LOCUS       NM_028800               3523 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus serine/threonine kinase 40 (Stk40), transcript variant
            2, mRNA.
ACCESSION   NM_028800
VERSION     NM_028800.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3523)
  AUTHORS   Ndoja,A., Reja,R., Lee,S.H., Webster,J.D., Ngu,H., Rose,C.M.,
            Kirkpatrick,D.S., Modrusan,Z., Chen,Y.J., Dugger,D.L., Gandham,V.,
            Xie,L., Newton,K. and Dixit,V.M.
  TITLE     Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading
            c/EBPbeta in Microglia
  JOURNAL   Cell 182 (5), 1156-1169 (2020)
   PUBMED   32795415
REFERENCE   2  (bases 1 to 3523)
  AUTHORS   Cai,B., Li,M., Zheng,Y., Yin,Y., Jin,F., Li,X., Dong,J., Jiao,X.,
            Liu,X., Zhang,K., Li,D., Wang,J. and Yin,G.
  TITLE     EZH2-mediated inhibition of microRNA-22 promotes differentiation of
            hair follicle stem cells by elevating STK40 expression
  JOURNAL   Aging (Albany NY) 12 (13), 12726-12739 (2020)
   PUBMED   32657761
  REMARK    GeneRIF: EZH2-mediated inhibition of microRNA-22 promotes
            differentiation of hair follicle stem cells by elevating STK40
            expression.
REFERENCE   3  (bases 1 to 3523)
  AUTHORS   Hu,J., Li,S., Sun,X., Fang,Z., Wang,L., Xiao,F., Shao,M., Ge,L.,
            Tang,F., Gu,J., Yu,H., Guo,Y., Guo,X., Liao,B. and Jin,Y.
  TITLE     Stk40 deletion elevates c-JUN protein level and impairs mesoderm
            differentiation
  JOURNAL   J Biol Chem 294 (25), 9959-9972 (2019)
   PUBMED   31092598
REFERENCE   4  (bases 1 to 3523)
  AUTHORS   Wang,L., Yu,H., Cheng,H., He,K., Fang,Z., Ge,L., Cheng,T. and
            Jin,Y.
  TITLE     Deletion of Stk40 impairs definitive erythropoiesis in the mouse
            fetal liver
  JOURNAL   Cell Death Dis 8 (3), e2722 (2017)
   PUBMED   28358362
  REMARK    GeneRIF: comparison of microarray data between wild type and
            Stk40(-/-) E14.5 fetal liver cells reveals a potential role of
            aberrantly activated TNF-alpha signaling in Stk40 depletion induced
            dyserythropoiesis with a concomitant increase in cleaved caspase-3
            and decrease in Gata1 proteins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3523)
  AUTHORS   He,K., Hu,J., Yu,H., Wang,L., Tang,F., Gu,J., Ge,L., Wang,H.,
            Li,S., Hu,P. and Jin,Y.
  TITLE     Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator
            of Skeletal Muscle Differentiation
  JOURNAL   J Biol Chem 292 (1), 351-360 (2017)
   PUBMED   27899448
  REMARK    GeneRIF: Loss of Stk40 is associated with impaired fetal skeletal
            muscle formation.
REFERENCE   6  (bases 1 to 3523)
  AUTHORS   Wacker,B.K., Perfater,J.L. and Gidday,J.M.
  TITLE     Hypoxic preconditioning induces stroke tolerance in mice via a
            cascading HIF, sphingosine kinase, and CCL2 signaling pathway
  JOURNAL   J Neurochem 123 (6), 954-962 (2012)
   PUBMED   23043544
REFERENCE   7  (bases 1 to 3523)
  AUTHORS   Li,L., Sun,L., Gao,F., Jiang,J., Yang,Y., Li,C., Gu,J., Wei,Z.,
            Yang,A., Lu,R., Ma,Y., Tang,F., Kwon,S.W., Zhao,Y., Li,J. and
            Jin,Y.
  TITLE     Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway
            and controls extraembryonic endoderm differentiation
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1402-1407 (2010)
   PUBMED   20080709
  REMARK    GeneRIF: report identification of a target gene of Oct4,
            serine/threonine kinase 40 (Stk40), which is able to activate the
            Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn)
            differentiation in mouse embryonic stem cells.
REFERENCE   8  (bases 1 to 3523)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 3523)
  AUTHORS   Matsuki,T., Hori,G. and Furuichi,T.
