LOCUS       NM_011494               2885 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus serine/threonine kinase 16 (Stk16), transcript variant
            1, mRNA.
ACCESSION   NM_011494
VERSION     NM_011494.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2885)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2885)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2885)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2885)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2885)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2885)
  AUTHORS   Berson,A.E., Young,C., Morrison,S.L., Fujii,G.H., Sheung,J., Wu,B.,
            Bolen,J.B. and Burkhardt,A.L.
  TITLE     Identification and characterization of a myristylated and
            palmitylated serine/threonine protein kinase
  JOURNAL   Biochem Biophys Res Commun 259 (3), 533-538 (1999)
   PUBMED   10364453
REFERENCE   7  (bases 1 to 2885)
  AUTHORS   Chodosh,L.A., D'Cruz,C.M., Gardner,H.P., Ha,S.I., Marquis,S.T.,
            Rajan,J.V., Stairs,D.B., Wang,J.Y. and Wang,M.
  TITLE     Mammary gland development, reproductive history, and breast cancer
            risk
  JOURNAL   Cancer Res 59 (7 Suppl), 1765-1771s (1999)
   PUBMED   10197594
  REMARK    Review article
REFERENCE   8  (bases 1 to 2885)
  AUTHORS   Kurioka,K., Nakagawa,K., Denda,K., Miyazawa,K. and Kitamura,N.
  TITLE     Molecular cloning and characterization of a novel protein
            serine/threonine kinase highly expressed in mouse embryo
  JOURNAL   Biochim Biophys Acta 1443 (3), 275-284 (1998)
   PUBMED   9878782
REFERENCE   9  (bases 1 to 2885)
  AUTHORS   Stairs,D.B., Perry Gardner,H., Ha,S.I., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Chodosh,L.A.
  TITLE     Cloning and characterization of Krct, a member of a novel subfamily
            of serine/threonine kinases
  JOURNAL   Hum Mol Genet 7 (13), 2157-2166 (1998)
   PUBMED   9817935
REFERENCE   10 (bases 1 to 2885)
  AUTHORS   Ligos,J.M., Gerwin,N., Fernandez,P., Gutierrez-Ramos,J.C. and
            Bernad,A.
  TITLE     Cloning, expression analysis, and functional characterization of
            PKL12, a member of a new subfamily of ser/thr kinases
  JOURNAL   Biochem Biophys Res Commun 249 (2), 380-384 (1998)
   PUBMED   9712705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237826.1, AK030404.1 and AK149539.1.
            
            On Aug 13, 2009 this sequence version replaced NM_011494.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030404.1, AK032162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY237826.1         2-27
            27-743              AK030404.1         2-718
            744-749             AK149539.1         717-722
            750-2885            AK030404.1         725-2860
FEATURES             Location/Qualifiers
     source          1..2885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.63 cM"
     gene            1..2885
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /note="serine/threonine kinase 16"
                     /db_xref="GeneID:20872"
                     /db_xref="MGI:MGI:1313271"
     exon            1..224
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..399
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1231
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="kinase related to cerevisiae and thaliana;
                     embryo-derived protein kinase; TGF-beta-stimulated factor
                     1; myristoylated and palmitoylated
                     serine/threonine-protein kinase; tyrosine-protein kinase
                     STK16"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 16"
                     /protein_id="NP_035624.3"
                     /db_xref="CCDS:CCDS15067.1"
                     /db_xref="GeneID:20872"
                     /db_xref="MGI:MGI:1313271"
                     /translation="MGHALCVCSRGTVIIDNKRYLFVQKLGEGGFSYVDLVEGLHDGH
                     FYALKRILCHEQQDQEEAQREAEMHRLFQHPNILRLMAYSLKERGAKHEAWLLLPFFK
                     KGTLWNEIERLKDQGSFLTEDQILPLLLGISRGLEAIHAKGYAHRDLKPTNILLGDEG
                     QPVLMDLGSMNQACIQVEGSRQALALQDWAAQRCTISYRAPELFSVQSHCVIDERTDV
                     WSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNELSIPQSPRHSSALRQLLSSMMTVD
                     PQQRPHIPVLLSQLEALQPPAPGQHTTQI"
     exon            400..619
