LOCUS       NM_028839               3754 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus STIM activating enhancer (Stimate), mRNA.
ACCESSION   NM_028839 NM_026978
VERSION     NM_028839.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Tremblay,M.G. and Moss,T.
  TITLE     Loss of all 3 Extended Synaptotagmins does not affect normal mouse
            development, viability or fertility
  JOURNAL   Cell Cycle 15 (17), 2360-2366 (2016)
   PUBMED   27399837
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ180452.1, AK009341.1, CT025528.10 and BE944885.1.
            
            On Mar 13, 2009 this sequence version replaced NM_028839.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076341.1, SRR7345562.1914910.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               CJ180452.1         5-118
            115-905             AK009341.1         94-884
            906-3541            CT025528.10        112361-114996       c
            3542-3754           BE944885.1         1-213               c
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..3754
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /note="STIM activating enhancer"
                     /db_xref="GeneID:69179"
                     /db_xref="MGI:MGI:1921500"
     exon            1..297
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1004
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /note="STIM-activating enhancer encoded by TMEM110;
                     transmembrane protein 110"
                     /codon_start=1
                     /product="store-operated calcium entry regulator STIMATE"
                     /protein_id="NP_083115.3"
                     /db_xref="CCDS:CCDS26899.1"
                     /db_xref="GeneID:69179"
                     /db_xref="MGI:MGI:1921500"
                     /translation="MQGPGGNVSRGLPSGPASTVASGAGRCESGALMHSFGIFLQGLL
                     GVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSL
                     YLINFLLDATVGMLLIYVGVRAVGVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIV
                     IMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNAFMFWVVDNFLM
                     RKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDAEEDLRR
                     PVKKKHRFGLPV"
     exon            298..346
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     exon            347..442
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     exon            443..564
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     exon            565..677
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     exon            678..755
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     exon            756..905
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     exon            906..3738
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1652
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /note="major polyA site"
     regulatory      3702..3707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
                     /note="hexamer: AATAAA"
     polyA_site      3732
                     /gene="Stimate"
                     /gene_synonym="1810038N08Rik; 2310014H19Rik; Tmem110"
ORIGIN      
        1 gtcgggttac gcgcggcgcg gaggcggccg cgggctgaga taccggcacc cagctccagg
       61 tccggggtcg cggctgggca gcgcgacccg ggctgcagcg aggccggcgg cccctcgcgc
      121 cctcccgtca ggccgccatg caaggcccgg gagggaacgt gagccgcgga ttgccgagcg
      181 ggccggcctc cacggtcgcg tccggggcgg gccgctgtga gagcggcgcg ctcatgcaca
      241 gtttcggcat cttcctgcag gggctgctcg gcgtcgtggc cttcagcaca ttgatgctta
      301 aacgcttcag agaaccaaag catgaaagac ggccgtggag gatatggttt ttagacactt
      361 ccaaacaagc catagggatg ctcttcatcc actttgcaaa tgtgtaccta gcagatctca
      421 ctgaagagga cccttgttca ctgtacctca tcaactttct tctggacgcc actgtaggca
      481 tgctgctcat ttatgtgggc gtacgcgccg tcggtgtctt ggtggagtgg cagcagtggg
      541 aatccctgcg ttttggagaa tatggagacc ctctgcagtg cggggcctgg gtaggacagt
