LOCUS       NM_183262               6204 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine/threonine kinase 35 (Stk35), transcript variant
            1, mRNA.
ACCESSION   NM_183262
VERSION     NM_183262.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6204)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6204)
  AUTHORS   Miyamoto,Y., Whiley,P.A.F., Goh,H.Y., Wong,C., Higgins,G.,
            Tachibana,T., McMenamin,P.G., Mayne,L. and Loveland,K.L.
  TITLE     The STK35 locus contributes to normal gametogenesis and encodes a
            lncRNA responsive to oxidative stress
  JOURNAL   Biol Open 7 (8) (2018)
   PUBMED   29970477
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6204)
  AUTHORS   Yasuda,Y., Miyamoto,Y., Yamashiro,T., Asally,M., Masui,A., Wong,C.,
            Loveland,K.L. and Yoneda,Y.
  TITLE     Nuclear retention of importin alpha coordinates cell fate through
            changes in gene expression
  JOURNAL   EMBO J 31 (1), 83-94 (2012)
   PUBMED   21964068
REFERENCE   4  (bases 1 to 6204)
  AUTHORS   Goyal,P., Behring,A., Kumar,A. and Siess,W.
  TITLE     Identifying and characterizing a novel protein kinase STK35L1 and
            deciphering its orthologs and close-homologs in vertebrates
  JOURNAL   PLoS One 4 (9), e6981 (2009)
   PUBMED   19756140
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6204)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 6204)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808137.4, AK006778.1, BC047277.1, AK085193.1 and AI431080.1.
            
            On Jun 27, 2009 this sequence version replaced NM_183262.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The use of an alternative upstream start codon would result in a
            protein that is 137 aa longer at the N-terminal.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138905.1, AK006778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AL808137.4         155483-155717
            236-462             AK006778.1         2-228
            463-480             AL808137.4         156502-156519
            481-1880            BC047277.1         1-1400
            1881-2388           AL808137.4         182939-183446
            2389-5781           AK085193.1         1-3393
            5782-5874           AL808137.4         186840-186932
            5875-6204           AI431080.1         1-330               c
FEATURES             Location/Qualifiers
     source          1..6204
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.19 cM"
     gene            1..6204
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /note="serine/threonine kinase 35"
                     /db_xref="GeneID:67333"
                     /db_xref="MGI:MGI:1914583"
     exon            1..330
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1644
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     serine/threonine-protein kinase 35 L1; CLP-36 interacting
                     kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 35 isoform a"
                     /protein_id="NP_899085.3"
