LOCUS       NM_172734               4617 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus serine/threonine kinase 38 like (Stk38l), transcript
            variant 1, mRNA.
ACCESSION   NM_172734
VERSION     NM_172734.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4617)
  AUTHORS   Rosianu,F., Mihaylov,S.R., Eder,N., Martiniuc,A., Claxton,S.,
            Flynn,H.R., Jalal,S., Domart,M.C., Collinson,L., Skehel,M.,
            Snijders,A.P., Krause,M., Tooze,S.A. and Ultanir,S.K.
  TITLE     Loss of NDR1/2 kinases impairs endomembrane trafficking and
            autophagy leading to neurodegeneration
  JOURNAL   Life Sci Alliance 6 (2), e202201712 (2022)
   PUBMED   36446521
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4617)
  AUTHORS   Wang,S., Chu,F., Xia,R., Guan,J., Zhou,L., Fang,X., Dai,T., Xie,F.,
            Zhang,L. and Zhou,F.
  TITLE     LPA maintains innate antiviral immunity in a pro-active state via
            STK38L-mediated IRF3 Ser303 phosphorylation
  JOURNAL   Cell Rep 41 (8), 111661 (2022)
   PUBMED   36417850
  REMARK    GeneRIF: LPA maintains innate antiviral immunity in a pro-active
            state via STK38L-mediated IRF3 Ser303 phosphorylation.
REFERENCE   3  (bases 1 to 4617)
  AUTHORS   Madencioglu,D.A., Caliskan,G., Yuanxiang,P., Rehberg,K.,
            Demiray,Y.E., Kul,E., Engler,A., Hayani,H., Bergado-Acosta,J.R.,
            Kummer,A., Muller,I., Song,I., Dityatev,A., Kahne,T., Kreutz,M.R.
            and Stork,O.
  TITLE     Transgenic modeling of Ndr2 gene amplification reveals disturbance
            of hippocampus circuitry and function
  JOURNAL   iScience 24 (8), 102868 (2021)
   PUBMED   34381982
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4617)
  AUTHORS   Waldt,N., Seifert,A., Demiray,Y.E., Devroe,E., Turk,B.E.,
            Reichardt,P., Mix,C., Reinhold,A., Freund,C., Muller,A.J.,
            Schraven,B., Stork,O. and Kliche,S.
  TITLE     Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine
            Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells
  JOURNAL   Front Immunol 9, 2852 (2018)
   PUBMED   30568657
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4617)
  AUTHORS   Leger,H., Santana,E., Leu,N.A., Smith,E.T., Beltran,W.A.,
            Aguirre,G.D. and Luca,F.C.
  TITLE     Ndr kinases regulate retinal interneuron proliferation and
            homeostasis
  JOURNAL   Sci Rep 8 (1), 12544 (2018)
   PUBMED   30135513
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4617)
  AUTHORS   Zhang,L., Tang,F., Terracciano,L., Hynx,D., Kohler,R., Bichet,S.,
            Hess,D., Cron,P., Hemmings,B.A., Hergovich,A. and Schmitz-Rohmer,D.
  TITLE     NDR functions as a physiological YAP1 kinase in the intestinal
            epithelium
  JOURNAL   Curr Biol 25 (3), 296-305 (2015)
   PUBMED   25601544
  REMARK    GeneRIF: NDR1/2 functions as a physiological YAP1 kinase in the
            intestinal epithelium.
REFERENCE   7  (bases 1 to 4617)
  AUTHORS   Rehberg,K., Kliche,S., Madencioglu,D.A., Thiere,M., Muller,B.,
            Meineke,B.M., Freund,C., Budinger,E. and Stork,O.
  TITLE     The serine/threonine kinase Ndr2 controls integrin trafficking and
            integrin-dependent neurite growth
  JOURNAL   J Neurosci 34 (15), 5342-5354 (2014)
   PUBMED   24719112
REFERENCE   8  (bases 1 to 4617)
  AUTHORS   Stork,O., Zhdanov,A., Kudersky,A., Yoshikawa,T., Obata,K. and
            Pape,H.C.
  TITLE     Neuronal functions of the novel serine/threonine kinase Ndr2
  JOURNAL   J Biol Chem 279 (44), 45773-45781 (2004)
   PUBMED   15308672
  REMARK    GeneRIF: Ndr2 is an interesting candidate gene for the regulation
            of structural processes in differentiating and mature neuronal
            cells.
REFERENCE   9  (bases 1 to 4617)
  AUTHORS   Stegert,M.R., Tamaskovic,R., Bichsel,S.J., Hergovich,A. and
            Hemmings,B.A.
  TITLE     Regulation of NDR2 protein kinase by multi-site phosphorylation and
            the S100B calcium-binding protein
  JOURNAL   J Biol Chem 279 (22), 23806-23812 (2004)
   PUBMED   15037617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ082246.1, AK052288.1 and AC164631.5.
