LOCUS       NM_011492               2571 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus serine/threonine kinase 11 (Stk11), transcript variant
            1, mRNA.
ACCESSION   NM_011492
VERSION     NM_011492.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Li,M., Wang,Y., Wei,X., Cai,W.F., Wu,J., Zhu,M., Wang,Y., Liu,Y.H.,
            Xiong,J., Qu,Q., Chen,Y., Tian,X., Yao,L., Xie,R., Li,X., Chen,S.,
            Huang,X., Zhang,C., Xie,C., Wu,Y., Xu,Z., Zhang,B., Jiang,B.,
            Wang,Z.C., Li,Q., Li,G., Lin,S.Y., Yu,L., Piao,H.L., Deng,X.,
            Han,J., Zhang,C.S. and Lin,S.C.
  TITLE     AMPK targets PDZD8 to trigger carbon source shift from glucose to
            glutamine
  JOURNAL   Cell Res 34 (10), 683-706 (2024)
   PUBMED   38898113
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Haberman,N., Cheung,R., Pizza,G., Cvetesic,N., Nagy,D., Maude,H.,
            Blazquez,L., Lenhard,B., Cebola,I., Rutter,G.A. and
            Martinez-Sanchez,A.
  TITLE     Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse
            pancreatic beta cells
  JOURNAL   FASEB J 38 (16), e23885 (2024)
   PUBMED   39139039
  REMARK    GeneRIF: Liver kinase B1 (LKB1) regulates the epigenetic landscape
            of mouse pancreatic beta cells.
REFERENCE   3  (bases 1 to 2571)
  AUTHORS   Lan,T., Arastu,S., Lam,J., Kim,H., Wang,W., Wang,S., Bhatt,V.,
            Lopes,E.C., Hu,Z., Sun,M., Luo,X., Ghergurovich,J.M., Su,X.,
            Rabinowitz,J.D., White,E. and Guo,J.Y.
  TITLE     Glucose-6-phosphate dehydrogenase maintains redox homeostasis and
            biosynthesis in LKB1-deficient KRAS-driven lung cancer
  JOURNAL   Nat Commun 15 (1), 5857 (2024)
   PUBMED   38997257
  REMARK    GeneRIF: Glucose-6-phosphate dehydrogenase maintains redox
            homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2571)
  AUTHORS   Ollila,S. and Makela,T.P.
  TITLE     The tumor suppressor kinase LKB1: lessons from mouse models
  JOURNAL   J Mol Cell Biol 3 (6), 330-340 (2011)
   PUBMED   21926085
  REMARK    Review article
REFERENCE   5  (bases 1 to 2571)
  AUTHORS   Denison,F.C., Hiscock,N.J., Carling,D. and Woods,A.
  TITLE     Characterization of an alternative splice variant of LKB1
  JOURNAL   J Biol Chem 284 (1), 67-76 (2009)
   PUBMED   18854309
  REMARK    GeneRIF: the physiological significance of the different forms of
            LKB1 is not related directly to differences in the C-terminal
            sequences but may be due to their differential patterns of tissue
            distribution.
REFERENCE   6  (bases 1 to 2571)
  AUTHORS   Towler,M.C., Fogarty,S., Hawley,S.A., Pan,D.A., Martin,D.M.,
            Morrice,N.A., McCarthy,A., Galardo,M.N., Meroni,S.B.,
            Cigorraga,S.B., Ashworth,A., Sakamoto,K. and Hardie,D.G.
  TITLE     A novel short splice variant of the tumour suppressor LKB1 is
            required for spermiogenesis
  JOURNAL   Biochem J 416 (1), 1-14 (2008)
   PUBMED   18774945
  REMARK    GeneRIF: LKB1(S) is a novel form in which last 63 residues are
            replaced by unique 39-residue sequence lacking known
            phosphorylation & farnesylation sites. Both isoforms are widely
            expressed in rodent & human, LKB1(S) is particularly abundant in
            haploid spermatids.
REFERENCE   7  (bases 1 to 2571)
  AUTHORS   Sapkota,G.P., Kieloch,A., Lizcano,J.M., Lain,S., Arthur,J.S.,
            Williams,M.R., Morrice,N., Deak,M. and Alessi,D.R.
  TITLE     Phosphorylation of the protein kinase mutated in Peutz-Jeghers
            cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and
            cAMP-dependent protein kinase, but not its farnesylation at
            Cys(433), is essential for LKB1 to suppress cell vrowth
  JOURNAL   J Biol Chem 276 (22), 19469-19482 (2001)
   PUBMED   11297520
REFERENCE   8  (bases 1 to 2571)
  AUTHORS   Collins,S.P., Reoma,J.L., Gamm,D.M. and Uhler,M.D.
