LOCUS       NM_054103               2402 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus serine/threonine kinase 33 (Stk33), transcript variant
            1, mRNA.
ACCESSION   NM_054103 XM_358897 XM_489715 XM_910887
VERSION     NM_054103.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Ku,A.F., Sharma,K.L., Ta,H.M., Sutton,C.M., Bohren,K.M., Wang,Y.,
            Chamakuri,S., Chen,R., Hakenjos,J.M., Jimmidi,R., Kent,K., Li,F.,
            Li,J.Y., Ma,L., Madasu,C., Palaniappan,M., Palmer,S.S., Qin,X.,
            Robers,M.B., Sankaran,B., Tan,Z., Vasquez,Y.M., Wang,J.,
            Wilkinson,J., Yu,Z., Ye,Q., Young,D.W., Teng,M., Kim,C. and
            Matzuk,M.M.
  TITLE     Reversible male contraception by targeted inhibition of
            serine/threonine kinase 33
  JOURNAL   Science 384 (6698), 885-890 (2024)
   PUBMED   38781365
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Yu,W., Li,Y., Chen,H., Cui,Y., Situ,C., Yao,L., Zhang,X., Lu,S.,
            Liu,L., Li,L., Ren,J., Guo,Y., Huo,Z., Chen,Y., Li,H., Jiang,T.,
            Gu,Y., Wang,C., Zhu,T., Li,Y., Hu,Z. and Guo,X.
  TITLE     STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate
            Sperm Flagella Assembly in Spermiogenesis
  JOURNAL   Mol Cell Proteomics 22 (6), 100564 (2023)
   PUBMED   37146716
  REMARK    GeneRIF: STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to
            Regulate Sperm Flagella Assembly in Spermiogenesis.
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   Xie,Y., Lv,X., Ni,D., Liu,J., Hu,Y., Liu,Y., Liu,Y., Liu,R.,
            Zhao,H., Lu,Z. and Zhou,Q.
  TITLE     HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis
            induces tyrosinemia and neurological damage
  JOURNAL   Nat Commun 10 (1), 4266 (2019)
   PUBMED   31537781
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2402)
  AUTHORS   Zhou,M., Sun,G., Zhang,L., Zhang,G., Yang,Q., Yin,H., Li,H.,
            Liu,W., Bai,X., Li,J. and Wang,H.
  TITLE     STK33 alleviates gentamicin-induced ototoxicity in cochlear hair
            cells and House Ear Institute-Organ of Corti 1 cells
  JOURNAL   J Cell Mol Med 22 (11), 5286-5299 (2018)
   PUBMED   30256516
  REMARK    GeneRIF: he findings from this work indicate that STK33 decreases
            the sensitivity to the apoptosis dependent on mitochondrial
            apoptotic pathway by regulating ROS generation after gentamicin
            treatment, which provides a new potential target for protection
            from the aminoglycoside-induced ototoxicity.
REFERENCE   6  (bases 1 to 2402)
  AUTHORS   Castro,D.S., Skowronska-Krawczyk,D., Armant,O., Donaldson,I.J.,
            Parras,C., Hunt,C., Critchley,J.A., Nguyen,L., Gossler,A.,
            Gottgens,B., Matter,J.M. and Guillemot,F.
  TITLE     Proneural bHLH and Brn proteins coregulate a neurogenic program
            through cooperative binding to a conserved DNA motif
  JOURNAL   Dev Cell 11 (6), 831-844 (2006)
   PUBMED   17141158
REFERENCE   7  (bases 1 to 2402)
  AUTHORS   Mujica,A.O., Brauksiepe,B., Saaler-Reinhardt,S., Reuss,S. and
            Schmidt,E.R.
  TITLE     Differential expression pattern of the novel serine/threonine
            kinase, STK33, in mice and men
  JOURNAL   FEBS J 272 (19), 4884-4898 (2005)
   PUBMED   16176263
  REMARK    GeneRIF: STK33/Stk33 expression pattern resembles those of some
            related members of the calcium/calmodulin dependent kinase group
REFERENCE   8  (bases 1 to 2402)
  AUTHORS   Mujica,A.O., Hankeln,T. and Schmidt,E.R.
  TITLE     A novel serine/threonine kinase gene, STK33, on human chromosome
            11p15.3
  JOURNAL   Gene 280 (1-2), 175-181 (2001)
   PUBMED   11738831
REFERENCE   9  (bases 1 to 2402)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
REFERENCE   10 (bases 1 to 2402)
  AUTHORS   Cichutek,A., Brueckmann,T., Seipel,B., Hauser,H., Schlaubitz,S.,
            Prawitt,D., Hankeln,T., Schmidt,E.R., Winterpacht,A. and Zabel,B.U.
  TITLE     Comparative architectural aspects of regions of conserved synteny
            on human chromosome 11p15.3 and mouse chromosome 7 (including genes
            WEE1 and LMO1)
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 277-283 (2001)
   PUBMED   11528126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014819.1, BB614724.1 and AW061264.1.
