AL845466.4         71672-71814         c
            5025-5173           AL845466.4         71357-71505         c
            5174-5271           AL845466.4         71163-71260         c
            5272-5419           AL845466.4         70924-71071         c
            5420-5757           AL845466.4         70378-70715         c
FEATURES             Location/Qualifiers
     source          1..5757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..5757
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /note="stereocilin"
                     /db_xref="GeneID:140476"
                     /db_xref="MGI:MGI:2153816"
     exon            1..136
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..5508
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /codon_start=1
                     /product="stereocilin precursor"
                     /protein_id="NP_536707.2"
                     /db_xref="CCDS:CCDS16641.1"
                     /db_xref="GeneID:140476"
                     /db_xref="MGI:MGI:2153816"
                     /translation="MALSLQPQLLLLLSLLPQEVTSAPTGPQSLDAGLSLLKSFVATL
                     DQAPQRSLSQSRFSAFLANISSSFQLGRMGEGPVGEPPPLQPPALRLHDFLVTLRGSP
                     DWEPMLGLLGDVLALLGQEQTPRDFLVHQAGVLGGLVEALLGALVPGGPPAPTRPPCT
                     RDGPSDCVLAADWLPSLMLLLEGTRWQALVQLQPSVDPTNATGLDGREPAPHFLQGLL
                     GLLTPAGELGSEEALWGGLLRTVGAPLYAAFQEGLLRVTHSLQDEVFSIMGQPEPDAS
                     GQCQGGNLQQLLLWGMRNNLSWDARALGFLSGSPPPPPALLHCLSRGVPLPRASQPAA
                     HISPRQRRAISVEALCENHSGPEPPYSISNFSIYLLCQHIKPATPRPPPTTPRPPPTT
                     PQPPPTTTQPIPDTTQPPPVTPRPPPTTPQPPPSTAVICQTAVWYAVSWAPGARGWLQ
                     ACHDQFPDQFLDMICGNLSFSALSGPSRPLVKQLCAGLLPPPTSCPPGLIPVPLTPEI
                     FWGCFLENETLWAERLCVEDSLQAVPPRNQAWVQHVCRGPTLDATDFPPCRVGPCGER
                     CPDGGSFLLMVCANDTLYEALVPFWAWLAGQCRISRGGNDTCFLEGMLGPLLPSLPPL
                     GPSPLCLAPGPFLLGMLSQLPRCQSSVPALAHPTRLHYLLRLLTFLLGPGTGGAETQG
                     MLGQALLLSSLPDNCSFWDAFRPEGRRSVLRTVGEYLQREEPTPPGLDSSLSLGSGMS
                     KMELLSCFSPVLWDLLQREKSVWALRTLVKAYLRMPPEDLQQLVLSAEMEAAQGFLTL
                     MLRSWAKLKVQPSEEQAMGRLTALLLQRYPRLTSQLFIDMSPLIPFLAVPDLMRFPPS
                     LLANDSVLAAIRDHSSGMKPEQKEALAKRLLAPELFGEVPDWPQELLWAALPLLPHLP
                     LESFLQLSPHQIQALEDSWPVADLGPGHARHVLRSLVNQSMEDGEEQVLRLGSLACFL
                     SPEELQSLVPLSDPMGPVEQGLLECAANGTLSPEGRVAYELLGVLRSSGGTVLSPREL
                     RVWAPLFPQLGLRFLQELSETQLRAMLPALQGASVTPAQAVLLFGRLLPKHDLSLEEL
                     CSLHPLLPGLSPQTLQAIPKRVLVGACSCLGPELSRLSACQIAALLQTFRVKDGVKNM
                     GAAGAGSAVCIPGQPTTWPDCLLPLLPLKLLQLDAAALLANRRLYRQLPWSEQQAQFL
                     WKKMQVPTNLSLRNLQALGNLAGGMTCEFLQQISSMVDFLDVVHMLYQLPTGVRESLR
                     ACIWTELQRRMTMPEPELTTLGPELSELDTKLLLDLPIQLMDRLSNDSIMLVVEMVQG
                     APEQLLALTPLHQTALAERALKNLAPKETPISKEVLETLGPLVGFLGIESTRRIPLPI
                     LLSHLSQLQGFCLGETFATELGWLLLQEPVLGKPELWSQDEIEQAGRLVFTLSAEAIS
                     SIPREALGPETLERLLGKHQSWEQSRVGHLCGESQLAHKKAALVAGIVHPAAEGLQEP
                     VPNCADIRGTFPAAWSATQISEMELSDFEDCLSLFAGDPGLGPEELRAAMGKAKQLWG
