LOCUS       NM_001162476            3095 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus stimulated by retinoic acid gene 6 (Stra6), transcript
            variant 1, mRNA.
ACCESSION   NM_001162476
VERSION     NM_001162476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Yang,Y., Zhang,S., Su,S., Yang,X., Chen,J. and Sang,A.
  TITLE     The Effects of STRA6 Regulation of the Circadian Rhythm on
            Choroidal Neovascularization
  JOURNAL   Invest Ophthalmol Vis Sci 65 (11), 21 (2024)
   PUBMED   39269368
  REMARK    GeneRIF: The Effects of STRA6 Regulation of the Circadian Rhythm on
            Choroidal Neovascularization.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Ramkumar,S., Jastrzebska,B., Montenegro,D., Sparrow,J.R. and von
            Lintig,J.
  TITLE     Unraveling the mystery of ocular retinoid turnover: Insights from
            albino mice and the role of STRA6
  JOURNAL   J Biol Chem 300 (3), 105781 (2024)
   PUBMED   38395306
  REMARK    GeneRIF: Unraveling the mystery of ocular retinoid turnover:
            Insights from albino mice and the role of STRA6.
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   He,W., Cheng,Z., Huo,Z., Lin,B., Wang,X., Sun,Y., Yu,S., Cao,S.,
            Xue,J., Liu,R., Lv,W., Li,Y., Hong,S. and Xiao,H.
  TITLE     STRA6 Promotes Thyroid Carcinoma Progression via Activation of the
            ILK/AKT/mTOR Axis in Cells and Female Nude Mice
  JOURNAL   Endocrinology 164 (3) (2023)
   PUBMED   36592123
  REMARK    GeneRIF: STRA6 Promotes Thyroid Carcinoma Progression via
            Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Marsh,B. and Blelloch,R.
  TITLE     Single nuclei RNA-seq of mouse placental labyrinth development
  JOURNAL   Elife 9, e60266 (2020)
   PUBMED   33141023
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Sapin,V., Bouillet,P., Oulad-Abdelghani,M., Dastugue,B., Chambon,P.
            and Dolle,P.
  TITLE     Differential expression of retinoic acid-inducible (Stra) genes
            during mouse placentation
  JOURNAL   Mech Dev 92 (2), 295-299 (2000)
   PUBMED   10727869
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Sapin,V., Dolle,P., Hindelang,C., Kastner,P. and Chambon,P.
  TITLE     Defects of the chorioallantoic placenta in mouse RXRalpha null
            fetuses
  JOURNAL   Dev Biol 191 (1), 29-41 (1997)
   PUBMED   9356169
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Bouillet,P., Sapin,V., Chazaud,C., Messaddeq,N., Decimo,D.,
            Dolle,P. and Chambon,P.
  TITLE     Developmental expression pattern of Stra6, a retinoic
            acid-responsive gene encoding a new type of membrane protein
  JOURNAL   Mech Dev 63 (2), 173-186 (1997)
   PUBMED   9203140
REFERENCE   9  (bases 1 to 3095)
  AUTHORS   Chazaud,C., Bouillet,P., Oulad-Abdelghani,M. and Dolle,P.
