LOCUS       NM_001033260            3490 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus storkhead box 1 (Stox1), transcript variant 1, mRNA.
ACCESSION   NM_001033260 XM_125685 XM_905594
VERSION     NM_001033260.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3490)
  AUTHORS   Parchem,J.G., Kanasaki,K., Lee,S.B., Kanasaki,M., Yang,J.L., Xu,Y.,
            Earl,K.M., Keuls,R.A., Gattone,V.H. 2nd and Kalluri,R.
  TITLE     STOX1 deficiency is associated with renin-mediated gestational
            hypertension and placental defects
  JOURNAL   JCI Insight 6 (2), 141588 (2021)
   PUBMED   33301424
  REMARK    GeneRIF: STOX1 deficiency is associated with renin-mediated
            gestational hypertension and placental defects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3490)
  AUTHORS   Miralles,F., Collinot,H., Boumerdassi,Y., Ducat,A., Duche,A.,
            Renault,G., Marchiol,C., Lagoutte,I., Bertholle,C., Andrieu,M.,
            Jacques,S., Mehats,C. and Vaiman,D.
  TITLE     Long-term cardiovascular disorders in the STOX1 mouse model of
            preeclampsia
  JOURNAL   Sci Rep 9 (1), 11918 (2019)
   PUBMED   31417152
  REMARK    GeneRIF: Long-term cardiovascular disorders in the STOX1 mouse
            model of preeclampsia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3490)
  AUTHORS   Erlandsson,L., Ducat,A., Castille,J., Zia,I., Kalapotharakos,G.,
            Hedstrom,E., Vilotte,J.L., Vaiman,D. and Hansson,S.R.
  TITLE     Alpha-1 microglobulin as a potential therapeutic candidate for
            treatment of hypertension and oxidative stress in the STOX1
            preeclampsia mouse model
  JOURNAL   Sci Rep 9 (1), 8561 (2019)
   PUBMED   31189914
  REMARK    GeneRIF: Alpha-1 microglobulin as a potential therapeutic candidate
            for treatment of hypertension and oxidative stress in the STOX1
            preeclampsia mouse model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3490)
  AUTHORS   Collinot,H., Marchiol,C., Lagoutte,I., Lager,F., Siauve,N.,
            Autret,G., Balvay,D., Renault,G., Salomon,L.J. and Vaiman,D.
  TITLE     Preeclampsia induced by STOX1 overexpression in mice induces
            intrauterine growth restriction, abnormal ultrasonography and BOLD
            MRI signatures
  JOURNAL   J Hypertens 36 (6), 1399-1406 (2018)
   PUBMED   29465714
  REMARK    GeneRIF: Studied association of overexpression of storkhead box 1
            (STOX1) protein, preeclampsia, intrauterine growth restriction and
            fetal imaging pathology in mice.
REFERENCE   5  (bases 1 to 3490)
  AUTHORS   Zhang,C., Ji,Z., Wang,M., Zhang,W., Yang,R., An,H., Yang,R., van
            Abel,D., van Dijk,M., Yang,X., Ou,G., Zhu,H.H. and Gao,W.Q.
  TITLE     Stox1 as a novel transcriptional suppressor of Math1 during
            cerebellar granule neurogenesis and medulloblastoma formation
  JOURNAL   Cell Death Differ 23 (12), 2042-2053 (2016)
   PUBMED   27564589
  REMARK    GeneRIF: This study illustrates a SHH-Stox1-Math1 regulatory axis
            in normal cerebellar development and medulloblastoma formation.
REFERENCE   6  (bases 1 to 3490)
  AUTHORS   Nie,X., Zhang,K., Wang,L., Ou,G., Zhu,H. and Gao,W.Q.
  TITLE     Transcription factor STOX1 regulates proliferation of inner ear
            epithelial cells via the AKT pathway
  JOURNAL   Cell Prolif 48 (2), 209-220 (2015)
   PUBMED   25677106
  REMARK    GeneRIF: STOX1 is a novel stimulatory factor for inner ear
            epithelial cell proliferation and might be an important target to
            be considered in regeneration or repair of inner ear epithelium.