                     PPRGFRPEQILQLGRLLIGLGERELQELTLVDWGVLSSLGQIDGWSSMQLRAVVSSFL
                     RQSGRHVSHLDFIYLTALGYTVCGLRPEELQHISSWEFSQAALFLGSLHLPCSEEQLE
                     VLAYLLVLPGGFGPVSNWGPEIFTEIGTIAAGIPDLALSALLRGQIQGLTPLAISVIP
                     APKFAVVFNPIQLSSLTRGQAVAVTPEQLAYLSPEQRRAVAWAQHEGKEIPEQLGRNS
                     AWGLYDWFQASWALALPVSIFGHLL"
     exon            137..922
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            923..947
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            948..2325
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2388
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2499
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2666
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2853
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2969
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3102
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3285
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3324
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3492
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3558
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3678
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3737
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3861
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3974
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4110
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4307
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4398
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4555
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..4725
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4726..4881
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5024
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..5173
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            5174..5271
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            5272..5419
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
     exon            5420..5757
                     /gene="Strc"
                     /gene_synonym="DFNB16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccgtctt cacctggcta tcccttcatg gtgagcatag ccagaactca cctctaggcc
       61 cagtgtgcac ctggaaatat ggctctgagc ctccagcccc agctgctcct tctcctgtcg
      121 ctcctgccgc aggaagtgac ttcagcccct actgggcctc agtctttgga tgctggtctc
      181 tcccttctga agtcattcgt agccactctg gaccaagctc ctcagcgttc cctcagccag
      241 tcacggttct ctgcgttcct ggccaacatt tcttcatcct tccagcttgg gaggatgggg
      301 gagggaccgg tgggagagcc cccacctctc cagccccctg cacttcgact tcatgatttc
      361 ctcgtgacac tgagaggtag cccagactgg gagccaatgc tagggcttct gggagatgtg
      421 ctggcactcc tgggacagga acagactccc cgggactttt tggtgcacca ggcaggtgta
      481 ctgggtggac ttgtagaggc attgttggga gcgttagttc ctggaggccc ccctgccccc
      541 actcgacccc catgcacccg tgatggccct tctgactgtg tcctggctgc tgattggttg
      601 ccttctctga tgttgttatt agagggtaca cgctggcagg ccctggtgca gttgcagccc
      661 agtgtggacc caaccaatgc cacaggtctt gatggtagag agccagctcc tcacttttta
      721 cagggtctgc tgggcttgct taccccagca ggagagttgg gctctgagga ggctctttgg