            
            On Apr 9, 2010 this sequence version replaced NM_172734.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY223819.1, AK052288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CJ082246.1         1-65
            66-1708             AK052288.1         2-1644
            1709-4617           AC164631.5         96439-99347         c
FEATURES             Location/Qualifiers
     source          1..4617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..4617
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /note="serine/threonine kinase 38 like"
                     /db_xref="GeneID:232533"
                     /db_xref="MGI:MGI:1922250"
     exon            1..118
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            119..263
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1524
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase 38-like; nuclear
                     Dbf2-related kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 38-like isoform
                     1"
                     /protein_id="NP_766322.1"
                     /db_xref="CCDS:CCDS39712.1"
                     /db_xref="GeneID:232533"
                     /db_xref="MGI:MGI:1922250"
                     /translation="MAMTAGATTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERET
                     RQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFG
                     EVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDK
                     RNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDVKPDN
                     LLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNR
                     RQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQETYRK
                     VMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFFEGVDWGHIR
                     ERPAAIPIEIRSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLT
                     QRGSIPTYMKAGKL"
     exon            264..315
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            316..438
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            439..522
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            523..646
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            647..801
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            802..904
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            905..966
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1084
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1208
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1304
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1396
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..4617
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2334..2339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /note="hexamer: ATTAAA"
     polyA_site      2359
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /note="major polyA site"
     regulatory      4350..4355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /note="hexamer: AATAAA"
     polyA_site      4377
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
     regulatory      4591..4596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /note="hexamer: AATAAA"
     polyA_site      4610
                     /gene="Stk38l"
                     /gene_synonym="4930473A22Rik; Ndr2; Ndr54"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgctt tggcaccgcc tcacggggcg ggacgaggcg gggcctggcg cgagagacgc
       61 gcgccgcggg ctgcggtgac tgaggaggag gctgagcggg cgcgggcgac accggcagtt
      121 ccagttacta tggcaatgac ggcaggggca acaactacct ttcctatgag caaccatacc
      181 cgggaaagag taactgtggc caagctcaca ctggagaatt tttacagcaa cctaatttta
      241 cagcatgaag agagagaaac caggcagaag aagttagaag tggctatgga agaagaagga
      301 ttggcagatg aggagaaaaa gttacgtcga tcgcagcatg ctcgtaaaga aacagagttc
      361 ttacgcctta agaggaccag acttggccta gatgactttg agtctctgaa ggttatagga
      421 agaggagctt tcggagaggt gcggctggtc cagaagaaag acacggggca catctatgcc
      481 atgaagatcc tgaggaaagc tgacatgctt gagaaagagc aggtggctca tatccgagca
      541 gaaagggaca ttttggtgga agcagatgga gcctgggtgg tgaagatgtt ctacagtttt
      601 caggacaaac ggaatctcta tctcatcatg gaatttcttc ctggaggtga catgatgaca
      661 ttgctgatga agaaggacac cttaacagaa gaagagacac agttctacat ctcagagact
      721 gtcttggcga tagatgcaat tcaccagctg ggcttcatcc accgggacgt caaaccagac
      781 aaccttttac tggatgccaa gggacatgta aaattatctg attttggttt gtgcacgggg
      841 ttaaagaaag ctcacaggac tgaattctac agaaacctca cacataaccc gccaagcgac
      901 ttctcatttc agaacatgaa ttcaaagcgg aaagcagaga catggaagaa gaacaggaga
