LOCUS       NM_001419082            1671 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus stomatin (Epb7.2)-like 2 (Stoml2), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001419082
VERSION     NM_001419082.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1671)
  AUTHORS   Fan,R., Jiang,H., Hu,Y., Xu,Y., Zhou,Y., Chen,G., Liu,Y., Yao,Y.,
            Qin,W., Chen,W., Huang,F. and Chen,X.
  TITLE     Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2
            cells apoptosis by protecting mitochondrial function
  JOURNAL   Biochem Biophys Res Commun 636 (Pt 1), 112-120 (2022)
   PUBMED   36332472
REFERENCE   3  (bases 1 to 1671)
  AUTHORS   Mitsopoulos,P., Lapohos,O., Weraarpachai,W., Antonicka,H.,
            Chang,Y.H. and Madrenas,J.
  TITLE     Stomatin-like protein 2 deficiency results in impaired
            mitochondrial translation
  JOURNAL   PLoS One 12 (6), e0179967 (2017)
   PUBMED   28654702
  REMARK    GeneRIF: resting or activated T cells from T cell-specific Slp-2
            knockout mice showed a significant impairment in the production of
            several mitochondrial DNA-encoded polypeptides following T cell
            activation. Measurement of mitochondrial DNA stability and
            mitochondrial transcription revealed that this impairment was at
            the post-transcriptional level.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1671)
  AUTHORS   Feng,Q., Hu,Z.Y., Liu,X.Q., Zhang,X., Lan,X., Geng,Y.Q., Chen,X.M.,
            He,J.L., Wang,Y.X. and Ding,Y.B.
  TITLE     Stomatin-like protein 2 is involved in endometrial stromal cell
            proliferation and differentiation during decidualization in mice
            and humans
  JOURNAL   Reprod Biomed Online 34 (2), 191-202 (2017)
   PUBMED   27986413
  REMARK    GeneRIF: Slp2 is involved in endometrial stromal cell proliferation
            and differentiation during decidualization in mice and humans
REFERENCE   5  (bases 1 to 1671)
  AUTHORS   Chowdhury,S.M., Zhu,X., Aloor,J.J., Azzam,K.M., Gabor,K.A., Ge,W.,
            Addo,K.A., Tomer,K.B., Parks,J.S. and Fessler,M.B.
  TITLE     Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for
            Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor
            Signaling
  JOURNAL   Mol Cell Proteomics 14 (7), 1859-1870 (2015)
   PUBMED   25910759
  REMARK    GeneRIF: SLP-2 is an ABCA1-dependent regulator of raft composition
            and of the innate immune response.
REFERENCE   6  (bases 1 to 1671)
  AUTHORS   Tondera,D., Grandemange,S., Jourdain,A., Karbowski,M.,
            Mattenberger,Y., Herzig,S., Da Cruz,S., Clerc,P., Raschke,I.,
            Merkwirth,C., Ehses,S., Krause,F., Chan,D.C., Alexander,C.,
            Bauer,C., Youle,R., Langer,T. and Martinou,J.C.
  TITLE     SLP-2 is required for stress-induced mitochondrial hyperfusion
  JOURNAL   EMBO J 28 (11), 1589-1600 (2009)
   PUBMED   19360003
REFERENCE   7  (bases 1 to 1671)
  AUTHORS   Da Cruz,S., Parone,P.A., Gonzalo,P., Bienvenut,W.V., Tondera,D.,
            Jourdain,A., Quadroni,M. and Martinou,J.C.
  TITLE     SLP-2 interacts with prohibitins in the mitochondrial inner
            membrane and contributes to their stability
  JOURNAL   Biochim Biophys Acta 1783 (5), 904-911 (2008)
   PUBMED   18339324
REFERENCE   8  (bases 1 to 1671)
  AUTHORS   Chan,W.L., Chang,J.G., Chen,Y.F., Chan,Y.K. and Chu,Y.P.
