LOCUS       NM_029916               3238 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus serine threonine kinase 31 (Stk31), transcript variant
            1, mRNA.
ACCESSION   NM_029916
VERSION     NM_029916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3238)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3238)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3238)
  AUTHORS   Ge,W., Wang,J.J., Zhang,R.Q., Tan,S.J., Zhang,F.L., Liu,W.X.,
            Li,L., Sun,X.F., Cheng,S.F., Dyce,P.W., De Felici,M. and Shen,W.
  TITLE     Dissecting the initiation of female meiosis in the mouse at
            single-cell resolution
  JOURNAL   Cell Mol Life Sci 78 (2), 695-713 (2021)
   PUBMED   32367190
REFERENCE   4  (bases 1 to 3238)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3238)
  AUTHORS   Zhou,J., Stein,P., Leu,N.A., Chmatal,L., Xue,J., Ma,J., Huang,X.,
            Lampson,M.A., Schultz,R.M. and Wang,P.J.
  TITLE     Accelerated reproductive aging in females lacking a novel
            centromere protein SYCP2L
  JOURNAL   Hum Mol Genet 24 (22), 6505-6514 (2015)
   PUBMED   26362258
REFERENCE   6  (bases 1 to 3238)
  AUTHORS   Zhou,J., Leu,N.A., Eckardt,S., McLaughlin,K.J. and Wang,P.J.
  TITLE     STK31/TDRD8, a germ cell-specific factor, is dispensable for
            reproduction in mice
  JOURNAL   PLoS One 9 (2), e89471 (2014)
   PUBMED   24586802
  REMARK    GeneRIF: The function of STK31 may be redundant with other Tdrd
            proteins in germ cell development.
            GeneRIF: STK31 is expressed in embryonic gonocytes of both sexes
            and postnatal spermatocytes and round spermatids in males.
            Disruption of the tudor domain and kinase domain of STK31
            respectively does not affect fertility in mice.  Our data suggest
            that the function of STK31 may be redundant with other Tdrd
            proteins in germ cell development.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3238)
  AUTHORS   Bao,J., Yuan,S., Maestas,A., Bhetwal,B.P., Schuster,A. and Yan,W.
  TITLE     Stk31 is dispensable for embryonic development and spermatogenesis
            in mice
  JOURNAL   Mol Reprod Dev 80 (10), 786 (2013)
   PUBMED   23929668
  REMARK    GeneRIF: Stk31 is dispensable for both embryonic development and
            spermatogenesis in mice.
REFERENCE   8  (bases 1 to 3238)
  AUTHORS   Bao,J., Wang,L., Lei,J., Hu,Y., Liu,Y., Shen,H., Yan,W. and Xu,C.
  TITLE     STK31(TDRD8) is dynamically regulated throughout mouse
            spermatogenesis and interacts with MIWI protein
  JOURNAL   Histochem Cell Biol 137 (3), 377-389 (2012)
   PUBMED   22205278
  REMARK    GeneRIF: Our findings suggest mouse STK31 could be a potential
            nuage-associated protein in the cytoplasm of mid-to-late
            spermatocytes and play pivotal roles related to fertilization.
REFERENCE   9  (bases 1 to 3238)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153385.3.
            
            On Sep 17, 2009 this sequence version replaced NM_029916.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF285580.1, BC137989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC153385.3         14392-14472
            82-128              AC153385.3         16849-16895
            129-181             AC153385.3         16984-17036
            182-280             AC153385.3         23554-23652
            281-355             AC153385.3         25538-25612
            356-514             AC153385.3         27841-27999
            515-873             AC153385.3         35977-36335
            874-1048            AC153385.3         37943-38117
            1049-1164           AC153385.3         40472-40587
            1165-1324           AC153385.3         42164-42323
            1325-1447           AC153385.3         44484-44606
            1448-1630           AC153385.3         56138-56320
            1631-1747           AC153385.3         56761-56877
            1748-1867           AC153385.3         57237-57356
            1868-1999           AC153385.3         57887-58018
            2000-2101           AC153385.3         59645-59746
