LOCUS       NM_175367               9923 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus stonin 2 (Ston2), transcript variant 1, mRNA.
ACCESSION   NM_175367
VERSION     NM_175367.7
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9923)
  AUTHORS   Ma,Y., Gao,K., Sun,X., Wang,J., Yang,Y., Wu,J., Chai,A., Yao,L.,
            Liu,N., Yu,H., Su,Y., Lu,T., Wang,L., Yue,W., Zhang,X., Xu,L.,
            Zhang,D. and Li,J.
  TITLE     STON2 variations are involved in synaptic dysfunction and
            schizophrenia-like behaviors by regulating Syt1 trafficking
  JOURNAL   Sci Bull (Beijing) 69 (10), 1458-1471 (2024)
   PUBMED   38402028
  REMARK    GeneRIF: STON2 variations are involved in synaptic dysfunction and
            schizophrenia-like behaviors by regulating Syt1 trafficking.
REFERENCE   2  (bases 1 to 9923)
  AUTHORS   Bolz,S., Kaempf,N., Puchkov,D., Krauss,M., Russo,G., Soykan,T.,
            Schmied,C., Lehmann,M., Muller,R., Schultz,C., Perrais,D.,
            Maritzen,T. and Haucke,V.
  TITLE     Synaptotagmin 1-triggered lipid signaling facilitates coupling of
            exo- and endocytosis
  JOURNAL   Neuron 111 (23), 3765-3774 (2023)
   PUBMED   37738980
  REMARK    Erratum:[Neuron. 2023 Dec 6;111(23):3900. doi:
            10.1016/j.neuron.2023.11.003.. PMID: 38061332]
REFERENCE   3  (bases 1 to 9923)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   4  (bases 1 to 9923)
  AUTHORS   Kaempf,N., Kochlamazashvili,G., Puchkov,D., Maritzen,T.,
            Bajjalieh,S.M., Kononenko,N.L. and Haucke,V.
  TITLE     Overlapping functions of stonin 2 and SV2 in sorting of the calcium
            sensor synaptotagmin 1 to synaptic vesicles
  JOURNAL   Proc Natl Acad Sci U S A 112 (23), 7297-7302 (2015)
   PUBMED   26015569
REFERENCE   5  (bases 1 to 9923)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   6  (bases 1 to 9923)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   7  (bases 1 to 9923)
  AUTHORS   Kononenko,N.L., Diril,M.K., Puchkov,D., Kintscher,M., Koo,S.J.,
            Pfuhl,G., Winter,Y., Wienisch,M., Klingauf,J., Breustedt,J.,
            Schmitz,D., Maritzen,T. and Haucke,V.
  TITLE     Compromised fidelity of endocytic synaptic vesicle protein sorting
            in the absence of stonin 2
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E526-E535 (2013)
   PUBMED   23345427
  REMARK    GeneRIF: Loss of Stn2 leads to selective missorting of
            synaptotagmin 1 to the neuronal surface, an elevated synaptic
            vesicle (SV) pool size, and accelerated SV protein endocytosis.
REFERENCE   8  (bases 1 to 9923)
  AUTHORS   Walther,K., Diril,M.K., Jung,N. and Haucke,V.
  TITLE     Functional dissection of the interactions of stonin 2 with the
            adaptor complex AP-2 and synaptotagmin
  JOURNAL   Proc Natl Acad Sci U S A 101 (4), 964-969 (2004)
   PUBMED   14726597
REFERENCE   9  (bases 1 to 9923)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154375.2 and AC154709.2.
