LOCUS       NM_001081103            4930 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus stromal interaction molecule 2 (Stim2), transcript
            variant 2, mRNA.
ACCESSION   NM_001081103 XM_132038
VERSION     NM_001081103.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4930)
  AUTHORS   Woo,M.S., Mayer,C., Binkle-Ladisch,L., Sonner,J.K.,
            Rosenkranz,S.C., Shaposhnykov,A., Rothammer,N., Tsvilovskyy,V.,
            Lorenz,S.M., Raich,L., Bal,L.C., Vieira,V., Wagner,I., Bauer,S.,
            Glatzel,M., Conrad,M., Merkler,D., Freichel,M. and Friese,M.A.
  TITLE     STING orchestrates the neuronal inflammatory stress response in
            multiple sclerosis
  JOURNAL   Cell 187 (15), 4043-4060 (2024)
   PUBMED   38878778
REFERENCE   2  (bases 1 to 4930)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4930)
  AUTHORS   Yada,Y., Matsumoto,M., Inoue,T., Baba,A., Higuchi,R., Kawai,C.,
            Yanagisawa,M., Kitamura,D., Ohga,S., Kurosaki,T. and Baba,Y.
  TITLE     STIM-mediated calcium influx regulates maintenance and selection of
            germinal center B cells
  JOURNAL   J Exp Med 221 (1) (2024)
   PUBMED   37902601
REFERENCE   4  (bases 1 to 4930)
  AUTHORS   Yang,F., Suo,M., Weli,H., Wong,M., Junidi,A., Cummings,C.,
            Johnson,R., Mallory,K., Liu,A.Y., Greenberg,Z.J., Schuettpelz,L.G.,
            Miller,M.J., Luke,C.J., Randolph,G.J., Zinselmeyer,B.H.,
            Wardenburg,J.B. and Clemens,R.A.
  TITLE     Staphylococcus aureus alpha-toxin impairs early neutrophil
            localization via electrogenic disruption of store-operated calcium
            entry
  JOURNAL   Cell Rep 42 (11), 113394 (2023)
   PUBMED   37950870
REFERENCE   5  (bases 1 to 4930)
  AUTHORS   Wasilewska,I., Majewski,L., Adamek-Urbanska,D., Mondal,S.S.,
            Baranykova,S., Gupta,R.K., Bielecki,D., Winata,C.L. and Kuznicki,J.
  TITLE     Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to
            Hypoxia
  JOURNAL   Zebrafish 20 (4), 146-159 (2023)
   PUBMED   37590563
  REMARK    GeneRIF: Lack of Stim2 Affects Vision-Dependent Behavior and
            Sensitivity to Hypoxia.
REFERENCE   6  (bases 1 to 4930)
  AUTHORS   Berna-Erro,A., Braun,A., Kraft,R., Kleinschnitz,C., Schuhmann,M.K.,
            Stegner,D., Wultsch,T., Eilers,J., Meuth,S.G., Stoll,G. and
            Nieswandt,B.
  TITLE     STIM2 regulates capacitive Ca2+ entry in neurons and plays a key
            role in hypoxic neuronal cell death
  JOURNAL   Sci Signal 2 (93), ra67 (2009)
   PUBMED   19843959
  REMARK    GeneRIF: show that STIM2, but not STIM1, is essential for
            capacitive Ca(2+) entry and ischemia-induced cytosolic Ca(2+)
            accumulation in neurons.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4930)
  AUTHORS   Bojarski,L., Pomorski,P., Szybinska,A., Drab,M.,
            Skibinska-Kijek,A., Gruszczynska-Biegala,J. and Kuznicki,J.
  TITLE     Presenilin-dependent expression of STIM proteins and dysregulation
            of capacitative Ca2+ entry in familial Alzheimer's disease
  JOURNAL   Biochim Biophys Acta 1793 (6), 1050-1057 (2009)
   PUBMED   19111578
  REMARK    GeneRIF: Data demonstrate that cellular levels of STIM1 and STIM2,
            which are key players in capacitative Ca2+ entry, depend on
            presenilins.
REFERENCE   8  (bases 1 to 4930)
  AUTHORS   Oh-Hora,M., Yamashita,M., Hogan,P.G., Sharma,S., Lamperti,E.,
            Chung,W., Prakriya,M., Feske,S. and Rao,A.
