LOCUS       NM_134115               3361 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus serine/threonine kinase 38 (Stk38), transcript variant
            1, mRNA.
ACCESSION   NM_134115 XM_973705
VERSION     NM_134115.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3361)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3361)
  AUTHORS   Rawat,P., Thakur,S., Dogra,S., Jaswal,K., Dehury,B. and Mondal,P.
  TITLE     Diet-induced induction of hepatic serine/threonine kinase STK38
            triggers proinflammation and hepatic lipid accumulation
  JOURNAL   J Biol Chem 299 (5), 104678 (2023)
   PUBMED   37028764
  REMARK    GeneRIF: Diet-induced induction of hepatic serine/threonine kinase
            STK38 triggers proinflammation and hepatic lipid accumulation.
REFERENCE   3  (bases 1 to 3361)
  AUTHORS   Rosianu,F., Mihaylov,S.R., Eder,N., Martiniuc,A., Claxton,S.,
            Flynn,H.R., Jalal,S., Domart,M.C., Collinson,L., Skehel,M.,
            Snijders,A.P., Krause,M., Tooze,S.A. and Ultanir,S.K.
  TITLE     Loss of NDR1/2 kinases impairs endomembrane trafficking and
            autophagy leading to neurodegeneration
  JOURNAL   Life Sci Alliance 6 (2), e202201712 (2022)
   PUBMED   36446521
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3361)
  AUTHORS   Wang,H., Bu,L., Shu,F., Bai,Y., Xue,F., Shi,S. and Sun,D.
  TITLE     Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related
            kinase 1 in Regulating Innate Immune Response to Interleukin
            17-induced Viral Pneumonia
  JOURNAL   Bioengineered 12 (2), 10335-10344 (2021)
   PUBMED   34699306
  REMARK    GeneRIF: Molecular Mechanism of Biofilm Locator Protein Kinase
            Dbf2p-related kinase 1 in Regulating Innate Immune Response to
            Interleukin 17-induced Viral Pneumonia.
REFERENCE   5  (bases 1 to 3361)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3361)
  AUTHORS   Pot,I., Patel,S., Deng,L., Chandhoke,A.S., Zhang,C., Bonni,A. and
            Bonni,S.
  TITLE     Identification of a Novel Link between the Protein Kinase NDR1 and
            TGFbeta Signaling in Epithelial Cells
  JOURNAL   PLoS One 8 (6), e67178 (2013)
   PUBMED   23840619
  REMARK    GeneRIF: a novel and intimate link between the protein kinase NDR1
            and TGFbeta signaling
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3361)
  AUTHORS   Zhou,Y., Adolfs,Y., Pijnappel,W.W., Fuller,S.J., Van der
            Schors,R.C., Li,K.W., Sugden,P.H., Smit,A.B., Hergovich,A. and
            Pasterkamp,R.J.
  TITLE     MICAL-1 is a negative regulator of MST-NDR kinase signaling and
            apoptosis
  JOURNAL   Mol Cell Biol 31 (17), 3603-3615 (2011)
   PUBMED   21730291
  REMARK    GeneRIF: Findings show a biological role for MICAL-1 in apoptosis
            and define a novel negative regulatory mechanism of MST-NDR
            signaling.
REFERENCE   8  (bases 1 to 3361)
  AUTHORS   Cornils,H., Stegert,M.R., Hergovich,A., Hynx,D., Schmitz,D.,
            Dirnhofer,S. and Hemmings,B.A.
  TITLE     Ablation of the kinase NDR1 predisposes mice to the development of
            T cell lymphoma
  JOURNAL   Sci Signal 3 (126), ra47 (2010)
   PUBMED   20551432
  REMARK    GeneRIF: reduction in the abundances of the NDR proteins NDR1 and
            NDR2 results in defective responses to proapoptotic stimuli,
            thereby facilitating the development of tumors
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3361)
  AUTHORS   Stegert,M.R., Tamaskovic,R., Bichsel,S.J., Hergovich,A. and
            Hemmings,B.A.
  TITLE     Regulation of NDR2 protein kinase by multi-site phosphorylation and
            the S100B calcium-binding protein
  JOURNAL   J Biol Chem 279 (22), 23806-23812 (2004)
   PUBMED   15037617
REFERENCE   10 (bases 1 to 3361)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167363.3, CT025867.20 and BE686860.1.
