LOCUS       NM_025285               1904 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus stathmin-like 2 (Stmn2), mRNA.
ACCESSION   NM_025285
VERSION     NM_025285.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Krus,K.L., Benitez,A.M., Strickland,A., Milbrandt,J., Bloom,A.J.
            and DiAntonio,A.
  TITLE     Two cardinal features of ALS, reduced STMN2 and pathogenic TDP-43,
            synergize to accelerate motor decline in mice
  JOURNAL   Exp Neurol 384, 115068 (2025)
   PUBMED   39603486
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Zhou,X. and Lin,S.
  TITLE     HOXC10 promotes hypertrophic scar fibroblast fibrosis through the
            regulation of STMN2 and the TGF-beta/Smad signaling pathway
  JOURNAL   Histochem Cell Biol 162 (5), 403-413 (2024)
   PUBMED   39152325
  REMARK    GeneRIF: HOXC10 promotes hypertrophic scar fibroblast fibrosis
            through the regulation of STMN2 and the TGF-beta/Smad signaling
            pathway.
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Chen,T., Chen,Z., Wu,P., Luo,J., Liu,Q., Yang,H., Peng,C.,
            Zhang,G., Lin,H. and Ji,Z.
  TITLE     The Interaction between ADK and SCG10 Regulate the Repair of Nerve
            Damage
  JOURNAL   Neuroscience 544, 75-87 (2024)
   PUBMED   38423163
  REMARK    GeneRIF: The Interaction between ADK and SCG10 Regulate the Repair
            of Nerve Damage.
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1904)
  AUTHORS   Lopez-Erauskin,J., Bravo-Hernandez,M., Presa,M., Baughn,M.W.,
            Melamed,Z., Beccari,M.S., Agra de Almeida Quadros,A.R.,
            Arnold-Garcia,O., Zuberi,A., Ling,K., Platoshyn,O., Nino-Jara,E.,
            Ndayambaje,I.S., McAlonis-Downes,M., Cabrera,L., Artates,J.W.,
            Ryan,J., Hermann,A., Ravits,J., Bennett,C.F., Jafar-Nejad,P.,
            Rigo,F., Marsala,M., Lutz,C.M., Cleveland,D.W. and
            Lagier-Tourenne,C.
  TITLE     Stathmin-2 loss leads to neurofilament-dependent axonal collapse
            driving motor and sensory denervation
  JOURNAL   Nat Neurosci 27 (1), 34-47 (2024)
   PUBMED   37996528
  REMARK    GeneRIF: Stathmin-2 loss leads to neurofilament-dependent axonal
            collapse driving motor and sensory denervation.
REFERENCE   6  (bases 1 to 1904)
  AUTHORS   Conlon,R.A., Reaume,A.G. and Rossant,J.
  TITLE     Notch1 is required for the coordinate segmentation of somites
  JOURNAL   Development 121 (5), 1533-1545 (1995)
   PUBMED   7789282
REFERENCE   7  (bases 1 to 1904)
  AUTHORS   Schoenherr,C.J. and Anderson,D.J.
  TITLE     The neuron-restrictive silencer factor (NRSF): a coordinate
            repressor of multiple neuron-specific genes
  JOURNAL   Science 267 (5202), 1360-1363 (1995)
   PUBMED   7871435
REFERENCE   8  (bases 1 to 1904)
  AUTHORS   Guillemot,F., Lo,L.C., Johnson,J.E., Auerbach,A., Anderson,D.J. and
            Joyner,A.L.
  TITLE     Mammalian achaete-scute homolog 1 is required for the early
            development of olfactory and autonomic neurons
  JOURNAL   Cell 75 (3), 463-476 (1993)
   PUBMED   8221886
REFERENCE   9  (bases 1 to 1904)
  AUTHORS   Mori,N., Schoenherr,C., Vandenbergh,D.J. and Anderson,D.J.
  TITLE     A common silencer element in the SCG10 and type II Na+ channel
            genes binds a factor present in nonneuronal cells but not in
            neuronal cells
  JOURNAL   Neuron 9 (1), 45-54 (1992)
   PUBMED   1321646
REFERENCE   10 (bases 1 to 1904)
  AUTHORS   Pampfer,S., Fan,W., Schubart,U.K. and Pollard,J.W.
  TITLE     Differential mRNA expression of the phosphoprotein p19/SCG10 gene
            family in mouse preimplantation embryos, uterus, and placenta
  JOURNAL   Reprod Fertil Dev 4 (2), 205-211 (1992)
   PUBMED   1438949
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124554.5.
