LOCUS       NP_082537                378 aa            linear   ROD 12-JUN-2025
DEFINITION  stimulator of interferon genes protein isoform 1 [Mus musculus].
ACCESSION   NP_082537 XP_128954 XP_897592 XP_905219 XP_915440 XP_926696
            XP_926699 XP_991329 XP_994801
VERSION     NP_082537.1
DBSOURCE    REFSEQ: accession NM_028261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 378)
  AUTHORS   Lai,P., Liu,L., Bancaro,N., Troiani,M., Cali,B., Li,Y., Chen,J.,
            Singh,P.K., Arzola,R.A., Attanasio,G., Pernigoni,N., Pasquini,E.,
            Mosole,S., Rinaldi,A., Sgrignani,J., Qiu,S., Song,P., Li,Y.,
            Desbats,M.A., Angel,A.R., Mestre,R.P., Cavalli,A., Barile,L., de
            Bono,J. and Alimonti,A.
  TITLE     Mitochondrial DNA released by senescent tumor cells enhances
            PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
  JOURNAL   Immunity 58 (4), 811-825 (2025)
   PUBMED   40203808
REFERENCE   2  (residues 1 to 378)
  AUTHORS   Liu,D.H., Li,F., Yang,R.Z., Wu,Z., Meng,X.Y., Li,S.M., Li,W.X.,
            Li,J.K., Wang,D.D., Wang,R.Y., Li,S.A., Liu,P.P. and Kang,J.S.
  TITLE     Pulmonary mitochondrial DNA release and activation of the
            cGAS-STING pathway in Lethal Stx12 knockout mice
  JOURNAL   Cell Commun Signal 23 (1), 174 (2025)
   PUBMED   40200300
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 378)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 378)
  AUTHORS   Chenuet,P., Mellier,M., Messaoud-Nacer,Y., Culerier,E.,
            Marquant,Q., Fauconnier,L., Rouxel,N., Ledru,A., Rose,S.,
            Ryffel,B., Apetoh,L., Quesniaux,V.F.J. and Togbe,D.
  TITLE     Birch pollen allergen-induced dsDNA release activates cGAS-STING
            signaling and type 2 immune response in mice
  JOURNAL   iScience 28 (5), 112324 (2025)
   PUBMED   40276777
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 378)
  AUTHORS   Lai,Y.G., Liao,H.T., Chen,Y.H., Huang,S.W., Liou,Y.H., Wu,Z.Q. and
            Liao,N.S.
  TITLE     cGAS and STING in Host Myeloid Cells Are Essential for Effective
            Cyclophosphamide Treatment of Advanced Breast Cancer
  JOURNAL   Cancers (Basel) 17 (7), 1130 (2025)
   PUBMED   40227734
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 378)
  AUTHORS   Ishikawa,H., Ma,Z. and Barber,G.N.
  TITLE     STING regulates intracellular DNA-mediated, type I
            interferon-dependent innate immunity
  JOURNAL   Nature 461 (7265), 788-792 (2009)
   PUBMED   19776740
  REMARK    GeneRIF: STING is essential for host defence against DNA pathogens
            such as HSV-1 and facilitates the adjuvant activity of DNA-based
            vaccines
REFERENCE   7  (residues 1 to 378)
  AUTHORS   Sun,W., Li,Y., Chen,L., Chen,H., You,F., Zhou,X., Zhou,Y., Zhai,Z.,
            Chen,D. and Jiang,Z.
  TITLE     ERIS, an endoplasmic reticulum IFN stimulator, activates innate
            immune signaling through dimerization
  JOURNAL   Proc Natl Acad Sci U S A 106 (21), 8653-8658 (2009)
   PUBMED   19433799
REFERENCE   8  (residues 1 to 378)
  AUTHORS   Zhong,B., Yang,Y., Li,S., Wang,Y.Y., Li,Y., Diao,F., Lei,C., He,X.,
            Zhang,L., Tien,P. and Shu,H.B.