REFERENCE   7  (bases 1 to 3490)
  AUTHORS   Lui,J.H., Nowakowski,T.J., Pollen,A.A., Javaherian,A.,
            Kriegstein,A.R. and Oldham,M.C.
  TITLE     Radial glia require PDGFD-PDGFRbeta signalling in human but not
            mouse neocortex
  JOURNAL   Nature 515 (7526), 264-268 (2014)
   PUBMED   25391964
REFERENCE   8  (bases 1 to 3490)
  AUTHORS   Doridot,L., Chatre,L., Ducat,A., Vilotte,J.L., Lombes,A.,
            Mehats,C., Barbaux,S., Calicchio,R., Ricchetti,M. and Vaiman,D.
  TITLE     Nitroso-redox balance and mitochondrial homeostasis are regulated
            by STOX1, a pre-eclampsia-associated gene
  JOURNAL   Antioxid Redox Signal 21 (6), 819-834 (2014)
   PUBMED   24738702
  REMARK    GeneRIF: Our data posit STOX1 as a genetic switch in the ROS/RNS
            balance and suggest an explanation for elevated blood pressure in
            pre-eclampsia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137978.1, AK133671.1 and AI842662.1.
            
            On Jun 29, 2018 this sequence version replaced NM_001033260.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028920.1, BC137978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3097              BC137978.1         6-3102
            3098-3457           AK133671.1         1691-2050
            3458-3490           AI842662.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..3490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.45 cM"
     gene            1..3490
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="storkhead box 1"
                     /db_xref="GeneID:216021"
                     /db_xref="MGI:MGI:2684909"
     exon            1..327
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2999
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="isoform 1 is encoded by transcript variant 1;
                     storkhead-box protein 1"
                     /codon_start=1
                     /product="storkhead-box protein 1 isoform 1"
                     /protein_id="NP_001028432.1"
                     /db_xref="CCDS:CCDS48580.1"
                     /db_xref="GeneID:216021"
                     /db_xref="MGI:MGI:2684909"
                     /translation="MARPVQLAPGSLALVLSPREAGQAAGEPGGRALFRAFRRANARC
                     FWNARLARAASRLAFLGWLRRGVLLVRAPQPCVQVLRDAWRRRALRPPRGFRITAVGD
                     VFPVQMSPIAQCRFVPLAEVLCCAIADMNAAQVMVTQQSLLEHLIKHYPGIAVPSPDI
                     LYSTLGALIQERKIYHTGEGYFIVTPSTYFITNTPMQGNKSALLSNEGCSGPTSGTYL
                     VSVDCCAEPTQENEALFSHCPSCQCYPDTSMCDSKDLLTAAEVTRKSQEGLEETTALT
                     ENQVVSASEDTHICVNPKPLPYTKDKGKRFGFGFLWRSLSRKEKPKAEYHSFSAQFPP
                     EEWPVRDEDSSTKIPRDVEHALIKRINPVLTVDNLTKHTALMQKYEEQKKYNSQGTSM
                     DILTTRHKDSSKEVIGKRQGQFAKSRRRGSSHKGRHKARSQGSELEPGNPGQEKEKQP
                     KVPAAQPAPRTKSPSEQVHHLQGRNPAVLGSHLIYKKQINNPFQGMHLRKHSVSKGHA
                     VQKTHGLKPTCVGPEEKPFWSAGSSDPSGVFDGEAQPPYPEQCRDKLEAGSTQVAKAP
                     VHPVSDDFRGGPGNYPPRRVLPGPSRCCSFRESMLRPGVYHEENKDLPEVLRKSWSTC
