LOCUS       NM_133729               3246 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus serine/threonine kinase 26 (Stk26), transcript variant
            1, mRNA.
ACCESSION   NM_133729 XM_985225
VERSION     NM_133729.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3246)
  AUTHORS   Eden,M., Leye,M., Hahn,J., Heilein,E., Luzarowski,M., Volschow,B.,
            Tannert,C., Sossalla,S., Lucena-Porcel,C., Frank,D. and Frey,N.
  TITLE     Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates
            cardiomyocyte growth and survival and is upregulated in human
            cardiomyopathy
  JOURNAL   J Biol Chem 300 (5), 107255 (2024)
   PUBMED   38579991
  REMARK    GeneRIF: Mst4, a novel cardiac STRIPAK complex-associated kinase,
            regulates cardiomyocyte growth and survival and is upregulated in
            human cardiomyopathy.
REFERENCE   2  (bases 1 to 3246)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3246)
  AUTHORS   Caputo,M., Andersson,E., Xia,Y., Hou,W., Cansby,E., Erikson,M.,
            Lind,D.E., Hallberg,B., Amrutkar,M. and Mahlapuu,M.
  TITLE     Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate
            Diet-Induced MASLD Susceptibility in Mice
  JOURNAL   Int J Mol Sci 25 (4), 2446 (2024)
   PUBMED   38397122
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3246)
  AUTHORS   Cao,J., Ji,L., Zhan,Y., Shao,X., Xu,P., Wu,B., Chen,P., Cheng,L.,
            Zhuang,X., Ou,Y., Hua,F., Sun,L., Li,F., Chen,H., Zhou,Z. and
            Cheng,Y.
  TITLE     MST4 kinase regulates immune thrombocytopenia by phosphorylating
            STAT1-mediated M1 polarization of macrophages
  JOURNAL   Cell Mol Immunol 20 (12), 1413-1427 (2023)
   PUBMED   37833401
  REMARK    GeneRIF: MST4 kinase regulates immune thrombocytopenia by
            phosphorylating STAT1-mediated M1 polarization of macrophages.
            Erratum:[Cell Mol Immunol. 2023 Dec;20(12):1533. doi:
            10.1038/s41423-023-01094-x.. PMID: 37907780]
REFERENCE   5  (bases 1 to 3246)
  AUTHORS   Wu,X., Zhang,Y., Zhang,Y., Xia,L., Yang,Y., Wang,P., Xu,Y., Ren,Z.
            and Liu,H.
  TITLE     MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and
            affects the prognosis after intracerebral hemorrhage in mice
  JOURNAL   Brain Res Bull 177, 31-38 (2021)
   PUBMED   34534636
  REMARK    GeneRIF: MST4 attenuates NLRP3 inflammasome-mediated
            neuroinflammation and affects the prognosis after intracerebral
            hemorrhage in mice.
REFERENCE   6  (bases 1 to 3246)
  AUTHORS   An,L., Nie,P., Chen,M., Tang,Y., Zhang,H., Guan,J., Cao,Z., Hou,C.,
            Wang,W., Zhao,Y., Xu,H., Jiao,S. and Zhou,Z.
  TITLE     MST4 kinase suppresses gastric tumorigenesis by limiting YAP
            activation via a non-canonical pathway
  JOURNAL   J Exp Med 217 (6) (2020)
   PUBMED   32271880
REFERENCE   7  (bases 1 to 3246)
  AUTHORS   Luan,D., Zhang,Y., Yuan,L., Chu,Z., Ma,L., Xu,Y. and Zhao,S.
  TITLE     MST4 modulates the neuro-inflammatory response by regulating
            IkappaBalpha signaling pathway and affects the early outcome of
            experimental ischemic stroke in mice
  JOURNAL   Brain Res Bull 154, 43-50 (2020)
   PUBMED   31722252
  REMARK    GeneRIF: MST4 modulates the neuro-inflammatory response by
            regulating IkappaBalpha signaling pathway and affects the early
            outcome of experimental ischemic stroke in mice.
REFERENCE   8  (bases 1 to 3246)
  AUTHORS   Jiao,S., Zhang,Z., Li,C., Huang,M., Shi,Z., Wang,Y., Song,X.,
            Liu,H., Li,C., Chen,M., Wang,W., Zhao,Y., Jiang,Z., Wang,H.,
            Wong,C.C., Wang,C. and Zhou,Z.
