LOCUS       NM_145465               2575 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus serine/threonine kinase 24 (Stk24), mRNA.
ACCESSION   NM_145465 XM_980463 XM_980739
VERSION     NM_145465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2575)
  AUTHORS   Wang,N., Jiang,Y., Li,M., Wang,H., Pan,J., Tang,Y., Xie,S., Xu,Y.,
            Li,X., Zhou,X., Xu,P., Lin,W. and Wang,X.
  TITLE     Protein Kinase STK24 Promotes Tumor Immune Evasion via the
            AKT-PD-L1 Axis
  JOURNAL   Adv Sci (Weinh) 11 (12), e2304342 (2024)
   PUBMED   38229183
  REMARK    GeneRIF: Protein Kinase STK24 Promotes Tumor Immune Evasion via the
            AKT-PD-L1 Axis.
REFERENCE   2  (bases 1 to 2575)
  AUTHORS   Chan,C.H., Lin,P., Yang,T.Y., Bao,B.Y., Jhong,J.Y., Weng,Y.P.,
            Lee,T.H., Cheng,H.F. and Lu,T.L.
  TITLE     Epithelial polarization in the 3D matrix requires MST3 signaling to
            regulate ZO-1 position
  JOURNAL   PLoS One 18 (5), e0285217 (2023)
   PUBMED   37155619
  REMARK    GeneRIF: Epithelial polarization in the 3D matrix requires MST3
            signaling to regulate ZO-1 position.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2575)
  AUTHORS   Yang,X., Wu,S.T., Gao,R., Wang,R., Wang,Y., Dong,Z., Wang,L.,
            Qi,C., Wang,X., Schmitz,M.L., Liu,R., Han,Z., Wang,L. and Zheng,X.
  TITLE     Release of STK24/25 suppression on MEKK3 signaling in endothelial
            cells confers cerebral cavernous malformation
  JOURNAL   JCI Insight 8 (5), e160372 (2023)
   PUBMED   36692953
  REMARK    GeneRIF: Release of STK24/25 suppression on MEKK3 signaling in
            endothelial cells confers cerebral cavernous malformation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2575)
  AUTHORS   Tang,J., Xu,C., Fu,M., Liu,C., Zhang,X., Zhang,W., Pei,R., Wang,Y.,
            Zhou,Y., Chen,J., Miao,Z., Pan,G., Yang,Q. and Chen,X.
  TITLE     Sterile 20-like kinase 3 promotes tick-borne encephalitis virus
            assembly by interacting with NS2A and prM and enhancing the
            NS2A-NS4A association
  JOURNAL   J Med Virol 95 (3), e28610 (2023)
   PUBMED   36840407
  REMARK    GeneRIF: Sterile 20-like kinase 3 promotes tick-borne encephalitis
            virus assembly by interacting with NS2A and prM and enhancing the
            NS2A-NS4A association.
REFERENCE   5  (bases 1 to 2575)
  AUTHORS   Liu,Y., Wang,T.V., Cui,Y., Gao,S. and Rao,Y.
  TITLE     Biochemical purification uncovers mammalian sterile 3 (MST3) as a
            new protein kinase for multifunctional protein kinases AMPK and
            SIK3
  JOURNAL   J Biol Chem 298 (5), 101929 (2022)
   PUBMED   35413286
  REMARK    GeneRIF: Biochemical purification uncovers mammalian sterile 3
            (MST3) as a new protein kinase for multifunctional protein kinases
            AMPK and SIK3.
REFERENCE   6  (bases 1 to 2575)
  AUTHORS   Zhang,Y., Tang,W., Zhang,H., Niu,X., Xu,Y., Zhang,J., Gao,K.,
            Pan,W., Boggon,T.J., Toomre,D., Min,W. and Wu,D.
  TITLE     A network of interactions enables CCM3 and STK24 to coordinate
            UNC13D-driven vesicle exocytosis in neutrophils
  JOURNAL   Dev Cell 27 (2), 215-226 (2013)
   PUBMED   24176643
  REMARK    GeneRIF: STK24 appears to suppress exocytosis by interacting and
            competing with UNC13D C2B domain for lipid binding, whereas CCM3
            has dual roles in exocytosis regulation.
REFERENCE   7  (bases 1 to 2575)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 2575)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   9  (bases 1 to 2575)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2575)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK154959.1, BY730101.1 and BE687884.1.