      961 cagctggctt actccacagt tggaacacca gactacattg ctccagaagt attcatgcag
     1021 actggctaca acaaattgtg tgactggtgg tccttgggag tgattatgta cgagatgcta
     1081 ataggctttc cacctttctg ctctgaaaca ccacaagaaa catacagaaa agttatgagc
     1141 tggaaggaga ctctggcatt tcctccggaa gtgcccgtct ctgagaaagc caaggacttg
     1201 attctcagat tttgtactga ttctgaaaac agaattggga atggtggtgt ggaagaaatc
     1261 aaaggtcatc cgttctttga gggtgtagac tgggggcaca taagggaaag accagcagct
     1321 attcctatag aaatccggag tatagatgac acctcaaact ttgatgactt ccctgagtct
     1381 gatatcttac agccagtgcc gaataccaca gagcccgact acaaatccaa agactgggtt
     1441 tttctcaatt acacctacaa aaggtttgaa gggctgaccc agagaggctc cattcctaca
     1501 tacatgaaag ctgggaagtt atgatgatca cagtcgccca tagccaggag aactcaggta
     1561 gctgcatccg caggctggct cggcatcagc accaggagct ctgggacagt gctgctctcc
     1621 agccagagga acgactacag cttgggaatc tgaggctgct atggctatgg gaattgctca
     1681 gctttttttt ttctttttct ttttttttgt attaacttta ttatacaaag gtactggaac
     1741 aaaagaaaca gacattccct cctaactgca ctgcctacgt gcatgttgag aggtccatcc
     1801 tgcccatgtg ctgcgcttcc gattgcaaca ctaatccagc cagaactgca ttgcactgac
     1861 ggcaccatga cagcctgagg ttgctctcag tgtccctgct tcactgcaga gcccgtgggt
     1921 ctagaatcag tgaaaagcca tcttctgtag ctgctgttag tagaacattt gccctgttgg
     1981 tttggacatt gtgggctcta catgaagaca gtttctgtac cggctccaag gaacttaagg
     2041 acgctgactt caacgacatt agaatttcct gtcaggctct cacgcagacc ctgtgatagg
     2101 gaagatgagc ttctgttagg gtgagggcat ttctcacctt cgctccggca tctccaaggc
     2161 tgacggtgct gagagattgt gacttgacga ctgatgtgca cacatggaga tggacctgaa
     2221 tgattgtcag ctactcactt ttaacaatgc tgtagcattg ttttagtttg aggatggtga
     2281 gctgagtttc agaaatgacc atgaaagctg cttgtagaac ctagtatgtt tttattaaac
     2341 tatttttttt aatgtcaaac ttctgatcag tcaatggaca ctgtggagag cagagtgtgg
     2401 ctcactgtgg ctttctgcag aggtggtact tgtccagctg gtgacccttt gttcccttga
     2461 ttgcactagt gccattgttt tccaatgaac caaagatcct gaacagtggc tgtcagcagg
     2521 gagtggagct ccggctttac aggggagctg cgctcccttg acagaggcca gccctgttca
     2581 ctgttagctc atcactgtgg ttaaagccca ttatgaaata caggaagtgg gtgctggctg
     2641 ggagggtgtg actggagact gggcagaaaa gtcagcatca gattcttggg gtgtttccct
     2701 aaggattaca tcatcttttc ttgcttagca ttttgattct gaaacaactt tctgaggaga
     2761 tgtagttttg tgagttgtag ttgtagtaac ttctcaggga atggctaatg tttatcatct
     2821 atgattgata tagtgagact ttatgggagg aatgcttctc ctgagggcac tgagcaatgc
     2881 cttgtgaccc ctctttcatc aaggccatca gctcctgatt tattttggtg agtcctttaa
     2941 ggcccccccc attttgctgt tgagtctggt aatcaacacc acttgttatc tactggctca
     3001 gctgtagcct gatcaatcct atgccaagta tttggagaaa gcactgaaaa tggtagataa
     3061 gcctccctga ctttagctgc cttaatatct gcagggtata tgagcttctc caagtagtct
     3121 gtctcaaggg tacttaagca gcagagaccc ctgaatatag ggattctacc ttttctttta
     3181 gaatgggact tttctagtgt gagtgtctag gttggatagg agaccttgcc aaattctcta
     3241 gctcaggtgt gataactacc taactatcgt agggtgggtg ttgtcaatcc aggtaactgg
     3301 ggtagtttga gattagtgta caggagaatt accaaactta tgtttccatg atgtagggac
     3361 agagcacttt gtctgatctc tctgttgtgg ttgtaaaagc tgtgagaggc aggtttcctg
     3421 gtggtggaga ggcattttgg gaagtttgct ttgcagcatt aacatggctg cccacttttc
     3481 aggaatttct tgtggaagcg ttccctaagc tagtgtaagg cccctaaaga ctgtctgcct
     3541 gttgaagcaa aaatacgagg catggtgcaa attgtgcaaa taatttgcag agatcctctg
     3601 atactgactt tttcccatta tacacttccc atattttagg taaataatgt aatttaagtg
     3661 ataaaaccct atcttaatca actgggcata gtgacatttt ctcttaatct ctattttgag
     3721 tctaggaagt tttattataa acggtggttt gggtttttct aaagatacag aaaatgtgta
     3781 taatccagat gtattggttt cctgattgag tagagacttg tactttttca ttaaaacctt
     3841 tgtgttgaag cagttgttca cagctaagtc tggagatgta tgaaacctgg gctgtccaaa
     3901 gtaagttgtg accacttaac caccgatcag ctgtgtggtg aaagtgccag ctatggaata
     3961 ttaaatgcgt tctttggctg ctaaggctta agatagggct cctttatttc cgtatcagca
     4021 tagctcttaa acacatgcat agctctgtac aagctgtaca ttttaaaata tcttgaagca
     4081 cagtttgttt tggtgttgag aatctagtcc accagtcagt ctctgacagc aggagagata
     4141 gctagccacc tacctatctt ttggcagtct acaagtaagt tacttgaggg tcagaaaagg
     4201 gtcctggcac atcctctctt tgaattgtta aaatttggaa aattcaaaag caactgtttt
     4261 gctatgatca tgattatttc tcattttatt tcaaaattat tttctctgta gaagtgcact
     4321 tatttctgaa aaatcttaag ccaacactta ataaatatga gacacttgag actactagaa
     4381 atattttaga tttttattac aaaatgtgag gagatgaagg aataaagtaa tagaagtgta
     4441 ttgtagtttt tgggggggtt ttgtttgttt ttttttttaa gcaatataat ccagcagttg
     4501 tccagaacca tcaggcttct gagcccatcc agcgtttcga agactgttgg gcaggggcat
     4561 tgagggcctc ttcattcacg gcacaacgag aataaagcca cgtttacaaa gctctgt
//
