LOCUS       NM_028261               2302 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus stimulator of interferon response cGAMP interactor 1
            (Sting1), transcript variant 1, mRNA.
ACCESSION   NM_028261 XM_128954 XM_892499 XM_900126 XM_910347 XM_921603
            XM_921606 XM_986235 XM_989707
VERSION     NM_028261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Sun,T., Wang,P., Zhai,X., Wang,Z., Miao,X., Yang,Y. and Wu,J.
  TITLE     Neutrophil extracellular traps induce barrier dysfunction in
            DSS-induced ulcerative colitis via the cGAS-STING pathway
  JOURNAL   Int Immunopharmacol 143 (Pt 1), 113358 (2024)
   PUBMED   39388893
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Danielson,M., Nicolai,C.J., Vo,T.T., Wolf,N.K. and Burke,T.P.
  TITLE     Cytosolic bacterial pathogens activate TLR pathways in tumors that
            synergistically enhance STING agonist cancer therapies
  JOURNAL   iScience 27 (12), 111385 (2024)
   PUBMED   39669426
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Liang,X., Liu,H., Hu,H., Ha,E., Zhou,J., Abedini,A.,
            Sanchez-Navarro,A., Klotzer,K.A. and Susztak,K.
  TITLE     TET2 germline variants promote kidney disease by impairing DNA
            repair and activating cytosolic nucleotide sensors
  JOURNAL   Nat Commun 15 (1), 9621 (2024)
   PUBMED   39511169
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Lv,B., Dion,W.A., Yang,H., Xun,J., Kim,D.H., Zhu,B. and Tan,J.X.
  TITLE     A TBK1-independent primordial function of STING in lysosomal
            biogenesis
  JOURNAL   Mol Cell 84 (20), 3979-3996 (2024)
   PUBMED   39423796
  REMARK    GeneRIF: A TBK1-independent primordial function of STING in
            lysosomal biogenesis.
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Ishikawa,H., Ma,Z. and Barber,G.N.
  TITLE     STING regulates intracellular DNA-mediated, type I
            interferon-dependent innate immunity
  JOURNAL   Nature 461 (7265), 788-792 (2009)
   PUBMED   19776740
  REMARK    GeneRIF: STING is essential for host defence against DNA pathogens
            such as HSV-1 and facilitates the adjuvant activity of DNA-based
            vaccines
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Sun,W., Li,Y., Chen,L., Chen,H., You,F., Zhou,X., Zhou,Y., Zhai,Z.,
            Chen,D. and Jiang,Z.
  TITLE     ERIS, an endoplasmic reticulum IFN stimulator, activates innate
            immune signaling through dimerization
  JOURNAL   Proc Natl Acad Sci U S A 106 (21), 8653-8658 (2009)
   PUBMED   19433799
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Zhong,B., Yang,Y., Li,S., Wang,Y.Y., Li,Y., Diao,F., Lei,C., He,X.,
            Zhang,L., Tien,P. and Shu,H.B.
  TITLE     The adaptor protein MITA links virus-sensing receptors to IRF3
            transcription factor activation
  JOURNAL   Immunity 29 (4), 538-550 (2008)
   PUBMED   18818105
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Ishikawa,H. and Barber,G.N.
  TITLE     STING is an endoplasmic reticulum adaptor that facilitates innate
            immune signalling
  JOURNAL   Nature 455 (7213), 674-678 (2008)
   PUBMED   18724357
  REMARK    GeneRIF: identification, following expression cloning, of a
            molecule (STING; stimulator of interferon genes) that appears
            essential for effective innate immune signalling processes
            GeneRIF: STING (TMEM173) is an endoplasmic reticulum adaptor
            protein that facilitates innate immune signaling
            Erratum:[Nature. 2008 Nov 13;456(7219):274]
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Jin,L., Waterman,P.M., Jonscher,K.R., Short,C.M., Reisdorph,N.A.
            and Cambier,J.C.
  TITLE     MPYS, a novel membrane tetraspanner, is associated with major
            histocompatibility complex class II and mediates transduction of
            apoptotic signals
  JOURNAL   Mol Cell Biol 28 (16), 5014-5026 (2008)
   PUBMED   18559423
  REMARK    GeneRIF: A novel plasma membrane tetraspanner (MPYS) that is
            associated with type II major histocompatibility complex and
            mediates its transduction of death signals, is described.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872463.1, AK089405.1, AK077788.1, AK158458.1 and AC132837.11.
