LOCUS       NM_133810               3298 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus serine/threonine kinase 17b (apoptosis-inducing)
            (Stk17b), mRNA.
ACCESSION   NM_133810
VERSION     NM_133810.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3298)
  AUTHORS   Mandarano,A.H., Harris,T.L., Creasy,B.M., Wehenkel,M., Duggar,M.,
            Wilander,B.A., Mishra,A., Crawford,J.C., Mullen,S.A.,
            Williams,K.M., Pillai,M., High,A.A. and McGargill,M.A.
  TITLE     DRAK2 contributes to type 1 diabetes by negatively regulating IL-2
            sensitivity to alter regulatory T cell development
  JOURNAL   Cell Rep 42 (2), 112106 (2023)
   PUBMED   36773294
  REMARK    GeneRIF: DRAK2 contributes to type 1 diabetes by negatively
            regulating IL-2 sensitivity to alter regulatory T cell development.
REFERENCE   2  (bases 1 to 3298)
  AUTHORS   Li,Y., Xu,J., Lu,Y., Bian,H., Yang,L., Wu,H., Zhang,X., Zhang,B.,
            Xiong,M., Chang,Y., Tang,J., Yang,F., Zhao,L., Li,J., Gao,X.,
            Xia,M., Tan,M. and Li,J.
  TITLE     DRAK2 aggravates nonalcoholic fatty liver disease progression
            through SRSF6-associated RNA alternative splicing
  JOURNAL   Cell Metab 33 (10), 2004-2020 (2021)
   PUBMED   34614409
  REMARK    GeneRIF: DRAK2 aggravates nonalcoholic fatty liver disease
            progression through SRSF6-associated RNA alternative splicing.
REFERENCE   3  (bases 1 to 3298)
  AUTHORS   Wu,Q.W. and Kapfhammer,J.P.
  TITLE     Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje
            cell dendritic development and is altered in multiple
            spinocerebellar ataxias
  JOURNAL   Eur J Neurosci 54 (7), 6673-6684 (2021)
   PUBMED   34536317
  REMARK    GeneRIF: Serine/threonine kinase 17b (STK17B) signalling regulates
            Purkinje cell dendritic development and is altered in multiple
            spinocerebellar ataxias.
REFERENCE   4  (bases 1 to 3298)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3298)
  AUTHORS   Harris,T.L. and McGargill,M.A.
  TITLE     Drak2 Does Not Regulate TGF-beta Signaling in T Cells
  JOURNAL   PLoS One 10 (5), e0123650 (2015)
   PUBMED   25951457
  REMARK    GeneRIF: Data provide insight into the role of Drak2 in autoimmune
            diseases by showing that Drak2 may not suppress TGF-beta signaling
            in T cells, and therefore may contribute to autoimmune disease via
            other molecular pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3298)
  AUTHORS   Friedrich,M.L., Cui,M., Hernandez,J.B., Weist,B.M., Andersen,H.M.,
            Zhang,X., Huang,L. and Walsh,C.M.
  TITLE     Modulation of DRAK2 autophosphorylation by antigen receptor
            signaling in primary lymphocytes
  JOURNAL   J Biol Chem 282 (7), 4573-4584 (2007)
   PUBMED   17182616
  REMARK    GeneRIF: DRAK2 kinase activity is regulated in a calcium-dependent
            manner and that Ser(12) phosphorylation is necessary for optimal
            suppression of T cell activation by this kinase
REFERENCE   7  (bases 1 to 3298)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
REFERENCE   8  (bases 1 to 3298)
  AUTHORS   Mao,J., Qiao,X., Luo,H. and Wu,J.
  TITLE     Transgenic drak2 overexpression in mice leads to increased T cell
            apoptosis and compromised memory T cell development
  JOURNAL   J Biol Chem 281 (18), 12587-12595 (2006)
   PUBMED   16517594
  REMARK    GeneRIF: Drak2 expresses in the T cell compartment but is not T
            cell-specific; it plays critical roles in T cell apoptosis and
            memory T cell development
REFERENCE   9  (bases 1 to 3298)
  AUTHORS   Friedrich,M.L., Wen,B.G., Bain,G., Kee,B.L., Katayama,C., Murre,C.,
            Hedrick,S.M. and Walsh,C.M.
