LOCUS       NM_009287               4072 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus stromal interaction molecule 1 (Stim1), transcript
            variant 1, mRNA.
ACCESSION   NM_009287 XM_909246 XM_921206 XM_921215 XM_921239 XM_921249
VERSION     NM_009287.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4072)
  AUTHORS   Wang,H., Zeng,P., Zhu,P.H., Wang,Z.F., Cai,Y.J., Deng,C.Y.,
            Yang,H., Mai,L.P., Zhang,M.Z., Kuang,S.J., Rao,F. and Xu,J.S.
  TITLE     Downregulation of stromal interaction molecule-1 is implicated in
            the age-associated vasoconstriction dysfunction of aorta,
            intrarenal, and coronary arteries
  JOURNAL   Eur J Pharmacol 979, 176832 (2024)
   PUBMED   39038639
  REMARK    GeneRIF: Downregulation of stromal interaction molecule-1 is
            implicated in the age-associated vasoconstriction dysfunction of
            aorta, intrarenal, and coronary arteries.
REFERENCE   2  (bases 1 to 4072)
  AUTHORS   Woo,M.S., Mayer,C., Binkle-Ladisch,L., Sonner,J.K.,
            Rosenkranz,S.C., Shaposhnykov,A., Rothammer,N., Tsvilovskyy,V.,
            Lorenz,S.M., Raich,L., Bal,L.C., Vieira,V., Wagner,I., Bauer,S.,
            Glatzel,M., Conrad,M., Merkler,D., Freichel,M. and Friese,M.A.
  TITLE     STING orchestrates the neuronal inflammatory stress response in
            multiple sclerosis
  JOURNAL   Cell 187 (15), 4043-4060 (2024)
   PUBMED   38878778
REFERENCE   3  (bases 1 to 4072)
  AUTHORS   Fresquez,A.M., Hogan,J.O., Rivera,P., Patterson,K.M., Singer,K.,
            Reynolds,J.M. and White,C.
  TITLE     STIM1-dependent store-operated calcium entry mediates sex
            differences in macrophage chemotaxis and monocyte recruitment
  JOURNAL   J Biol Chem 300 (7), 107422 (2024)
   PUBMED   38815866
  REMARK    GeneRIF: STIM1-dependent store-operated calcium entry mediates sex
            differences in macrophage chemotaxis and monocyte recruitment.
REFERENCE   4  (bases 1 to 4072)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   5  (bases 1 to 4072)
  AUTHORS   Knapp,M.L., Alansary,D., Poth,V., Forderer,K., Sommer,F.,
            Zimmer,D., Schwarz,Y., Kunzel,N., Kless,A., Machaca,K., Helms,V.,
            Muhlhaus,T., Schroda,M., Lis,A. and Niemeyer,B.A.
  TITLE     A longer isoform of Stim1 is a negative SOCE regulator but
            increases cAMP-modulated NFAT signaling
  JOURNAL   EMBO Rep 23 (3), e53135 (2022)
   PUBMED   34942054
REFERENCE   6  (bases 1 to 4072)
  AUTHORS   Ramesh,G., Jarzembowski,L., Schwarz,Y., Poth,V., Konrad,M.,
            Knapp,M.L., Schwar,G., Lauer,A.A., Grimm,M.O.W., Alansary,D.,
            Bruns,D. and Niemeyer,B.A.
  TITLE     A short isoform of STIM1 confers frequency-dependent synaptic
            enhancement
  JOURNAL   Cell Rep 34 (11), 108844 (2021)
   PUBMED   33730587
  REMARK    GeneRIF: A short isoform of STIM1 confers frequency-dependent
            synaptic enhancement.
REFERENCE   7  (bases 1 to 4072)
  AUTHORS   Williams,R.T., Manji,S.S., Parker,N.J., Hancock,M.S., Van
            Stekelenburg,L., Eid,J.P., Senior,P.V., Kazenwadel,J.S.,
            Shandala,T., Saint,R., Smith,P.J. and Dziadek,M.A.
  TITLE     Identification and characterization of the STIM (stromal
            interaction molecule) gene family: coding for a novel class of
            transmembrane proteins
  JOURNAL   Biochem J 357 (Pt 3), 673-685 (2001)
   PUBMED   11463338
REFERENCE   8  (bases 1 to 4072)
  AUTHORS   Overall,M.L., Parker,N.J., Scarcella,D.L., Smith,P.J. and
            Dziadek,M.
  TITLE     Murine Stim1 maps to distal chromosome 7 and is not imprinted
  JOURNAL   Mamm Genome 9 (8), 657-659 (1998)
   PUBMED   9680387
REFERENCE   9  (bases 1 to 4072)
  AUTHORS   Parker,N.J., Begley,C.G., Smith,P.J. and Fox,R.M.
  TITLE     Molecular cloning of a novel human gene (D11S4896E) at chromosomal
            region 11p15.5
  JOURNAL   Genomics 37 (2), 253-256 (1996)
   PUBMED   8921403
REFERENCE   10 (bases 1 to 4072)
  AUTHORS   Oritani,K. and Kincade,P.W.