  TITLE     Identification of mouse mslp2 gene from EST databases by repeated
            searching, comparison, and assembling
  JOURNAL   Comput Biol Med 36 (1), 101-108 (2006)
   PUBMED   16324911
REFERENCE   9  (bases 1 to 1671)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1671)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672276.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2003536.1,
                                           SRR13422590.6423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AL672276.9         167432-167610       c
            180-317             AL672276.9         167179-167316       c
            318-417             AL672276.9         166644-166743       c
            418-476             AL672276.9         166448-166506       c
            477-578             AL672276.9         166257-166358       c
            579-713             AL672276.9         165978-166112       c
            714-858             AL672276.9         165701-165845       c
            859-938             AL672276.9         165487-165566       c
            939-1067            AL672276.9         165146-165274       c
            1068-1671           AL672276.9         163898-164501       c
FEATURES             Location/Qualifiers
     source          1..1671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.99 cM"
     gene            1..1671
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /note="stomatin (Epb7.2)-like 2"
                     /db_xref="GeneID:66592"
                     /db_xref="MGI:MGI:1913842"
     exon            1..179
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1196
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /note="isoform a is encoded by transcript variant 1;
                     stomatin-like protein 2, mitochondrial"
                     /codon_start=1
                     /product="stomatin-like protein 2, mitochondrial isoform
                     a"
                     /protein_id="NP_001406011.1"
                     /db_xref="GeneID:66592"
                     /db_xref="MGI:MGI:1913842"
                     /translation="MLARAARGTGALLLRVRARQPSPEARDRHHLGLELGRSGLLTLG
                     EGLWSQGSVQASGRVPRRASSGLPRNTVILFVPQQEAWVVERMGRFHRILEPGLNVLI
                     PVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYA
                     VTQLAQTTMRSELGKLSLDKVFRERESLNANIVDAINQAADCWGIRCLRYEIKDIHVP
                     PRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAA
                     GEASAVLAKAKAKAEAIRILAGALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTVLLP
                     SNPSDVTSMVAQAMGVYGALTKAPVPGAQNSSQSRRDVQATDTSIEELGRVKLS"
     exon            180..317
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..417
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..476
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..578
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..713
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..858
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..938
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1067
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1671
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1342
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /note="major polyA site"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1671
                     /gene="Stoml2"
                     /gene_synonym="0610038F01Rik; MSLP2; SLP-2"
ORIGIN      
        1 ggttccggag gtcgccgagg ctgtgggaaa tgctggcgcg cgcggcgcgg ggcactggag
       61 cccttttgct gagggtgaga gcgaggcaac cttcaccaga ggctcgggac cgacatcacc
      121 tgggtcttga gctgggaagg agtgggcttc taactttggg ggaaggactg tggtcacagg
      181 gctcggtgca ggcttctggc cgcgttccgc gccgcgcctc ctctggactg ccccgaaaca
      241 ccgtgatcct gtttgtgcct cagcaggagg cctgggtggt ggagcgaatg ggccgattcc
      301 accggatcct ggaaccgggc ctgaacgtcc tgatccccgt gttagaccga atccggtatg
      361 tgcagagtct caaggaaatt gttatcaacg tgcctgagca gtcagccgta actcttgaca
      421 atgtaacact acaaatagat ggagtccttt atctgcgcat catggatcct tacaaggcaa
      481 gttacggtgt ggaagaccca gagtatgctg tcacccagtt agctcagacg actatgagat
      541 cagagcttgg caaactctct ctggacaaag tttttcggga gcgtgagtcc ctgaatgcca
      601 acattgtgga tgccatcaac caggctgcag actgctgggg tatccgatgc ctgcgatacg
      661 agatcaagga catccatgtg ccacctcgag tgaaagagtc tatgcagatg caggtagagg
      721 cagagcgccg gaagcgggcc acagttctag agtccgaagg gacacgagag tcagctatta
      781 atgtggcaga ggggaagaaa caggcccaga ttctggcctc cgaagcagaa aaggctgaac
      841 agataaatca ggcggcagga gaagccagtg cagttctggc caaggccaag gctaaagccg
      901 aagcgattcg aattctggct ggggctctga ctcaacataa tggagatgca gcagcttcgc
      961 tcactgtggc tgagcagtat gtcagcgcat tctccaaact ggccaaggat tccaacacag
     1021 tgctactgcc ctccaatccc agcgacgtca cgagtatggt ggctcaggcc atgggtgtct
     1081 atggggctct caccaaagcc ccagtgcccg gagcccagaa ctccagccag agcagaagag
     1141 atgtccaggc tacagacacg agtattgaag aactgggtag agtcaagctc agttagtaga
     1201 gatgactcgg ccagggagtc taggggccgg gagctgctct caaaaaagat tctggttcca
     1261 gcctcccggc caaattttag tttttatttt tttatttgaa cttactaatc atgtaataaa
     1321 gtgaccagtg gcaaatggga aactgtcctc attgattggg ggatgaagtt aggaaagcca
     1381 ctcgggtcgt ctttggccgt ccacttccac ccttcagtcc aggtcggtgt gaggagttga
     1441 ttctccacgc gtgacaagga ttcacttcat gtgaagtgaa gtcatcctgt cgtcaagaga
     1501 aacctcggct gtacggggat tgaggcatgg tctgctgaac tgccagctgc acagtggtgc
     1561 aggggcttgg ggacacacgg gaaaggacag cttgccctta tggtatggcg gtcttaaagg
     1621 gcagagggtg tagactatta agctattaat aaactagggt ttacaaaagc a
//