  TITLE     DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation
            threshold during thymocyte selection
  JOURNAL   Int Immunol 17 (11), 1379-1390 (2005)
   PUBMED   16172133
  REMARK    GeneRIF: DRAK2 transduces non-apoptotic signals during thymocyte
            differentiation.
REFERENCE   10 (bases 1 to 3298)
  AUTHORS   McGargill,M.A., Wen,B.G., Walsh,C.M. and Hedrick,S.M.
  TITLE     A deficiency in Drak2 results in a T cell hypersensitivity and an
            unexpected resistance to autoimmunity
  JOURNAL   Immunity 21 (6), 781-791 (2004)
   PUBMED   15589167
  REMARK    GeneRIF: T cells from Drak2(-/-) mice exhibited enhanced
            sensitivity to T cell receptor-mediated stimulation with a reduced
            requirement for costimulation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY034689.1, AK165291.1 and AY092028.1.
            
            On May 15, 2009 this sequence version replaced NM_133810.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY092028.1, AK165291.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BY034689.1         11-71
            62-2689             AK165291.1         2-2629
            2690-3298           AY092028.1         2643-3251
FEATURES             Location/Qualifiers
     source          1..3298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..3298
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /note="serine/threonine kinase 17b (apoptosis-inducing)"
                     /db_xref="GeneID:98267"
                     /db_xref="MGI:MGI:2138162"
     exon            1..142
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            143..305
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..518
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..663
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..790
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            791..839
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1019
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..3278
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /note="hexamer: AATACA"
     polyA_site      2685
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /note="hexamer: AATAAA"
     polyA_site      3278
                     /gene="Stk17b"
                     /gene_synonym="3110009A03Rik; Drak2"
                     /note="major polyA site"
ORIGIN      
        1 gaagtacagt gtcccagacg cggctgcact tttcaaacct caactgtaag aagcgtcggt
       61 cagcgtctgt gcggtcgccg ccgggagtcg cctcacaggg gcctggctga cggcgaccag
      121 ccgttgtggg gaagagtgcg aggtaaaagt ctgcctagag aagcaggtct ggcagtcatc
      181 aacatgtctc ggaggagatt cgattgccga agtgtctcag gcttgctaac tacaacccct
      241 caaacgccga ttaaaacaga gaattttaat aatttctata ctcttacccc aaaagaactt
      301 gggagaggaa aatttgctgt ggttagacaa tgtatatcaa aatcaactgg acaagagtat
      361 gctgccaaat ccctgaaaaa gaggagaaga gggcaggatt gccgggcgga aattctgcat
      421 gagatagctg tgctggagct ggccaggtct tgtccccacg tgattaatct gcatgaggtc
      481 tacgaaaatg caacggaaat cattttggtg ttagaatatg ctgcgggtgg agaaattttc
      541 aacctgtgtt tacctgagtt agccgaaatg gtatctgaaa atgatgttat cagactcatt
      601 aaacaaatcc ttgaaggagt tcattatcta catcagaata acattgttca ccttgattta
      661 aagccacaga atatactttt gagcagtata tacccactcg gggacataaa aattgtagat
