LOCUS       NM_153156               2161 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus stomatin (Epb7.2)-like 3 (Stoml3), mRNA.
ACCESSION   NM_153156
VERSION     NM_153156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Liang,X., Taylor,M., Napier-Jameson,R., Calovich-Benne,C. and
            Norris,A.
  TITLE     A Conserved Role for Stomatin Domain Genes in Olfactory Behavior
  JOURNAL   eNeuro 10 (3) (2023)
   PUBMED   36858824
  REMARK    GeneRIF: A Conserved Role for Stomatin Domain Genes in Olfactory
            Behavior.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Agostinelli,E., Gonzalez-Velandia,K.Y., Hernandez-Clavijo,A., Kumar
            Maurya,D., Xerxa,E., Lewin,G.R., Dibattista,M., Menini,A. and
            Pifferi,S.
  TITLE     A Role for STOML3 in Olfactory Sensory Transduction
  JOURNAL   eNeuro 8 (2) (2021)
   PUBMED   33637538
  REMARK    GeneRIF: A Role for STOML3 in Olfactory Sensory Transduction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Wetzel,C., Pifferi,S., Picci,C., Gok,C., Hoffmann,D., Bali,K.K.,
            Lampe,A., Lapatsina,L., Fleischer,R., Smith,E.S., Begay,V.,
            Moroni,M., Estebanez,L., Kuhnemund,J., Walcher,J., Specker,E.,
            Neuenschwander,M., von Kries,J.P., Haucke,V., Kuner,R.,
            Poulet,J.F., Schmoranzer,J., Poole,K. and Lewin,G.R.
  TITLE     Small-molecule inhibition of STOML3 oligomerization reverses
            pathological mechanical hypersensitivity
  JOURNAL   Nat Neurosci 20 (2), 209-218 (2017)
   PUBMED   27941788
  REMARK    GeneRIF: STOML3 inhibitors in the skin also reversibly attenuate
            fine touch perception in normal mice.
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Munoz,I., Danelli,L., Claver,J., Goudin,N., Kurowska,M.,
            Madera-Salcedo,I.K., Huang,J.D., Fischer,A., Gonzalez-Espinosa,C.,
            de Saint Basile,G., Blank,U. and Menasche,G.
  TITLE     Kinesin-1 controls mast cell degranulation and anaphylaxis through
            PI3K-dependent recruitment to the granular Slp3/Rab27b complex
  JOURNAL   J Cell Biol 215 (2), 203-216 (2016)
   PUBMED   27810912
  REMARK    GeneRIF: PI3K-dependent formation of a kinesin-1/Slp3/Rab27b
            complex is critical for the microtubule-dependent movement of
            secretory granules required for mast cell degranulation.
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Qi,Y., Andolfi,L., Frattini,F., Mayer,F., Lazzarino,M. and Hu,J.
  TITLE     Membrane stiffening by STOML3 facilitates mechanosensation in
            sensory neurons
  JOURNAL   Nat Commun 6, 8512 (2015)
   PUBMED   26443885
  REMARK    GeneRIF: In C57BL/6N, but not STOML3(-/-) mice, tactile allodynia
            is attenuated by cholesterol depletion, suggesting that membrane
            stiffening by STOML3 is essential for mechanical sensitivity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Lapatsina,L., Brand,J., Poole,K., Daumke,O. and Lewin,G.R.
  TITLE     Stomatin-domain proteins
  JOURNAL   Eur J Cell Biol 91 (4), 240-245 (2012)
   PUBMED   21501885
  REMARK    GeneRIF: [review] Generation of stoml3-deficient mice demonstrates
            that murine STOML3 is functionally orthologous to the MEC-2 memrane
            protein.
            Review article
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Wetzel,C., Hu,J., Riethmacher,D., Benckendorff,A., Harder,L.,
            Eilers,A., Moshourab,R., Kozlenkov,A., Labuz,D., Caspani,O.,
            Erdmann,B., Machelska,H., Heppenstall,P.A. and Lewin,G.R.