            
            On Nov 17, 2006 this sequence version replaced NM_025285.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003659.1, AK149212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC124554.5         113907-114010       c
            105-200             AC124554.5         81601-81696         c
            201-373             AC124554.5         77792-77964         c
            374-565             AC124554.5         68554-68745         c
            566-1904            AC124554.5         61933-63271         c
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.15 cM"
     gene            1..1904
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /note="stathmin-like 2"
                     /db_xref="GeneID:20257"
                     /db_xref="MGI:MGI:98241"
     exon            1..104
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..625
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /note="superior cervical ganglion-10 protein;
                     superiorcervical ganglia, neural specific 10"
                     /codon_start=1
                     /product="stathmin-2"
                     /protein_id="NP_079561.1"
                     /db_xref="CCDS:CCDS17231.1"
                     /db_xref="GeneID:20257"
                     /db_xref="MGI:MGI:98241"
                     /translation="MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQ
                     INKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQV
                     LKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEK
                     ERHAAEVRRNKELQVELSG"
     exon            105..200
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..373
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..565
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..1904
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      774..779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /note="hexamer: AATAAA"
     polyA_site      790
                     /gene="Stmn2"
                     /gene_synonym="SCG10; Scgn10; Stmb2"
                     /note="major polyA site"
ORIGIN      
        1 agactcctct ctcgctctct ccgcggctac agctggaccc ttctcctttg ccttcgccac
       61 cactccgtgc gtgcacatcc ctacaatggc taaaacagca atggcctaca aggaaaaaat
      121 gaaggagctg tctatgctgt cactgatctg ctcctgcttc tacccggagc cgcgcaacat
      181 caacatctac acctacgacg acatggaggt gaagcagatc aacaagcggg cctctggcca
      241 ggcttttgag ctgatcttga agccaccatc tcccatctca gaagctccac gaactctagc
      301 ttctccaaag aagaaagacc tgtctctgga ggagattcag aaaaagctgg aggctgcaga
      361 ggagcgaaga aagtctcaag aggctcaggt gctgaagcag ttggcagaga agagggagca
      421 cgagcgagag gtgctccaga aggcgctgga ggagaacaac aacttcagca agatggcgga
      481 ggagaagctg atcctgaaga tggaacagat taaggaaaac cgtgaggcta atctagctgc
      541 tatcattgaa cgtctgcagg aaaaggagag gcatgctgca gaggttcgca ggaacaagga
      601 actgcaggtt gaactgtctg gctgaagcaa tggcgggtat ggcaagcccc tcccatagta
      661 aatccccctg cctatattat aatggatcat gcgatatcag tatgggaagt gtatgacatg
      721 gtttaaaaag aactcattat gaaaaacaaa acaaaaaaca gaatcaaaaa taaaataaaa
      781 atcaatgcgg tctctttgca gaatgttttg cttgatgttt aaaaaagtac cttggatctt
      841 attttgtaaa tatttacatt tttgttaaaa aatacaagta ttgcattatg caagttattt
      901 catgatctta catgtcctgt aacaggcttt tgacgttgtg tctttccact cagatggatt
      961 tgctaggtct gttcttttgg aagccccact cagtccctgc ccttttcatt ccaaccgaaa
     1021 aatgaggtca gtagacagtc tatggtgcta gaaacccacc attgcctaat gacctagatg
     1081 actccgtaat ctctgagcgt gaccaagacc acacctagat cgtgggtact gtgtgtccat
     1141 gtgaacctcc acatttgctc gtaatctgct tcctgcctag aagcggcaaa gccaggctaa
     1201 gggaatctac cagtcatagc acttatgtct gctcctcatg gattacgcgc tacacatgtg
     1261 tttgggtttt agaaacaggt gcatgtgaag acaaatctga gctcagtcag ggtagaagcg
     1321 aaaggctgaa ccttccaacg tgctgatcac aaacgcaaag ccagagggtt caagcagcca
     1381 tgggattgtt cttcatgaag tgggcttatt tctctcattt tagttattat gatgggatga
     1441 attaattgac atgtcgggtg gcttatctgt gggtgccatg ggtgatgatg ttcattttaa
     1501 gcttttgcct gtagtacaag cacataatgc tactgaacgt ttttccactt ggagactgtg
     1561 agctggttgc tgcattaaaa acacaaacaa aatcacaagc actgtggact tttactcaag
     1621 ctggtctttc ttccccagtg tagggcaatc ctgcctataa acaagaccaa accactccat
     1681 ctgtgatgct gacgcagtga aggggccagg cagggcattt gtgccaagta taagaatcag
     1741 cagacaccca gcatacgtac ctattgcagt tttgaagttg tttctcccta actcccaact
     1801 cccaactccc aaactgcctg catatttact cttcgtcagt gctatcttct tgtatgtcat
     1861 tgtgagcaag ctgtgatgaa taaagaattg gagttctgtg aact
//