                     /db_xref="CCDS:CCDS16732.2"
                     /db_xref="GeneID:67333"
                     /db_xref="MGI:MGI:1914583"
                     /translation="MGHQESPLTRAAAGGAAYIKRLRKVLSWRELGDGHGNLEAEASP
                     GSVAVITRAAPRRATRSARLPASRPTRLCRQARLGTDHPPARAPRGNRFARKRNSAGQ
                     ITIQGPAPPHLGARRRDEARGARAAPLLLPPPPAAMETGKENGARRGTKSPERKRRSP
                     VQRVLCEKLRPAAQAMDPAGAEVPGEAFLARRRPDGGGGDVPARPRYSLLAEIGRGSY
                     GVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQR
                     NGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEGGDLNQYVLS
                     RRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKV
                     CAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIW
                     AMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGVK
                     QLLKDMLAANPQDRPDAFELETRMDQVTCAA"
     exon            331..931
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1681
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..6195
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6150..6155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /note="hexamer: AATAAA"
     polyA_site      6195
                     /gene="Stk35"
                     /gene_synonym="1700054C12Rik; CLIK1; Stk35l1"
                     /note="major polyA site"
ORIGIN      
        1 ggctctccgc tggcctcctg ggggatgggc caccaggaat ctccgctgac cagagcggcg
       61 gcgggaggtg cagcttacat aaagaggtta cgtaaagtgc tcagctggcg tgaactcggg
      121 gacggccacg ggaacctgga agccgaggcc tcccccggga gcgttgctgt catcacaaga
      181 gcagcgccgc gacgcgctac acgctcagcc aggctccccg cctcgcgccc tacccggctc
      241 tgcagacaag cccggctcgg aacggaccat cctccggcgc gggctccaag ggggaaccgg
      301 ttcgcccgga agaggaacag cgccggccag atcaccatcc aaggtcccgc tcctccacat
      361 ctcggggcta gacggaggga tgaggcaagg ggggcccggg cggcgccgtt gctgctcccc
      421 ccgccccccg cagccatgga aacggggaaa gagaacggag cccgcagagg gacaaaaagc
      481 ccggagcgga aaaggcgaag cccagtccag cgggtactgt gcgagaagct gaggccggcg
      541 gcccaggcca tggatccggc tggggccgag gtcccgggcg aggccttcct ggcccggcgg
      601 cggccggatg gcggcggcgg ggatgttcct gcacggccgc gctacagcct cttggcggag
      661 atcgggcgcg gcagctacgg cgtggtttat gaggctgtgg ctgggcgcag tggggccagg
      721 gtggcagtca agaagatccg ctgcgacgct cccgagaacg tggagttggc actagcagaa
      781 ttctgggccc tcaccagtct caagcggcgg caccagaata tcgtgcagtt tgaggagtgc
      841 gtcctacagc gcaacgggtt agcccagcgc atgagtcacg gcaacaagaa ctcacagctt
      901 tacctgcgcc tggtggagac ctcgctcaaa ggagaaagga tcctgggcta tgctgaggag
      961 ccctgctatc tctggtttgt catggagtac tgtgaaggtg gagacctcaa tcagtatgtc
     1021 ctgtcccgga gacctgaccc agccaccaac aaaagtttca tgctacagct tacaagcgcc
     1081 attgccttcc tgcataaaaa ccacatcgtg cacagggacc taaagccaga caacatcctg
     1141 atcacagagc ggtctggcac ccccatcctc aaggtggcag actttggact gagcaaggtc
     1201 tgtgcagggc tggcaccccg aggcaaagag ggcaatcaag ataacaaaaa tgtgaatgtg
     1261 aataaatact ggctgtcctc agcttgtggc tcagacttct acatggctcc cgaagtctgg