      781 ggtggtctgc tgcgcacagt gggggccccc ctctatgctg ccttccagga ggggctactg
      841 cgagtcactc attctctgca agatgaggtc ttttctatta tgggacagcc agagcctgat
      901 gccagtgggc agtgccaggg aggcaacctt caacagctgc ttttatgggg catgcggaac
      961 aacctttctt gggacgcccg agcactgggt tttctatctg gatcaccacc tccaccccct
     1021 gctctcctgc actgcctgag cagaggtgtg cctctgccca gggcttccca gcctgcggct
     1081 cacatcagcc ctcgacagcg gcgagccatc tctgtggagg ccctctgcga gaaccactca
     1141 ggcccagagc caccctacag catctccaac ttctccatct acttgctctg ccagcacatc
     1201 aagcctgcca ccccgcggcc ccctcctacc accccacggc ctcctcctac caccccacag
     1261 ccccctccta ccactacaca gcccattcct gacactacac agccccctcc tgtcacccca
     1321 aggcctcctc ctaccacccc acaaccccct cctagcacag ctgtcatctg ccagacagct
     1381 gtatggtacg cagtctcgtg ggcaccaggt gcccgaggtt ggctccaagc ctgccatgat
     1441 cagtttcctg atcaatttct ggatatgatc tgcggcaacc tctcattttc agccctgtct
     1501 ggccccagtc gtcctttggt aaagcagctc tgtgctggct tgctcccacc ccccactagc
     1561 tgtccaccag gcctgatccc tgtgcccctc accccagaaa tattctgggg ctgtttcctg
     1621 gagaatgaga cactgtgggc tgaacggttg tgtgtggagg acagtctgca ggctgtgccc
     1681 ccgaggaacc aggcttgggt tcagcatgtg tgtcggggcc ccaccttgga cgccactgat
     1741 tttccaccgt gccgcgttgg accctgtggg gaacgctgcc cagatggggg cagcttcctg
     1801 ctcatggtct gtgccaatga cactctgtat gaagccttgg ttcccttctg ggcttggcta
     1861 gcaggccaat gcagaattag tcgtggagga aatgatactt gctttctaga aggcatgctg
     1921 ggccccttgt tgccctctct gccccctctg ggaccatccc cactctgtct ggctcctggt
     1981 ccttttctgc ttggcatgtt atcccagttg ccacgctgtc agtcctccgt gccagccctc
     2041 gcccacccca cgcgcctaca ttacctcctg cgcctactga ccttccttct gggtccaggg
     2101 actgggggtg ccgagacgca ggggatgtta ggtcaagccc tgctgctctc tagtctccca
     2161 gacaactgtt cattctggga tgccttccgc ccagagggcc ggagaagtgt actgaggaca
     2221 gtcggagagt acttgcagcg ggaagagcca accccaccag gcttagactc ctccctcagc
     2281 ctcggctctg gtatgagcaa gatggagctt ctgtcctgct tcagtcctgt actgtgggat
     2341 ctactccaga gagagaagag cgtttgggcc ctgaggaccc tggtgaaggc ctacctgcgc
     2401 atgcctccag aagaccttca gcagcttgtg ctttcagcag agatggaggc tgcacagggc
     2461 ttcctgacgc tcatgcttcg ttcctgggct aagctgaagg ttcaaccatc cgaggagcag
     2521 gccatgggcc gcctgacagc cttgctgctc cagcggtacc cacgcctcac ctcccaactc
     2581 tttatcgaca tgtcaccgct catccccttc ctggctgtcc ctgacctcat gcgcttccca
     2641 ccgtcccttt tggccaacga cagtgtcctg gctgccatca gggatcacag ctcaggaatg
     2701 aagcctgaac agaaggaggc cctggcaaaa cgactgctgg cccctgagct gtttggagaa
     2761 gtgcctgatt ggccccagga gctgctgtgg gcagccctgc ctctgcttcc ccatctgcct
     2821 ctggagagct ttctccagct cagccctcac cagatccagg ccctggagga tagctggcca
     2881 gtagcagatc ttgggccggg acacgcccga catgtgcttc gtagcctagt aaaccagagc
     2941 atggaggatg gggaggagca ggtgctcagg cttgggtccc tcgcctgttt cctgagtcct
     3001 gaggagctac agagtctggt gcccttgagt gatccaatgg ggcctgtaga acagggtctg
     3061 ctggaatgtg cggccaatgg gaccctcagc ccagaaggac gggtggcata tgaacttctg
     3121 ggagtgttgc gttcatctgg aggaactgtc ttaagccccc gagagctgag ggtctgggca
     3181 cctctctttc cccagctggg cctccgcttc ctgcaggagc tctcagagac ccagcttaga