            
            On Apr 1, 2022 this sequence version replaced NM_175367.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036612.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AC154375.2         131096-131432       c
            338-610             AC154375.2         88575-88847         c
            611-886             AC154375.2         85440-85715         c
            887-1084            AC154375.2         58896-59093         c
            1085-2923           AC154709.2         34477-36315
            2924-3126           AC154709.2         41624-41826
            3127-9923           AC154709.2         43742-50538
FEATURES             Location/Qualifiers
     source          1..9923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 45.02 cM"
     gene            1..9923
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /note="stonin 2"
                     /db_xref="GeneID:108800"
                     /db_xref="MGI:MGI:1918272"
     exon            1..337
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /inference="alignment:Splign:2.1.0"
     exon            338..610
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /inference="alignment:Splign:2.1.0"
     CDS             523..3210
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stoned B"
                     /codon_start=1
                     /product="stonin-2 isoform 1"
                     /protein_id="NP_780576.1"
                     /db_xref="CCDS:CCDS26090.1"
                     /db_xref="GeneID:108800"
                     /db_xref="MGI:MGI:1918272"
                     /translation="MTTLDHVIATHQSEWVSFSEEPLFPTPLEGGTEEHFPGLSSSSE
                     RSESSSGENHVVDEGSQDLSHSEQDDSSEKMGLISEAASPPGSPVQPTPDLASAISNW
                     VQFEDDTPWSSTSPPHKETALTLTMPCWTCPSFDSLRRCPLTSESSWTTHSEDTSSPS
                     VAPSYTDLQLINTEEQASGRASGTDSTDNSSSLQEDEEVEMEAISWWAGSPAMNGHPA
                     APPVTTARFPSWVTFEDNEVGCPSPPVPSPKKPNTPSAATAAPDVPFNSTGSFKRDRP
                     KSTLMNLPKVQKLDISSLNRPPSVIEAPPWRATNPFLNETLQDVQPSPINPFSAFFEE
                     QERRSQNSSVSSTTGKSQRDSLIVVYQDAISFDDSGKSQPHPDAIEKLKQLQIDDPDP
                     VGNTALPDDDPTASVELDAPSPASALSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKL
                     TASGYLQLYYEQGLEKPFREFKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKK
                     YQPKPAVAHAAEREQVIKLGTTNYDDFRSFIHAVQDRLMDLPVLSMDLSTVGLNYLEE
                     EITVDVRDEFSGTVGKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILIKGNEIVS
                     RQDIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKT
                     LPFTLRTAASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFR
                     RDSVLGEKSLKAKVNRGASFGSAGASGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDK
                     NSASGHPHCFFCHLELGSDREVPSRFANYVNVEFSMPTTSASKAAVRSVSVEDKPDVR
                     KWVNYSAHYSYKVEIEQKKSLKPDFEGEDLENPKECGVQ"
     exon            611..886
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1084
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..2923
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3126
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..9923
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3624..3629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /note="hexamer: TATAAA"