                     DMFLGTKEKKQALPAQRCSLDPDSSSVHAEDKTVDKILHQFQNLGLLDCPAGANRLRT
                     HERQDGNSEELSRKALQIPEAEIVNMENEGLSDSEQDQVALSHSDPGAGDDGGCSSLC
                     LEDDDFSETDDFCPSLPGHTQHSFAGGGTWNHLGTPAMTGKSLTDCNSKAHRLELLAI
                     ERNPWYKATGLFSNAGESPNPDLSDNPGQNSRIPWGFNYEGEPTVAHVQTPAAAAGRS
                     LLACSTVRTTSFPVEILQESPGDRGKSPIVWRQSLPSQEMKEHFTDKLQLVKTSHGPV
                     SAQEPQGEHLEGTENYSMTGDSGIDSPRTQSLVSTNSAILDGFKRRQHFLPNREGVQK
                     SQNLASNSLFQLTPAINV"
     exon            328..480
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /inference="alignment:Splign:2.1.0"
     exon            481..2851
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3476
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3133..3138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="hexamer: ATTAAA"
     polyA_site      3156
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="major polyA site"
     regulatory      3309..3314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="hexamer: AATAAA"
     polyA_site      3337
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="major polyA site"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="hexamer: AATAAA"
     regulatory      3443..3448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="hexamer: AATAAA"
     polyA_site      3460
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
                     /note="major polyA site"
     polyA_site      3469
                     /gene="Stox1"
                     /gene_synonym="4732470K04Rik; Gm63"
ORIGIN      
        1 gatctcgagt cccgcgagcg ggcggcatgg cgcggcccgt gcagctggca ccgggttcgc
       61 tggcgttggt gctgagcccg cgggaggccg ggcaggcggc gggggagccg ggcggtcgcg
      121 cgctcttccg cgccttccgc cgcgccaacg cgcgctgctt ctggaacgca cggctggcgc
      181 gcgccgcctc gcggctggcc tttctcggct ggctgcggcg cggggtgctg ctggtgcgcg
      241 cgccccagcc ctgtgtgcag gtgctgcggg atgcgtggcg tcgccgagcc ctgcggccgc
      301 cccgaggctt ccgcatcacc gcggtgggtg atgtcttccc agtgcaaatg agtcccatag
      361 cccagtgccg gtttgtgccc ttggctgaag ttctctgctg tgctatagct gatatgaacg
      421 cggctcaggt gatggtaaca caacagtccc tcttggagca cttgatcaaa cattacccag
      481 gtattgctgt tccctcccca gacattctct acagcacact gggagctcta attcaagaga
      541 ggaagattta ccacactgga gaaggctact tcatagttac cccaagcaca tacttcatca
      601 caaatacgcc aatgcaggga aataaaagtg ctctcctgtc aaacgaaggg tgctcagggc
      661 ccacttctgg aacctatctg gtaagtgtgg attgctgtgc agagccgacc caggagaatg
      721 aggctctctt ttcccactgt ccttcatgtc agtgctaccc tgatacaagc atgtgcgact
      781 ctaaggacct cctgactgct gcagaagtga ctagaaaaag ccaggaaggt cttgaggaga
      841 ccacagcttt gaccgagaat caggtagttt cagcctctga agatacccac atctgtgtga
      901 accccaaacc attaccatac accaaagaca aaggcaaaag atttggtttt ggtttcttgt
      961 ggcgcagctt atctagaaaa gagaagccca aagccgagta ccacagtttc tcagcacagt
     1021 tcccacccga agagtggcct gtccgagatg aggacagttc caccaaaatc ccccgagatg