  TITLE     A stomatin-domain protein essential for touch sensation in the
            mouse
  JOURNAL   Nature 445 (7124), 206-209 (2007)
   PUBMED   17167420
  REMARK    GeneRIF: SLP3 is therefore indispensable for the function of a
            subset of cutaneous mechanoreceptors, and our data support the idea
            that this protein is an essential subunit of a mammalian
            mechanotransducer
REFERENCE   8  (bases 1 to 2161)
  AUTHORS   Fricke,B., Stewart,G.W., Treharne,K.J., Mehta,A., Knopfle,G.,
            Friedrichs,N., Muller,K.M. and von During,M.
  TITLE     Stomatin immunoreactivity in ciliated cells of the human airway
            epithelium
  JOURNAL   Anat Embryol (Berl) 207 (1), 1-7 (2003)
   PUBMED   12759749
REFERENCE   9  (bases 1 to 2161)
  AUTHORS   Goldstein,B.J., Kulaga,H.M. and Reed,R.R.
  TITLE     Cloning and characterization of SLP3: a novel member of the
            stomatin family expressed by olfactory receptor neurons
  JOURNAL   J Assoc Res Otolaryngol 4 (1), 74-82 (2003)
   PUBMED   12239636
  REMARK    GeneRIF: characterization of an olfactory neuronal protein, SLP3,
            which shares extensive homology with the stomatin family of
            membrane proteins; expressed selectively in the receptor neurons of
            the olfactory epithelium
REFERENCE   10 (bases 1 to 2161)
  AUTHORS   Kobayakawa,K., Hayashi,R., Morita,K., Miyamichi,K., Oka,Y.,
            Tsuboi,A. and Sakano,H.
  TITLE     Stomatin-related olfactory protein, SRO, specifically expressed in
            the murine olfactory sensory neurons
  JOURNAL   J Neurosci 22 (14), 5931-5937 (2002)
   PUBMED   12122055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158162.13.
            
            On Jun 19, 2019 this sequence version replaced NM_153156.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058224.1, SRR5189670.130329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC158162.13        174016-174141
            127-230             AC158162.13        183249-183352
            231-303             AC158162.13        183433-183505
            304-386             AC158162.13        186061-186143
            387-590             AC158162.13        188476-188679
            591-725             AC158162.13        190740-190874
            726-2161            AC158162.13        192737-194172
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 25.21 cM"
     gene            1..2161
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /note="stomatin (Epb7.2)-like 3"
                     /db_xref="GeneID:229277"
                     /db_xref="MGI:MGI:2388072"
     exon            1..126
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..950
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /note="stomatin related olfactory protein SRO; SLP-3;
                     stomatin-related olfactory protein"
                     /codon_start=1
                     /product="stomatin-like protein 3"
                     /protein_id="NP_694796.1"
                     /db_xref="CCDS:CCDS17347.1"
                     /db_xref="GeneID:229277"
                     /db_xref="MGI:MGI:2388072"
                     /translation="MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLVTFPISVW
                     MCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEIL
                     TRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILSGR
                     EEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAE
                     GEMNASKSLKSASMVLAESPVALQLRYLQTLTTVATEKNSTIVFPLPMNILEGIGGIS
                     YGNNKKVTAKA"