  TITLE     Identification of stromal cell products that interact with pre-B
            cells
  JOURNAL   J Cell Biol 134 (3), 771-782 (1996)
   PUBMED   8707854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139579.3 and AC102535.17.
            
            On Jun 5, 2018 this sequence version replaced NM_009287.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041944.1, BC021644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AC139579.3         53053-53787
            736-866             AC139579.3         139735-139865
            867-981             AC139579.3         171321-171435
            982-1093            AC139579.3         193601-193712
            1094-1209           AC102535.17        219016-219131       c
            1210-1387           AC102535.17        214865-215042       c
            1388-1565           AC102535.17        208850-209027       c
            1566-1733           AC102535.17        204240-204407       c
            1734-1834           AC102535.17        203580-203680       c
            1835-2070           AC102535.17        203063-203298       c
            2071-2137           AC102535.17        199429-199495       c
            2138-4072           AC102535.17        193062-194996       c
FEATURES             Location/Qualifiers
     source          1..4072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..4072
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /note="stromal interaction molecule 1"
                     /db_xref="GeneID:20866"
                     /db_xref="MGI:MGI:107476"
     exon            1..735
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             597..2654
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="stromal interaction molecule 1 isoform 1
                     precursor"
                     /protein_id="NP_033313.2"
                     /db_xref="CCDS:CCDS21530.1"
                     /db_xref="GeneID:20866"
                     /db_xref="MGI:MGI:107476"
                     /translation="MDVCARLALWLLWGLLLHQGQSLSHSHSEKNTGASSGATSEEST
                     EAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPT
                     VKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVIQWLITYVELPQYEETFRKLQLT
                     GHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVV
                     SIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVE
                     VEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKE
                     LESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLFG
                     TFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSL
                     VAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQL
                     GLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMGRAADEALNAMPSNGSHRLIEGVHPG
                     SLVEKLPDSPALAKKTFMALNHGLDKAHSLMELNPSVPPGGSPLLDSSHSLSPSSPDP
                     DTPSPVGDNRALQGSRNTRIPHLAGKKAMAEEDNGSIGEETDSSPGRKKFPLKIFKKP
                     LKK"
     exon            736..866
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            867..981
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1093
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1209
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1387
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1565
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1733
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1834
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2070
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2137
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..4072
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4045..4050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /note="hexamer: AATAAA"
     polyA_site      4072
                     /gene="Stim1"
                     /gene_synonym="SIM"
                     /note="major polyA site"
ORIGIN      
        1 gctgtcccgg gcctggcccg tgcgcgtccg cctgctgcac cggggcacca ggagccgcag
       61 aggtaccgga cccggcgggg gcgctgacct cggcctagga gtcttaggat cccggagaca
      121 tccgtgtctg ctggggcctg taggtcgcac gccgaagccc tagctgctga ggctcaccgc
      181 tgtttctcgg ggcgaggtca ggtgcccccc ttctctcctc tcttctctcc ctcccccacc
      241 tcagtgcggg cgggagattc tgcccgcctc ctcccgcagg ggtgcagcag gctgcggagc
      301 tgacagcggc cccgcagcca ccctgctcaa actctccgga agcagataga gctcaggccg
      361 ccgccgcagc cccggcggac ctacagttgg accggagact ccgatccttc tgcgtccaaa
      421 cttggggcac ttgaccttcg cttatcggag gaggtaagcc cgcaggtggc tggacagctg