     polyA_site      3648
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /note="major polyA site"
     regulatory      9794..9799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /note="hexamer: AATAAA"
     polyA_site      9815
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /note="major polyA site"
     regulatory      9901..9906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
                     /note="hexamer: AATAAA"
     polyA_site      9915
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
     polyA_site      9923
                     /gene="Ston2"
                     /gene_synonym="4933401N24Rik; EG666955; Gm8378"
ORIGIN      
        1 aagggcgtct tccctgggag accagacaca gaggtctagg cggctgggaa aagggagcac
       61 agggtcacag ggcgtcccca gaagcctgca gaggtgtgtc cctccacagc cgaaatctca
      121 gtgccagctg tttgtttctc caccatagca gctgggaaac tgttcctcgg gagccgcacc
      181 ttcagcaaga aaaccattct ctctagagag gaccaatgga gccatgtaat ttgaaagctc
      241 ttggatcatt ttaactggac agccaaggtt gacaccagct gaagtccctg gacaagtatc
      301 actcccttgg aagcctgctt cgaatttaga acttcagatc tctgcctggc agattaacta
      361 acgacaagga agactggcct tacctccgtt cccagtgctg ccctttacaa gacctctgcg
      421 acagactgta gcccaagccc ccttgctgcc ctgtttaccc cagacatctt tctggggtcc
      481 acttgaagtc agcagcttga agatgagcag caccctctta gcatgacgac cttggaccat
      541 gtcattgcca cccaccagtc agagtgggtc tccttcagtg aagagccatt gttccccacc
      601 cctttagagg ggggcactga agagcacttc ccaggactgt catcttcctc agagcggtct
      661 gagagctcct ctggggagaa ccatgtcgtg gatgaaggct cccaggacct ttcacactct
      721 gagcaggatg actcctctga gaaaatggga ctcatctctg aagcagcctc ccctccgggg
      781 agccccgtgc agcccacacc tgacctggcc tcagccatca gcaactgggt ccagtttgaa
      841 gatgacacac cctggagcag cacctcacca cctcacaagg aaacagccct cacattgacc
      901 atgccctgct ggacatgccc ttccttcgac tctctgagaa gatgcccttt gacgtcggag
      961 agcagttgga ccacgcattc tgaggacacc agcagtccca gcgttgctcc ttcctacaca
     1021 gacctgcagc tcatcaatac cgaggaacag gcaagcggca gggcttccgg gaccgactct
     1081 accgacaact cgtcctccct ccaggaagat gaagaagtag aaatggaagc catcagttgg
     1141 tgggcaggca gtccagccat gaatgggcat cctgccgctc caccggtgac cacagctcgt
     1201 ttccccagct gggtcacttt tgaagacaat gaagtcggct gcccttcgcc gccagtcccc
     1261 tctccaaaga agccaaacac cccatctgcc gcaactgccg ccccagatgt acctttcaac
     1321 tcaactgggt catttaagag ggaccgtccc aagagcacac tgatgaactt acccaaagtt
     1381 caaaagttgg acatttcctc cttaaaccgg ccaccttctg taatcgaggc cccaccctgg
     1441 agggccacca atcctttcct gaatgagact ctgcaggacg tacagccctc gcctatcaac
     1501 ccgttcagtg ctttctttga agagcaggaa aggcgctccc aaaacagttc cgtttccagt
     1561 accaccggca aaagccaaag agattctctg attgtcgtct accaggatgc catcagcttt
     1621 gatgattcag gcaaaagcca gccccacccc gacgccatcg aaaagctcaa gcaactccaa
     1681 attgatgatc ctgatcccgt cggcaataca gccctgcccg atgacgaccc cacggcctcg
     1741 gttgaactgg acgccccctc acctgcctca gcgctctctc agcccaggga cgggtggcca
     1801 atgatgctgc gaatccccga gaagaaaaac atcatgtcct ctaggcactg gggaccaatc
     1861 tacatcaaac tgacagccag cggttacctg cagctgtatt acgagcaagg cttagaaaag
     1921 ccattccggg aattcaagct ggagatctgc cacgaggtgt cggagccccg gctccaaaac
     1981 tatgacgaga acgggaggat ccacagcttg aggatagacc gggtcactta caaggagaag
     2041 aagaaatacc agcccaaacc tgctgtggcc cacgcagcgg aacgggaaca ggtaattaaa
