LOCUS       NM_021420               5246 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus serine/threonine kinase 4 (Stk4), mRNA.
ACCESSION   NM_021420
VERSION     NM_021420.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5246)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5246)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5246)
  AUTHORS   Zhang,J., Chen,W., Song,K., Song,K., Kolls,J. and Wu,T.
  TITLE     YAP activation in liver macrophages via depletion of MST1/MST2
            enhances liver inflammation and fibrosis in MASLD
  JOURNAL   FASEB J 38 (17), e70026 (2024)
   PUBMED   39215627
REFERENCE   4  (bases 1 to 5246)
  AUTHORS   Guo,Z.F., Tongmuang,N., Li,C., Zhang,C., Hu,L., Capreri,D.,
            Zuo,M.X., Summer,R. and Sun,J.
  TITLE     Inhibiting endothelial cell Mst1 attenuates acute lung injury in
            mice
  JOURNAL   JCI Insight 9 (17), e178208 (2024)
   PUBMED   39253972
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5246)
  AUTHORS   Wang,K., Yang,J., An,Y., Wang,J., Tan,S., Xu,H. and Dong,Y.
  TITLE     MST1/2 regulates fibro/adipogenic progenitor fate decisions in
            skeletal muscle regeneration
  JOURNAL   Stem Cell Reports 19 (4), 501-514 (2024)
   PUBMED   38552635
REFERENCE   6  (bases 1 to 5246)
  AUTHORS   Lee,K.K. and Yonehara,S.
  TITLE     Phosphorylation and dimerization regulate nucleocytoplasmic
            shuttling of mammalian STE20-like kinase (MST)
  JOURNAL   J Biol Chem 277 (14), 12351-12358 (2002)
   PUBMED   11805089
REFERENCE   7  (bases 1 to 5246)
  AUTHORS   Khokhlatchev,A., Rabizadeh,S., Xavier,R., Nedwidek,M., Chen,T.,
            Zhang,X.F., Seed,B. and Avruch,J.
  TITLE     Identification of a novel Ras-regulated proapoptotic pathway
  JOURNAL   Curr Biol 12 (4), 253-265 (2002)
   PUBMED   11864565
  REMARK    GeneRIF: MST1 is a phylogenetically conserved partner of the
            NORE/RASSF polypeptide family, and the NORE-MST1 complex is a novel
            Ras effector unit that mediates the apoptotic effect of Ki-RasG12V
REFERENCE   8  (bases 1 to 5246)
  AUTHORS   Lee,K.K., Ohyama,T., Yajima,N., Tsubuki,S. and Yonehara,S.
  TITLE     MST, a physiological caspase substrate, highly sensitizes apoptosis
            both upstream and downstream of caspase activation
  JOURNAL   J Biol Chem 276 (22), 19276-19285 (2001)
   PUBMED   11278283
REFERENCE   9  (bases 1 to 5246)
  AUTHORS   Osada,S., Izawa,M., Saito,R., Mizuno,K., Suzuki,A., Hirai,S. and
            Ohno,S.
  TITLE     YSK1, a novel mammalian protein kinase structurally related to
            Ste20 and SPS1, but is not involved in the known MAPK pathways
  JOURNAL   Oncogene 14 (17), 2047-2057 (1997)
   PUBMED   9160885
REFERENCE   10 (bases 1 to 5246)
  AUTHORS   Bagrodia,S., Taylor,S.J., Creasy,C.L., Chernoff,J. and Cerione,R.A.
  TITLE     Identification of a mouse p21Cdc42/Rac activated kinase
  JOURNAL   J Biol Chem 270 (39), 22731-22737 (1995)
   PUBMED   7559398
  REMARK    Erratum:[J Biol Chem 1996 Jan 12;271(2):1250]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY242850.1, AK028838.1 and AW046698.1.