     3241 gccatgcttc ctgccctaca gggagccagt gtcacacctg cccaggctgt tctgttgttt
     3301 ggaaggctcc ttcctaagca tgatctgtcc ctggaggaac tctgctccct gcaccctctc
     3361 ctgccaggtc tcagccccca gacactccag gccatcccta agagagttct ggttggtgct
     3421 tgttcctgcc tgggccctga actgtcaagg ctttcagctt gccagattgc agctctgctg
     3481 cagacctttc gggtaaaaga tggtgttaaa aatatgggtg cagcaggtgc cggctcagcc
     3541 gtgtgcattc ctgggcagcc caccacttgg ccagactgcc tgcttcccct gctcccatta
     3601 aagctgctac agctggacgc tgcagctctt ctggcaaacc gaagactcta tcggcagctg
     3661 ccttggtctg agcaacaggc acagtttctc tggaagaaaa tgcaagtgcc taccaacctg
     3721 agcctgagga atctgcaggc tctgggcaac ttggcaggag gcatgacctg cgagtttctg
     3781 cagcagatca gctcaatggt tgactttctt gatgtggtac acatgctcta ccagctgccc
     3841 actggtgttc gagagagcct gcgggcctgt atctggacag agctacagcg gaggatgaca
     3901 atgccagagc cagagctgac caccctaggg ccagaactga gtgaacttga cacaaagcta
     3961 ctcctggact tgccgatcca gctgatggac agattgtcca atgattccat tatgttggtg
     4021 gtggagatgg tccaaggcgc tccagagcag ctgctggcac tgaccccact ccaccagaca
     4081 gccttggcag agcgagcact taaaaacctg gctccaaagg agaccccaat ctccaaagaa
     4141 gtgctggaga cactgggccc cttggttgga ttcctgggaa tagagagcac gcgacggatc
     4201 cctttaccca ttctactgtc tcatctcagt cagctgcagg gcttctgcct aggagagaca
     4261 tttgccacag agctgggatg gctgctgttg caggagcctg ttcttggaaa accagaattg
     4321 tggagccagg atgaaataga gcaagctgga cgcctagtat tcactctgtc tgctgaggct
     4381 atttcctcga tccccaggga ggctttgggc ccagagacac tggagaggct tctgggaaag
     4441 catcaaagct gggagcagag cagagtgggc catctgtgtg gggagtcaca gcttgcccac
     4501 aagaaagcag ctctggtagc tgggattgtg catccagctg ctgagggtct ccaagagcct
     4561 gtaccaaact gtgcagacat acggggaacc ttcccagcgg cctggtctgc gacacaaatc
     4621 tcagagatgg aactctcaga ctttgaagac tgcctgtcac tatttgctgg agatccagga
     4681 cttggtcctg aggaactacg ggcagccatg ggcaaggcca agcagttgtg gggtccccct
     4741 cgaggattcc gtcctgagca gatcttgcag ctgggccgtc tcctgatagg tctaggagaa
     4801 cgggaactgc aggagcttac cttggtggac tggggtgtgc tgagcagcct ggggcaaata
     4861 gatggctgga gttccatgca gctccgagcc gtggtctcca gtttcctaag gcagagtggt
     4921 cggcatgtga gccacctgga cttcatttat ctgacagcac tgggttacac agtctgtgga
     4981 ttgcgaccag aggagttaca gcacatcagc agttgggagt ttagccaagc agctctcttc
     5041 ctgggtagct tgcatctccc gtgctctgag gaacagctgg aagttctggc ctatctcctt
     5101 gtgttgcctg gtggctttgg cccagtcagt aactgggggc ctgagatctt cactgaaatt
     5161 ggcacaatag cagctggcat cccagacctg gctctttcag cattactgcg gggacagatc
     5221 caaggcctga ctcctcttgc catttctgtc attcctgctc ccaagtttgc agtggtcttc
     5281 aaccccatcc agttatctag tctcaccagg ggtcaggccg tagctgttac tcctgaacag
     5341 ctggcctatc tgagtcctga gcagcggcga gcagttgcat gggcccaaca cgaagggaag
     5401 gagatcccag agcagctggg tcgaaactca gcctggggtc tctacgactg gttccaagcc
     5461 tcctgggccc tggcattgcc cgtcagcatt tttggccacc tattatgata actgttcctt
     5521 cagttgaggg agaaaattta catcatactg aacaacttgt aaatggaagt gcatactaat
     5581 tattctcagt aagtggatga ggattgtggg taaaattcca atgcattcca cccacctgag
     5641 aactgtgctc ctggcatata cgcctcttgc catcatgaat aacctcactg tttcttttca
     5701 tttcctactt cctcctcacc acaccaatag aaataacaca gacagctgca acataat
//
