LOCUS       NM_175360               1992 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus STN1, CST complex subunit (Stn1), mRNA.
ACCESSION   NM_175360
VERSION     NM_175360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1992)
  AUTHORS   Nguyen,D.D., Kim,E., Le,N.T., Ding,X., Jaiswal,R.K., Kostlan,R.J.,
            Nguyen,T.N.T., Shiva,O., Le,M.T. and Chai,W.
  TITLE     Deficiency in mammalian STN1 promotes colon cancer development via
            inhibiting DNA repair
  JOURNAL   Sci Adv 9 (19), eadd8023 (2023)
   PUBMED   37163605
  REMARK    GeneRIF: Deficiency in mammalian STN1 promotes colon cancer
            development via inhibiting DNA repair.
REFERENCE   2  (bases 1 to 1992)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   3  (bases 1 to 1992)
  AUTHORS   Wan,M., Qin,J., Songyang,Z. and Liu,D.
  TITLE     OB fold-containing protein 1 (OBFC1), a human homolog of yeast
            Stn1, associates with TPP1 and is implicated in telomere length
            regulation
  JOURNAL   J Biol Chem 284 (39), 26725-26731 (2009)
   PUBMED   19648609
REFERENCE   4  (bases 1 to 1992)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
  REMARK    GeneRIF: OBFC1 is identical to the previously described 44 kDa
            subunit of DNA-pol-alpha/primase associated factor (AAF) which
            increases polymerase-alpha/primase template affinity and stimulate
            both DNA primase and polymerase-alpha activities in vitro.
REFERENCE   5  (bases 1 to 1992)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125075.4, AK075574.1 and AK164386.1.
            
            On Apr 14, 2018 this sequence version replaced NM_175360.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164386.1, AK146929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC125075.4         67854-67952         c
            100-1977            AK075574.1         1-1878
            1978-1992           AK164386.1         1889-1903
FEATURES             Location/Qualifiers
     source          1..1992
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 39.64 cM"
     gene            1..1992
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /note="STN1, CST complex subunit"
                     /db_xref="GeneID:108689"
                     /db_xref="MGI:MGI:1915581"
     exon            1..306
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            307..482
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1465
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /note="oligonucleotide/oligosaccharide-binding
                     fold-containing protein 1; alpha accessory factor 44;
                     replication protein A 32 kDa subunit; alpha-accessory
                     factor of 44 kDa; suppressor of cdc thirteen homolog;
                     oligonucleotide/oligosaccharide-binding fold containing 1"
                     /codon_start=1
                     /product="CST complex subunit STN1"
                     /protein_id="NP_780569.1"
                     /db_xref="CCDS:CCDS29892.1"
                     /db_xref="GeneID:108689"
                     /db_xref="MGI:MGI:1915581"
                     /translation="MPQPCLLMECESSPREEEIPPLFWGLDPVFLAFAKLYIKDILEM
                     KESQQVPGTYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKKLSNA
                     ESSSDPAILSTARELSMTSQLKKLQETIEQKTRIGIGDIIRVRGSVRMFREEREICAN
                     IYYKVDDPVWNMQIARMLELPKLYQKVYDQPFRNPALQEEEALNNKDNLDLAGLTSLL
                     SEKIKEFLQEKKMQSFYQQELETVESLQSLASRPVTHSTGSDQVELKDSGTSGVAQRV