  TITLE     Dual functions for the endoplasmic reticulum calcium sensors STIM1
            and STIM2 in T cell activation and tolerance
  JOURNAL   Nat Immunol 9 (4), 432-443 (2008)
   PUBMED   18327260
  REMARK    GeneRIF: Promote store-operated entry of calcium ions into T cells;
            required for the development and function of regulatory T cells.
REFERENCE   9  (bases 1 to 4930)
  AUTHORS   Wissenbach,U., Philipp,S.E., Gross,S.A., Cavalie,A. and
            Flockerzi,V.
  TITLE     Primary structure, chromosomal localization and expression in
            immune cells of the murine ORAI and STIM genes
  JOURNAL   Cell Calcium 42 (4-5), 439-446 (2007)
   PUBMED   17659338
REFERENCE   10 (bases 1 to 4930)
  AUTHORS   Williams,R.T., Manji,S.S., Parker,N.J., Hancock,M.S., Van
            Stekelenburg,L., Eid,J.P., Senior,P.V., Kazenwadel,J.S.,
            Shandala,T., Saint,R., Smith,P.J. and Dziadek,M.A.
  TITLE     Identification and characterization of the STIM (stromal
            interaction molecule) gene family: coding for a novel class of
            transmembrane proteins
  JOURNAL   Biochem J 357 (Pt 3), 673-685 (2001)
   PUBMED   11463338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK173183.1, AC139037.10 and BF472598.1.
            
            [WARNING] On Jan 17, 2025 this sequence was replaced by
            NM_001081103.3.
            
            On Dec 15, 2009 this sequence version replaced NM_001081103.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to represent an
            alternate splicing pattern and to use a downstream start codon.
            PMID:11463338 provides experimental evidence for the use of the
            downstream start codon, but no data is available regarding the use
            of the upstream start codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173183.1, BC137881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3559              AK173183.1         1-3559
            3560-4866           AC139037.10        31660-32966         c
            4867-4930           BF472598.1         347-410
FEATURES             Location/Qualifiers
     source          1..4930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 29.69 cM"
     gene            1..4930
                     /gene="Stim2"
                     /note="stromal interaction molecule 2"
                     /db_xref="GeneID:116873"
                     /db_xref="MGI:MGI:2151156"
     exon            1..512
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..2602
                     /gene="Stim2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="stromal interaction molecule 2 isoform 2
                     precursor"
                     /protein_id="NP_001074572.2"
                     /db_xref="CCDS:CCDS39089.2"
                     /db_xref="GeneID:116873"
                     /db_xref="MGI:MGI:2151156"
                     /translation="MLLFGLLVAGVADGCDLVPRHLRGRRASGSAGAAASPSAAAAGE
                     RQALLTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVDESDEFIREDMKY
                     KDATNKHSHLHREDKHITVEDLWKQWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRD
                     NNVKGTTLPRIAVHETSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDF
                     ILTISIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEEN
                     RTVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKK
                     AEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRS
                     TVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSG
                     LPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVPQFPGTVAKPAGSLAR
                     SSSLCRSRRSIVPSSPQSQRAQLPAHAPLAAHPRHPHHPQHPQHSLPSPDPDILSVSS
                     CPALYRNEEEEEAIYFTAEKQWEVPDTASECDSLNSSSGRKPSPPSSLEMYQTLSSRK