  TITLE     The adaptor protein MITA links virus-sensing receptors to IRF3
            transcription factor activation
  JOURNAL   Immunity 29 (4), 538-550 (2008)
   PUBMED   18818105
REFERENCE   9  (residues 1 to 378)
  AUTHORS   Ishikawa,H. and Barber,G.N.
  TITLE     STING is an endoplasmic reticulum adaptor that facilitates innate
            immune signalling
  JOURNAL   Nature 455 (7213), 674-678 (2008)
   PUBMED   18724357
  REMARK    GeneRIF: identification, following expression cloning, of a
            molecule (STING; stimulator of interferon genes) that appears
            essential for effective innate immune signalling processes
            GeneRIF: STING (TMEM173) is an endoplasmic reticulum adaptor
            protein that facilitates innate immune signaling
            Erratum:[Nature. 2008 Nov 13;456(7219):274]
REFERENCE   10 (residues 1 to 378)
  AUTHORS   Jin,L., Waterman,P.M., Jonscher,K.R., Short,C.M., Reisdorph,N.A.
            and Cambier,J.C.
  TITLE     MPYS, a novel membrane tetraspanner, is associated with major
            histocompatibility complex class II and mediates transduction of
            apoptotic signals
  JOURNAL   Mol Cell Biol 28 (16), 5014-5026 (2008)
   PUBMED   18559423
  REMARK    GeneRIF: A novel plasma membrane tetraspanner (MPYS) that is
            associated with type II major histocompatibility complex and
            mediates its transduction of death signals, is described.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872463.1, AK089405.1, AK077788.1, AK158458.1 and AC132837.11.
            
            On or before Jul 26, 2009 this sequence version replaced
            XP_926699.1, XP_915440.1, XP_926696.1, XP_991329.1, XP_128954.2,
            XP_897592.1, XP_905219.1, XP_994801.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170724.1, AK089405.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18818105
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.23 cM"
     Protein         1..378
                     /product="stimulator of interferon genes protein isoform
                     1"
                     /note="mitochondrial mediator of IRF3 activation;
                     stimulator of interferon genes protein; endoplasmic
                     reticulum interferon stimulator; stimulator of interferon
                     protein; transmembrane protein 173"
                     /calculated_mol_wt=42699
     Region          1..189
                     /region_name="Mediates interaction with ZDHHC1 and
                     ZDHHC11. /evidence=ECO:0000250|UniProtKB:Q86WV6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            18..34
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          44..336
                     /region_name="TMEM173"
                     /note="Transmembrane protein 173; pfam15009"
                     /db_xref="CDD:464441"
     Site            45..69
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            92..106
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            116..133
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          152..339
                     /region_name="Cyclic dinucleotide-binding domain (CBD).
                     /evidence=ECO:0000269|PubMed:23519410"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WV6; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          339..378
                     /region_name="C-terminal tail (CTT).
                     /evidence=ECO:0000250|UniProtKB:Q86WV6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            354
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:37832545; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000305|PubMed:25636800; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          362..365
                     /region_name="pLxIS motif.
                     /evidence=ECO:0000250|UniProtKB:Q86WV6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000269|PubMed:25636800,
                     ECO:0000269|PubMed:27637147; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     CDS             1..378
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /coded_by="NM_028261.1:339..1475"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50253.1"
                     /db_xref="GeneID:72512"
                     /db_xref="MGI:MGI:1919762"
ORIGIN      
        1 mpysnlhpai prprghrsky valiflvasl milwvakdpp nhtlkylalh lashelglll
       61 knlcclaeel chvqsryqgs ywkavraclg cpihcmamil lssyfyflqn tadiylswmf
      121 gllvlyksls mllglqsltp aevsavceek klnvahglaw syyigylrli lpglqarirm
      181 fnqlhnnmls gagsrrlyil fpldcgvpdn lsvvdpnirf rdmlpqqnid ragiknrvys
      241 nsvyeileng qpagvciley atplqtlfam sqdakagfsr edrleqaklf crtleeiled
      301 vpesrnncrl ivyqeptdgn sfslsqevlr hirqeekeev tmnapmtsva pppsvlsqep
      361 rllisgmdqp lplrtdli
//