            2102-2182           AC153385.3         61019-61099
            2183-2308           AC153385.3         63956-64081
            2309-2434           AC153385.3         64882-65007
            2435-2521           AC153385.3         65179-65265
            2522-2671           AC153385.3         66032-66181
            2672-2794           AC153385.3         76444-76566
            2795-2863           AC153385.3         84257-84325
            2864-3238           AC153385.3         87916-88290
FEATURES             Location/Qualifiers
     source          1..3238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.87 cM"
     gene            1..3238
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /note="serine threonine kinase 31"
                     /db_xref="GeneID:77485"
                     /db_xref="MGI:MGI:1924735"
     exon            1..81
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..3088
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase 31"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 31 isoform 1"
                     /protein_id="NP_084192.2"
                     /db_xref="CCDS:CCDS39487.1"
                     /db_xref="GeneID:77485"
                     /db_xref="MGI:MGI:1924735"
                     /translation="MWGQRLFAGTAVAQSVSFPGLVQMDEDTHYNKVEDVVGSHVEDA
                     VTFWAQNVSKNKDIMKIGCSLSEVCPLANSVFGNLDPKKIYGGLFSEDKCWYRCKVLK
                     TISDDKCLVRYIDYGNTEILNRSDIVEIPPELQFSSIAKKYRLWGLQIPSGQEVTQFD
                     QGRTFLGSLIFEKEIKMRIKATYQDGTVIAQAEYGTVDIGEEVAKKGFAEKCRLTSGI
                     DACEAKKPDPNQLALRSLKNPIPLWGRRSNQSTFSRPKGHFNGRLTLDVKYETSAGNH
                     VTFPKESLAAGDFNLGSNVSLAKIKQDQKLIEENEKLKTEKEVLLENYKALELKVEQT
                     AQELQQEKTATMDLTKHLESTLKTCVGTRLKNLAAKVELLKEIRHINISIRFGNDLSD
                     AMQVLDEGSFTTLASLNELEKIWAEYNVAQEKIQTCLNENEGNILIAERNEVQQKLFV
                     AVDVFILEVDDLPLDKRLKTLQDLATSLESVYGKAKEGTNNSEETLRKFYDWQCTKRE
                     EFASIRSETEASLQHLVAWFQSSQKVFDLSLDEPLTSEDLIGNIDEILEKTESCVCKE
                     LELSLIEQGVIDKEIILSTYSQVLQKIHSEEKFIATLLSKYKDSVEFKKQMIDCLNKN
                     PNVDYLLSIKKTLKGLKAQLRWKLVEKSNLEESDDHDGTEIEKIKQEITQLRNSVFQE
                     IYHEREEYEKLNSLTQKWFPELPLLYPEIGLLKYMNSGGLLTMSLERDLLDTEPMKEL
                     SSKRPLVCSEVNGQPVLLKGYSVDVDTEGRVIQRAASYHRACGYAKEESGLLPLIFLF
                     LCKSDPVAYLMVPYYPKANLSAVQASMPLTSEEALKVMKGVARGLHTLHSANIIHGSL
                     HQNNVFALNREQGIVGDYDFTKSESQRASVNAMVGGLSLLSPELKTGKPPSASSDLYA
                     YGCLFLWLSVQNQEFETNEDGIPKVDQFHLDDNVKSLLCSLIYFRSSMTAEQVLNAEC
                     FLLPKGKSVPIPEKEIECTQHSREDESKMESLDRYSEKTRNGEANP"
     exon            82..128
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            129..181
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            182..280
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            281..355
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..514
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            515..873
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1048
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1164
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1324
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1447
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1630
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1747
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1867
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1999
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2101
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2182
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2308
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2434
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2521
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2671
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2794
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2863
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..3238
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3211..3216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3232
                     /gene="Stk31"