            
            On or before Jun 27, 2009 this sequence version replaced
            XM_489715.3, XM_910887.2, XM_358897.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014819.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               AK014819.1         2-407
            407-407             BB614724.1         315-315
            408-742             AK014819.1         409-743
            743-743             BB614724.1         643-643
            744-2387            AK014819.1         744-2387
            2388-2402           AW061264.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.21 cM"
     gene            1..2402
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /note="serine/threonine kinase 33"
                     /db_xref="GeneID:117229"
                     /db_xref="MGI:MGI:2152419"
     exon            1..137
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            138..331
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            332..682
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            683..793
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            794..907
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1012
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1151
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1240
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1328
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1404
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1517
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1603
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1753
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2394
                     /gene="Stk33"
                     /gene_synonym="4921505G21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaccccg tccacctcct gggtcggcat cccgggcctt agaaaagttc agcttcttta
       61 ggtgtggcgt tcggggctgg gggaccactc gggtccaagt gtgtgcctct gtcaggggca
      121 gcccgccggc cgttgtgaac agaccctgct gtggtgagaa gcagagcctc actttgacaa
      181 atgtattggc tgttttgttg gagaacagaa atgaagctcc tgggtgactc atagaagctc
      241 tccacgtcct ggatgcagct actggatact tctttgttaa caggcaaatc agaaggctgg
      301 agcaagaaag aactgcgaag ctgatgtcat tctcccatgt gtgaagtgtg gtacctcatt
      361 aacccaagga cttcaccaac aggaagctgt attctttacc agcaacccac cacgtccctt
      421 ttaatctggt tttctttttc aaaaagtgga aaccttcttt tgagttctaa tggctgaccc
      481 cagcttgaat gacaacccta cagcatgccc tcactgtgca tcctctcagg ctggcctact
      541 gtgtgtatgt ccagcaggca agtctccagt cctggtggtg gaaatgtcac agacatcgag
      601 tattggtagt acagaatttt ttgcttcaca agaaagaaaa aaggaaagaa ataccagcag
      661 agaatcttct ctaaaagatt tgtccataag aacttcaaat gtggagagaa aacctcaggc
      721 acaatggagt cggagcaatg tcacagtagg aaaaatccca cacataagaa tggacgatgg
      781 agcaggtatc gaggaattct atacctttgg aagaatattg ggacagggga gctttggaat
      841 ggtctttgaa gctatagaca aggaaacagg agctaagtgg gcaattaaaa aagtgaataa
      901 agaaaaggct ggaagttctg caatgaagct actggagcgg gaggtgagca tcctgaagac
      961 tgtcaaccat caacacatca tccacctgga acaagtgttt gagtcgcctc agaaaatgta
     1021 tctcgtgatg gagctttgtg aggatggaga actcaaagca gttatggatc aaagagggca
     1081 cttctcagag aacgagacaa ggctgataat tcaaagtctt gcatcagcca tcgcatatct
     1141 tcataacaag gatatagtgc acagagatct aaagctggaa aacataatgg ttaaaagcag
     1201 ctttatagat gataacaatg aaatgaactt aaacataaag gtgactgatt ttggcttgtc
     1261 tgtgcagaag catggctcca ggagtgaagg catgatgcag actacatgtg ggactcctat
     1321 ctatatggca ccagaggtca tcaatgccca tgactacagc cagcagtgtg acatttggag
     1381 cataggtgtc ataatgttca ttttactgtg tggagagcca ccctttttgg caaattcaga
     1441 agaaaagctc tatgaattaa taaaaaaggg agaactacga tttgaaaatc cagtctggga
     1501 atctgtaagt gattctgcaa aaaatacttt gaaacaactc atgaaagtag atcctgctca
     1561 cagaatcaca gctaaggaac ttctagataa ccaatggttg acaggcaata ccctttcttc
     1621 agcaagacca accaatgtat tagaaatgat gaaagaatgg aaaaataacc cagaaagtga
     1681 tgaggagacc aacacagatg aggagactga gcagagcgct gtctacagtc catctgcaaa
     1741 cacagcaaag cagcccacca atgcagccaa gaagcctgct gcagagagtg ttggcatgac
     1801 ctcttcaaac tcatcgtcca gcaaactcct gtctgctgaa agcaaagcag aaccagagaa
     1861 aagctccgag actgtaggcc atgcatcagt ggctaaaacc actctgaaat ccactacctt
     1921 gtttcgaggc aagaaaaggc tctaaggttc tgtccagtgc tgagcagttc aagaacagac
     1981 cactcttcca gcaccgaagg gaggggacag gaggaagcag cccagcaccg agctttcagc
     2041 caccggctct catgagccct gcccctttac accagtttaa aattgaagct agttacctcc
     2101 aagcagcaca gcctgcgcag ggcactaaag gacagccatg ggtatgcttg gggcaggctg
     2161 ctgccctcac cagctcaagg cgttgttcca cgattgttaa agggataagt gctggggcca
     2221 tgctcgctta gttctactca aatccttata tttaggcaca gttatttata agagaacaca
     2281 agaggccaaa tgcagtgatg ggggttctaa ataattatgt gcactctgca ctgggagact
     2341 ttgttagagg attactaata aaatggccac aggcattgtg gcagaagtga tgcaaaaaaa
     2401 aa
//