            
            On Apr 24, 2018 this sequence version replaced NM_021420.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054521.1, SRR1660811.128766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY242850.1         2-41
            41-5229             AK028838.1         3-5191
            5230-5246           AW046698.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..5246
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.6 cM"
     gene            1..5246
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /note="serine/threonine kinase 4"
                     /db_xref="GeneID:58231"
                     /db_xref="MGI:MGI:1929004"
     exon            1..110
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            111..191
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..320
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            321..435
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..600
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..768
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..906
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1035
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1222
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1380
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..5232
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5210..5215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /note="hexamer: AATAAA"
     polyA_site      5232
                     /gene="Stk4"
                     /gene_synonym="Kas-2; Mst1; Ysk3"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgggag ggttcgcggg gcgggctccg ggaggatgga gcattgaggc agtctgggcg
       61 gctgccggca gcgccatgga gaccgtgcag ctgaggaacc caccgcgcag gcagctgaaa
      121 aagttggatg aagatagttt aaccaagcag cccgaggaag tgtttgatgt cttagagaag
      181 cttggagagg ggtcttatgg cagcgtgtac aaggctattc ataaagagac tggccagatt
      241 gttgcaatca agcaagtgcc cgtggaatcg gacctgcagg agataatcaa ggaaatctcc
      301 atcatgcagc agtgtgacag ccctcacgta gtcaagtatt atggcagcta ctttaagaac
      361 acagacctgt ggattgttat ggagtactgt ggggctggtt ctgtatctga tatcattcgg
      421 ctacggaaca agacgttaac agaagatgaa atagctacaa tattacaatc aactcttaag
      481 ggactagaat accttcattt tatgagaaaa atacaccgag atatcaaggc gggaaatatt
      541 ttgctaaaca cagaaggcca tgcaaagctt gcagactttg gagtcgcagg tcaacttaca
      601 gataccatgg caaagaggaa tacagtaata gggaccccgt tttggatggc tcctgaagtt
      661 attcaggaaa ttgggtacaa ctgtgtggca gacatctggt ctctgggaat aactgccata
      721 gaaatggctg aaggaaagcc cccatatgct gatatccatc caatgagggc aatattcatg
      781 attcctacaa accctcctcc cacattccgt aagccagagc tgtggtcaga caacttcatg
      841 gattttgtga agcagtgtct ggtaaaaagc ccggagcaga gagccacagc cactcagctc
      901 ctacagcacc cgtttgttaa gagtgccaaa ggagtgtcaa tattgcgaga cttaattaac
      961 gaagccatgg atgtgaaact gaagcgccag gaagcccagc agcgggaagt ggaccaggac
     1021 gacgaggaga actcagagga ggatgaaatg gattccggca cgatggttcg agctgccggt
     1081 gatgagatgg gcactgtccg agtagccagc acgatgagcg gaggagccaa tactatgatt
     1141 gagcacggtg acacgttgcc gtcccagctg ggcaccatgg tgatcaacac ggaggacgag
     1201 gaagaggaag gaaccatgaa aagaagagat gagaccatgc agcctgcaaa accgtctttc
     1261 cttgaatact ttgaacaaaa agaaaaggaa aatcagatca acagctttgg caagaatgta
     1321 tctggctctc tgaagaattc ttccgattgg aaaatccctc aggatggaga ctatgagttt
     1381 ctcaagagct ggactgtgga ggaccttcag aagaggctct tggccctcga ccccatgatg
     1441 gaacaggaaa tggaagagat ccggcagaag taccggtcca agcggcagcc aatcctggat
     1501 gccattgaag ccaagaagag gaggcaacag aacttctgac aacaccagcc cagccttggt
     1561 ggcttctggg ttgctagact catgtctgtt agccagcact tctgctctgt catctctcca
     1621 cagcaccttt gtgaactcag gaatgtgcgc cagtgggaag ggctgcttgg cagtcacagt
     1681 gccatttggt gtgtgcattt acactggcaa ggtgtatctt gaagggtttg tattggtgct
     1741 tttaactcag aattctagac cccaggagca gagactccta gttcagtgat agctgggaaa
     1801 ttttttacat tgtttctttt tgttttcctt ctagtaatag cttttggttg ctcgccctgg
     1861 aagacttttt aaaaatctat aaatatgcat atattatata tatatataaa ttataaatag
     1921 attccccact ctgtggtggt gtctctgtac aggtacagtt tcaaacactt tgcctctttc
