LOCUS       NM_172656               2387 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus STE20-related kinase adaptor beta (Stradb), transcript
            variant 1, mRNA.
ACCESSION   NM_172656
VERSION     NM_172656.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2387)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2387)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2387)
  AUTHORS   Veleva-Rotse,B.O., Smart,J.L., Baas,A.F., Edmonds,B., Zhao,Z.M.,
            Brown,A., Klug,L.R., Hansen,K., Reilly,G., Gardner,A.P.,
            Subbiah,K., Gaucher,E.A., Clevers,H. and Barnes,A.P.
  TITLE     STRAD pseudokinases regulate axogenesis and LKB1 stability
  JOURNAL   Neural Dev 9, 5 (2014)
   PUBMED   24594058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2387)
  AUTHORS   Smith,C.D., Compton,R.A., Bowler,J.S., Kemp,J.T., Sudweeks,S.N.,
            Thomson,D.M. and Winder,W.W.
  TITLE     Characterization of the liver kinase B1-mouse protein-25
            -Ste-20-related adaptor protein complex in adult mouse skeletal
            muscle
  JOURNAL   J Appl Physiol (1985) 111 (6), 1622-1628 (2011)
   PUBMED   21903876
  REMARK    GeneRIF: Quantitative PCR revealed significantly reduced LKB1,
            MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings
            demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK
            in skeletal muscle.
REFERENCE   5  (bases 1 to 2387)
  AUTHORS   Ling,K.H., Hewitt,C.A., Beissbarth,T., Hyde,L., Banerjee,K.,
            Cheah,P.S., Cannon,P.Z., Hahn,C.N., Thomas,P.Q., Smyth,G.K.,
            Tan,S.S., Thomas,T. and Scott,H.S.
  TITLE     Molecular networks involved in mouse cerebral corticogenesis and
            spatio-temporal regulation of Sox4 and Sox11 novel antisense
            transcripts revealed by transcriptome profiling
  JOURNAL   Genome Biol 10 (10), R104 (2009)
   PUBMED   19799774
REFERENCE   6  (bases 1 to 2387)
  AUTHORS   Barnes,A.P., Lilley,B.N., Pan,Y.A., Plummer,L.J., Powell,A.W.,
            Raines,A.N., Sanes,J.R. and Polleux,F.
  TITLE     LKB1 and SAD kinases define a pathway required for the polarization
            of cortical neurons
  JOURNAL   Cell 129 (3), 549-563 (2007)
   PUBMED   17482548
REFERENCE   7  (bases 1 to 2387)
  AUTHORS   Nishigaki,K., Thompson,D., Yugawa,T., Rulli,K., Hanson,C.,
            Cmarik,J., Gutkind,J.S., Teramoto,H. and Ruscetti,S.
  TITLE     Identification and characterization of a novel Ste20/germinal
            center kinase-related kinase, polyploidy-associated protein kinase
  JOURNAL   J Biol Chem 278 (15), 13520-13530 (2003)
   PUBMED   12574163
REFERENCE   8  (bases 1 to 2387)
  AUTHORS   Welch,C.L., Xia,Y.R., Hong,H., Stallcup,M.R. and Lusis,A.J.
  TITLE     Localization of the mouse glucocorticoid receptor-interacting
            protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis
  JOURNAL   Mamm Genome 8 (8), 620-621 (1997)
   PUBMED   9250876
REFERENCE   9  (bases 1 to 2387)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 2387)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140272.1, AK080096.1 and AI643873.1.
            
            On Oct 27, 2017 this sequence version replaced NM_172656.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037003.1, AK046790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AK140272.1         2-87
            87-2362             AK080096.1         2-2277
            2363-2387           AI643873.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.2 cM"
     gene            1..2387
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /note="STE20-related kinase adaptor beta"
                     /db_xref="GeneID:227154"
                     /db_xref="MGI:MGI:2144047"
     exon            1..329
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            330..436
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1681
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /note="polyploidy associated protein kinase; STRAD beta;
                     pseudokinase ALS2CR2; ILP-interacting protein homolog;
                     amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 2 protein homolog"
                     /codon_start=1
                     /product="STE20-related kinase adapter protein beta"
                     /protein_id="NP_766244.4"
                     /db_xref="CCDS:CCDS14981.1"
                     /db_xref="GeneID:227154"
                     /db_xref="MGI:MGI:2144047"
                     /translation="MSLLDCFCASRTRVESLRPEKQSETSIHQYLVDESAISRPPPSA