            
            On Oct 21, 2017 this sequence version replaced NM_134115.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009658.1, SRR7345562.1271774.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC167363.3         26027-26311         c
            286-418             AC167363.3         18325-18457         c
            419-470             AC167363.3         10733-10784         c
            471-593             AC167363.3         9614-9736           c
            594-677             AC167363.3         6494-6577           c
            678-801             AC167363.3         2393-2516           c
            802-956             CT025867.20        91164-91318         c
            957-1059            CT025867.20        88335-88437         c
            1060-1121           CT025867.20        86672-86733         c
            1122-1239           CT025867.20        84951-85068         c
            1240-1363           CT025867.20        83678-83801         c
            1364-1459           CT025867.20        83414-83509         c
            1460-1554           CT025867.20        82177-82271         c
            1555-2932           CT025867.20        80431-81808         c
            2933-3361           BE686860.1         1-429               c
FEATURES             Location/Qualifiers
     source          1..3361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.03 cM"
     gene            1..3361
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /note="serine/threonine kinase 38"
                     /db_xref="GeneID:106504"
                     /db_xref="MGI:MGI:2442572"
     exon            1..285
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..418
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1685
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /EC_number="2.7.11.1"
                     /note="NDR1 protein kinase; nuclear Dbf2-related kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 38"
                     /protein_id="NP_598876.1"
                     /db_xref="CCDS:CCDS28589.1"
                     /db_xref="GeneID:106504"
                     /db_xref="MGI:MGI:2442572"
                     /translation="MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMR
                     QKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGE
                     VRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKL
                     NLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNL
                     LLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRR
                     QLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKV
                     MNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKNNLFFEGVDWEHIRE
                     RPAAISIEIKSIDDTSNFDEFPESDILKPTVTTSSHPETDYKNKDWVFINYTYKRFEG
                     LTARGAIPSYMKAAK"
     exon            419..470
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..593
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..677
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..801
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..956
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1059
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1121
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1239
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1363
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1459
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1554
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..3351
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3326..3331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /note="hexamer: AATAAA"
     polyA_site      3346
                     /gene="Stk38"
                     /gene_synonym="5830476G13Rik; 9530097A09Rik; Ndr1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgctg cccggcgagc gccgctggcg gggggcgcat gcgcagtctc agccgcggcg
       61 gcccctctcc acagtctgag ggggtaccgg gggagccttg gcccctccgc gccgccgtct
      121 tttccggcag ttggggttct tccttttgtc ctgtcctgtc gcggatcggc agctgcgctc