     2101 ctgggcacca ccaactacga cgacttccgg agcttcatcc atgcggttca ggaccgtctc
     2161 atggatttac cagtgctgtc catggacctg agcacagtcg gcttaaacta cctcgaagag
     2221 gagatcacgg tggacgtccg agacgagttc tctggcacag tgggcaaggg agacaaccag
     2281 atcttacagc atcatgtctt gacacggatc cacatactga gtttcctctc tgggctcgcc
     2341 gagtgccgct tgggcctcaa tgacatcctc atcaaaggga acgaaatcgt ttcccggcag
     2401 gacatcatgc ccaccaccac caccaagtgg atcaagctcc acgagtgccg tttccacggg
     2461 tgcgtggacg aggacgtgtt taacagttcc cgggttattc tgttcaaccc tttggacgca
     2521 tgccggtttg agctcatgag gtttaggacc gtatttgccg agaagacctt gcccttcaca
     2581 ctcaggaccg cagcgagcat taacggggcg gaagtagagg tgcagagctg gctgaggatg
     2641 tcccccggct tctcctctaa ccgcgaccct ctcactcagg ttccctgtga gaacgtaatg
     2701 gtccgctacc cagtgcccag cgagtgggtg aaaaacttcc gcagggacag cgttctaggg
     2761 gaaaagtctt tgaaagccaa agtgaaccgg ggggcaagtt ttggttctgc cggtgcctct
     2821 ggctccgagc ccgtcatgag agtaactctg ggaacggcca agtatgagca cgccttcaac
     2881 tccattgtgt ggaggataaa ccggctgcca gacaagaact cagcttctgg ccacccacac
     2941 tgtttctttt gccaccttga gcttggctct gaccgggaag tgccttccag atttgccaac
     3001 tatgtaaacg ttgagttcag catgcccacg acttctgcct ccaaagcagc cgtgagatcc
     3061 gtgtctgtgg aggacaagcc tgacgtcagg aagtgggtca attattctgc acactacagc
     3121 tacaaggtgg aaattgaaca gaaaaagagt ttgaagccag actttgaggg agaggacttg
     3181 gaaaacccaa aggaatgtgg ggtacagtga cagggaccac ccctcaagga actcaagagt
     3241 gtcttcccga ataactcaag tttaagtcaa cacctgctgt ggctgctctg tggggggcag
     3301 tctccctggg tttcctgtgt gcccttacct gtgggcccca gggaatcctc agggggctgc
     3361 ttccaatagg ctccccggca ctgagcatgc ctgaagcatg tgacgccccc ggcttctgga
     3421 gtttactatg gattgagccc ccttgtctct tttctgctta catcgtggcg ctggtatgtg
     3481 gttggcagtg acgatcagag acctgaaaag aagctccaac atcagtgtca gcagtttgtc
     3541 cccagtactc acgggtccct tgtatgtttc tggaaaaaag tagccttgac agttgattaa
     3601 gaatccatct ctgatgctcc ctctataaaa gattcaaaga ctcccaaagc catttctctg
     3661 ggcctgcttt tcgagatacc tctatttctt ttttaaatgg tggcattctg cagcagaggg
     3721 tttccaaatg tctcccttct ggttctggat ttgttcaaga tcaaaacgct cttccagatc
     3781 cctcctctcc catttgctat cctaaatcag ggcgctctgt ggcaaagccc tccctatctg
     3841 atcatttcaa attcgggtgt tgcagcttaa gtctacagat ggactagact ggattcacag
     3901 tctgttgggg gggaaaaaaa aaacgatctt atttttcttc ccttgaagga aaaggagcat
     3961 taaatgtcag cttatattca gttcagagga cagcttcaat cataaaatat gccagattct
     4021 cactggtcac tttaaattcc cgaaatagag tcatggctgt aatttcatgt gtgtagaaga
     4081 gacacttgga atttcctttt atacctcaga tacaatgact gttacacatc tcttccctca
     4141 aaatctagag acatttaagc ttaaaagatc gttgtaaaag ctgtgtttga atgatcttta
     4201 ccccaaattc caaggttggt agttaaaata gtgtcaaagt tcaaaaggca ccaggtggcg
     4261 gcggcacaca cctttaatcc cagcatttgg aaggcagagg caagtctgcc tgagttcaaa
     4321 gtcagcctga cctatagagt gagttccagg acagccctgg gtgcagagag aaatcctgtc
     4381 tagaaaaacc aaaaccaaaa caaaaaggca gaaggctcca gagtagagct ggggaaagcc
     4441 agtctccagt gccaagaatg tgaaatcctg attccaggac tcaggccagc ctccttttcc
     4501 ctccctcccc gccccctgct tatttgtact ctggtaaatt ctctcaagaa gaagacagtg
     4561 agaggacaga atgcatattt tatcagactt ggggaatatg tggaaataaa tagaaaagat
     4621 ctgtagtttg ggacaaagcg actcgagctt tttttcagct catattcagt gagctatgta