                     ISRDELSLEDSSRGESPVTADVSRGSPECVGLTETKSMIFSPASRVYNGILEKSCSMH
                     QLSSGIPVPHPRHTSCSSAGNDSKPVQEASNVSRVSSIPHDLCHNGEKSKKPSKIKSL
                     FKKKSK"
     exon            513..643
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..758
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..870
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..986
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1164
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1342
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1510
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1611
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1850
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2124
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..4910
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3537..3542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stim2"
                     /note="hexamer: AATAAA"
     polyA_site      3554
                     /gene="Stim2"
                     /note="major polyA site"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stim2"
                     /note="hexamer: TATAAA"
     polyA_site      3787
                     /gene="Stim2"
                     /note="major polyA site"
     regulatory      4892..4897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stim2"
                     /note="hexamer: ATTAAA"
     polyA_site      4910
                     /gene="Stim2"
ORIGIN      
        1 cgcggcggcg gcgcgggcgc tgggctgggg cttggccgcg ccagagcagc ggatcccggt
       61 gtcgccgcgg cagctgcgcg ggtgtcgcgc tgggtcggaa gacgccgtac cactgcgctc
      121 ccccactttt tttttttttt ttttttttaa ataaccggaa ccaatgaacg cggcggcgag
      181 ccgagcttcg cgggccgccg gtgaagggag cgggtcagca cccggcggga gtccgcttcc
      241 gaggcggccg ggccccgggc agctggcggt gagcgagtgg ccggcggctc ctgtgagcgc
      301 tcctcccgcc gtggcaccgg gccgggcctc gggccgccct ctccggcggc gctgggcagc
      361 aatgctgctc ttcgggttgt tggtggccgg cgtggcggac ggatgcgatc tggtgccccg
      421 gcacctccgc gggcggcgcg cgtcgggatc ggccggagcg gcggcgtctc cttcggctgc
      481 ggctgcgggc gagcgccagg cgctgctgac agatccctgt atgtcgctga gtccaccttg
      541 cttcactgaa gaagacaggt ttagcttgga agcacttcag acaatacaca aacagatgga
      601 cgacgacaag gacggcggga tcgaagtgga cgagagtgat gagtttatca gagaagatat
      661 gaaatataaa gatgctacga ataaacatag tcacctgcac agagaagata agcacataac
      721 tgttgaggat ttgtggaaac agtggaaaac atcagaagtt cacaattgga cacttgagga
      781 taccctgcag tggttaatag aatttgttga actgccacaa tatgagaaga attttaggga
      841 taataatgtg aagggaacaa cactccccag gatagcagtt catgaaactt catttatgat
      901 ttcccagttg aaaatcagcg accgaagtca cagacagaaa ctccaactca aagccctgga
      961 tgtggttctg tttgggcctc tgacacgccc acctcataac tggatgaagg attttattct
     1021 cacaatttcc atagtaattg gtgttggggg ttgttggttt gcttatacac aaaataagac
     1081 atcaaaggaa catgttgcaa aaatgatgaa agacttagag agtctgcaga ctgcagagca
     1141 gagtctcatg gacttacaag agagacttga aaaggcacag gaagaaaaca gaactgttgc
     1201 tgtagaaaag caaaatctgg aacggaaaat gatggatgaa atcaactatg ccaaggagga
     1261 ggcctgtcgg ctgcgggagc tgagggaggg cgcagagtgt gagctgagca ggcgccagta
     1321 tgcagagcag gaactggagc aggtccgcat ggctctaaaa aaggccgaaa aggagtttga
     1381 actgagaagc agctggtctg tccctgacgc actacagaaa tggcttcagc taacacacga
     1441 agttgaagta cagtactaca atattaagag gcaaaatgct gagatgcagc tagccatcgc
     1501 taaggacgag gcagaaaaaa ttaaaaagaa gagaagcaca gtctttggga ccctgcacgt
     1561 tgcacacagc tcctccctgg acgaagtaga ccacaagatt ctggaagcca agaaagccct
     1621 ctctgagctg accacgtgct tgcgagaacg gctttttcgc tggcagcaga ttgagaagat
     1681 ctgtggcttt cagatagctc acaactctgg gctccccagt ctcacctcct ctctgtactc
     1741 tgaccacagc tgggtggtga tgcctagagt ctccattcca ccctacccta ttgctggagg
     1801 agttgatgac ctcgatgaag acacaccccc aatcgtgcca cagtttccag ggaccgtggc