  TITLE     The kinase MST4 limits inflammatory responses through direct
            phosphorylation of the adaptor TRAF6
  JOURNAL   Nat Immunol 16 (3), 246-257 (2015)
   PUBMED   25642822
  REMARK    GeneRIF: Findings reveal a mechanism by which TRAF6 is regulated
            and highlight a role for MST4 in limiting inflammatory responses.
REFERENCE   9  (bases 1 to 3246)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 3246)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671907.6 and AL670230.12.
            
            On Feb 1, 2022 this sequence version replaced NM_133729.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005708.1, AK034609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AL671907.6         125224-125329
            107-263             AL671907.6         125462-125618
            264-494             AL670230.12        11923-12153
            495-551             AL670230.12        21156-21212
            552-660             AL670230.12        27256-27364
            661-818             AL670230.12        27454-27611
            819-1004            AL670230.12        28318-28503
            1005-1153           AL670230.12        29528-29676
            1154-1247           AL670230.12        30683-30776
            1248-1310           AL670230.12        31356-31418
            1311-1447           AL670230.12        31500-31636
            1448-3246           AL670230.12        32967-34765
FEATURES             Location/Qualifiers
     source          1..3246
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 27.5 cM"
     gene            1..3246
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /note="serine/threonine kinase 26"
                     /db_xref="GeneID:70415"
                     /db_xref="MGI:MGI:1917665"
     exon            1..106
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            107..263
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1472
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; Mst3
                     and SOK1-related kinase; serine/threonine-protein kinase
                     MST4; STE20-like kinase MST4; mammalian STE20-like protein
                     kinase 4; serine/threonine-protein kinase 26"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 26 isoform 1"
                     /protein_id="NP_598490.1"
                     /db_xref="CCDS:CCDS40968.1"
                     /db_xref="GeneID:70415"
                     /db_xref="MGI:MGI:1917665"
                     /translation="MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDN
                     RTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYL
                     GGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKL
                     ADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPP
                     NSDMHPMRVLFLIPKNNPPTLIGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK
                     NSKKTSYLTELIDRFKRWKAEGHSDEESDSEGSDSESSSRESNPHPEWSFTTVRKKPD
                     PKKLQNGEEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAETAC
                     PGITDKMVKKLIEKFQKCSADESP"
     exon            264..494
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            495..551
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            552..660
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            661..818
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1004
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1153
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1247
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1310
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1447
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..3246
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /note="hexamer: AATAAA"
     polyA_site      3246
                     /gene="Stk26"
                     /gene_synonym="2610018G03Rik; Mst4"
                     /note="major polyA site"
ORIGIN      
        1 atcactggag cccaggtccc aggcaccgcc acaggtcaag ccctgcattc aggaaagaga