      601 gcgccctcta catcgtgatc atgatctttg aaaagtccgt ggtcttcatc gtcctcctca
      661 tactccagtg gaaaaaggtg gccctattga atccaattga aaaccccgac ctgaagctgg
      721 ccatcgtcat gctgatagtc cccttctttg tcaatgcttt catgttctgg gtagtggaca
      781 atttcctcat gagaaagggg aagacgaaag ctaaactaga agaaagagga gccaaccagg
      841 actcaaggaa tgggagcaag gttcgctacc gaagggcagc atcccatgag gagtctgagt
      901 ctgagatcct gatctcagct gacgacgaga tggaggagtc tgacgccgag gaggacctcc
      961 ggagacctgt gaaaaagaag caccgcttcg ggctgcctgt atgacacatt cccacgctgc
     1021 gggtgacagt cctggggccc agccctgcag caacagcgtc tctgccctcc tctctgccct
     1081 cctcttctac ctctgctcct cctgctgtct ctgcccgctc tccacccgcc ccagacgact
     1141 gtgacttaaa agagggaaga ggacccatgc ccgagggggc tgtgggcagc tggagtgccc
     1201 actcagttgc actacaaaca ctgaccaaat atgcaagcga agagctttgt ttgtttgttg
     1261 ttgtccctta ggggttctgt aagaccccct gtcctgtctg accaggtggc atggtggaag
     1321 gaaacagcac acagactgtt gcgggtcctg gagctgaggc tgccggcctt gtggacaagc
     1381 gctgtgcttg aggttagcag ttgctggttg acccaagttg gaacaggaat gctttcttaa
     1441 ctcaaaatgg cttttgtaac tctttatttc taaagccagt tttatgagct gtgacagtgt
     1501 tactgttttt tgagtatgtg ttcatttcct acaaagtatc tatgggtcta atgggcaaac
     1561 agatttttaa gtcttccgta tactgttgga cttttatatt tttaagttat attttcatac
     1621 tattgtattt aaaactcttt ttaatcccca aagacatgga tttgtttgcc tttcatgggg
     1681 aatgagctag ggggaggtgg gtaaaaatga ggagttttgg aggcaggaat attgttaagt
     1741 aacatcgatg gtgagataaa cggccctggt gggaaggtag agagatagcg cttatctgcg
     1801 ctcacagatc catagttaag gtcagaacct gcacaggagg cagctgctcc agtgtgggga
     1861 cagacagagc cctgccaggg catacaagct gccgtgttgg aggcaatggt taaacttcac
     1921 tcaggagtta cacgtttgtg tccagaggac tcaagaccgc ctccggctac tcctgttggt
     1981 ttcctgccta tctcagtctc taaattgcaa gtgttagaat ggcctcagcc ttgactgcct
     2041 gtacagcagc cttgactgta cagcagcttg cagagccaac ctttgccctg gtctgtcacc
     2101 agctgccacc tgcttgcttg cttagctgtc tagagaactc ttcctggccg gaagagcctg
     2161 tcatgatgcc ctacaaagtt gtgaaataac tgcagcagag cagacactgg tgtgagtcgt
     2221 gtttgaatgt gtaggttgta tgaggcattt ctaactggct cctctctgct ggccacaccc
     2281 actcctcagc cgggctgtgg tttacctgtg ggccagcctg gcctggcact gtccctgctg
     2341 tgggagcagc agggcgggac tgtctgatgg cctctcagtg gtaaggagca caagaacacc
     2401 caccgcctca cgggctgagg ccttaggtga gacaagcaca gaggacagct ctcctcagaa
     2461 cccctaagcc taggtcagag tgtgctttgc ataagcatac aggctctaaa tatgcttgtg
     2521 gcccgtgacc ctagcccttg cccaggatac ctgggctgtc ttctgccact tgaaaccttc
     2581 cttgtcacag acagaagggt atgctctggg tggccctctc agctcactgt ctagcgcaag
     2641 tcactgagaa gagtgagtct gctgtgggag gctgcacatt cctgtcaggc agaggccatg
     2701 acctggaacg ggtccgccag gccctgcctt ggtctcagtt cccattttct tccatcgttc
     2761 agcagtggtc attctctccc cttctctagt gagcttccac tgagctcaaa ctcctggtga
     2821 gctggtcagc gcccgggtgt tgctgacgtc atcctcacgt ccccttcccc tttgctgtgc
     2881 tttagctggc ctttgctgcg cacacccctg ccatccctct ggagctcaga gctgaaacct
     2941 cattttcaga ctcaagctcc tggagtttcc aagctagaca cagaggtggg ggaaatgctg
     3001 ttaaggacgg aaggatggca actccgggtg cacagcctca cagaggtggt ctgtaaggtc
     3061 ctcccagctc ccaggcacag ggcctggagg acaggaagca agtgagtgca agttccttct
     3121 gcaccctgat ttccgctaag gactgtcgtc tctgggctgc agctgtggag ttggctcagt
     3181 aggagaggag gtccaacagg gatctgccac tagagcctgt ctgtgtgcaa gcgtggtgtg
     3241 tgtctgtcct tccctctccc tgtggatgtg cgcatgcaac catacagcaa aagcacatac
     3301 aattccgcat cccttgggag agcctccggt ggccgacaag gcctttctgt caccgtggtg
     3361 cactgtctca ctggagtgga tgtagagggc tctggtcagg acttcttcct gagctgtccc
     3421 ccctccccgg aacaagtgtc cacatcactt gttccaagtt gccttatgag gtgggaccct
     3481 ttactggctg attgcgggcg acaccgagct agggaaaaaa aaaaaaaaaa aaaaaaacaa
     3541 gaagtgtgga atgctgacct agctgtggtg tgctgtcaat ctgatttgtc caaataggta
     3601 ccttggccaa gctgctcttg gtagaagctt gccagccacg gtgaagaatg aggttttttt
     3661 gtttttgttt ttgtttttgt tttttttttg taactaacag aaataaacca atgagagaga
     3721 gctgacacct aactcggaaa aaaaaaaaaa aaaa
//