     1321 gagggacact atacagccaa ggcggacatc tttgctctgg gcattatcat ctgggcaatg
     1381 atagaaagaa ttacctttat tgactctgaa accaagaagg agctcctggg gacctacatt
     1441 aagcaaggga ctgagatcgt ccctgttggt gaggcgctgc tagaaaaccc aaagatggag
     1501 ttgcatatcc cccagaaacg taggacttcc atgtctgagg gggtcaagca gctcttgaaa
     1561 gacatgttag ctgctaaccc acaggaccga cctgatgctt ttgaacttga aacccgaatg
     1621 gaccaggtca catgtgctgc ttaaactcca gggctgaacg tcttgggtgt ttttaaacta
     1681 ggtcgatcct tcgggaccca cagtctcatc gtgtctcgga caggatggca gagggtacag
     1741 gtggtggtga tctcctgaca gctggacctc ccacaatgtg aagctcacgc ttgggctgcc
     1801 cactctaccc ttctctttct ccttcagtag aataataatt gtttttctaa acattaaacc
     1861 atcaagactt ctgaagagca gaaggctaca ctctggacag gcaccttttt attgtttttg
     1921 ttttgttttg ttttgttttt tttaagaaca ttgaatgtgg acaaagctta tgcatatagt
     1981 cactgttaat ctgttgagtt cttaagttag gaagcagttt tggttttctc tttcacgttc
     2041 tgttttcttt ctttacacac atctcagttc tgctttagca ccccacttcc cacagaattc
     2101 tgtctcccca gagtttggta tttctcctgg aaagggatgc gaacaaagag ctaaggaagc
     2161 agcctctgag ttgcctcccc cagatgtggg agctgctgac tcctgggaag ggctggttgg
     2221 tcctggcctc agacaggatc agagatgaag aacctctcag aagaggaaca ccaggggttg
     2281 gcccgaggga ctctagaaag aagacctaaa ccatgggttt ggttctcgtt aagttcttga
     2341 gagccccagg ccacaccagg actccctgta gtgggcattg cttccctctt ttgccctgag
     2401 tccctgagga aagaaaccaa gagtggtcat cccatcactt ggggattgag actccatccc
     2461 cactctttgc acaagcctat cttctattag gactgttgtg ccaaccccct gtcaaacttg
     2521 gtcttccttg gcctcttgtc actactatga gaccagtacc tttcatcctc tcctggattg
     2581 tcttctctgt gtgctacaag tccagcctgt cacagacact acctaggtct caagatccag
     2641 ttttgatcct tgcagagtac ccttaactgg ctgctgacat catttcctca cagtgaaagg
     2701 tgtgccctgt gtaccaggat ccctagtgtc accactgggt gacactgtca agcgccatct
     2761 ctcttacccc cagggacttc atgttaggtg atcaacctcc atgtcactgt tgtctgataa
     2821 gcagagaaag gacctgcctt gaagagggag gtctgaggca gatgggagtg tccaggtggc
     2881 taatagaggc ccatgtagca gctagccata taaagcactg cgacacacat tttgacttgt
     2941 acctccttgc agtgttctga cagcctcctg agggaagatc tcctccctcc agctgcctca
     3001 tggacccacc attctctctg gtgttgccct ctacttagac gcacctttgg ttgctccaaa
     3061 acttttccag acttttcacc ttgttctggc cttgtgggat ggggtctctg gacaaggaaa
     3121 gaaggtatct gtgttcattc ttgtttatac ttcctaaact agcacagggt ggatagagat
     3181 ataagaggtc agggggagct ttccctcaag caggggtccc ttgttcctgc agcgtggggg
     3241 aaggccagca cagctgaccc tgacagctgg ccccgcttag cagcgctgtc cacgtttctc
     3301 tttccagcct tctggtaggc aactcagcac caaagtttct ttctcctctt ggccagaggt
     3361 cagctgctgt tcctgtgggt acatgactgc aggtgggagc cctaccttgt gctgcactgt
     3421 gatagcatct cgtctccttg agtgacttta taagcagcct cctgagccta atcagagtgg
     3481 cccctgggag agtgggaaca gcggcgtccc ctaagtgcaa gatacattcc atttctgttc
     3541 tgctgccctc cctccccttg ggtgctgcaa tctctttgtg cctgagcaga tgggaaaagc
     3601 agtctctgag ctcaggaccc cgactcttcc tgctctagtc ctgctctggg ttcctgataa
     3661 aggctcacta tctaccttat tcttttcttt cccgtctcta acaaggcctg ggttatagtg
     3721 ctttcccacc gtacttttct tggtgtcagt gtagcctctg cagtttgcag gtgggtagcc