  TITLE     Restricted expression of a novel retinoic acid responsive gene
            during limb bud dorsoventral patterning and endochondral
            ossification
  JOURNAL   Dev Genet 19 (1), 66-73 (1996)
   PUBMED   8792610
REFERENCE   10 (bases 1 to 3095)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158996.2, CF536552.1, BC075657.1 and CO043377.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.137491.1,
                                           SRR7652917.197350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC158996.2         23672-23894         c
            224-747             CF536552.1         1-524
            748-868             CF536552.1         526-646
            869-3036            BC075657.1         558-2725
            3037-3095           CO043377.1         1-59                c
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.63 cM"
     gene            1..3095
                     /gene="Stra6"
                     /note="stimulated by retinoic acid gene 6"
                     /db_xref="GeneID:20897"
                     /db_xref="MGI:MGI:107742"
     exon            1..374
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            375..503
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..2403
                     /gene="Stra6"
                     /note="stimulated by retinoic acid gene 6 protein;
                     retinoic acid-responsive protein; retinol-binding protein
                     receptor STRA6"
                     /codon_start=1
                     /product="receptor for retinol uptake STRA6"
                     /protein_id="NP_001155948.1"
                     /db_xref="CCDS:CCDS23236.1"
                     /db_xref="GeneID:20897"
                     /db_xref="MGI:MGI:107742"
                     /translation="MESQASENGSQTSSGVTDDYSSWYIEEPLGAEEVQPEGVIPLCQ
                     LTAPPALLHACLASLSFLVLLLLALLVRRRRLWPRCGHRGLGLPSPVDFLAGDLSWTV
                     PAAVFVVLFSNLCLLLPDENPLPFLNLTAASSPDGEMETSRGPWKLLALLYYPALYYP
                     LAACASAGHQAAFLLGTVLSWAHFGVQVWQKAECPQDPKIYKHYSLLASLPLLLGLGF
                     LSLWYPVQLVQSLRHPTGAGSQGLQTSYSEKYLRTLLCPKKLDSCSHPASKRSLLSRA
                     WAFSHHSIYTPQPGFRLPLKLVISATLTGTATYQVALLLLVSVVPTVQKVRAGINTDV
                     SYLLAGFGIVLSEDRQEVVELVKHHLWTVEACYISALVLSCASTFLLLIRSLRTHRAN
                     LQALHRGAALDLDPPLQSIHPSRQAIVSWMSFCAYQTAFSCLGLLVQQVIFFLGTTSL
                     AFLVFVPLLHGRNLLLLRSLESTWPFWLTVALAVILQNIAANWIFLRTHHGYPELTNR
                     RMLCVATFLLFPINMLVGAIMAVWRVLISSLYNTVHLGQMDLSLLPQRAASLDPGYHT
                     YQNFLRIEASQSHPGVIAFCALLLHAPSPQPRPPLAPQDSLRPAEEEEGMQLLQTKDL
                     MAKGAGHKGSQSRARWGLAYTLLHNPSLQAFRKAALTSAKANGTQP"
     exon            504..570
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            571..656
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            657..796
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            797..820
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            821..987
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1110
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1178
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1258
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1320
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1483
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1559
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1693
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1811
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1913
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2077
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2233
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..3078
                     /gene="Stra6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3016..3021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stra6"
                     /note="hexamer: AATAAA"
     polyA_site      3036
                     /gene="Stra6"
                     /note="major polyA site"