     1861 taaacctgca ggatctttag ccagaagcag tagtttatgc cgctctcgtc gcagcatcgt
     1921 gccatcctcc ccacagtctc agcgagctca gcttcctgct catgctcctc tggcagccca
     1981 ccctcggcac cctcaccatc cgcagcatcc ccagcactcg ttgccttccc cagatccaga
     2041 catcctgtct gtgtcaagtt gccctgctct gtatcggaac gaagaggagg aggaggctat
     2101 ctacttcact gctgagaaac aatgggaagt gccagacaca gcttcagaat gtgactcctt
     2161 aaactcttcc agtgggagaa aaccgtctcc cccttcaagc cttgagatgt accaaacatt
     2221 gtcttcccga aaaatctcaa gagacgagct ttccctggag gactcttcca ggggggagtc
     2281 acccgtgaca gcagatgtct cccggggctc ccctgagtgt gtgggtctga cggagaccaa
     2341 gagcatgatc ttcagccctg caagcagagt gtacaatggc atcctggaga aatcctgcag
     2401 catgcaccag ctctccagcg gcatcccggt gcctcatccc cgacacacat cgtgctcctc
     2461 agccggcaat gatagcaagc cagttcagga agcctcgaat gtttccagag taagcagcat
     2521 cccacatgac ctctgtcata atggtgagaa aagcaaaaag ccatccaaaa tcaaaagcct
     2581 tttcaagaag aagtctaagt gactcggctg acgtgatgga attccattca agtggcatct
     2641 gtaaactgtt atctcccacc ctccactccg tttttatttt acttttagga atgtaactcc
     2701 actggggctt tccagacttg atgccatagt ggaaatgtcc gtaagggcag ctgtctactg
     2761 tctgcttata tctaactgac tacgcaatca attcatcaag tcagatacca ccaccggagc
     2821 catcggcagg aggcagttta cagttctttc cgcctattta tttctgcatt gatgttagtg
     2881 atgtacacac agcattctgt cgaaagccgc catggactta caagctttaa tggactgtaa
     2941 gccagcatgg gcttgcaaaa ttttcttgtt taccagaata tcttcttatc tttccacaga
     3001 gctgtttcca tcatggacta aataacttaa aagaagtaaa actgattgca ctactgtttt
     3061 ccagactgga aaaaaaaatc tctgcaagta aaactgtata gagtttataa actgactgtg
     3121 gatagggaat tgttttcact tttagataaa atggattttt aagtagaaac tagggtttct
     3181 aattgacttg atttctgaaa atgaaaaccc acacttttat tatgggacgc ttcctcaaat
     3241 gcatttatta ttataaagtt tcaagtcctg ctgtaaagac catgttgttt tgttttcccc
     3301 agggctttca ctgtgattta ctgcactgca ggctgtatga taaaatataa ataatgtaaa
     3361 ggcagaaggc tcttgattcc ttatccaagt ggaagagtaa aacttgatcg aaggacttaa
     3421 aacattcaca tgcttaaact gcggtctggg gcgtggggac ccaggcactt gtttacagac
     3481 tttgaataaa tgcaaagaat ttatggtttg tgaaaaattt gtactgtgga aaagataata
     3541 aattggagac attattgtgt ggggttgtgc tgatttttgt tgataacact ccactgaaaa
     3601 cactgttttc tggagagcca tgtaagctgt cttgctgctg aattgcagta taagaaatag
     3661 cgatgttttg gaactaagtt gtcaacaaat ttctttgttt tatattgttt gtcatatttt
     3721 tatgtagttt gaaatcttta aatgttctca tatcaagatt aacaaatata aattgctggt
     3781 gcatttagat tgtgttgaat gagtttgtaa agtttggaac tggttagctg ctgggcaggt
     3841 cagagagaag cctgagagta gcctcgcata ggacagcagt gcacatttcg tttccacctt
     3901 ctcagctctt aagacctcag gcagaactat ctggaaatac aggaagatgg gtggttgggt
     3961 gaacacggat atgttaacta gaattttttt ttggtgctgg ctatctggga atgctgatgg
     4021 ataagtaaga agtccccttg agatttgcat aaaaggagtg ctttattaag gatccaaatc
     4081 tcaaagcctc ctgtgagttg tgattattta cttccattgc tctggttgtt ataatcgtca
     4141 gggtctcact gggctcgatg actaccaatc agctcctaag atcagaagct gactgtctga
     4201 cataaagatg ctttgcaaga tagcgtgaaa catggagttc agagaccact ctagagttct
     4261 actggaagga aagcaatttt gcataaagaa ttagaaagtg tccaggaaac cccccagact
     4321 aaaggggatg ttttgtcttt gtcacagctg gaccagaggc gttctctttg ggaattgcaa
     4381 cagaaataag cgctttttag tttgatggac agaaaggtca aagctaccag agtgtggagt
     4441 gcatacagaa ggcttggctg cgagattgct tatagctagg gttggtaggg cgtcctgggt
     4501 cagagccagg tagaaactag cggaggttgg gctgagagag taggggtggg tttaggaaag
     4561 gagtgtattg tgtatacctg attacacatt tataaacagg tccaatggag ggatatgtac
     4621 tgttgtatgg tgtgatattt atttgcatta gtaacagtat ttggaaaaga acagaaatcc
     4681 agaggaaaga aactagtttt ggaaagccat catcattttg gtatcacatc acatgcgaag
     4741 cgttgggcat ttctgtaagt tttacatata ttgccttcct ctactcttta aaaactgatg
     4801 ctctcctatt tctccctaac tataagatga gaaagattcc tggtagtgaa gtgcaaaaaa
     4861 gaaaacagca gcatggcagt caaatcacgc tattaaaatt acttttacta aaaaaaaaaa
     4921 aaaaaaaaaa
//