                     /gene_synonym="C330007K24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggctggagg gctgagggtg gagcgcctgg tatgtggggc cagcggctct ttgctgggac
       61 ggctgtggcg caaagtgtaa gttttccagg acttgtccaa atggatgaag atacacatta
      121 caataaagtt gaagatgttg ttggaagtca tgtagaagat gcagtaacat tttgggccca
      181 gaatgtcagt aaaaataagg atattatgaa gattggttgt tcactctcag aagtttgtcc
      241 tcttgctaat tcagtttttg gcaatcttga tcctaagaag atttatggtg gattgttttc
      301 tgaagataag tgctggtaca gatgcaaagt gctaaaaact atcagcgatg ataagtgcct
      361 ggtgaggtac attgactatg gaaatactga aattctaaac cgatctgata tagtagaaat
      421 tcctccggag ctacaatttt ctagtattgc caagaagtat agactttggg gactacagat
      481 tccttctggc caagaagtta cccagtttga tcagggtaga acatttttgg ggagtttgat
      541 ttttgaaaaa gaaattaaaa tgagaataaa agcaacatat caagatggaa cagttattgc
      601 tcaggctgag tatggcactg tcgatatagg ggaagaagtg gcaaagaaag gatttgcaga
      661 aaagtgcaga ctgacctcag gcattgatgc ctgtgaggca aagaaacctg atcctaatca
      721 gcttgctctc aggagtctca agaaccctat ccccctgtgg gggcgcagat caaaccagtc
      781 aaccttcagc aggccaaagg ggcattttaa cgggaggctg actcttgatg tgaagtatga
      841 gaccagtgca ggcaatcacg tgacatttcc aaaggaaagt ttggctgctg gtgactttaa
      901 tttagggtct aatgtcagct tggcaaaaat taaacaggac cagaaactta ttgaagagaa
      961 tgaaaagctt aaaacagaga aagaggttct tctagaaaat tacaaagcat tagaattaaa
     1021 agttgagcag actgcccagg agctgcagca agagaaaaca gctaccatgg atctgactaa
     1081 gcatttagaa agcactctga agacgtgtgt aggaaccagg ctgaagaatt tggcagctaa
     1141 agtagaacta ttgaaagaaa ttaggcatat taacatcagt attcgctttg gaaatgacct
     1201 ttcagatgct atgcaagtgt tggatgaagg gtcctttact actctagcat ctttgaatga
     1261 gttagagaaa atttgggctg aatataatgt tgctcaggag aagatccaaa cttgtcttaa
     1321 tgagaatgaa ggtaatattt tgattgctga aagaaatgaa gtacaacaga agctgttcgt
     1381 ggctgtagat gtttttattc tggaagtaga tgacttacca cttgataaac gcttaaaaac
     1441 attgcaggac ttagcaactt ctttagaatc agtgtatgga aaggccaaag aaggaactaa
     1501 taactctgaa gaaacactta gaaagtttta tgactggcag tgtaccaaaa gagaagagtt
     1561 cgccagtatt aggagtgaaa cagaggcatc tctgcagcac cttgtggcat ggttccagag
     1621 cagccagaag gtttttgatc tgtccttgga tgaaccattg acttcagaag acctgattgg
     1681 taatattgat gaaattctag agaagactga gtcatgtgtc tgcaaagagc tagagctgtc
     1741 tctcattgag caaggtgtca tagacaagga gattatttta agtacataca gtcaagtgct
     1801 gcaaaagatc cattctgagg aaaagttcat tgccaccttg ctgtccaagt ataaggacag
     1861 tgttgagttt aaaaagcaga tgattgactg tttaaataag aaccccaatg tggattactt
     1921 gctttctatt aagaagacat tgaaaggctt aaaagcacaa ctgagatgga aattggttga
     1981 gaagagtaat ttggaagaat ctgatgacca tgatggaact gaaattgaga aaataaagca
     2041 agaaataact caattgcgaa atagtgtttt ccaggaaatt tatcatgaga gggaggaata
     2101 tgagaagctg aatagcttga cccagaaatg gttccctgag ctgcctctgc tgtatcctga
     2161 aataggattg cttaaatata tgaattctgg tggtcttctt actatgagct tagagcggga
     2221 ccttcttgac actgagccca tgaaggaact tagcagcaag cgtcctctgg tgtgctccga
     2281 ggttaatggg cagccagttc tcttaaaggg ctattccgtg gatgttgaca cagaaggcag
     2341 ggtgattcag agagcagcct cttaccatag agcttgtgga tatgctaaag aagagtctgg
     2401 gttactgcca ttaatattct tgtttttgtg taagtctgat cctgttgcct atctgatggt
     2461 cccatattat cctaaggcaa acctgagtgc agttcaagcc agtatgcctt taacttcaga
     2521 agaagcttta aaagtcatga aaggtgttgc ccgaggactg catacattgc atagtgctaa
     2581 cataattcat ggatcacttc atcagaacaa tgtatttgcc ttaaatcgtg aacaagggat
     2641 tgttggagat tatgacttca ccaaatctga gagccagcga gcttcagtca acgcgatggt
     2701 tggtggattg agtttgctct cacctgaatt gaaaactgga aaacctcctt ctgcaagttc
     2761 agacttatat gcttatggtt gccttttctt atggctttct gttcaaaatc aagagtttga
     2821 gacaaatgaa gatggaattc caaaagtaga tcagtttcat ttggatgata atgtcaagtc
     2881 cctcctttgt agcttgatat attttagaag ttcaatgact gctgagcagg ttttgaatgc
     2941 tgaatgtttc ttgcttccaa aggggaaatc agttccaatc ccagaaaaag agattgaatg
     3001 tactcagcat agcagagaag atgaatcaaa gatggagagt ctggatagat atagtgaaaa
     3061 gacaagaaat ggtgaagcca acccttgact aacaaattaa tcctttattg ttgctgtata
     3121 tgtccctttt aaaaactttg ttctgtttgc ttagtagaca aaaatgttct ggaactagtt
     3181 ggattgcatc tttggatttg ggttgtaaaa aataaaagaa atgttttgat tacacctg
//
