LOCUS       NM_009185               5333 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Scl/Tal1 interrupting locus (Stil), transcript variant
            1, mRNA.
ACCESSION   NM_009185
VERSION     NM_009185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5333)
  AUTHORS   Moussa,A.T., Cosenza,M.R., Wohlfromm,T., Brobeil,K., Hill,A.,
            Patrizi,A., Muller-Decker,K., Holland-Letz,T., Jauch,A., Kraft,B.
            and Kramer,A.
  TITLE     STIL overexpression shortens lifespan and reduces tumor formation
            in mice
  JOURNAL   PLoS Genet 20 (10), e1011460 (2024)
   PUBMED   39466849
  REMARK    GeneRIF: STIL overexpression shortens lifespan and reduces tumor
            formation in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5333)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5333)
  AUTHORS   David,A., Liu,F., Tibelius,A., Vulprecht,J., Wald,D., Rothermel,U.,
            Ohana,R., Seitel,A., Metzger,J., Ashery-Padan,R., Meinzer,H.P.,
            Grone,H.J., Izraeli,S. and Kramer,A.
  TITLE     Lack of centrioles and primary cilia in STIL(-/-) mouse embryos
  JOURNAL   Cell Cycle 13 (18), 2859-2868 (2014)
   PUBMED   25486474
  REMARK    GeneRIF: STIL(-/-) mouse embryos do not contain centrioles or
            primary cilia, suggesting that these organelles are not essential
            for mammalian development until mid gestation.
REFERENCE   4  (bases 1 to 5333)
  AUTHORS   Vulprecht,J., David,A., Tibelius,A., Castiel,A., Konotop,G.,
            Liu,F., Bestvater,F., Raab,M.S., Zentgraf,H., Izraeli,S. and
            Kramer,A.
  TITLE     STIL is required for centriole duplication in human cells
  JOURNAL   J Cell Sci 125 (Pt 5), 1353-1362 (2012)
   PUBMED   22349705
REFERENCE   5  (bases 1 to 5333)
  AUTHORS   Castiel,A., Danieli,M.M., David,A., Moshkovitz,S., Aplan,P.D.,
            Kirsch,I.R., Brandeis,M., Kramer,A. and Izraeli,S.
  TITLE     The Stil protein regulates centrosome integrity and mitosis through
            suppression of Chfr
  JOURNAL   J Cell Sci 124 (Pt 4), 532-539 (2011)
   PUBMED   21245198
  REMARK    GeneRIF: Stil protein regulates centrosome integrity and mitosis
            through suppression of Chfr.
REFERENCE   6  (bases 1 to 5333)
  AUTHORS   Gottgens,B., Gilbert,J.G., Barton,L.M., Grafham,D., Rogers,J.,
            Bentley,D.R. and Green,A.R.
  TITLE     Long-range comparison of human and mouse SCL loci: localized
            regions of sensitivity to restriction endonucleases correspond
            precisely with peaks of conserved noncoding sequences
  JOURNAL   Genome Res 11 (1), 87-97 (2001)
   PUBMED   11156618
REFERENCE   7  (bases 1 to 5333)
  AUTHORS   Izraeli,S., Lowe,L.A., Bertness,V.L., Good,D.J., Dorward,D.W.,
            Kirsch,I.R. and Kuehn,M.R.
  TITLE     The SIL gene is required for mouse embryonic axial development and
            left-right specification
  JOURNAL   Nature 399 (6737), 691-694 (1999)
   PUBMED   10385121
REFERENCE   8  (bases 1 to 5333)
  AUTHORS   Izraeli,S., Colaizzo-Anas,T., Bertness,V.L., Mani,K., Aplan,P.D.
            and Kirsch,I.R.
  TITLE     Expression of the SIL gene is correlated with growth induction and
            cellular proliferation
  JOURNAL   Cell Growth Differ 8 (11), 1171-1179 (1997)
   PUBMED   9372240
REFERENCE   9  (bases 1 to 5333)
  AUTHORS   Collazo-Garcia,N., Scherer,P. and Aplan,P.D.