            
            On Jul 14, 2006 this sequence version replaced NM_145465.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154596.1, AK154959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2116              AK154959.1         2-2117
            2117-2427           BY730101.1         315-625
            2428-2575           BE687884.1         1-148               c
FEATURES             Location/Qualifiers
     source          1..2575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 64.95 cM"
     gene            1..2575
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /note="serine/threonine kinase 24"
                     /db_xref="GeneID:223255"
                     /db_xref="MGI:MGI:2385007"
     exon            1..333
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            334..564
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            565..621
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            622..730
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            731..888
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1074
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1220
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1344
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1413
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1550
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..2574
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2556..2561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /note="hexamer: AATAAA"
     polyA_site      2573
                     /gene="Stk24"
                     /gene_synonym="1810013H02Rik; MST-3; Mst3; STE20"
                     /note="major polyA site"
ORIGIN      
        1 agcgctcgcg ggcccaggcc gcccggctcg acctgagcac cgcggcggcg cagcgacggg
       61 atccctggag aagcagccgc agtctcgaga cgtcccccgc gccccccact gcccgcccca
      121 ggctcagtgt atggggccgc ggcccgccaa ccttcgttga gaccgtcccc ggggtgcggt
      181 ggcctcgggc tccagagccc gccccgccac ccgagggctg cgcgcggccc cgggcctgct
      241 cgccgcgcgg ctccgcgcgt cccgggccag gaagtggcgg cgccgagcgc catggcccac
      301 tccccggtgc agtcgggcct gccgggcatg cagaacctga aagcagaccc agaagagctt
      361 tttaccaagc tagagaagat tggaaagggc tcttttggtg aagtgttcaa aggcattgac
      421 aatcggactc agaaagtggt ggccataaaa atcattgatc tggaagaagc cgaggacgag
      481 atagaggaca tccaacaaga gatcacagtg ctgagccagt gtgacagtcc ctacgtcacc
      541 aagtactatg gatcctatct caaggatact aagttgtgga taatcatgga gtatcttggt
      601 ggaggctctg ccctggatct gttagagcct ggccctttag atgaaattca gattgcaacc
      661 atattacgag aaattctgaa aggacttgat tatctacact cggagaagaa aattcacaga
      721 gatattaaag cggccaatgt tctgctctct gaacatggag aggtgaagct ggcagacttt
      781 ggagtggccg gccagctgac ggatacccag atcaaaagga acaccttcgt gggtaccccc
      841 ttctggatgg cgccggaggt catcaagcag tcagcctacg actcaaaggc agacatctgg
      901 tcccttggca tcaccgcaat agaactggcc aaaggagagc caccacattc tgagctgcac
      961 cccatgaagg tgttattcct catcccaaag aacaaccctc ccacactgga agggaactac
     1021 agcaaacccc tcaaggagtt cgtggaggcc tgcctgaaca aggagcccag ctttaggccc
     1081 actgctaagg aattattgaa gcacaaattc ataatccgca atgcaaagaa aacgtcctac
     1141 ttgaccgagc ttatcgacag gtacaagagg tggaaggcgg agcagagcca cgaggactcc
     1201 agctcggagg actctgacgt ggagacagat ggccaggcgt ctggaggcag cgactctggg
     1261 gactggatct tcactatccg ggagaaagat cccaagaatc tggagaacgg aactcttcag
     1321 ctctcggact tggaaagaaa taagatgaaa gatatcccaa agaggccttt ctctcagtgt
     1381 ttatccacaa tcatttctcc tctgtttgcg gagctgaaag agaagagcca ggcatgcgga
     1441 gggaacttgg ggtcaataga agagctgcgg ggagccatct acttggcgga agaggcctgc
     1501 cctgggatct cagacactat ggtggcacag cttgtgcagc ggctgcagag atattctctg
     1561 agtggcggag gagcctcagc gcactgaagg cccatggcgc ccgggttggt ttttcctttc
     1621 ttcttcatct tccttctttt taaaagtcaa cgagagcctt tgccgactct gcgaagaggt
     1681 gtcacggagg ggcccacccg ccctcccata gcgccggcac ctgtccaggg acggcctcgt
     1741 cgtgccacag ccagatggag tctttcccga tagggtgggg gagggtcttc tccttcaagc
     1801 aattatttta tttttttatc gtttttaatt ttaatcatag tgcacatatt caaagaaagt
     1861 atctttaaac acaaaaaacc ctgaaatgta tatttggatc gttttaaggc aattgaagac
     1921 acgcaacctc aggtatcccg ctttatatcg atagctcctc ccccgggaga cagagagtcg
     1981 ctctggtgga tcagtgtaca gattgtatat agcgtcattt ttacggaaac ccttttggcg
     2041 tgcataagga tcactgtgta cacattggcc aagtgcttct gtagataatg tctgtggagt
     2101 aaatatttga caggccagaa cttgagtctt ttgccttgcc tttattacat gtaaattttg
     2161 aatctcgtga ccagtgattt ggattttatt ttgtatttac agggtctgtc attaataata
     2221 attaaccccc ctcccctcat ggaacactcc cgtttgtacc tcaacagatg caaattcccc
     2281 tctcgttcac cctacgccct ttttggtaca cttagaagtt ttccttttcc atcaatggta
     2341 ctgtttctta gtgttttcaa ttggaacata tcttgtctca cagagcttta aattattctc
     2401 ctaagtttct tgtggatgaa gcgctctcat ctaacctatg ttgggttgtg ccaccacgtc
     2461 tgtaccagat gtcccatccg gcatctttcc attgaatctt gtagtgcaac ttgcgtatca
     2521 tcttctccac ctccaagtgt ctgaatgctt acacaaataa attttataac tcaca
//