                     FKNALQLLQEKGLVFQRDSGSDKLYYVTTKDKDLQQKIYHIIKEDCQKPNHMEKGCHL
                     LHILNCVHLNLRWDLSKAVLQRVLELLEDQSDIVSTADHYYAAF"
     exon            483..578
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            579..647
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            648..815
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            816..939
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1111
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1234
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1307
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1992
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1961..1966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /note="hexamer: AATAAA"
     polyA_site      1978
                     /gene="Stn1"
                     /gene_synonym="0610009H20Rik; 2310057J23Rik; AAF-44;
                     AAF44; Obfc1; RPA-32"
                     /note="major polyA site"
ORIGIN      
        1 gggcgtggcc tcagcgggag tggctggcgg tagctaggcg cgggtggcgg gaaggaaata
       61 cgccggcggg agtgtgctcg cttccttctc gcaaccggaa ctggttcggc aatcttggct
      121 ggctgctcct gcttcgggag aagttgtaaa ctgctctgat ttctgcctct ttttcctttc
      181 ctccgctctt cccagaggtg aaaggtcgaa gcttggatag acacaccttc agggccccca
      241 aagtccacgg ccacagggac tctctccatt actctccgga ttcactcgtt aaaactcctt
      301 tttgggagtc ttggctctgg gttagcagat gccacagccc tgcctcttga tggagtgtga
      361 atccagtcca agggaagagg agatcccgcc cctcttttgg ggtctggatc ctgtgtttct
      421 agcctttgca aaactctaca tcaaggatat cctggagatg aaggagtccc aacaagtgcc
      481 aggtacatat ttttacaacg ggcatccaat aaggcgggta gatatcatgg gagctgtcat
      541 cagcgtgaaa gaaagagaga ctttctacag ctacggagtg gacgatgcca ctggggttat
      601 aaactgcgtc tgctggaaga agctgagcaa cgctgagtct tcctcagacc cagctattct
      661 gagcactgcg agagagctta gcatgacatc acagcttaag aagctgcagg agaccatcga
      721 gcagaaaacc aggataggga ttggagatat catccgagtc cgaggctctg tgcgcatgtt
      781 ccgagaagag cgagagatct gtgccaacat ttattataag gtggacgatc cagtgtggaa
      841 catgcaaatc gcaaggatgc ttgagctgcc caagctctac cagaaggtgt acgaccagcc
      901 cttccgtaac ccagccctac aggaggagga ggcactaaac aataaagaca atttggatct
      961 cgctggcctc acgtctttgc tgagtgagaa aattaaagaa ttcctccagg agaagaaaat
     1021 gcaaagcttc taccagcagg agttagagac agtggagtct ttgcagtctc tggccagtcg
     1081 gcctgtgacc cacagcacgg gctcggacca agtggagtta aaggacagtg gcacttctgg
     1141 cgtagcgcag agagtgttta agaatgctct ccagctgctt caggaaaaag gactcgtgtt
     1201 ccagagagac agtggctctg ataagctgta ctacgtaacc accaaagaca aagacctgca
     1261 gcagaagatc taccacatca ttaaggaaga ctgtcagaaa ccaaaccata tggagaaggg
     1321 ctgccacctg ctacacatcc tgaactgtgt gcacctcaac ctccgctggg acctgagcaa
     1381 ggctgtgctg cagcgggtgc tggagctcct ggaggaccag agtgacatcg tcagcaccgc
     1441 ggaccactac tacgcggcct tctgagcaga gccgcggagc aaagcgggag gctctaccct
     1501 aggttctgct cacaggccca gtaaagactt acacatccca tagtaagctc tgataagtca
     1561 caggaaaata ggactgagac agatggctct gatgtcagcc atgacacaca caagccctcc
     1621 ttgtcagctc cctggctgga cttcccatca ctcagaacag aatgggagaa aacggtgttg
     1681 ctggtttaat cactgtgtct gaattcaggg gccccgtctc gatagagggg catcccaggg
     1741 cgaaggctcc tccacatctg aactggagca gaaatagcag actacaccgt ctgaaaacgt
     1801 cacactccaa gctaccacat acatccccac caggctcccc tgatgtgtca agagctcgta
     1861 taggcgcatc gtctcctaca gtaattgacg tttgcctcag tttcctggga cttcagcagt
     1921 agcggtgagg gctgctgagg cttgcagatc tgcattgaag aataaaaact ccaatgcatg
     1981 gcttggcatt tc
//