      721 tttggaatgt ctcgaaaaat tgggaatgca agtgagcttc gggaaatcat gggaacacct
      781 gaatacttag ctccagaaat cctcaactat gatcccatta ccacagcaac agatatgtgg
      841 aatattggca taatagcgta tatgttgtta actcatacat caccatttgt aggagaagat
      901 aatcaagaaa catatctgaa tatttctcaa gtgaatgtag attattcaga agaaatgttt
      961 tcatcagttt cacagctggc cacagacttc atccagagcc ttctagtaaa gaacccagag
     1021 aaaagaccaa cagcagaatc ctgcctatcc cactcatggc tgcagcagtg ggactttgga
     1081 agcttgtttc atcctgagga aacttcaggc tcctctcaaa ttcaggatct gactctcagg
     1141 tcctctgaag agaagacctc caagtcctcc tgtaatggga gctgtggagc ccgggaggac
     1201 aaggagaaca tccctgaaga tggcagctta gtttctaaaa gatttcgatt cgatgactcc
     1261 ttgcccagcc cccatgaact tgttccagat ttgttctgtt agcatttttc tctgtgactc
     1321 atctggactg actcggaaat ttgaaatctc tggtgtgaga ttgtgtttgt agcttcatat
     1381 attatgttta tattataaat gcacttctgc ttagaagaac ttaaggaaca gtttaaatgc
     1441 taggcttctg ttggctagca tatcatttct tgtcctgaaa ttgttttgca gaggaaaata
     1501 tttaagtata tgacaaaaaa tgtaaattgt gtttaagaga acacatgcaa ctgaaagaac
     1561 tcaagttcag tcagacttat aaaatgggtt atattatggt tagtaaaagt tgaaaaaaaa
     1621 tgaaaacagg aatttagtag gttctaaggt aagccctata ccataactct attacagaga
     1681 atctgtttgg ggaaatgctg tcaagggtaa accacaacat atactgcttt ataaatactc
     1741 cagagagagt ttatagttga aagtatttcc cagttaccaa taatagcttg aaactgtaag
     1801 attttctttg tgtgccatgt gctcggtgag aggacacagt caaccagagc agggttgatc
     1861 caggctgttt ctctgcaaac cgagtcaaaa ctcgacatca tttccagctc atgtattttg
     1921 tacgtgcatc atatatcaga tctaataaga tctggaagat ggatatgcaa ataagaggcc
     1981 tttgtcttct agaatgatta gagtagagga gaattggata gtacagaata tgctctagtt
     2041 tcagtcagac atattcataa agggaaatgt taagttctgg cagctgactt agtgttggat
     2101 gtctcctaag tctcaggata gaagcccatc attagagcat aggcacttca ggaattcttg
     2161 tgtgaaattc tagtgagtga ggaggtgtga catgcagcta tctttgggct ccttttgtgt
     2221 gtgttctgct ggacacaaca catgggagtg ttcagtgttg tccgtggtca atatctatgt
     2281 tcagtcctga tgggaggggc ctagggactg ctttggagat ttcccactgg tgtccatttt
     2341 aaggtctgta ataatgtcat gttaagataa cagatctcat aaatatgcta ctctatcaga
     2401 ctccgttgcc aaaacaaatt aaaagcctgt gtattgaagt gggtgttagt ctaacaacct
     2461 gtaaattctt gaaattgtta ctaaaattcc aaattcttta gataacttta aactatttaa
     2521 attgagcatt gctgtctttg tttgattaaa ggttgagttc ctttatatct gttattttta
     2581 aaggaaaagt tgtttgcctt ttgtatatgt gtgtgcatat gtgtatgtgt acaggtatat
     2641 gtatatatgt attgatagat aaaatacagc ctttaaacaa cttcatgtta gatattcttt
     2701 ccttgtgtat tatgttcaac tcaggtgcca aaagagccct cttatctgaa taataagtat
     2761 gcccatacat tctttaagaa gtagtctgtt ggtccaagaa gccaaacact aaagatgcta
     2821 aatttaactc ttgtgtttct gaaattgaga agctgttggt aaattattac ttgtatactt
     2881 tccatcagtg ttaattcagg taatgtcatt agtctgtcat taggaaatgt ggttactttc
     2941 ccaaacagtg atattttatt gtaaaacttt aaaaagtatt atgccactca ccaaaagtaa
     3001 gcatttgaaa atttaatttt aagtcatttg tttaaaacca ctttttattg tctatatata
     3061 tacatttttt ccccctgagg aatcctgaga tagtttgtgt gttccccttc gttaattggc
     3121 taccaggttg taaactccca tacctttcct tgggacattg cttattgtaa aagagtagct
     3181 agtggttgca cacaataaaa aagcagtctt tccataaaag caaatttaca aatttcccat
     3241 gttgaagtgt ggcaataaat gtcttctgag agagttaaaa aaaaaaaaaa aaaaaaaa
//
