LOCUS       NM_027886               4474 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus serine/threonine kinase 11 interacting protein
            (Stk11ip), mRNA.
ACCESSION   NM_027886
VERSION     NM_027886.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4474)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4474)
  AUTHORS   Zi,Z., Zhang,Z., Feng,Q., Kim,C., Wang,X.D., Scherer,P.E., Gao,J.,
            Levine,B. and Yu,Y.
  TITLE     Quantitative phosphoproteomic analyses identify STK11IP as a
            lysosome-specific substrate of mTORC1 that regulates lysosomal
            acidification
  JOURNAL   Nat Commun 13 (1), 1760 (2022)
   PUBMED   35365663
  REMARK    GeneRIF: Quantitative phosphoproteomic analyses identify STK11IP as
            a lysosome-specific substrate of mTORC1 that regulates lysosomal
            acidification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4474)
  AUTHORS   Tian,M., Jiang,X., Li,X., Yang,J., Zhang,C. and Zhang,W.
  TITLE     LKB1IP promotes pathological cardiac hypertrophy by targeting
            PTEN/Akt signalling pathway
  JOURNAL   J Cell Mol Med 25 (5), 2517-2529 (2021)
   PUBMED   33486894
  REMARK    GeneRIF: LKB1IP promotes pathological cardiac hypertrophy by
            targeting PTEN/Akt signalling pathway.
            Erratum:[J Cell Mol Med. 2022 Mar;26(5):1722-1723. doi:
            10.1111/jcmm.17194. PMID: 35253382]
REFERENCE   4  (bases 1 to 4474)
  AUTHORS   Moren,A., Raja,E., Heldin,C.H. and Moustakas,A.
  TITLE     Negative regulation of TGFbeta signaling by the kinase LKB1 and the
            scaffolding protein LIP1
  JOURNAL   J Biol Chem 286 (1), 341-353 (2011)
   PUBMED   20974850
  REMARK    GeneRIF: LKB1 and LIP1 provide negative control of TGFbeta
            signaling.
REFERENCE   5  (bases 1 to 4474)
  AUTHORS   Smith,D.P., Rayter,S.I., Niederlander,C., Spicer,J., Jones,C.M. and
            Ashworth,A.
  TITLE     LIP1, a cytoplasmic protein functionally linked to the
            Peutz-Jeghers syndrome kinase LKB1
  JOURNAL   Hum Mol Genet 10 (25), 2869-2877 (2001)
   PUBMED   11741830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ147230.1, AK165911.1, AK004757.2 and AI853947.1.
            
            [WARNING] On Aug 5, 2024 this sequence was replaced by NM_027886.4.
            
            On Mar 13, 2008 this sequence version replaced NM_027886.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061635.1, AK165911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               CJ147230.1         2-201
            201-1761            AK165911.1         192-1752
            1762-4055           AK004757.2         1715-4008
            4056-4164           AK165911.1         4082-4190
            4165-4474           AI853947.1         1-310               c
FEATURES             Location/Qualifiers
     source          1..4474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 39.16 cM"
     gene            1..4474
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /note="serine/threonine kinase 11 interacting protein"
                     /db_xref="GeneID:71728"
                     /db_xref="MGI:MGI:1918978"
     exon            1..114
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            115..200
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..3358
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /note="LKB1-interacting protein 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 11-interacting
                     protein"
                     /protein_id="NP_082162.3"
                     /db_xref="CCDS:CCDS15079.1"
                     /db_xref="GeneID:71728"
                     /db_xref="MGI:MGI:1918978"
                     /translation="MTTAPRDSVVWKLAGLLRESGDAVLSGCSTLSLLTATLQQLNRV
                     FELYLGPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHIPGVGLPGPI
                     KIFPFKSLRQLELRGVPIHSLCGLRGIYSQLESLVCNRSIQALEELLSACGGDLCSAL
                     PWLALLSADFSYNALRSLDSSLRLLSALRFLNLSHNHLQDCKGFLMDLCELYHLDISY
                     NHLRLVPRVGPSGAALGTLILRANELRSLQGLEQLKNLRHLDVAYNLLEGHTELAPLW
                     LLAELRKLYLEGNPLWFHPAHRAATAQYLSPRARDAAHGFLLDGKVLSLKDLQQTSDS
                     SGLGPVIQPLSWPVGSTTETSGGPELSDSLSSGGIVAQAPLRKVKSRVRVRRASISEP