     exon            127..230
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /inference="alignment:Splign:2.1.0"
     exon            231..303
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /inference="alignment:Splign:2.1.0"
     exon            304..386
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /inference="alignment:Splign:2.1.0"
     exon            387..590
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /inference="alignment:Splign:2.1.0"
     exon            591..725
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /inference="alignment:Splign:2.1.0"
     exon            726..2161
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /note="hexamer: AATAAA"
     polyA_site      2161
                     /gene="Stoml3"
                     /gene_synonym="Epb7.2l; SLP3; sro"
                     /note="major polyA site"
ORIGIN      
        1 acacaccact gagctgatgc ctgctgccag gctcgaatcc cgacccagga gcacctgcaa
       61 gatttgaaag gcacctcaag aatgagatgg attcaccgga gaaactggag aagaacaatt
      121 tagtgggcac caacaaaagc cggcttggtg tgtgcggctg gatcctgttt ttcctttcct
      181 tcctgctgat gctcgttacc ttcccaatct cagtatggat gtgcttgaag atcattaagg
      241 agtatgagcg cgctgttgtc ttcagactgg gacgcatcca agctgataaa gccaagggac
      301 caggtttgat cctggtcctg ccttgcattg acgtgtttgt caaagtagat cttcgaacgg
      361 ttacttgtaa cattcctcca caagagatcc tcacgagaga ctctgtgacc acccaagtgg
      421 atggagtcgt ctattacaga atctacagcg ccgtctcagc cgtggccaat gtgaacgatg
      481 ttcaccaggc cacgttcctg ctggctcaga ccactctgag aaatgtctta gggacacaga
      541 ccttgtccca gatcttgtct gggcgagaag agatcgcaca tagcatccag accttgcttg
      601 atgatgccac cgagctctgg ggaatccgag tggcccgggt ggaaatcaaa gatgtccgga
      661 ttcctgtgca gctgcagagg tccatggcgg ctgaggctga ggctacccgg gaagccagag
      721 ccaaggtcct tgcagcagag ggagaaatga atgcttcaaa gtctctgaag tcagcttcca
      781 tggtgctggc agagtccccc gtcgccctcc aacttcggta cctgcagacc ttgaccacag
      841 tggccacgga gaaaaattcc accattgtgt ttcccttgcc gatgaacata cttgagggca
      901 ttggtggcat cagctatggc aacaataaga aggtcactgc taaagcctga ggtcttccac
      961 gtaacagcct gctacttaga aaggcctttc tgtaccatgg agaagtcagc cagtagagac
     1021 caatgcacgc gcacacacac acacacacac acacacacac acacacacac acacacacac
     1081 actcatgcac catgaataaa atacggtaac tccacagcta gcagaattcc cagagagaca
     1141 tagaagctac acaaacaaaa acaaaatcga gagccatgca ctgctttgat tttaaaggca
     1201 taaccaatat tcaatattca tatataatta gttagtggtt gtccctgact atcaacagag
     1261 aatctctcag ggtgggcgga gactctaggt gactgataag aactttagaa tttaagctgt
     1321 gttggagaag gaccctaggt catttgtaaa gaaaaagcag atcccacatt tatgatatgc
     1381 atttgatcca ctgttccaat aaaacgactt gctttagttc aagtaagaaa acgactcaag
     1441 gctgaaactt aggacggatt tggatgtaga aaataaaaaa ccgctgcagc atagcagcaa
     1501 cacggggcaa aggtaccagg tcaggcccag ctctcttgac accctggatg tcctgttaaa
     1561 gtgctggcgt tctcagcacc ctcacacctt tgtcagggcc agaggcacag caaggcagcc
     1621 tagcacaggg taatttgctt actagtaaga ccttcagagc cactggggag gtaggtctgt
     1681 gaattgcatg ttttcactct gtaagtccca agagccatag tgattaaggg ctgtttgtaa
     1741 tctttcccca gctcaaacaa cttgttgcaa ataaaaaaaa aaaggaagtc atagaaagtg
     1801 aacatgattt ttaaaattgc tttaatagtg ttagcatttt gtctaggctc cgccccagag
     1861 ttacctggca agagccaggt gtgcctgact cactataaaa ggggctgctt gctgcttgct
     1921 gcttgccccc tcttgccttc ttgctcccgc tctggccagc ctctctactc ctcttctctc
     1981 tctctctctc tctctctctc tctctctctc tctctctctc cctctccctc tccctctccc
     2041 tctccctctc cctccctctc tctctctctc tctctctctc tctctctctc cctctctctc
     2101 cctttctctg tctctactgc tctctcaact ccatgccctg aataaactct atcctatatt
     2161 a
//