     4681 ctgacttagg cattagaaac cattgccgtg ttttgaacca tatgtttaac tctctaagca
     4741 ttagattgaa atgaaaagga caagctgcat gggcctagat gggaagacct gtattttgag
     4801 agtttaaaat gtcacccttt gagcacagag gtgtgtgtgt gtatgtgtgt gtggtgtgtg
     4861 tgtgtgtgta gtgtggtgtg tgttgatgag aactagggag atttgatatt gtaacagtcc
     4921 atatagaaat gtttttttga ggagttcagt tttgaagcag gaatagatcc acggctggtc
     4981 acaaagctaa tgccgtccat ctgtggtggt aggtctttaa cagctgtgca tgatgcatcg
     5041 gccagcacac gcctgagtgg aggcttacat tcaagtctag ctactgtatt ttaggggaga
     5101 cattaataag ttgaccgtat ccacaggcag gtgacccctg gttatagaag gaggggggag
     5161 gtgcagctct ccagcagagc agagggcatg gccgggaagg gagcgcaggg aagttgggga
     5221 atgaggtaat ggtcaattac caaccagggt ttccgcagag ctataaaaag gaagaagggt
     5281 tagctttgtt ttgcataact tcaaaggcaa aaagaaatag gaacagaaga gaactttaca
     5341 gatgacagtt acaggaatct tctaggaaag aagtgttcta aagaagaacg ggtaaagtaa
     5401 gatgtcctgc tgcagcaagt gcccagaggt taacccggcc agctatccca gggacggtca
     5461 cgctgggttg ggcaagatgg caggaaagct ctttttcaaa caatcttgat aggagtgagg
     5521 ctgtctaagc cccaggcagc ctttccgcta tgtgttttgt gctgttggag ggcagtagag
     5581 ttgtcgagaa gaagtctgtg tttttccaca cttgggttaa aggccttgag agtctcagct
     5641 gaccagtggg ctgaagagtt ggttgaaagg gtgaaggtca tctctggctt agccctgtgt
     5701 caggagccct gcctgggctg ctagcaggca cagcacctgt tttgccttgt tcttcccatc
     5761 cccttggcta attcttctgc cttggtactt cacctgaact atttggactt tttaagattt
     5821 gttttgcctt aatcaaaaga tgaaacaaaa agtccctctg ccctatttat atttggcaag
     5881 caatttatca ctaattttta agtatggact accctcttgg ttccatcaaa tttggtcggc
     5941 ctctactgtg cttagggtca ttacggatca cacgtaggga ggtgatgtgt agttcaggac
     6001 ttactgataa cctacctaaa aaacatatag ttgggcagat taccttttga tatgcagaat
     6061 gtttgcttgc cacagtggtc ctcaactttt atttttctgt gcttacaaaa acaaaaacaa
     6121 aacccaaatc tatattatca atatcataaa aatatgaaaa gtggtagaaa ccaatccaaa
     6181 cgtattagtt gccacgtagt atcaaaaact tgtttttgtg tctaggactt ctgtttcgac
     6241 tttacagtga aacaagacaa aaagataatt aagcattcta atgtatcaga caagaggtct
     6301 gctcagtgat agagagcctg cctagggtgc acaaggtcca atgagtgtgg ttcaaacccc
     6361 agtgtccccg aaacaaacaa caacagaaaa gagtggcagt tattttgagg gcagagagat
     6421 ccctaaagcc ccccttgttg acatagtatg gttacccttt aggaaaagct agccccttcc
     6481 tccttactct ctagacttct tttccaattt gctttctgat ctgcccaaga cctccccacg
     6541 ttcactgtga gagcttatcc tcatgagtgc tccttaattg aaaagacttc atatctgaag
     6601 tgagatggat ctctgtttag aaacatagtt gagatcagga gttcatgtcc ctagaagctc
     6661 tgttcctgag aaatgtaaca cgtgagccta tttattcatt gtgattcaaa cgcctataga
     6721 gtgtgagcca cagcagggct cggccgcttt aaatacttct aaatcaaacg tactcattaa
     6781 agaaatggaa attattgaca ctctgactct gagactatcc tgtgcttaca gctagcaagc
     6841 cgcaatcatt ttctggagga cttaagtcat gatttggctc tgctttcatc cctgcctcca
     6901 gtgtcaccca agtgtcagga tggtggcact caatgtgttg ctgagtctga cctacagagt
     6961 cacctattca catcaaggaa cacttgtgct ctacactcag aggggggggg ggggggacga
     7021 cacaggtgct gtccacagtt acgctattga ttcagtttcg ttgctgccaa tcaaacaaac
     7081 ctgtgagcct ctgcctcctc actgtgacag tgactcatgg aagacgctca catctgatgg
     7141 agtgctcagc cagtcctgct gagtcgggtg tttgtcctcc catctgtaac catgtcctca
     7201 caggagatgg gagtctgagc caggaaggcg gggctcacag gtgaaatcat gatttcaaag
     7261 ctggcttata ttttgtcttt tttttttttt ttggtttttt caagacaggg tttctctgta