  TITLE     Gene expression profiling during the embryonic development of mouse
            brain using an oligonucleotide-based microarray system
  JOURNAL   Brain Res Mol Brain Res 136 (1-2), 231-254 (2005)
   PUBMED   15893606
REFERENCE   10 (bases 1 to 3523)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ170090.1, AY336057.1, DV660319.1 and BQ030783.1.
            
            On Mar 12, 2009 this sequence version replaced NM_028800.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and uses a downstream translational
            start codon, compared to variant 1. The encoded isoform (b) is
            shorter at the N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.188116.1, AY336057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ170090.1         1-15
            16-2324             AY336057.1         1-2309
            2325-2653           DV660319.1         305-633
            2654-3363           AY336057.1         2639-3348
            3364-3523           BQ030783.1         1-160               c
FEATURES             Location/Qualifiers
     source          1..3523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 59.89 cM"
     gene            1..3523
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /note="serine/threonine kinase 40"
                     /db_xref="GeneID:74178"
                     /db_xref="MGI:MGI:1921428"
     exon            1..190
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            191..310
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1506
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /EC_number="2.7.11.1"
                     /note="isoform b is encoded by transcript variant 2;
                     serine/threonine-protein kinase 40; ortholog of
                     Ser/Thr-like protein kinase Lyk4; serine/threonine-protein
                     kinase lyk4"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 40 isoform b"
                     /protein_id="NP_083076.3"
                     /db_xref="CCDS:CCDS51300.1"
                     /db_xref="GeneID:74178"
                     /db_xref="MGI:MGI:1921428"
                     /translation="MKRRASDRGAGETSANAKALGTGIAGNNAKRAGPFVLGPRLGNS
                     PVPSIVQCLARKDGTDDFYQLKILTLEERGEQGIESQEERQGKMLLHTEYSLLSLLHT
                     QDGVVHHHGLFQDRTCEAVEDTESGRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQ
                     HYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFC
                     LGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD
                     SIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIAS
                     WQSLSSLSGPLQVVPDIDDQMSSSDSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSI
                     HEARAWVPKRQFGSMPPVRRLGHDAQPMTSLDTAILAQRYLRK"
     exon            311..396
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            397..540
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            541..768
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            769..821
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            822..937
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1082
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1202
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1287
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..3507
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3504
                     /gene="Stk40"
                     /gene_synonym="2310004N11Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttccgttgtc aggtggcggc gccgcagcca tggagggagg cggcggcggc agctctggcg
       61 gctgcgctgg gaggcggcgg tgagcggctc ccacgccccc ggcccggccc cggcccccgg
      121 gacggagcgc cgagcagccc cgactctggg ctgcggacta tgggcaagga gcgctgattc
      181 cccgggaaag aactgagaat gaagcggaga gcatcagaca gaggagctgg ggagacgtcc
      241 gccaacgcca aggctctagg aactggcatt gctggaaata acgcaaagag agcaggaccg
      301 ttcgtcctgg gtccccgcct gggcaactca ccggtaccga gcattgtgca gtgtttggca