            
            On or before Jul 26, 2009 this sequence version replaced
            XM_921606.2, XM_910347.2, XM_921603.2, XM_986235.1, XM_128954.7,
            XM_892499.2, XM_900126.2, XM_989707.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170724.1, AK089405.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18818105
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BB872463.1         3-26
            25-271              AK089405.1         3-249
            272-669             AK077788.1         173-570
            670-2296            AK089405.1         648-2274
            2297-2301           AK158458.1         2084-2088
            2302-2302           AC132837.11        65182-65182         c
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.23 cM"
     gene            1..2302
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /note="stimulator of interferon response cGAMP interactor
                     1"
                     /db_xref="GeneID:72512"
                     /db_xref="MGI:MGI:1919762"
     exon            1..248
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            249..338
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1475
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial mediator of IRF3 activation; stimulator of
                     interferon genes protein; endoplasmic reticulum interferon
                     stimulator; stimulator of interferon protein;
                     transmembrane protein 173"
                     /codon_start=1
                     /product="stimulator of interferon genes protein isoform
                     1"
                     /protein_id="NP_082537.1"
                     /db_xref="CCDS:CCDS50253.1"
                     /db_xref="GeneID:72512"
                     /db_xref="MGI:MGI:1919762"
                     /translation="MPYSNLHPAIPRPRGHRSKYVALIFLVASLMILWVAKDPPNHTL
                     KYLALHLASHELGLLLKNLCCLAEELCHVQSRYQGSYWKAVRACLGCPIHCMAMILLS
                     SYFYFLQNTADIYLSWMFGLLVLYKSLSMLLGLQSLTPAEVSAVCEEKKLNVAHGLAW
                     SYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNI
                     RFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKA
                     GFSREDRLEQAKLFCRTLEEILEDVPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQ
                     EEKEEVTMNAPMTSVAPPPSVLSQEPRLLISGMDQPLPLRTDLI"
     exon            339..565
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            566..746
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            747..855
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1094
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1281
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..2302
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /note="hexamer: AATAAA"
     polyA_site      1953
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /note="major polyA site"
     regulatory      2277..2282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /note="hexamer: AATAAA"
     polyA_site      2299
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
ORIGIN      
        1 tgaaactatt aaattccttg ctcagatttc aggaagtaaa gtgtgctgtt catctcaatc
       61 tctcctgtct aacccctccc ctcccgattt ccgggggatc aatgatagta gagagctttg
      121 gggcctctgg aaatcctgtg gggccctgtc acttttggtc cttgtatgga gtcctgctag
      181 gtgtccactg gagtgtgtta catctcggga cctttagagg aattcggagt gcggggctgt
      241 ggctgctgtc tccccattca gaagccactt gctagtagct actgaaaggc tcttcattgt
      301 ctcttctgct ccaggaacac cggtctagga agcagaagat gccatactcc aacctgcatc
      361 cagccatccc acggcccaga ggtcaccgct ccaaatatgt agccctcatc tttctggtgg
      421 ccagcctgat gatcctttgg gtggcaaagg atccaccaaa tcacactctg aagtacctag
      481 cacttcacct agcctcgcac gaacttggac tactgttgaa aaacctctgc tgtctggctg
      541 aagagctgtg ccatgtccag tccaggtacc agggcagcta ctggaaggct gtgcgcgcct
      601 gcctgggatg ccccatccac tgtatggcta tgattctact atcgtcttat ttctatttcc
      661 tccaaaacac tgctgacata tacctcagtt ggatgtttgg ccttctggtc ctctataagt
      721 ccctaagcat gctcctgggc cttcagagct tgactccagc ggaagtctct gcagtctgtg
      781 aagaaaagaa gttaaatgtt gcccacgggc tggcctggtc atactacatt gggtacttgc
      841 ggttgatctt accagggctc caggcccgga tccgaatgtt caatcagcta cataacaaca
      901 tgctcagtgg tgcagggagc cgaagactgt acatcctctt tccattggac tgtggggtgc
      961 ctgacaacct gagtgtagtt gaccccaaca ttcgattccg agatatgctg ccccagcaaa
     1021 acatcgaccg tgctggcatc aagaatcggg tttattccaa cagcgtctac gagattctgg
     1081 agaacggaca gccagcaggc gtctgtatcc tggagtacgc cacccccttg cagaccctgt
     1141 ttgccatgtc acaggatgcc aaagctggct tcagtcggga ggatcggctt gagcaggcta
     1201 aactcttctg ccggacactt gaggaaatcc tggaagatgt ccccgagtct cgaaataact
     1261 gccgcctcat tgtctaccaa gaacccacag acggaaacag tttctcactg tctcaggagg
     1321 tgctccggca cattcgtcag gaagaaaagg aggaggttac catgaatgcc cccatgacct
     1381 cagtggcacc tcctccctcc gtactgtccc aagagccaag actcctcatc agtggtatgg
     1441 atcagcctct cccactccgc actgacctca tctgaggcat gggacagcct tgtctgggct
     1501 ctagtgatcc tttagcctcc tgactgagcc ttccttcaat ggttgggggc ctcagagact
     1561 tcacatctcc agatgagtcc cacattcctg ggcaagccat ttatttcacc tctctgagcc
     1621 tcaaccaacc ctactatgaa aggaggtcat aatgcgttcc ctgcccagcc aaaggatttt
     1681 atatatgtag aagttggtgt caatgcctgg taaacttgag agaaaggcca agtacttccc
     1741 gtggatgctg cagacattcc ctgctctctg ttgacctgtg tggatggtac cagcagactt
     1801 ccaaccctcc agcttctggt cacgtgtgtt caatgggagc ttaagtagat ggcgagaggg
     1861 agaaggaaca tttgttctgt tagctgtata caatcacagt gggctggcct gtcaactgcc
     1921 ttcttaataa acatatctat tctcagattt ctagaatggc ctcttcccct tgtctctagc
     1981 actggtattt gtgtgacact ggagtacttt ctgtctggtc tctttatatc atgtcccttg
     2041 cacatggtgt tggcatcagg acgtcccaaa ctcatgacat cacataggcg acagcatgac
     2101 ctgcaacctg cagaccggtt gccaagacaa caggcaccat attcccacct tccacttggc
     2161 tcacctccca cctttacctg tgttacgtca tcttccatat cttccatacg tcttccatct
     2221 tccatacgtc tctctcccct gcttctcttt ctgctgctac cttgtctctc ccttccaata
     2281 aaacctcttc catgcggaac tg
//