      481 cggcgccgcg agggcatctt gctttggaac cgtcggctgc actccctgac tctgggattt
      541 gcttctggga tccaaaggtg tctacagcag gcgcatgttg actgagacct accgtcatgg
      601 atgtgtgcgc ccgtcttgcc ctgtggcttc tttgggggct ccttctgcat cagggccaga
      661 gtctcagcca tagtcacagt gaaaagaata caggagctag ctccggggcg acttctgaag
      721 agtctaccga agcagagttt tgccgaattg acaagcccct gtgccacagt gaggatgaga
      781 agctcagctt tgaggccgtc cgaaacatcc ataagctgat ggatgacgat gccaatggtg
      841 atgtggatgt ggaagaaagt gatgagttcc taagggaaga cctcaattac catgacccaa
      901 cagtgaaaca tagcaccttc catggtgagg ataagcttat cagcgtggag gacctgtgga
      961 aggcgtggaa gtcatcagaa gtgtacaact ggactgtgga tgaggtgata cagtggctca
     1021 ttacgtatgt ggagctgcca cagtatgagg aaaccttccg gaagttgcag cttactggcc
     1081 acgccatgcc aaggctagca gtaaccaaca ccaccatgac agggactgta ctgaagatga
     1141 cagatcggag ccacaggcag aagctgcagc tgaaggccct ggacacagtg ctgtttgggc
     1201 ctcctctctt gactcggcat aatcacctga aggacttcat gctggtggtg tctatcgtta
     1261 ttggtgtggg tggctgctgg tttgcctata tccagaaccg ttactctaag gagcacatga
     1321 agaaaatgat gaaggatctg gaagggttac accgggctga gcagagtctg catgaccttc
     1381 aggaaaggct gcacaaggcc caggaggagc accgaactgt ggaagtagag aaggtccacc
     1441 tggagaagaa gctgcgagat gagatcaacc ttgccaagca ggaagctcag cggctgaagg
     1501 agctgaggga gggtactgag aatgagagga gccgtcaaaa atatgctgag gaagagctgg
     1561 agcaggttcg ggaggccttg aggaaagcag agaaggagct ggaatcacac agctcatggt
     1621 atgctcctga ggccctgcag aagtggctgc agctgaccca tgaggtggag gtgcagtact
     1681 acaacatcaa gaagcaaaat gcagagaggc agctgctggt ggccaaggag ggggctgaga
     1741 aaataaaaaa gaagagaaac acgctttttg gtaccttcca tgtggcccac agctcttccc
     1801 tggatgatgt ggatcataaa atcctaactg ctaagcaagc tctgagtgag gtgacagcgg
     1861 cactgaggga gcgcctgcac cggtggcagc agatcgagat cctctgcggt ttccagattg
     1921 tcaataaccc cggcatccac tccttggtgg ctgctctcaa catcgacccc agctggatgg
     1981 gcagcacccg ccctaacccc gcccacttca tcatgactga cgatgtggat gacatggatg
     2041 aggagattgt gtcgcccttg tccatgcagt cccccagcct gcagagcagt gtccggcagc
     2101 gcctgacgga gccacagctt ggcctgggat ctcagaggga tttgacccat tccgattcgg
     2161 agtcctccct ccacatgagt gaccgccagc gtgtggcccc caagcctcct cagatgggcc
     2221 gtgctgcaga tgaagctctc aatgccatgc cttccaatgg cagccatcgg ctgattgagg
     2281 gggtccatcc aggatctctg gtggagaaac tgcctgacag ccctgctctg gccaagaaga
     2341 catttatggc gttgaaccat ggcctagaca aggcccacag cctgatggag ctgaacccct
     2401 cagtcccacc tggtggctcc ccacttttgg attcttccca ttctcttagc cccagttccc
     2461 cagacccaga cacgccatct ccagttgggg acaaccgagc tctgcagggt agccgaaaca
     2521 cacgaattcc ccacttggct ggcaagaagg caatggctga ggaggataat ggttccattg
     2581 gtgaggagac agactccagt ccaggcagga agaagtttcc tctcaaaatt tttaagaagc
     2641 ctcttaagaa gtaggcagac tagggtggta gtgttgagac agcctgtcct tccctgggtc
     2701 ttctgccttc acctcccttc ctttctttgc aatatctggc tcctagagtg gggcacagag
     2761 gggctggccc aagggcctgg gcactgtaca tatctgccct gctcatcctt ggtccttcat
     2821 cattatttat taactgacca ccatggcctg cctgtcggga aacccttcca cccatgggct
     2881 gctgctgtca catcttctcc acttcagtgc atgtcttagt tgctcttccc tcagttccca
     2941 ctccactttt ggggtccagc ttctgtctct gctgtcccag ttttgaggtt tggtttttgt
     3001 ttctgtctcc tgctttcagg ctcctctctc ccattactcc ccaacgatcc tagcagttgt
     3061 ggggaagata ggaggagtaa cttctgacac ctgtacctca gatctgttca tcctactcac
     3121 agccattctg cctaccccag actgggccac ggtcctgatc tctggggttt gttctatgga
     3181 agtgtggtag actggaggga acctcatcct ggagctcctt tggatctcca gggctccatt
     3241 cagggagtgg aaccaactcc cagggaacaa gtcaccagag ttttaaagag agaccaggct
     3301 tgtgattgat gggagagact tctcccagtt ggaggatgag tagatgccaa agctgtgggc
     3361 tgtaaggcag ttgccatttc tctcttgccc tgcccacacc tgccttcctc ttacctctgc
     3421 tcccctatat tgcaggagtg tatctcttaa gaggtgctgc cctgaagctc cccatcagca
     3481 tcagcactac tggggctcag ggcaactggc tcccctggct atgggagcca cagtcatgac
     3541 acagggctct tgtggagccc tgggcaagga tgttatattt gaaccaaaag acaaacagtt
     3601 ttaaaataaa aaaataaaaa ataaaataaa taaatctcct gaatttccca agtgcctgca
     3661 cagcatcctc cctttgtcag attccatttt tgtgttactg catagcctgg gccacaggct
     3721 taaaacagac acaattggtt tggggcaggg gtggagaagg aagatggtat atgtatgtga
     3781 aggctgctgt gtgaccactt ctccccccac acctcccatc ttccagacaa ctctctcctt
     3841 tacctgtttt tgctatggct gtaaaggtat ttttccctct gccccattct gtcatgcctg
     3901 taccctgagt tcctaatttg ggcctgggtt gggtgcagct ggggctggtc ttaggcgggt
     3961 gctaggctgt agactgcctt gatgccccct ggacaccctc acatgggttt ttctgtgtta
     4021 ttttcataag attctttgaa gtccaataaa gcatgtagga gattttaacc tc
//