                     SDTDPELRTLDPSPAGWFVQQHRELELLASFRERFGCDWLQYRSHLETMGSSPLSTTK
                     TPALSTPPLDVQNLETVCSPPAIEDDTKESPEKVSEEGRVEPEPQEEEREEQDKEEGS
                     REDLEEEEEQEQKAVEAELCRPMLVCPLQGLGGVQGKECFLRVTSAHLFEVELQAART
                     LERLELQSLVAAELESETETQGEPVSEGSGPFPGAPVLVLRFSYICPDRQLRRYAVLE
                     PEAREAVQELLAVLTPFTSVKEQQPGANKDPQGARFQCLRCSCEFKPEESRLGLESDE
                     GWKPLFQNTESPVVCPNCGSDHVVLLAVSGEVPNREQNQEEQSADSACDLADHGGCPS
                     RPDGIPPQTSISHDRSSWSLSPSPGCSGFRSVDHRLRLFLDVEVFSDSEEEFQCCIKV
                     PVVLAGHTEEFPCLVVVSNHMLYLLKVLGAICGPPASWLQPTLAIALQDLSGMELGLA
                     GQSLRLEWAAGTGSCVLLPRDARQCRAFLEELTGVLQSLPRTQRNCISATEEEVTPQH
                     RLWPLLGKDPSAEVPQFFYLRAFLAEGSSTCPVSLLLTLSTLYLLDEDPGGSHAESPL
                     PVVSDETSEQPASLGPGPSLQVREQQPLSCLSSVQLYRTSPLDLRLIFYDEVSRLESF
                     WALHVVCGEQLTALLAWIREPWEELFSIGLRTVTQEALDLDR"
     exon            201..406
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            407..481
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            482..577
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            578..685
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            686..757
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            758..884
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            885..988
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1084
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1126
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1276
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1361
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1712
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1918
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2035
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2213
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2426
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2530
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2628
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2807
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2889
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2960
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3208
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..4458
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4037..4042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /note="hexamer: AATAAA"
     polyA_site      4058
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /note="major polyA site"
     polyA_site      4090
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
     regulatory      4439..4444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
                     /note="hexamer: ATTAAA"
     polyA_site      4458
                     /gene="Stk11ip"
                     /gene_synonym="1200014D22Rik; LIP1; LKB1IP"
ORIGIN      
        1 tttgccttcc ggggcgggac ttcctgccct aaaagagccc ggctgccaaa gtgattggag
       61 tgcgaattac gcgggcccat gggctcccga ggcccaatgc tttttggaaa aggggctccg
      121 cccccagcgt cccgtggcta tgacgaccgc tccgcgggat tcagtagtgt ggaagctggc
      181 gggacttttg cgggagtcgg gcgatgcggt tctctctggc tgtagcacac tgagcctgct
      241 gacagccaca ctgcagcagc tgaacagagt gtttgaactg tacctggggc catggggccc
      301 aggccagaca ggctttgtgg ctcttccctc ccaccctgca gactcacccg tcatcctcca
      361 gcttcagttc ctcttcgatg tgctgcagaa aacactgtca ctcaagctgg tccatatccc
      421 tggtgttggc cttccagggc ctatcaagat tttccccttc aagtccctac ggcagctgga
      481 gcttcgagga gtccctatcc acagcctgtg tggcctccgt ggcatctact cacagctgga
      541 gtccctggtt tgcaacagaa gcatccaggc actggaggag ctcttgtcag cctgtggtgg
      601 ggatctctgc tctgccctcc cctggctagc cttgctttct gccgacttca gctacaatgc
      661 gctcaggagc ttagacagct ccctgcgtct cctgtccgct ctccgcttcc tcaacctgag
      721 ccacaatcat ctccaggact gcaaaggctt cctgatggat ttatgtgagc tgtaccattt
      781 ggacatctcc tataaccacc tgcgcttggt gccaagagtg ggaccatcag gggctgcgct
      841 ggggactttg atactgaggg ccaatgagct ccgcagcctt cagggcctgg agcagctaaa
      901 gaacctgcgg catctcgatg tggcctataa ccttctagaa ggacacacag agcttgcgcc
      961 attatggctg ctggccgagc tccgtaagct ctatctggaa ggtaaccctt tgtggttcca
     1021 ccctgcacac cgtgcagcca ccgcccagta cttgtcacca cgggccaggg atgctgctca
