LOCUS       NM_019635               2928 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus serine/threonine kinase 3 (Stk3), transcript variant
            1, mRNA.
ACCESSION   NM_019635
VERSION     NM_019635.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   Zhang,J., Chen,W., Song,K., Song,K., Kolls,J. and Wu,T.
  TITLE     YAP activation in liver macrophages via depletion of MST1/MST2
            enhances liver inflammation and fibrosis in MASLD
  JOURNAL   FASEB J 38 (17), e70026 (2024)
   PUBMED   39215627
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Guo,Z.F., Tongmuang,N., Li,C., Zhang,C., Hu,L., Capreri,D.,
            Zuo,M.X., Summer,R. and Sun,J.
  TITLE     Inhibiting endothelial cell Mst1 attenuates acute lung injury in
            mice
  JOURNAL   JCI Insight 9 (17), e178208 (2024)
   PUBMED   39253972
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Feng,P., Luo,L., Yang,Q., Meng,W., Guan,Z., Li,Z., Sun,G., Dong,Z.
            and Yang,M.
  TITLE     Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by
            orchestrating metabolic state and transcriptional activity
  JOURNAL   Cell Death Dis 15 (6), 430 (2024)
   PUBMED   38898027
  REMARK    GeneRIF: Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis
            by orchestrating metabolic state and transcriptional activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Praskova,M., Xia,F. and Avruch,J.
  TITLE     MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell
            proliferation
  JOURNAL   Curr Biol 18 (5), 311-321 (2008)
   PUBMED   18328708
  REMARK    GeneRIF: MST1 and MST2 are activated in mitosis and catalyze the
            mitotic phosphorylation of MOBKL1A/MOBKL1B, which is sufficient to
            inhibit proliferation through actions at several points in the cell
            cycle.
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   O'Neill,E., Rushworth,L., Baccarini,M. and Kolch,W.
  TITLE     Role of the kinase MST2 in suppression of apoptosis by the
            proto-oncogene product Raf-1
  JOURNAL   Science 306 (5705), 2267-2270 (2004)
   PUBMED   15618521
  REMARK    GeneRIF: proteomic analysis of Raf-1 signaling complexes was used
            to show that Raf-1 counteracts apoptosis by suppressing the
            activation of mammalian sterile 20-like kinase (MST2)
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   Lee,K.K. and Yonehara,S.
  TITLE     Phosphorylation and dimerization regulate nucleocytoplasmic
            shuttling of mammalian STE20-like kinase (MST)
  JOURNAL   J Biol Chem 277 (14), 12351-12358 (2002)
   PUBMED   11805089
  REMARK    GeneRIF: Phosphorylation and dimerization regulate
            nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST).
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Lee,K.K., Ohyama,T., Yajima,N., Tsubuki,S. and Yonehara,S.
  TITLE     MST, a physiological caspase substrate, highly sensitizes apoptosis
            both upstream and downstream of caspase activation
  JOURNAL   J Biol Chem 276 (22), 19276-19285 (2001)
   PUBMED   11278283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY783841.1, U28726.1, AY058922.1 and BC049123.1.
            
            On Nov 19, 2006 this sequence version replaced NM_019635.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049123.1, AY058922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               BY783841.1         1-124
            125-1413            U28726.1           4-1292
            1414-2174           AY058922.1         1300-2060
            2175-2928           BC049123.1         2045-2798
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.34 cM"
     gene            1..2928
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /note="serine/threonine kinase 3"
                     /db_xref="GeneID:56274"
                     /db_xref="MGI:MGI:1928487"
     exon            1..280
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1748
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase homolog; serine/threonine-protein kinase 3;
                     MST-2; STE20-like kinase MST2; mammalian STE20-like
                     protein kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 3 isoform 1"
                     /protein_id="NP_062609.2"
                     /db_xref="CCDS:CCDS37059.1"
                     /db_xref="GeneID:56274"
                     /db_xref="MGI:MGI:1928487"
                     /translation="MEQPPASKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKA
                     IHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYC
                     GAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA
                     KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK
                     PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHP
                     FIKNAKPVSILRDLIAEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSSESV
                     GTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEEEEEEEEEEEEDGTMKRNATSP
                     QVQRPSFMDYFDKQDFKNKSHENCDQSMREPGPMSNSVFPDNWRVPQDGDFDFLKNLS
                     LEELQMRLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKRRQQNF"
     exon            281..361
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            362..490
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            491..605
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            606..770
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            771..938
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1076
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1202
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1413
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1589
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..2911
                     /gene="Stk3"
                     /gene_synonym="0610042I06Rik; mess1; MST; Mst2; Mst3;
                     Ste20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgtccc gcccaccctc gctgcgccgg cctcttccca ccagctcgga gctgcaggcc
       61 acggccgagg ggcggggcgg ggcggccggg aggaaccgcg ttgaggagcg ggagggagat
      121 ccgccgcgga gttacgtgaa agttggttcg agtttcccgg tgtgatccct tgcgttcggc
      181 cggctgctcc cgggctcctt tcctccctac ggccttcacg gtccattcgg cccttctttc
      241 tgccaccggc cgccatggag cagccgccgg cgtccaagag taagctaaaa aagctgagtg
      301 aagacagttt gactaagcag cctgaagaag tttttgatgt actggagaag cttggagaag
      361 ggtcttatgg aagtgttttt aaagcaatac ataaggaatc tggtcaagtg gttgcaatta
      421 agcaagtacc tgttgagtca gatcttcagg aaataatcaa agaaatttcc ataatgcaac
      481 aatgtgacag tccatatgtt gtgaagtact atggcagtta ctttaagaac acagacctct
      541 ggattgttat ggagtactgt ggagcggggt ccgtttcaga cataattaga ttgcgaaaca
      601 agacattaac agaagatgaa attgcaacta ttctaaaatc cacattgaaa ggattagaat
      661 atttgcattt tatgaggaaa atacacagag atataaaagc cgggaatatt ctcctcaata
      721 cagaaggaca tgcaaagctt gcagattttg gagtggctgg ccagttaaca gatacaatgg
      781 caaaacgcaa cactgtaata ggaaccccat tttggatggc tcctgaggta attcaagaaa
      841 taggttacaa ctgtgtggct gacatctggt cccttggcat tacttctata gaaatggcag
      901 aaggaaaacc tccttatgct gatatacatc cgatgagggc tatttttatg atccctacaa
      961 acccaccacc aacattcagg aaacctgaac tttggtctga tgacttcacc gattttgtga
     1021 agaagtgctt ggtgaagagt cctgagcaga gagccactgc gacacagctg ttacagcatc
     1081 cttttatcaa gaatgcaaaa cccgtgtcga tattaagaga cctgatcgca gaagccatgg
     1141 aaatcaaagc caaacggcat gaagagcagc agcgggagct agaggaggag gaagaaaact
     1201 cggatgaaga tgagctggat tcacacacta tggtgaagac gagttcagaa agcgtgggca
     1261 caatgcgggc caccagcacg atgagtgaag gagcccagac gatgattgaa cataacagca
     1321 ccatgttaga gtcggacctg gggaccatgg ttataaacag tgaagaagag gaggaagagg
     1381 aagaggagga ggaggaggac ggaactatga aaagaaatgc aacgtcacct caagtacaaa
     1441 gaccttcttt catggactac tttgataagc aggacttcaa gaacaagagt catgaaaatt
     1501 gtgatcagag catgcgtgag ccaggcccta tgtccaacag tgtttttcct gacaactgga
     1561 gagttcctca agatggagac tttgatttct taaaaaatct aagtttagaa gaactacaga
     1621 tgcggctaaa agcactagac cccatgatgg aacgagaaat agaagaactg catcaaagat
     1681 acagtgcaaa aagacaacct atcctggatg ccatggatgc gaagaagagg aggcagcaga
     1741 atttctgacc agattccctc tgtctcagga tgaccagaaa ccaagcaacc acaagaattg
     1801 aaggaattct actttttaat ccctaaaatg tatattctac aattttttaa aactcaaaaa
     1861 tgatggtaca cacctagata aatttcccaa aagcaaactt tacagttgtc tccactctga
     1921 tgtcgttttg aaaggatgag aacaacaaac gtgcgcactt ctctctctgc ctgctattcc
     1981 acctgcaaga gaactaatct aaaatgaaag ctgtatgtgg agactagaaa tccaaagctg
     2041 ttgcttagtc aatcatacag cactggaggg ctttgtgttc caatgtcctt tattcctatg
     2101 gagaagccta tttattgatc cccctcccac cccccaggta gacttattta tttatgcagt
     2161 ttcactttct tggggttttt ttgttttttt taagaccaga tcaggatagt tttggtgaat
     2221 gtccagacac attgcggatt ataacacaca accaaattgt acactaagca gggagctctg
     2281 agtgtactcc ttcaactcca atagacacaa agtcatggct gtaatgttca aatggaccag
     2341 acattttata ctgaagactt aataccattt ctaccttttg aagtgttaat tcctgatttt
     2401 gatattggta aaaataaaac tatatataca taggtcaaaa agagtacagt gtaaaaccaa
     2461 agaaatcaat gaactcttgc acgaaaaagt gtgggaaata tttttaaaga catgaaactg
     2521 agggaaaaaa atgtaattgt taatgtttct tttattggtc tgcaataact catcaggttt
     2581 atcctatggg aatatgcttc tgtcacagga ctttttgttg atttcattta tttcctggga
     2641 attggtaagc atcatgtatc tgacaataaa acagtaaaaa caaaaacaaa aacttttata
     2701 ctaaaaactg tatccttagg gcctaaaaaa aaaaaaatta aagtattaga aaaagactca
     2761 tttctgcaga gcattagcat ttgtgtaatt gacctgggac cagtcatttc ctgcactaca
     2821 catgtccttt ttgactgtgt gtgtgtgttc ttttatgtgt taattactat gtgtgcctca
     2881 caaagacaaa taaattccat tgtgccaccc aaaaaaaaaa aaaaaaaa
//