  TITLE     Cloning and characterization of a murine SIL gene
  JOURNAL   Genomics 30 (3), 506-513 (1995)
   PUBMED   8825637
REFERENCE   10 (bases 1 to 5333)
  AUTHORS   Aplan,P.D., Lombardi,D.P. and Kirsch,I.R.
  TITLE     Structural characterization of SIL, a gene frequently disrupted in
            T-cell acute lymphoblastic leukemia
  JOURNAL   Mol Cell Biol 11 (11), 5462-5469 (1991)
   PUBMED   1922059
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ098467.1, AK049223.1,
            AK019471.1 and BC060706.1.
            
            On Jan 15, 2008 this sequence version replaced NM_009185.2.
            
            Summary: This gene encodes a centrosomal protein ubiquitously
            expressed in proliferating cells and during early embryonic
            development. Mice lacking the encoded protein die in utero with
            marked growth retardation, defects in the developing neural fold
            and randomization of left-right asymmetry. Alternative splicing of
            this gene results in multiple transcript variants. [provided by
            RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U36778.1, BC141175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                CJ098467.1         2-65
            65-3586             AK049223.1         2-3523
            3587-5325           AK019471.1         1938-3676
            5326-5333           BC060706.1         5349-5356
FEATURES             Location/Qualifiers
     source          1..5333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.73 cM"
     gene            1..5333
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /note="Scl/Tal1 interrupting locus"
                     /db_xref="GeneID:20460"
                     /db_xref="MGI:MGI:107477"
     exon            1..230
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            231..315
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..4093
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SCL-interrupting locus protein homolog; Tal1 interrupting
                     locus"
                     /codon_start=1
                     /product="SCL-interrupting locus protein homolog isoform
                     1"
                     /protein_id="NP_033211.2"
                     /db_xref="CCDS:CCDS18485.1"
                     /db_xref="GeneID:20460"
                     /db_xref="MGI:MGI:107477"
                     /translation="MNTRFPSSKMVPFHFPPSKLALWNPMPIGECIYLHLSYYRKPKL
                     MVTEKAIRLAYRHAKQNKKNVPCFLLGSLTVDEDEEGVTLTIDRFDPGREIPECLERT
                     PTASLPGDFLIPCRVHIQGLGSRDVIVHNADDFSSALKALQYHVCSKDFLDCGKLLCL
                     RAQITPRESLDGVDFNLQWTAVTLANSFKCVPVKPIPIIPTALARNLSSNLNISQVQG
                     TYKHGYITMDETRKLLLLLQSDPKVSSLPLVGIWLAGIIHVYSPQVWACCLRYMFSSS
                     IQERVFSESGNFIIVLYSLTHKEPEFYECLPCESRTPDLQFQLLTNKETLHLFNNVEP
                     SGKNPIHFELSAESQDAEAEAEVLSKISKTLPVKRSSQKLSPGKIPINKHDTDLEDED
                     FSPRPIPSPHPVSQKISKVQPSVPELSLVLDNNFTESSNQSNPLEMMTVENPLLIKPS