     1981 ctgtgagatt atggtactgt gcagcaagcg ggcagaagac actgggaggc tcgtaggtgg
     2041 tcactgaatc ccagacgtca gcttcaccca ttgcagggtt gcatggagaa attagtcttg
     2101 ggatggttgt gccaccacag tgacgagcct cccatggtcc ccactggcct cggaagctgt
     2161 cggtgacgcc aggaaaaaat gtggagaact tgagagtttg ctcttttccc aggagacgcc
     2221 tgcaccctct ttgcagagta gcctttgctg tctcaacgcc tttcatccat cgccaccctc
     2281 ccagctgcct aaagtcgcat ccaagatact gcccagtgcc ttaagaggag acacatctgt
     2341 gaaaggacag gctttcaaga actttccagc aaaccaggcc ctatccagtc cagaaaatct
     2401 cagtgttcct gggtaaaatc acacacggca tttgttcttc atttcgtaga tacagggtaa
     2461 agggcattgc ttccatagtc cacatccaaa tacgtgattg tttatttttt cattcactgt
     2521 ggaggctctg gcaagggtaa attaatgccc aactgaggct cactcccaga aggcttagtt
     2581 ggattcagaa tggtagggaa gggactgtca tagtcatagt aggtctgatt gtattgtcca
     2641 ggtggaaaaa tgagactcag aggagaggtg acattaccaa caccacaaat cagggtagac
     2701 tagaagtagg gattggaatt cagagcattt gtcctgtacc actggaccaa gagcctcttc
     2761 actgagagaa tgaagctacc actgtacatc aggttggccc aggaacccct gctctttcct
     2821 tgcctctttg gtacctgagc tgctatggaa aggctcccca gaggagccgt gtcattcagt
     2881 cccagctact agtgggttcc ttactgtgtc ccagagacag acagtctctc atggagggcc
     2941 tgcagcaggg tagaggactt tgcagaagac agttacggag tcatccccgc atctttggct
     3001 caaaactgca gtcagaagga actgggaagc cagtcgccct attatttctt ctcatttcat
     3061 ccctccgatg ggagccctga tggggctgca cctgagcatt ctgaaattcg actccataat
     3121 tgcttttgct ccctaacctg agagtcgata aagtggcagg ggatgttctc ttctgtgacc
     3181 agattctgtt ctttgcaatt aaagcaagct ttaaaaaatg caagaggcag ctggtctgca
     3241 ggacttagcc aataaggtaa ctgtgtgaca gagagaatta ggacaattcg gggatcttgc
     3301 tgagatgata aatggctgct aggacttcct gggaagcacg tgtcaggcac tggcctaggt
     3361 gtactacagg tttcatcggg attccctggg cttattaagt tatttctcac atgatgaaat
     3421 ttcgtttgaa aggttccttc ccatgacact gtggattggg atgcatgaca tcatcctgtg
     3481 gggctggtag tcacagggac agcaaagtcc taaatgctta gaatgaagtg accgtggctt
     3541 ctcacgaaga cttaagtcta agtggtatgt tcttttaaag cttagaaacc aggtgaatta
     3601 atagtctagt ccccaagtca agaaagcttt taaaacccag tacacagggc ctgcataaca
     3661 tttgctgtgc tacttaatag cccagcttcg agctctttcc tcttgaagga aaatgctttg
     3721 ggctttgcca gacaaggaaa acgcccacag ctcccttctg aagcaagatg ggtgtacagg
     3781 aaaatagcct ttcctgtgac tcttctgcag ccatgaacct agatctggag tctatttggt
     3841 tgcaggcagg catgcatgtc tgcactgcgc ccacagcttg gtccacagtc aggtgcctgg
     3901 caggtcagct caccagccgt ttgccggaag ccggctgttt tggattcctg gcgaggcgta
     3961 tgtgctgttc ggtggcagaa gggagcaaac tgtcctttcc ttgaggaccg aatccaagga
     4021 accccgtctc acttctctag agcttgaaca tttgtggctc aggcttgcag tggactctct
     4081 gcttccaaga tgtggaggcc acacataaat cttcttacta gcaaacaaac aaaacctcat
     4141 actctctgaa catattgtag tgttgctccc attcagaagc ttgaagcaca tttccatctt
     4201 tatttccttt atatacattt ttattttata taagatttta cattccccag tagattggac
     4261 gagaatttga ctggctggac gtgagagagg ttgctgggtg tgtgaataaa cagagtagta
     4321 atcggaagcc tcaggagttg ggtcttgagt tccttacact gtagactagc acctgacaat
     4381 gccagattct tattttacca tttaaaactc agtacccctg tctaatgtca ggaatgagag
     4441 agatgacatc actgcagatc ctgcagacac tcagagacta gtagtaataa tattatgaac
     4501 agcttcttgc taatacattc cccagcttaa gtgaaatgga cagataccca gaaaattaca
     4561 aaggaactaa gcttactcag agatgaaatg gccaatcgca acagccccca gccccttttc
     4621 taccggaact tggtagctct gagagacatg ggactgacgc tccggtaaca actgtccctc
     4681 agtgtcatgc cagcagacaa gtcccattct tatgccactg gccttcccag cctaagtttc
     4741 aggctctaaa gattgctgtc ctttattctg ggggaagttt ttccagctca aactacaccc
     4801 tcaccctcac cacccttttt aaagcactgt ttttgtattt ttattagaat tacatgcatt
     4861 gtctttggaa tccgtgttct ttgtgtctct tccaccagcc tgcactcaga ccaacttgga
     4921 gagaaaaaaa aaatcttaaa tgctgttgct gatgtaaatt taaaaaaaaa atgtgaagtt
     4981 tgtagcttta atcttttgta acaaaaacta attaacactg gctgtaagtg ctgactcgaa
     5041 atgctatttt gtaaggtttg gatgtaaata atagaggtca gctgtttgta tatgtgtgag
     5101 acatagcttc ttccactgcc atttggtctt aacttgaggt acttcctgtg tgcttttatg
     5161 ttagagttgt cccctcattt ctcccccaac acctgtcacc cttgtgttaa ataaactgtc
     5221 ctttagacca caaaaaaaaa aaaaaa
//