     1081 tggcttcctg cttgatggca aggttttgtc cctgaaggat cttcagcaaa cttcagactc
     1141 ttcagggctt ggtcccgtga tccagcctct gtcctggcca gtggggagta ccactgaaac
     1201 ctcaggtggc cctgagttga gtgatagcct ctcctcaggg ggcattgtgg cccaggcccc
     1261 gcttcgtaag gttaagagcc gagtccgtgt gaggcgggct agcatctctg agcccagtga
     1321 cacagaccca gagctccgaa ctctggaccc ctccccagct gggtggtttg tgcaacaaca
     1381 ccgggaactg gagctgctgg ccagcttccg ggagcggttt ggctgtgact ggctgcagta
     1441 caggagccac ctggagacca tggggagctc ccctcttagc accaccaaga ctcctgccct
     1501 tagcacccct cctctggatg tccagaacct ggagactgta tgcagccctc cagccataga
     1561 ggacgacact aaggaatcgc cagagaaggt gtcagaggaa ggcagggtgg agccagagcc
     1621 ccaggaagaa gagagggaag aacaggataa agaagaggga tcgagagagg acctggagga
     1681 ggaggaggag caggagcaga aggcagtgga agctgagctc tgtcgcccca tgttggtatg
     1741 tcccttgcag ggacttgggg gtgtgcaagg caaggagtgc tttctccggg tcacttctgc
     1801 ccacttgttt gaagtggaac tccaagcagc tcggactctg gagcggctgg agctacagag
     1861 tctggtggca gctgagctag agtccgagac tgaaacccaa ggagaaccag tgtctgaggg
     1921 ctcaggtcca ttccccgggg ctccagttct tgttcttcgc ttttcttaca tttgtcccga
     1981 ccggcagcta cgtcgatatg ctgtgctgga gccggaggcc cgtgaagccg tccaggagct
     2041 gcttgcagta ctgaccccat tcaccagtgt gaaagaacag cagcctgggg caaacaagga
     2101 cccacagggg gccagattcc agtgtctgcg ttgtagctgt gagttcaagc cagaggagtc
     2161 cagattggga ctggagagtg atgaaggctg gaagcctctg tttcaaaata cagaatctcc
     2221 tgttgtatgt ccaaactgtg ggagtgacca cgtggttctc ctagctgtgt ctggggaagt
     2281 cccgaataga gagcagaacc aggaagagca gtcagcagat tctgcctgtg acctcgctga
     2341 ccacggtggc tgtcccagca ggcctgatgg catcccacct cagacatcca tatcccatga
     2401 ccgtagcagc tggagtctca gcccatcccc tggatgctct ggttttcgct ctgtggacca
     2461 ccgactccgg ctcttcctgg atgtcgaggt gttcagtgac tccgaggagg agttccagtg
     2521 ctgtatcaag gtgccagtgg tgttagcagg ccacacggag gagtttccgt gccttgtggt
     2581 tgtgtctaac cacatgcttt acctgttgaa ggtgctaggg gccatctgcg ggcctcctgc
     2641 tagctggctc cagcccaccc tggccattgc tctgcaggac ctgagtggca tggagctcgg
     2701 cctcgcaggc cagagccttc gtctggagtg ggcagctggc actggcagct gtgtactact
     2761 gccccgagat gctaggcagt gccgagcctt ccttgaggag ctcactggtg tattgcagtc
     2821 tctgcctcgt acccaaagga actgcatcag tgccacagag gaggaggtga ccccgcagca
     2881 tcggctctgg ccattgctgg gaaaagaccc ttctgcagag gtgccccagt ttttctacct
     2941 tcgggccttc ctggctgaag gctcctctac ctgtcctgtg tccctgttgc tgacgttgtc
     3001 caccctgtac ctattagatg aagaccctgg agggtcccat gcagagtctc ctctcccagt
     3061 ggtgtctgat gaaacctcag agcagcctgc ttctctgggg ccaggtcctt ccctgcaggt
     3121 cagggagcag caaccactca gctgtctgag ttctgtgcag ctgtatcgca caagcccttt
     3181 ggacctgcgg ctgatcttct atgatgaggt gtctcgactg gagagtttct gggcccttca
     3241 tgttgtgtgt ggggagcagc tgacagccct gctggcctgg attcgggagc cctgggaaga
     3301 gttgttctcc attggactcc ggacagtaac ccaggaggct ctggacctgg accgatgagg
     3361 cctcttcact gacttcgctg cctccccctg gagttgcact gccgatgcga tgcccttttt
     3421 cctagtctct aggtctggct gcttgcctgg ctgctgttgg ccattggctt gggaagctcc
     3481 aatgaccaca gcttaagaga aggacaagag aatccatctg gcccttgggt gacctgccta
     3541 atagagcagg ctaagtggtc agtgcaaaca tttctccagc acttactctc aggtatcaat
     3601 aaagttgttg ccaggtgtca tgggtagtat gtagaaatgt ctcccagcaa gcctgccatc
     3661 ccctaatctc ttcccggaag caaccttgtt tgcactgaga cctgtcccca gcccttctct
     3721 agcaaagtag gattactgac cctgatgtac ccagtcccca agcaggttgc gacctatcca
     3781 gtggccttgc atgggatcac tgccagtcaa ttagttgggt cccttaagat ttttcattat
     3841 tctttttgag acagggtctc actgtgtaac cttggctagc ctggaacttt ctgtgtagac
     3901 caggctggcc ttgaactcat ggagacctgc ctacctctgc cttctaagtg ttgagattaa
     3961 tggcgtgagc caccaattgt gaaaaagttg tgaacttccc ctcttcccaa agtttacatt
     4021 ttatgtaaag acctgcaata aaaagtgaga tcctgtcatt gctgactctg gaagtcacct
     4081 cttgagcgaa gcactgtacc tgtccagaaa tttcaatgca tatacacgca catgtgcata
     4141 tcccccccca cacacccccc cccccccaca ttcccaaaaa gagtagctag ttcagctatc
     4201 aatggagaga cgattcttgg ggttggtttc tcccaggcga tgccctgtct ggtctgctgg
     4261 gagggtgagg gggaaatgct aagtcttagg actggctggc caatgggaag tgcccttgga
     4321 atagctgtcc tctggtactg cctgcagggg acccagacag gcctgttcag aggctctcaa
     4381 agtaatctca cctacttctg ttttgttcaa cgctgccctg aatttttaat tgaagtaaat
     4441 taaaacttcc ccaaagtaaa aaaaaaaaaa aaaa
//