                     QPELCDAKHSSEATTGEPFRRGPTNQLSQDTALRQSRGKQSSTCKKESLQFRNTNAKP
                     SLSVPSPDVAEKLQAVSAGSMQKEDYPVRPSTLDSRQPSLAPQAQPHNLVFSTHNSTR
                     PMELQVPTPSLPSYYPTNVCSCCQHHGHIQYSTINSWQGNTVGSIQDLRSESLPKHAF
                     FHSSGCPSLCPNAIYSSSSPVSMKQGGMGAYSPHSNGEPSPVAGPSHVDSCVPHPCAM
                     CMHMPNTAPDNGMMGLSPDAYRFVTEQDRQLRLLQAQIQRLLEAQSLDPGSHKTVATV
                     EDTVKAAKQMELVSMEAQSSPGLHMRKSVSIAVSTGASLFWNAAGDDQEPDSQPKQDD
                     TKISSEDMNFSVDINNEATSLPGSASSLKAVDIPSFEESNLAVEEVNQPLPESNSSSE
                     QSKEPGVPVFFPNALLAESVSMCLQTAPTEGASNSTELPQGTKDEPYRPSDNQKIYQD
                     LLGQVNHLLSNASQETEEPPTKAVVTNRECAKTQNTHHARKKRHNSGLVDKDCVLSAT
                     IKQLRSLGVKIDSPTKVKKNEQKVDHASVLACISPEAVISGLNYMSFGNVGMSSLSPT
                     GVDLSMEANAIALKYLSENQLSQLSLARSKQNNGDSSVGLLHINSDRSTVGLSLVSPS
                     NMSFATKKYMKRYGLLQSSDNSEDEEEPPSHADSESDHVLNRNPACRPVQCGHEKEPS
                     WNACEIAQCSDCGSADTRTDVPVLRNITNQAVQPRATEHLNEDSAISLRNLKPNPAMN
                     LRTGKAEFTHHPEKENERDIAVFPGTLPSPETLKQMNSMDSVGTFLDVKRLRQLPKLF
                     "
     exon            316..423
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            424..536
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            537..724
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            725..972
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1056
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1143
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1294
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1410
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1525
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..2461
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2630
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2859
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3052
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3303
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..5333
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5305..5310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /note="hexamer: ATTAAA"
     polyA_site      5333
                     /gene="Stil"
                     /gene_synonym="Sil"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgccct ttggttccct ccagcgagcg cttgccgcct cggttcccgc gaccccaacg
       61 tcccagaggc ggggccgcag tcatctgaga cgctacctgg atcctgactc tgcgtgccca
      121 acaaacgggc ccaacaacca aaccctagct tggcggcggc cgtgacaaca gcgacggtgg
      181 atctttgagc tcctgattcc ccgaggcgcc ctacgggccc gggaagcacg gtactgagga
      241 ttacaaattg actaaatcac tcaccaaata tagagcctgt agttccttca gcctgtaatt
      301 ccagatgaat accaggtttc cttcaagcaa gatggtacct ttccattttc ccccatcaaa
      361 attggcactt tggaacccaa tgccaattgg agagtgcatc tacttgcatc tcagttacta
      421 cagaaagcca aagcttatgg taactgaaaa ggccatccga cttgcttatc gtcatgctaa
      481 gcagaataaa aaaaatgtgc catgcttctt acttggttct ctcacagtgg atgaagatga