     3781 tagtgagggg tagcctgctt ccctgcacct tctcttccat gaatcccagc tgcttctggc
     3841 ctggagattg cacctctttc tctggctcca gtgagagcca tgtcttgagc cccaagtgcc
     3901 tcctcctgct gttttcattc ttccctccct gtagtccctg ctatctatca cctgccagcc
     3961 agctgcaggc tggccccagg acatgcttgc tgtgctgtgg ctggtgggtc aggacccctg
     4021 tgggctctgc agtcttctca gagtccagct ccctgtccct cttggagatg gacatccttt
     4081 tcctctgtta cttccctctt ctgcctctgt ctggggtgca gacttgccag tagaagctct
     4141 ggggcatctg atcttgggtg cctccaggtt tgttaaatct gttcacattc tagaagtttg
     4201 cagaactctt aacgtttgtc cttttggggg tggtggtgag gattgcctgt tgggagacta
     4261 gcctggcctc agttctcagt tctgagcgca ggatagatag atcatagtgc cttacttatt
     4321 ccattgtctt cccctgtcca gactcagcca gaagcaggtg gctgtcttct ggctcatttt
     4381 gtcacttata ctcacagtct cccacctgta tatagccaca ggagaaggaa acctgagccc
     4441 ccagccacct cctgtgggct atagccagac acacacccct ctcgcctgcc tccgtggccc
     4501 tcacagcagc tttagaccag gaccaaatgc tgctgcccac atatgcacac tgcctttgtt
     4561 cctccctgtt cttagctcta gccaggacga cactgactgc accatccaaa ctggcaccag
     4621 ctaaccccct ctggtcactg gagaccaagg ttcgggctct agcctcacct agcttatggg
     4681 gcactggggc agggagtaag aactccagtc ccaccttgta gggtttgccc tttggctgcc
     4741 tgagggatgt tttaatgttt acttaaagaa aataccctgt ttacagctgg aggagaaaca
     4801 cgctcacact aggtgaaggt ctgactctgg atagggcctg gcctcctttg tggcactgcc
     4861 agtagtaact gcagtggtgg tgaaggcgga gaagcccgga gggagcagag gctcttgact
     4921 cactcctctt cctaaccctg tggtgctgag accactccct gttttcctca tagccttttt
     4981 gcctcactaa tccccatggt gtcatttcct tcctccaaga ttctcagctc taacatatca
     5041 ctattttaga aaaccagtgt tttgcagcaa taaagttata ttgttttgtg tgaatcttat
     5101 tccaagaaga ggaaaagagc attgtgggaa tctgttgatg ctattagctg tttactgttt
     5161 gagaagatag ctcggaggga tggatgaata tggcttttaa cctttaggta tcttgaagag
     5221 tgggaagagc aagagtttga ctgctgtcct cccaggaggg actgtacggc cctcgcctta
     5281 ctctgatgtg ccccttcctg ccctgccctg cccaccagga gctcttccat ctctcttcct
     5341 cccaccccat ctgggggcac tgggggggct caactctagg caggtctttg ggttacccct
     5401 ccctgtgact ggatctctct ccctacaaga cagctgctgg gagtctacct ccgaattggc
     5461 tgagattgct gcttcggccc tccaggccag cagactctgg aggctgaggc ttctgccttc
     5521 tctgattccg agctcatgca cacaggtcag cacaggcctg actttgaggg aaaggagcct
     5581 tgtctggaca catgctctgg aaggagaacc cagtaggtac tggcatcttg gctgatgtcg
     5641 gtatccacag ccattactga gggccaagtc tgctaccatt cattgcctag ggcccctagt
     5701 attggggaga gtgccagaac aagtgggcct tccccccccc ccccgccttt taaaatccag
     5761 atgagatcat aggaaaaagg aaacctattt aggggacttc cccccccccc ccccaacact
     5821 tttaccccaa gggctccttg ccgtcaaaac tggaggatat ttcagttact cttaatgctc
     5881 atgtgggtca aacttggttt tgaaagaggt ttaaagccag gcacaaggtt agtttcaaat
     5941 actagttaat ccaatttttt tccttttttt tttttttttt gcacagaagc tggtaatata
     6001 ggacctatgt gtgaacttta tatgaatatt tttttgtact tggcttactt gggttgttat
     6061 gataacatat ttaagttcct tgaacactgt ggattccccc taatgtgtat gaatgactga
     6121 aacgttgtaa attaagggac gtttgtgtga ataaagttat ttgatggggt caaaaagcca
     6181 tacgctattt gaaaaaaaaa aaaa
//