     polyA_site      3078
                     /gene="Stra6"
                     /note="major polyA site"
ORIGIN      
        1 gcggcaggca ggcgaagttc atcttctccc aggtctggtt tgagtttgaa ggactcattt
       61 ccgcctgtgg gggtgagtta tcttcttgtg aaatcaagtc gtaagaacaa aaaggtttta
      121 ctagtgtaac acgtgtgctc tccctcatat atactcagga gaccatgtgg ataggttccc
      181 tccctgtctc tgtagccagc cccagtaggg tgttgcccta agatgccacg atgctgggtt
      241 ctgaagaggg gctatgctta ggcaggagag cttggggcag gtgctaggag gtaggcatgt
      301 gcacggtcag cagccatcca tcttcggggt ctcatcaaga attatggtgt gttcccagca
      361 gtgaggctga agaggaagaa gagctggagc atggagtccc aggcatctga gaatggaagc
      421 cagacctcct ccggggtgac agatgactac agcagctggt acatcgagga acctctagga
      481 gctgaggagg tgcagccaga gggggtgatt cccctttgcc agctcaccgc accccctgcc
      541 ctgctccatg cctgcctggc ttcactgtcg ttcctggttc tgctgctgct ggccttgctg
      601 gtgagacggc gcaggctttg gccacgctgt ggtcatcgcg gacttggact gcccagccct
      661 gtggatttct tggctgggga cctatcctgg acagtgcctg ctgctgtctt tgtggtcctc
      721 ttcagcaacc tatgcctgtt gctccctgat gagaacccac tgcctttcct gaacctcact
      781 gcagcatcaa gtccagatgg agagatggag acatcaagag ggccctggaa gctactggct
      841 ctgctctact atccagccct ctattaccct ctggctgctt gtgcttcggc agggcaccaa
      901 gctgcattcc tattgggtac tgtgttatct tgggcccact ttggtgttca ggtctggcag
      961 aaagctgagt gtcctcagga tcctaagatc tacaagcact actccttgct ggcctccctg
     1021 cctctacttc tgggtcttgg attcctgagc ctttggtatc cagtacaact tgtgcagagt
     1081 ctccgtcacc cgacaggagc aggctcccag gggctgcaga ccagctactc cgagaagtat
     1141 ctgagaactc ttctctgccc aaagaagttg gatagctgct cccatcctgc ctccaagcgt
     1201 agcctcctgt ctcgggcctg ggccttctcc catcattcca tctacactcc acagccagga
     1261 ttccgcctgc ccttgaagct ggtgatctcg gccaccctga caggaacagc cacttaccag
     1321 gtggccctgc tgctgctggt gagcgtggtg cctactgtgc agaaggtgag ggcggggatc
     1381 aacacagatg tctcctacct gctggctggc tttgggatcg tgctctctga agacaggcag
     1441 gaggtggtag agctggtgaa gcatcaccta tggactgtgg aagcatgcta catctcagct
     1501 ctggtcttgt cctgcgcatc aaccttcctg ctcctgatcc gatccctgag gacacacagg
     1561 gccaatcttc aagcactaca ccgaggggct gccctggatc tggacccccc tcttcagagt
     1621 attcatccct ctcgccaagc catagtcagc tggatgagct tctgtgccta ccagacggcc
     1681 ttcagctgcc ttgggctcct ggtgcagcag gtcatcttct tcttggggac cacatccctg
     1741 gccttcctgg tgtttgtgcc tttactgcat ggcaggaacc tcctgctgct gcgatccctg
     1801 gaatccacgt ggcccttctg gctgactgtg gccttagctg taatcctgca gaacatagca
     1861 gccaactgga tcttcctgag gactcaccat ggatacccag agctgaccaa ccggcgcatg
     1921 ctctgcgtag ctacttttct cctcttcccc atcaacatgc tggtgggagc cataatggct
     1981 gtctggcggg tgctcatctc ttctctctac aacactgttc acctcggcca gatggacctc
     2041 agcctgctgc cgcagagggc agcctccctg gatccaggct accacacata ccaaaacttc
     2101 ctgaggattg aggccagcca gtcacatcca ggagtcatag ccttctgtgc cctgctcctc
     2161 catgctccaa gtccacagcc ccggccccca ttggcccctc aggacagcct caggccggca
     2221 gaagaagaag aagggatgca gttgctacag accaaggacc tgatggccaa gggagcagga
     2281 cacaaaggca gccagagcag ggcccgctgg ggtctggcct acacattgct ccacaatcca
     2341 agcctacagg ccttccggaa ggcagccctt actagtgcca aggccaatgg cacccagccc
     2401 tgagggtgaa gaaaaccaca tcaccctgcc tttatgtgct gaggcacatt cctgtctccc
     2461 atcctccctc ccattcatgt ctgcaacccc ctcgccccag cagcagctct gccagccagc
     2521 tgatccctgt gggatcaggg gactggagtc actgtgtcta caccaccagc ttctagagga
     2581 atttggtcta tgcttgtcca ccaggctacc agctagggct ctagagaaag cagctagtgg
     2641 tttctttgtc ttggaacagg cagggtaagg gtgggcacat ttaggcctct tctcctcaca
     2701 ctggccctgc catcagcttt tggggcctca gcaaggcctc tctttctccc cgttggtgat
     2761 gaaaggcctg aatatctccc atcccagctg gccccacctc agccccagcc ctcccaccat
     2821 gaaagtggaa cctgtgtggg cttcctctct gccccagatc tctccttcct ctctcttcct
     2881 tccactcccg ccccttctct tgcagccaag tcagactcca agaggcccca ctgagctgcc
     2941 ctctccaaaa accagatttt tttttgtagt tttaatgcca ttagttgtca tgaaagaagt
     3001 tagtgtgctc tctgtaataa atgtgcctct gaggaacatt cctccttcct agaggagggc
     3061 tctaagagga accatctaaa aaaaaaaaaa aaaaa
//