     1081 tggaacatgc gctaatcaaa agaattaacc ctgtactgac tgttgacaac ttaaccaagc
     1141 acactgccct aatgcaaaaa tatgaagaac agaaaaaata taacagccag ggcacgtcaa
     1201 tggatatact gacaaccagg cataaagatt cctctaaaga ggtaattggg aaaaggcagg
     1261 gccaattcgc caagtcccgc aggcggggca gttctcataa gggtagacac aaagcacgga
     1321 gccaggggag tgagcttgag ccaggaaatc ctggacagga aaaggaaaag cagcccaagg
     1381 tccctgcagc ccagcccgcg ccccgcacga aaagccccag tgagcaagtt catcacttgc
     1441 aaggcaggaa tccagctgtg ctaggctccc acttgatata taaaaagcag atcaataatc
     1501 cgttccaggg catgcatctc cgaaagcact cagtatccaa agggcacgcc gttcagaaga
     1561 cccatggtct gaaacctact tgcgtcgggc cagaggaaaa gcctttctgg agcgcaggct
     1621 cttcagatcc ttccggagtc tttgatggtg aagcccaacc gccgtatccg gaacaatgcc
     1681 gtgataaact agaagcagga agcacgcagg tggcgaaggc tcctgtccac ccagtcagcg
     1741 acgatttcag aggtggccca ggaaattatc ctccacgtag agttttgcca ggcccctctc
     1801 ggtgctgttc ctttagggaa agtatgctgc gacctggtgt gtatcacgag gaaaacaagg
     1861 acctccctga ggtcttgcgg aaaagttggt ccacctgtga catgttcttg gggaccaagg
     1921 aaaagaagca ggccctgccc gcacaacgtt gctctttgga tccagactcc tcctctgtgc
     1981 acgcagagga taagacagtg gataagatac tccaccagtt ccaaaacctc ggcctcttag
     2041 attgcccagc tggtgcaaat cgtttgagga ctcatgaaag acaagatggc aactcagaag
     2101 aactaagtag aaaggcatta caaatccctg aggcggagat tgtgaatatg gagaacgaag
     2161 ggctttctga cagtgagcag gaccaggtgg ctttgagtca cagtgaccct ggggctgggg
     2221 atgacggggg ctgcagttct ctgtgtttag aggacgatga cttctctgag acagatgatt
     2281 tctgtccctc gttgccggga cacactcagc actcctttgc aggtggaggc acgtggaatc
     2341 atttgggaac accagccatg acagggaagt ctctgaccga ctgtaatagc aaagcccata
     2401 ggcttgagct tctggccatt gaaaggaatc cttggtacaa ggccacgggg ttgttttcaa
     2461 acgcagggga aagcccaaac cctgatctct ctgacaaccc tggtcaaaat tcaaggatcc
     2521 catggggttt caactacgaa ggcgagccca ctgttgccca tgtccagacc ccagcagctg
     2581 ctgctggcag aagtttactt gcgtgttcta ctgtaaggac aaccagtttc ccagttgaga
     2641 tcctgcaaga gtctcctggt gataggggaa agagtccaat tgtctggaga cagagccttc
     2701 caagtcagga aatgaaagag catttcacag acaagttaca acttgtcaag acctcacatg
     2761 ggccagtgtc agcccaggag ccacagggag aacaccttga agggacagag aattacagca
     2821 tgacgggaga cagtgggatc gattccccca ggacgcagag cctggtatct actaattccg
     2881 ccattttgga tggatttaaa agaagacagc attttctgcc aaaccgtgaa ggtgttcaga
     2941 agagccaaaa ccttgcatcg aattccttgt ttcaactaac cccagctata aatgtctaac
     3001 ttaatttttt tttaaatttt ttttgatatg tggtcttaca ctgtagttca ggctggcccg
     3061 tgactcaaca gcaatcccct gcctttgcct ctggagtgct aggattacag gccataaagc
     3121 caccatggca ggattaaaat tttaactgac tttggagaac tcttgtagaa actggataag
     3181 tgaaagtcct tggaagctgt acatatatgc tattattaac ctcgtcatat tgtattctaa
     3241 ttactcttcc ccccttttac gattttaaag caatttctag tgccttttac tagaaacttg
     3301 tagtttccaa taaaaaccat gagggctgga gagatgactc agtggttaag agcactgcct
     3361 gcacttccaa aggtcctgag ttcaattccc agcaacctga taccctcttc tgggcagata
     3421 gaacactcat atacataaaa taaataaatc ttaaaacaca cacaagaaac atgaaaaaaa
     3481 aaaaaaaaaa
//