      361 agaaaagatg gcacagatga cttctatcag ttgaagatcc tcacccttga ggagaggggt
      421 gagcaaggaa tagagagcca agaggagagg cagggcaaga tgctgctgca taccgagtac
      481 tctctgctct cgctgctgca cacacaggat ggcgtggtcc accaccatgg gctcttccag
      541 gaccgcacct gtgaagcggt cgaggacaca gagtctggtc ggatggtaaa gaagatgaag
      601 aaacgcattt gcctcgtcct tgactgcctc tgtgcacacg acttcagtga caagacggct
      661 gacctcatca acctgcagca ctatgtcatc aaggagaaga ggctcagtga gcgcgagact
      721 gtggtcattt tctacgacgt ggtccgggtg gtggaagccc tgcaccagaa aaacatcgtg
      781 caccgagacc tgaaacttgg gaacatggtg ctcaacaaaa ggacccatcg gataactatc
      841 accaacttct gccttgggaa gcaccttgtg agtgaagggg acctgctgaa ggaccagagg
      901 ggcagccccg cctacatcag tcctgatgtg ctcagcggcc ggccgtaccg gggcaagccg
      961 agtgacatgt gggccttggg cgtggtgctc ttcactatgc tctatggcca gttccccttc
     1021 tacgacagca tcccacagga gctcttccgc aagatcaagg ctgctgagta caccatccct
     1081 gaggatggga gagtctctga gaacacagtg tgtcttatcc ggaaactgct ggtccttgac
     1141 ccccagcaac gcctggctgc tgccgatgtc ctggaggctc tcagtgccat cattgcatct
     1201 tggcagtccc tgtcctctct gagtggccct ttgcaagtgg ttccggacat tgatgaccaa
     1261 atgagcagct ctgacagctc ccaggaggca aaggtgacag aggagtgctc ccaatacgag
     1321 tttgagaact acatgcgaca gcaactgctg ctggctgaag agaagagttc catccatgag
     1381 gcccgggcct gggtgcccaa gcggcaattc ggtagcatgc caccggtccg acggctaggc
     1441 cacgacgcac agccaatgac ctccttggac acagccatcc tggcacaacg ctatctgcgg
     1501 aaatagtgcc ctcagctagg gcactagccc agcacacctc ttctcggccc acctgaggcc
     1561 cagccatcgg gcctgcctgg gcccgggccc agcagtgctg gactgattct cccaggctgc
     1621 agtagggata gggcagggat agggacagcc caggtcacag ccagggtcaa cagaggtacc
     1681 acagagctac cttttgggat gattgcttga ttgttttttt atctgagaat tctagataga
     1741 tagctaatct gcttttaatc atgacatttt aatctacctc tgtctcttta accacgctgt
     1801 ctctggactg agtgtcagga gggaagaggg gagtctacgc tcacaaccca ggcactggac
     1861 agctgcagcc tggctaggcc actgacccca cagtccatat aagctgacca tgcagctcgc
     1921 tgctggcccc cagtaagcac cccttcccac cgtccactcc ccgtccccgg gggcctgccc
     1981 tcagtctaag ctttggaaca ctctcacctc acctgccgcc caagtcaaat ctatttattt
     2041 ttttactgaa cccaacttgt atctctaggt tcagcccttg gccactctgg ccctgagcct
     2101 ggctgaatag cagggcccgt gtgtgtaggc tcccttctca ccccaggcac ctaggagccc
     2161 tcttgccagt tcctctctcg ctctgtttcc agacctgtct ctctctctgt cctggcagct
     2221 tctctgaggt gctgctcgtt tgcattagtc ccgcctcctc catctttcat gtggtaccca
     2281 ggtaaatgtg gacatagtgt gaagggacct gtggccacca gaggatgctc tgggcctact
     2341 gaggacaggc cacttgtgct cagagaacct cacctcaccg cagaagtggt gcctcttcca
     2401 gaagactctg gaagattacc tacttggggg taggccttgg agggaaatct gtaggggtgg
     2461 ggaccttcct accttcctgg cttgagaaca gccctgctac cctttttgag ccgaaatttt
     2521 gaagtggatg cccgtcttgc cagaaacgct gttctctcca gaatgcccct ccctgcactg
     2581 gacttggcac acccaaaacc aagcaaagac ccaactccgg aggcctacct cctgtgtacc
     2641 ctcagagagg gcaatgtcac cctcctggta ggtagtccta gacccctcct gcctcttgct
     2701 ctccaatggg gagaccatgt ttcctagagt gtgagctgcc cctcaccccc tgaaaagctg
     2761 actcactgtg agtgaccttg ggcaagtccc caaacctcct tgtgcctcag tttccccatc
     2821 tggaaaaaat ggggccacct cttgccagca gtagcagggc tgcccatgcc ccttcctccc
     2881 catgccccat atccagccct gggctcctgt gcctctgttt tgctgggtct gtggagccca
     2941 cttgagccca gcagttaact cccctggcac tcagctctgc ctctagttca gccgcccagc
     3001 cactgagagt cagggcatgg tgctgcgggg gagggctctt ttctatattt atttgatagc
     3061 gataagtctc cgaagggagt ggaaatgcag tcagcctggg cccttagccc atgactaccc
     3121 tccagtgagg ctctgaggcc tggctagggc cctcctgggc agagcccctg cctagccctt
     3181 caggcctgat gcctcaggcc tgattccctc cttttaaagc aataccttca ggtctgccat
     3241 gccatcagcc agcctggttc cttctgaggg caacctgggt ctggtggtat ttctggtggt
     3301 gcagatgagg ggagggtggg gccctcgctg ctgtcaggca ctgagaagtc ctgttgtaaa
     3361 gaaaaacaaa aacaaaaaaa caaaaacaaa aacaaaaaaa acaaaatgga aaaagtcaca
     3421 aaaaagtttg tataaagacg tatttttgta ctacatgggg actcttcctg catgtcagca
     3481 ataaaacttc ctgatctgga gccaccaaaa aaaaaaaaaa aaa
//