      181 attcggagtc cccggcgtgt cgcggtcgct ctggagccgc ccgcacgtcg cgtctgcgcc
      241 gtctctgtag ccgtcggccc cgcgcctccc tcccccctgg gtctgccatg gcaatgacag
      301 gatcaacacc ttgctcatcc atgagtaatc atacgaagga gagggtgaca atgaccaaag
      361 tgacactgga gaatttttat agcaacctta tcgctcaaca tgaagaacga gaaatgagac
      421 aaaagaagtt agaaaaggtg atggaagaag aaggcctgaa agacgaagag aaacgactca
      481 gaagatccgc gcacgctcgg aaggaaacag agtttcttcg attaaagaga acaaggcttg
      541 gactggaaga ttttgagtct ttaaaagtca taggccgagg agcatttggt gaggtgcggc
      601 ttgttcagaa gaaagacaca gggcatgtgt acgcaatgaa aatcctgcgc aaagcagaca
      661 tgctcgagaa ggagcaggtt ggccacattc gtgcggagcg tgacattcta gtggaggcag
      721 acagtttgtg ggttgtgaaa atgttctata gttttcagga taagctaaac ctctacctaa
      781 tcatggagtt cctgcctgga ggggacatga tgactttatt gatgaaaaaa gatactctga
      841 cagaagagga gactcagttt tatatagcag agacagtatt agccatagac tccattcacc
      901 agctgggatt catccacaga gatatcaagc cagacaacct tctcttggac agcaagggcc
      961 atgtgaaact ttccgacttt ggcctttgca caggcctgaa aaaagcacac aggacagaat
     1021 tttataggaa cctgaaccac agcctgccca gtgatttcac ttttcagaac atgaattcca
     1081 aaaggaaagc agagacctgg aaaagaaaca gacgccagct agccttctct acagtgggca
     1141 ctcctgacta cattgctcca gaggtgttca tgcagacggg ttacaacaag ctctgcgatt
     1201 ggtggtcgct cggggtaatc atgtatgaga tgctcatcgg ctacccacca ttctgctccg
     1261 agaccccaca agagacatac aagaaagtga tgaactggaa ggaaactttg acctttcctc
     1321 cagaagttcc tgtctccgag aaagccaagg gcctgattct gaggttctgc tgtgaatggg
     1381 aacatagaat cggagcccct ggagttgaag aaataaaaaa taatcttttt tttgaaggtg
     1441 ttgactggga acacatcagg gagagaccag ctgcgatatc tattgaaatc aagagcatcg
     1501 atgatacctc aaacttcgat gaatttccag agtctgatat tcttaagccc acagtgacca
     1561 caagtagtca tcctgagacg gactacaaga acaaagactg ggtcttcatc aattacacat
     1621 acaagcgctt cgagggcctg acagccaggg gggccatacc ttcgtacatg aaagcagcaa
     1681 aatagggcct gtgctgggaa ccctaaatgg ggcagtggtc tctatacaac attgtggttt
     1741 tcctcttgcg ctcttgaaag aacttccaag aagtttgtag aattcattaa tacatcctag
     1801 tcaagtctct gaaatgtgat tgtaagtgga tattcctcca cggtgcaccg ggaagctgat
     1861 aggacagaga caagcatttt tccatcggcc ataagcagct gcttgcttct tttgaagccc
     1921 catgagccag tttggtatgt gctgtaaaga gaatttgatt tccccaagtt gatcagaatg
     1981 aaggggaaaa gcagctgccc actgttactg aactgttaca cactgagtac cagccaacgc
     2041 cctgtgctgt ggtgatgata tgccacctgc caagcccacc aagtattttt ctccttatag
     2101 ctgaaaattc tgtagttaaa taaggcaata atgaaagtct gtgtgaacag ccaacagtgt
     2161 ggcagaagga acaatctcgg tctcgcaggt gccggtggtt tctccccata ccttggccct
     2221 cacaagtggc tttccacagc cttcactcat ggtgcacttt acttatggta ctaggacaaa
     2281 gaccctgatc tactgacctg tctcccatcc aaaagactca tgctgctctt ctgttgatgg
     2341 gagaggtact agtgtgatcc tttttgatct tagaaagccc ataaaggcac tgggcactgc
     2401 caaggagttc tggaccctgt ggacaaccct tactttccct tcacggctgt agatcatctt
     2461 gaggcacaca ctgcctacca gcaagcaata cctgcaagtg ctgccatgca agtgcccaca
     2521 gcctccttgg gagtcaaggc aggaccagcc cgctgggtcc ttgagctcat tcctcaatcc
     2581 atggtgcaac cgtgtttgtc ttgatatttc cttaccccaa ctttagccat tttgccttgg
     2641 aatcatgatt acaaaatttt cctttgcaga tgccttcttg ggggcattct tgtccctcca
     2701 cccaaaaggg ttgcctgcag cttgggctga tacgcctctg ctgtggcgtt ctctcatgag
     2761 aaacactgaa tttagcacaa agtgccttct ctgtcatggc tgctgccacc tttagaagat
     2821 ttttcgctgt gtcagaaaaa tgtggaggtt ccatataatg actttggttt taagtgttga
     2881 taactgttaa ggcattattt gcacctgtgt ggtaacttgc agtcattggc caagctacaa
     2941 ctgggatcgg ccctccgctg gtcccgaagt ttgtgaagtc agctcagtct tagctcagcc
     3001 attcagagga tagaatttaa gacttataag cagaactgct ttgggttttc atgtcttaga
     3061 tgaagaaaaa ggaatgttag ggaagtctta actctgggtt aagatgttag ctccttaatc
     3121 ctctattcag agcctgctaa tgcaaaggag atagaagggc ctgggcgtgg ctttgtgttc
     3181 tattgataaa acagttgagg ctcgatcccc gtgtgtttgc aggagtgtgt ggtgagcatg
     3241 ggagaataag aatagtggta gagtctgtgt ggtggggatg attcatttgg ggggaaatgt
     3301 tcacatttta actattcaac ttttgaataa actgtgaaaa cgataatcga aaaaaaaaaa
     3361 a
//