       61 gcaacactgc agttagccaa aagccaggca ggcgagcggc agagaggcct cgatcgagaa
      121 gcctggtaga gctgcagaga tacctccgta ggaggagcca gtctctgccg gaggcgccac
      181 cgccaccacc gcagaagcag cgcgaagtag cagtcgccac catggcccac tcaccggtgg
      241 ctgttcaagt gcctgggatg cagaataata tagcagatcc agaagaactg ttcacaaaat
      301 tagagcgcat tggaaaaggc tcctttggag aagttttcaa aggaattgat aaccgtactc
      361 agcaagtggt tgcaattaaa atcattgacc ttgaggaagc tgaggatgaa atagaagaca
      421 tccaacaaga aataactgtt ttgagtcagt gcgacagctc atatgtaaca aaatactatg
      481 ggtcctattt aaagggttca aaactatgga taataatgga atacctaggt ggaggttcag
      541 cattggatct tctgcgtgct ggtccatttg atgagttcca gattgccacc atgctcaagg
      601 agattttgaa aggtctggac tatctacatt ctgaaaagaa aatccaccga gacattaaag
      661 ctgccaacgt cttgctttca gaacaaggtg atgttaaact ggctgacttt ggagttgctg
      721 gccagctgac agatacacaa atcaaaagaa acaccttcgt agggactccg ttttggatgg
      781 ctcctgaagt tattcaacag tcagcttatg actctaaagc tgacatatgg tctttgggaa
      841 ttactgctat tgaacttgcc aagggagagc ctccgaattc tgacatgcat ccaatgagag
      901 ttctgtttct tattccaaaa aacaaccctc caactcttat tggagacttt actaagtctt
      961 tcaaggagtt tattgatgct tgcctgaata aagacccgtc atttcgtcct acagctaaag
     1021 aacttttgaa gcataagttc atcgtaaaaa attcaaagaa gacttcttat ctgactgaat
     1081 tgatcgatcg atttaagaga tggaaggcag aaggccacag tgatgaggaa tctgattccg
     1141 agggctctga ctcggaatcc agcagcaggg aaagtaaccc tcaccctgaa tggagtttca
     1201 ccactgtgcg taagaagcct gatccaaaga aactgcagaa tggggaagag caagatcttg
     1261 tgcaaacctt gagctgtttg tctatgataa tcacacctgc atttgccgaa cttaaacagc
     1321 aggacgagaa taatgcgagt cgaaaccagg caattgaaga acttgagaaa agtattgctg
     1381 tggctgaaac cgcctgtcct ggcatcacag ataagatggt gaagaaacta atcgaaaaat
     1441 ttcaaaagtg ttctgcggat gaatcccctt aagaaatctg ttgtcattac ttttggcttc
     1501 tgtttcatgt ggaccaggag aaacccacca aagctatgtc aaccttataa atgcttaact
     1561 catgagctcc atgtgccttt tggatctttg ccacattgaa gatttagagg aagctattaa
     1621 actattttgt gatggtgatt atcattttgt attttaaaga gattattttg taaggaataa
     1681 ttttaatact atagttttgc cggtattgta gtaaatgctg agatacaggt tttttgtttt
     1741 ttgtttttta attttaggta ccattatttc ttatgttcat ggaatgaata ctgtttggtt
     1801 tggaatcttt agttaactgt atactcataa acatacaggt ctttcaaagt catcctaact
     1861 attaaatgtt tgtaaatcat caagcttcaa aaagcattct ttttccccca cacaagtata
     1921 ttctaaaaat gactatttgt aatgaggtgg aagtaagtaa taccttctta aaacaagtgt
     1981 ttttaagaag ctcttgaaaa aaaagaaaac cacctagacc tagaaagtat tgactttcct
     2041 agcaagttgt tctgaattca ggcagcccca tgtctagcac cttggagaac cttgtgtttg
     2101 aagcacttcc atgcaacatg taacagcaga agtacctctt ggtgtattta tcttctcttt
     2161 cagatggaag aagcaattaa cccttattta acatttaaag taatctcatt tagccgagaa
     2221 tggtggagtt ggtctggctt cagtctttaa atcttcagct caaatcacat attacatgct
     2281 tggatttaga aaacttttaa caaccttttt gtcttgtgat taaatacctg atcaataggt
     2341 atgagcgtaa ctttaaacca gcatttattt tgtcgtggca atgcattttt gtagaaacta
     2401 tttatacatt tttgtttata attatccact cataagtata gtgtgttcaa ttctgaaggg
     2461 gtatttaaat gaacattgtc caactcatag gaagatacca tagagcagga tcatttcttg
     2521 tcatataaaa gtaagataga ctgtgcagtt aattttcagt tctatttatg gtactgttaa
     2581 gtgagttata gcctttttta gccatatata tatatatata tatatatata ctatgtttgc
     2641 ctaagtgcta aactaggtct aatgtagaat tgttggtact gattaatttt gacagttatg
     2701 attttaatgt ttgcatcttc acatttgagc ttagcacgaa acattttaaa atatctgtgt
     2761 aactgccaaa tgtgaaaagg aaagacattg tacaagtagc caatgcagtt tttaattgaa
     2821 atgtcaatta catcccttct tttaaaaaag aaatacaaac atttgaaagg cagaacattg
     2881 tatgccaaga aaattctttt cattggtgcc tatcctgtac ctgttgcttt gagttgactg
     2941 taccttgaat tgatgacttg gttagatttt tagttttttt gtccatgctg taaatgacac
     3001 tcaatcgcag tttgttctcc atagtgctct aaaaataatt gtgtgacttg aataatgggt
     3061 gacattcata tttttgtgaa agtaaaaaca agttcataaa ttgattatgg aaaactgtac
     3121 cacacgcctg catcccaaat acagctggta ttgcttactc attatagcgt tagttctgta
     3181 gacctgtttc tatgtgaagc atatgtcact gtttggggga ttttaaaaat aaatatttaa
     3241 atttta
//