                     RASEVICSTDVSHYELQVEIGRGFDNLTSVHLARHTPTGTLVTVKITNLESCTEERLK
                     ALQRAVILSHFFQHPNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPDGMSETL
                     IRNILFGAVQGLNYLHQNGCIHRSFKASHILISGDGLVTLSGLSHLHSLLKHGQRHRA
                     VFDFPQFSTSVQPWLSPELLRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQM
                     LLQKLKGPPYSPLDVSIFPQSDSRMRNSQSGVDSGIGESVLVSTGTHTVNSDRLHTPS
                     TKTFSPAFFSLVQLCLQQDPEKRPSASSLLSHVFFKQMKEESQDSILPLLPPAYNRPS
                     ASLQPVSPWSELEFQFPDDKDPVWEF"
     exon            437..517
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            518..617
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            618..739
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            740..848
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            849..972
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1144
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1249
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1494
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1537
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..2367
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /note="hexamer: AATAAA"
     polyA_site      2367
                     /gene="Stradb"
                     /gene_synonym="Als2cr2; B830008M19; D1Ucla2; ILPIP;
                     ILPIPA; Papk; PRO1038; Syradb"
                     /note="major polyA site"
ORIGIN      
        1 gtttgctttc cgtcccgcct acagctcgag ggccccgcct cctcactcca gagctagaag
       61 ctggaggcgc ggtggggcgg agcggcgggc cccgaccccg ctggggtggg gcgaatcccg
      121 tcccggccgg ttgccccggg ctagggcaga agtccaggcc gaccggcctt ctccaggccg
      181 tgctgcactt ctgtgccttg aggctcaccc tggaagccgg cctagtgttt tcgcctcgcc
      241 ccttcgcgag gcaggtcccg gggctcgcgc gtgtcgcctc ccctcagcgc ccgctgtctg
      301 gagagtcgct ggccttggtc accgcctagt gggctatatc tgcaacttga agggaagata
      361 aaagaaacat cttctttgga atagatggga atttttttca ctttctgtga actaaagcga
      421 ttcaatgtct cttttggatt gtttctgtgc ttcacgaaca cgagtcgaat cactcagacc
      481 cgaaaaacag tctgaaacca gtatccatca gtacttggtt gatgagtcag ccatttcccg
      541 gccccctccg tctgctagag ccagtgaggt gatctgctcc actgacgtgt ctcactatga
      601 actgcaagtg gagataggaa gagggtttga caacttgacc tctgttcatc ttgcacggca
      661 cactcctaca ggaacactgg taactgtaaa gattacaaac ctggaaagct gcactgaaga
      721 acgtctgaaa gctttacaga gagcagtgat tctatctcac tttttccaac atcccaatat
      781 tacaacttat tggacagtgt tcactgttgg cagctggctt tgggttattt ctccatttat
      841 ggcctacggt tcagcaagtc agctcctaag gacctacttt cctgatggaa tgagtgagac
      901 tttaataaga aacattctct ttggagcagt acaagggttg aactatctgc accaaaatgg
      961 ctgtatccat aggagtttta aagccagcca tatcctcatt tctggtgatg gcctggtgac
     1021 cctctctggc ctgtcccacc tgcatagttt gcttaagcac ggacaaaggc atagggctgt
     1081 gtttgatttc ccacagttca gcacatcagt gcagccgtgg ctgagtccag aactactgag
     1141 acaggattta catggatata atgtgaagtc agatatttac agtgttggga tcacagcctg
     1201 tgaattggcc agcgggcagg tacctttcca ggacatgcat aggactcaga tgctattaca
     1261 gaaactgaaa ggtcctccgt atagcccact ggatgtcagt atttttcctc agtcagactc
     1321 tagaatgaga aattcccagt caggagtaga ctctgggatt ggagagagtg tgcttgtctc
     1381 cactggaact cacacagtca atagtgaccg gctccatacg ccatccacaa agacgttctc
     1441 tcctgccttt tttagcttgg tgcagctgtg tttgcagcaa gatcctgaga aaaggccatc
     1501 agcaagcagt ttgttgtccc atgtattctt caagcagatg aaagaagaaa gccaggattc
     1561 catacttccc ctgttgccac ctgcttataa caggccatca gcgtcactgc agccagtgtc
     1621 gccgtggagc gagctggaat tccagtttcc tgatgacaaa gacccagtgt gggaattcta
     1681 gggttgccaa atcatttcat gtcctctata cttgacagcc tctccttgct gcttgtcttc
     1741 ggtcctgtta ggtacaaatg acaaatctat acttgaaaat acagttggtg cactggagaa
     1801 tcgatcagtt aaaccactct gttcatgggg cgtggattta ccctctctgc ccagatcaga
     1861 gcacccgcac gacttcctcg tcagttactg cccagctcag ctagtgtccg ctcgcccgcc
     1921 cttccgcaca tcccccgctt cttttccacc ttttaagctg tgactggtac tttctggatc
     1981 tcagtgtaac ttttgagcta gttaattctc ttctacattt tactgttctc tggggaatga
     2041 acccttcctc ggaggacact gcttccagag catcttctct tccagattca ctagcctttt
     2101 tgatcagcta ttggtagatg aacaggctgg tttattctgg tataaagccc ttttttggag
     2161 aagggaaaat gtttgtacta ttccttttac atatggcaac atcaaactga gccttgctca
     2221 cattaaataa ttcacttgaa ctataaagag aagatgcaat ttgcatttta aaggggaagg
     2281 ggctaacaac acttttctac ctgtgtaaat tatagatcat taattcatgc accctgtggg
     2341 agctcaataa aaatgtataa aattaaaaaa aaaaaaaaaa aaaaaaa
//