     7321 tggccctggc tgtcctggaa ctcactttgt agaccaggct ggcctcaaac tcagaaatct
     7381 gcctgtctct gcctcccgag tgctgggatt aaaggcgtgt gccaccactg cccagctggt
     7441 ttatattttt taatcatctg ttaaagggta gaaaaacaag agaatgagct gacttttttt
     7501 ttccacctta aaggtcttgg gaattaattg ctatgagtag gaagcattgc catttatact
     7561 tttataaatt cccctgataa aaggtggtaa atttatctct tctaagaatg gttggctcag
     7621 attaatccta gcaggtctga agttgagatt gtgataagat tagaatgtga tagagaatcc
     7681 aatcgaaatt aacaaaaaat taaataaaaa tataccatct aataagtgaa tcttgtggta
     7741 acgcttcact gccactacca tgacagcatt ttatataaca ttcattgctc agtatattta
     7801 ttgcctctat ggttctgatg ggtgttttcg aaacatgacc actgtggcgt tgccaattct
     7861 gtacaaatca ccacatatta agtatgctct ttgaaaatga gattggcttt agacattctc
     7921 attcctaatc gtgtattaaa gagattaaga gtgaaggaga tacaggcggg cagatcttaa
     7981 gtgtgggaac aaatgcatgc cagtaacatc cccgcggtcg cctaagcaag agcatggaag
     8041 ttttctattt cttctagtgt gccttagcca atttgccaaa gtccagtcct gtactttaag
     8101 agttgaaagg gagtttggga agagcatgca tatgtcaact tacaattcca agccataaag
     8161 gcagaacatt tcaatagtac tatgttctgc agaacctgga aaaaggcaaa taaaaactgg
     8221 acataatgaa aagctacgaa aaaaacagac taaagaaaat aaatttcagt atgaaaagaa
     8281 ttggaaacta tccagcactg gaccctgaaa tttagtacga agctatagga aagaaggggc
     8341 atcgcggcca tagacagcaa aggtcttcag ctctgccagg attgctcaag tgctgtttaa
     8401 ggtactgtta gcagccagct tccctgcggg gacaagatgc cacacactaa gctgttggta
     8461 aggcatgctg tgacagcttt gtggaggaaa aagttgggct ttctgtgact atttaaagga
     8521 cccaagcatg gagccagcta gtattgctga ctgacctgtt atcttcttag tttccagaga
     8581 caaaaagaga gagcactggg cgtttgtttc ttcaggttgt ttttccagca atggttttat
     8641 gggttgtttc gcaaaatatc cctccctgcc actttttgtt gatattccat gtcagtatga
     8701 ttcttacaat tcttatgctt taagaaccaa gaagtttaaa gtaggagagt ggagaccagc
     8761 tttctcctgc tcagcccccc tcccccctcc ccctccccct cccccctccc cactgctcag
     8821 atgatggaaa tgcttgaaag cccccaatcc tattctgctg ttcaacttca gaataccagt
     8881 tgaatatgaa ggtcagaggg cagtctccca agtggatact ggggtgtgaa tacctcaata
     8941 cctccaagtt aaagatgtta ggatgttagg atgtaggatg ctgggatggt ctgtgatctg
     9001 tgaaagacca taggagagag gggggaaaca agctaatctg gagccatctg caattttagc
     9061 aaagccaagt gagagagaag gccgggcact gtacataaaa aaatgtgctt aatttctttt
     9121 tcttagtagc ttctctgtgt attgtgtttg aatatgcttt tagttttgtt ggagggggtt
     9181 ggttatactt actcagatag aatggatcaa ttctaactgg tcagatggaa ttccagcatc
     9241 ccctccgggt tcattcccat gttctgcctc agatgaaacc ccagttctca ctgtggacac
     9301 tagccacacg gtggctaaag ccttaagtgc caccactgct catgcccata tcttacaggg
     9361 agcctcgact gcaccagttc tgtggacaca ggtgaaccct tagctctcag catcagcctg
     9421 ttggatttaa gggttttcag gaatggttgg tgccttgtgt gtcatgaatc ccccgtcccc
     9481 tccgccagca ttcgtgtatc tcttatggtc acttgccaac aggaactgga caaccctctg
     9541 ccatatcgag aaggttcatc aggattggtg tttggaatgg aggagcatcc ttcttcaccc
     9601 tccatttctg taaggtccat atgaatttca gtgtgtcggt ggctgagccc acaatccagt
     9661 gaatgccctg accattctga ggcttgtatt tcctgtcatt tgtcattcat ccccactcag
     9721 tgtaacttct tgcactattg tggctcgttt tatgtaaaac cagttaactt taaaaagaat
     9781 gtgcctatgt aataataaag tctacacact ggcaatttct gcagaggtga tgttttgttt
     9841 tagatgtttt cctgaataat ctgtaatatc ttttgggggg gactatgaaa aggaagtatt
     9901 aataaaaaat ttaagcaaag tga
//