      541 agaaggtgtg acattgacca tagatcgctt tgatcctggt cgagaaatac ctgaatgctt
      601 agaaagaact cctactgctt ctcttcctgg agattttttg attccctgca gagttcatat
      661 tcaaggactt ggttcaaggg atgtgatagt tcataatgca gatgacttca gttcagcttt
      721 aaaggcttta caataccatg tgtgtagcaa agatttcttg gactgtggaa agttgctttg
      781 cctacgagcc caaatcaccc ccagggagag tttagatggt gtggatttta acttgcaatg
      841 gacagcagta actctagcaa attccttcaa gtgtgtgcct gtgaagccta tccccattat
      901 ccctacagca cttgcaagaa acctaagtag taatttgaat atttctcaag ttcagggaac
      961 ctataaacat ggatatatta ctatggatga aactcgcaaa ctgttacttt tgctgcaatc
     1021 agatcccaag gtctcttctc tcccgttagt gggaatctgg ctggctggaa ttatacatgt
     1081 ctatagccct caggtatggg cttgctgctt gagatacatg ttcagttctt ccattcagga
     1141 aagggttttt tcagaatctg gaaatttcat catagttctt tattcattga cacataagga
     1201 gcctgagttt tatgagtgcc ttccttgtga gagtaggacg cccgaccttc agtttcagtt
     1261 actaaccaac aaggagactt tgcatctttt caataacgtt gaaccttctg gcaaaaaccc
     1321 aatccatttt gaactcagtg ccgagagtca agatgccgaa gccgaggcag aggttcttag
     1381 caagatttcc aagactcttc cagtgaagag atcctcccaa aaattatctc ctgggaaaat
     1441 accaataaat aagcatgaca ctgaccttga agatgaagac ttttctccaa gaccgattcc
     1501 tagtcctcac ccagtgagtc agaagatttc taaggtccag ccatctgttc ctgaactttc
     1561 gctcgtgtta gacaacaact tcacagagtc aagtaaccag tctaaccctt tggaaatgat
     1621 gactgtggag aatcctttat tgattaagcc atcccagcct gagctttgtg atgccaaaca
     1681 cagctcagaa gctaccactg gggagccttt ccggaggggc ccaacaaatc agttaagtca
     1741 ggacactgct ttaagacaga gcagagggaa gcagtcatct acctgtaaga aagagagtct
     1801 ccagttcagg aacactaatg ctaaaccatc tctcagtgtg ccatctcctg atgtagctga
     1861 gaaacttcaa gcagtttctg ctgggagcat gcaaaaggaa gactaccctg tgagaccttc
     1921 cacactggac tcgaggcagc cctctcttgc tccacaagcc cagccacaca atcttgtttt
     1981 ttcaactcat aattcaacaa gaccaatgga gcttcaagtg cccactcctt cattaccatc
     2041 ctactatccc acaaacgtct gcagctgttg tcagcatcat ggccatattc agtatagtac
     2101 aataaattct tggcagggaa atacagtagg gtctattcaa gacctgcgat ctgagtccct
     2161 tccaaaacat gccttctttc actcaagtgg atgcccatct ctgtgtccta atgccatcta
     2221 ctcgtcaagt agccctgtta gcatgaagca aggaggcatg ggtgcctatt ctccccatag
     2281 caatggagaa ccgtctcctg tggcaggacc ttcacatgtg gactcgtgtg tgccacatcc
     2341 ctgtgccatg tgcatgcaca tgcccaatac agcaccagac aatggcatga tgggactgtc
     2401 tcctgatgca taccgttttg tcacagagca agacaggcag ctgagactac ttcaggcaca
     2461 gatccagcgc ttattagaag cacaatctct agatcctggc tcccataaga cagtagccac
     2521 cgtggaagac accgtgaaag cagcaaaaca aatggagctg gtttccatgg aagcacagtc
     2581 ttcgcctggc ttgcacatga gaaaaagtgt aagcattgct gtgagcacag gtgctagctt
     2641 gttttggaat gcagcaggtg atgatcaaga gcccgactca cagccgaagc aagatgatac
     2701 caagatttcc agtgaagaca tgaatttttc tgtagatatt aataatgaag cgacaagtct
     2761 tcctggtagt gcatcttcct taaaagcagt tgacattcct agttttgaag aaagcaacct
     2821 tgctgtggag gaagttaatc agccacttcc tgaatccaac agctcttcag agcagagcaa
     2881 agaacctggt gttcctgtgt tcttcccaaa tgcattgctg gctgaaagtg tgagcatgtg