  TITLE     LKB1, a novel serine/threonine protein kinase and potential tumour
            suppressor, is phosphorylated by cAMP-dependent protein kinase
            (PKA) and prenylated in vivo
  JOURNAL   Biochem J 345 Pt 3 (Pt 3), 673-680 (2000)
   PUBMED   10642527
REFERENCE   9  (bases 1 to 2571)
  AUTHORS   Smith,D.P., Spicer,J., Smith,A., Swift,S. and Ashworth,A.
  TITLE     The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear
            protein kinase
  JOURNAL   Hum Mol Genet 8 (8), 1479-1485 (1999)
   PUBMED   10400995
REFERENCE   10 (bases 1 to 2571)
  AUTHORS   Luukko,K., Ylikorkala,A., Tiainen,M. and Makela,T.P.
  TITLE     Expression of LKB1 and PTEN tumor suppressor genes during mouse
            embryonic development
  JOURNAL   Mech Dev 83 (1-2), 187-190 (1999)
   PUBMED   10381580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159999.6.
            
            On Jun 20, 2019 this sequence version replaced NM_011492.4.
            
            Summary: This gene encodes a member of the serine/threonine kinase
            family. The encoded protein, a known tumor suppressor, activates
            (via phosphorylation) adenine monophosphate-activated protein
            kinase (AMPK) and AMPK-related kinase proteins. This upstream
            regulation of the AMPK pathway is thought to regulate a number of
            different processes, including cell metabolism, cell polarity,
            apoptosis and DNA damage response. Mutations in a similar gene in
            human have been associated with Peutz-Jeghers syndrome. Alternative
            splicing results in multiple transcript variants, including the S
            isoform which plays a potential role in spermiogenesis. [provided
            by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (L, see PMID:18774945).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF129870.1, AK172528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1113              AC159999.6         115803-116915
            1114-1197           AC159999.6         124810-124893
            1198-1287           AC159999.6         125487-125576
            1288-1420           AC159999.6         126041-126173
            1421-1557           AC159999.6         126241-126377
            1558-1685           AC159999.6         126662-126789
            1686-1743           AC159999.6         127053-127110
            1744-1940           AC159999.6         127912-128108
            1941-2147           AC159999.6         129913-130119
            2148-2571           AC159999.6         130264-130687
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2571
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /note="serine/threonine kinase 11"
                     /db_xref="GeneID:20869"
                     /db_xref="MGI:MGI:1341870"
     exon            1..1113
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             824..2134
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /EC_number="2.7.11.1"
                     /note="isoform L is encoded by transcript variant 1;
                     serine/threonine-protein kinase 11;
                     serine/threonine-protein kinase LKB1; liver kinase B1
                     homolog; serine/threonine-protein kinase STK11"
                     /codon_start=1
                     /product="serine/threonine-protein kinase STK11 isoform L"
                     /protein_id="NP_035622.1"
                     /db_xref="CCDS:CCDS35974.1"
                     /db_xref="GeneID:20869"
                     /db_xref="MGI:MGI:1341870"
                     /translation="MDVADPEPLGLFSEGELMSVGMDTFIHRIDSTEVIYQPRRKRAK
                     LIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLL
                     RRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQL
                     IDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPA
                     FQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC
                     DCGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRS
                     MTVVPYLEDLHGRAEEEEEEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKA
                     VCVNGTEPQLSSKVKPEGRPGTANPARKVCSSNKIRRLSACKQQ"
     exon            1114..1197
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1287
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1420
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1557
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1685
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1743
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1940
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2147
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2571
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /note="hexamer: AATAAA"
     polyA_site      2362
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /note="major polyA site"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /note="hexamer: AATAAA"
     polyA_site      2571
                     /gene="Stk11"
                     /gene_synonym="Lkb1; Par-4"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcggcgc agggcggtaa acaagatggc ggcggcgtgt cggtctagga aaggggaggc
       61 ggctcacggc gtccgcgagt gaggcgcgag tcgccgaggg cggcgccggc gtggagttgt
      121 ctctcgcggg cagcatcttt ctgcctggag ttcgattccc ccctcgccgc tccggcctcc
      181 tgcctgtcgc gcggcggcta ggcggcgagg gggacgcgcc gcctggggtg gtttttttcc
      241 cccctcggtc cccggaagat ttcctgtccg gatttcgtgt ccgcgacttg cgggtgtccc
      301 ggtgtcccgc gtccgggtgg agtctgcgcc ccgagaagtc gtagaactaa ggggccgcgc
      361 gcggcttcgg cgcgggccgg acatggacgg cgcggaccgg cctcgacgcg gccgcctggg
      421 cccctgagcg cggggcccaa gtggcgaaca tgacctagcg gcccgcgcgc cgcgacggcg
      481 gaccgtcgcc tccgtcggaa gcagcgtccc cggggacccg aattgggggg acgcgagggt
      541 tgggggggct cattgctttt ttttttttca ttcttatttt catttttttt ctccctgagc
      601 acctagaaga aaaggggaaa atcaaaagtg aagaattggc gcccaggaag cggacgtgga
      661 cccggttgtg gggaccggga gagttgtgga ggtcgttcct gtttttcccc gttccttttt
      721 tccccttctt ggaacatttg gaagaagcgg gtgggggggg gggaattcga acttgaaaag
      781 aattggcgct cccgaagggg acgaggacaa agagtgggcc aggatggacg tggcggaccc
      841 cgagccgttg ggccttttct ccgagggcga gctgatgtcg gtgggcatgg acaccttcat
      901 ccaccgcatc gactccaccg aggtaatcta ccagccgcgc cgcaaacgcg ccaagctcat
      961 cggcaagtac ctgatggggg acctgctcgg ggagggctcg tacggcaagg tgaaggaggt
     1021 gctggactcc gagaccttat gccgcagggc ggtcaagatc ctcaagaaga aaaagctgcg
     1081 caggatcccc aatggagagg ccaacgtcaa gaaggagatc cagctgctgc ggcggctgcg
     1141 gcatcggaat gtgatccagc ttgtggacgt gctgtacaat gaggagaagc agaagatgta
     1201 tatggtgatg gagtactgcg tatgtggcat gcaggagatg ctggacagtg tgccggagaa
     1261 gcgcttccct gtgtgccaag ctcatgggta cttccgccag ctgattgacg gcctggaata
     1321 cctacacagc cagggcattg ttcacaagga catcaagccg ggcaacctgc tactcaccac
     1381 caatggcaca ctcaagatct ccgacctcgg tgttgccgag gccctgcacc ctttcgctgt
     1441 ggatgacacc tgccggacaa gccagggctc cccggccttc cagcctcctg agattgccaa
     1501 tggactggac accttttcag gtttcaaggt ggacatctgg tcagctgggg tcacacttta
     1561 caacatcacc acgggcctgt acccatttga gggggacaat atctacaagc tctttgagaa
     1621 cattgggaga ggagacttca ccatcccttg tgactgcggc ccaccactct ctgacctact
     1681 ccgagggatg ttggagtatg agccggccaa gaggttctcc atccgacaga ttaggcagca
     1741 cagctggttc cggaagaaac accctctggc tgaggcgctc gtacctatcc caccaagccc
     1801 agacactaag gaccgctggc gcagtatgac tgtagtgccc tacctggagg acctgcatgg
     1861 ccgtgcggag gaggaggagg aggaagactt gtttgacatt gaggacggca ttatctacac
     1921 ccaggacttc acagtgcctg gacaggtcct ggaagaggaa gtgggtcaga atggacagag
     1981 ccacagtttg cccaaggctg tttgtgtgaa tggcacagag ccccagctca gcagcaaggt
     2041 gaagccagaa ggccgacctg gcaccgccaa ccctgcgcgc aaggtgtgct ccagcaacaa
     2101 gatccgccgg ctctcggcct gcaagcagca gtgactgagg cctacagtgt gtcatcagga
     2161 tctctgggca ggtgtccctg caaggctggg ttttccaggc ctgcctgtcc actcacttcg
     2221 ggacgttgga gccgagggcg gacctgctgc cccagaagca ctttatgtcg agaccactgg
     2281 ccggccttgc ctgcatgccg ccctgcgagc ctcgctgtct ttgggttggt ttcttttttt
     2341 ttaataaaac aggtggattt gagctatggc tatgagggtg tttggaaata tggagcaggc
     2401 ggggcacagg gtggcctgca gagaaaaccc agagcaaaca aatatgcaga gacatttatg
     2461 attaaccaga caacacgacc aaccacagag ggcgcagggc agggagtggg caggcactca
     2521 cagcgagtct gccctatctt ttggcaataa ataaagcttg ggaaacttga a
//