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..753
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..874
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..970
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1092
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..2885
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1500..1505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /note="hexamer: AATAAA"
     polyA_site      1521
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /note="major polyA site"
     regulatory      2508..2513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="Stk16"
                     /gene_synonym="EDPK; Krct; MPSK; PKL12; TSF-1"
ORIGIN      
        1 gatgatgtca tccgggcttc cggtccctgg cccttcgcac aggccggaga ccggtcggtg
       61 tggagtttgt agtggcagac cctgtgctcg ttcccgagcg acggagggtg gactcggcca
      121 gaggtgggct cgagccccgc acctcctgcg ccgccacccc atgcctgacg ggtgcgagag
      181 ctggacctgg ccgaaggtgg gccggggttg aaagaagcgg cctgcatgac ccgccgggac
      241 cccaccgcat cgcctggaag agcccactct ccctggaagg aagaccatcc ctgaagagga
      301 tgactgagac gttatgggcc acgcactgtg tgtctgctcc cggggaactg tcatcattga
      361 caataagcgt tacctcttcg tccagaaatt gggggaaggt ggattcagct atgtggacct
      421 agtggagggc ttgcatgatg gacacttcta cgccctgaag cggatcctgt gccatgagca
      481 gcaagaccag gaagaagccc aacgagaggc agagatgcat cgcctcttcc agcatcccaa
      541 catccttcgc ctcatggctt actctctgaa agaacgaggt gctaagcatg aagcctggct
      601 gctgctgccc ttcttcaaga aaggtacact gtggaatgag atagaaaggc tgaaggacca
      661 aggcagcttc ctgactgaag accagatcct gccgctgttg ctgggtatca gcagaggcct
      721 tgaggctatt catgccaaag gttatgcaca cagggacctg aagcccacca atattttgct
      781 tggtgatgag gggcagccag ttttaatgga cttgggttct atgaatcaag catgcattca
      841 agtggagggc tctcgccagg cactagctct tcaggactgg gcagctcagc ggtgcaccat
      901 ctcctaccgg gcacctgaac ttttttctgt gcaaagccac tgtgtcatcg atgagcggac
      961 tgatgtctgg tccctaggct gtgtgcttta tgccatgatg tttggggaag gcccttacga
     1021 tatggtgttc cagaagggtg acagtgtggc ccttgctgtg cagaatgaac tcagcatccc
     1081 acaaagcccc aggcattctt cagcattgcg acagctattg tcttctatga tgactgtgga
     1141 cccccagcag aggcctcaca tccctgtcct cctcagtcag ttggaggcat tgcagccacc
     1201 agctcctggc cagcacacca cccaaatctg atcaaatcag tggacatatt gggaagatga
     1261 ccttgaagtg gctttcatcc ctcattggaa ctccttccat tcttccagga tggctctcac
     1321 agctagtggc aaggatagtg ggtccttgta tattctgcct tcttacccca atacctgggc
     1381 aaggaaccta gggtgagttg ggggaaaatg aaacagaaaa tatggctcaa agctaggctg
     1441 ctgggtgcac atctcattct gtctccagat ctgggagcag gagaatacat aaaaaggaga
     1501 ataaagtaaa aacagaccgt gtatatttta ggtcaatgtg tctggaggga aagaatgaac
     1561 tctctgcttg ctatttccaa gggaagctcc tggcaagaag tactggtatg atgtcttgag
     1621 gtagatctac ttcttgagtt ctggcagcag gcaggtcttt taagctggct tagtcaaaac
     1681 cagagagctt caagcttgag ctggtttctg tctgtgccaa gaagtgggac cagggtctcc
     1741 ttgaaagcac actcaaccag ttctgtcatt cattcccagg gtgggtagct tagaacagcc
     1801 cagctccgca ggtttgccaa gtccatgtga cctctgggtg gaagcacacc gggtcttttc
     1861 ccttcttcag cagaggacaa agggagtgga gctggcagcc atttttttcc agtttccctg
     1921 actattctag ctcacacatg gttaataatt gatgaggctg gtggcctgtg gcagtaccca
     1981 gcagccactt cctgccctat ttgctgagta aacaggcacc tgccttagtt gggtttcaaa
     2041 ctttcctcag ggaagggcac tgcttccctg agtcaccagg gaggggagac aagggcaggg
     2101 atggtgctcc tgttctggag attccacccc tacatgctga cgtcaacatg agtcctaggg
     2161 tgcctattag tgaagtataa tttatcccta gggtccaggc aggaggcttc caccccgagc
     2221 agaggctgaa gccaaaagaa agcacaaaca gaggggagac gacctgactt ttaatagcat
     2281 ggctccagcc ccagaaagca agatagacag caagctatgc aaagctgcca gaggtgctgt
     2341 ggcacaaaca actagattgc ccttgttcct gcccatcccc caagtttgtg aggtggctgt
     2401 atgcccggga actttgggcc cgcccagccc ccattcccaa atcctcagtg ttcaatgacg
     2461 cctgggccaa gccttctaga gctgttgagt gaagcagcag caagaagaat aaagtagtcc
     2521 aatcatccaa cacagactat cagatatttc agaaagtgaa gacttgtatc ttgcaatagc
     2581 ttgtagctag acagacaggt ccagggtttg gtccttgttt ctttcctatt ctgcgagtcc
     2641 ttaggacctt acattgaagt ccttgggttc ctgctttctg gggctcaata tggggccccc
     2701 ttggcaagtc tcactgtcag ccatgtgaag gtaaaattaa aaggtcacaa gcggccaata
     2761 gcgggaggta gcagccaaag cagaaagggg gacaagcaga ggctcaagca gttacaaagg
     2821 ggacaagaaa ccatgcaagg agactgttta tttcgaaagg attttgcaat aaacacagtg
     2881 aacag
//