     2941 cttacagact gcgccaacag agggagccag taacagcact gaattaccac agggaacaaa
     3001 agatgagcct taccggccat cagataacca gaaaatttac caggacttgt tgggccaagt
     3061 gaaccaccta ctaagtaacg cctcccaaga aaccgaagaa ccacctacca aagcggtagt
     3121 taccaaccgt gaatgcgcca agacccaaaa tactcaccat gcaaggaaaa aaagacacaa
     3181 ttcaggactg gtagacaaag attgtgtact cagtgcaact attaaacagc taaggagcct
     3241 aggagtgaaa atcgactctc ccactaaagt gaagaaaaat gaacagaaag tggatcatgc
     3301 cagtgttttg gcctgcatca gcccggaagc agtgatctct ggattaaact acatgtcgtt
     3361 tggtaatgtt ggcatgagca gcctaagtcc cactggtgtg gatctgagca tggaggccaa
     3421 tgccattgct ctgaagtact taagtgaaaa ccagctgtca caactgtctc ttgctcggtc
     3481 aaagcagaat aacggtgact cctctgtcgg ccttctacat attaattcag acaggagtac
     3541 agtggggctt agcttagttt caccaagcaa catgtcattt gcaaccaaaa aatacatgaa
     3601 gaggtatgga ctcttacaaa gcagtgacaa tagtgaggat gaagaggagc ctcccagcca
     3661 cgcagatagt gagagcgacc atgtgttgaa cagaaaccca gcatgcagac ctgtgcaatg
     3721 tggtcatgag aaagagcctt cttggaatgc ctgtgaaata gctcagtgct ctgactgtgg
     3781 ctctgcggac acacgcacag atgtgccagt actgagaaat atcacaaatc aagctgtgca
     3841 gcctagagca acagagcact tgaatgaaga ctctgctatt tcattaagga atcttaagcc
     3901 aaacccggca atgaacctcc gaactggaaa ggcagagttt actcatcatc ccgagaagga
     3961 aaatgaaaga gacattgcag tttttcccgg aaccttgcca tctcctgaga ctttaaaaca
     4021 aatgaatagc atggattctg tgggcacctt cttagacgta aagcgtctca gacagttacc
     4081 taagttattt taactcttca tttctctttt tgtggtgtga ggactgggtg tgtattgatg
     4141 gcacttaaga aatccagacc tttgggatta agacagggtt tctctgtgta gccctggctg
     4201 tccgggaact caatccatag accagggtag cctcgaactc acagagatcc acctacctct
     4261 gccttccagg tgctaagtag gactaaaggc ttgcatcatt gcctggcggc catgaccttt
     4321 ggaatttcta atacctttta gagtcttttc cctattagta gcaaattaac attggctggg
     4381 ggttgggggt ggttgaccca gttgtgaggt ggcttcttag tgggaaggct gggtttattc
     4441 agcatcactg aacctaaaac agaagcaaga ctctaagacc aggtgccgca gctaatcaag
     4501 ttcaaatgtg tttccctgta ccccagggcc ttgcatttgc taatgggctc cattactgag
     4561 cctgaccact gagctatatc ctcaactgta gattttttaa aagaaggtct caggtcaatc
     4621 tgtagcctag gctggcttca gacttagaat tctgccttcc tcgtctggct caggtatgca
     4681 ctttaccctg tgtctcccaa aaatagtttt tttacataat catagtttgt ttccaaacta
     4741 agaaattaca tagacacaat actgcataaa cagcagaact tttcattgcc ttgggttctt
     4801 attggtggga tgaggcagtg ctggggttga acccaggtac ctcacacaaa gtgctatagc
     4861 actgaacttt atacctcagt ccatgaggtg ttctgtgtac tcattgattc acagtttttg
     4921 tgtatagata catgaaatta tatcgcatag cttccactaa cctaagacct gtcctccctc
     4981 catccctacc gatagcccta ccatcaccag aatgttttta tcattttaag aacatttcat
     5041 aaacagaatt gtacttttaa aaacaatttt ttatttagca ttctaccttt tgaaatgtac
     5101 tgtcttactc caaataatat cctgagatct atccaagtgt tgggtgtgtt ggtaattaat
     5161 tcttttctta ttctttactt ctattccccc ccccccaagt tgtttcaaat tgttgtttcc
     5221 aaagaaaaaa gaaaagaaaa aaaaaaaccc tcattgactt gaaagattta ggtttctgct
     5281 gaagttaaaa tgtggttgcc ctgtattaaa gcttgtctca taactgaaaa aaa
//
